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  1. Article ; Online: Novel dyssynchrony evaluation by M-mode imaging in left bundle branch block and the application to predict responses for cardiac resynchronization therapy.

    Sakamaki, Fumiko / Seo, Yoshihiro / Atsumi, Akiko / Yamamoto, Masayoshi / Machino-Ohtsuka, Tomoko / Kawamura, Ryo / Yamasaki, Hiro / Igarashi, Miyako / Sekiguchi, Yukio / Ishizu, Tomoko / Aonuma, Kazutaka

    Journal of cardiology

    2014  Volume 64, Issue 3, Page(s) 199–206

    Abstract: Background: To determine an appropriate M-mode method in assessing left ventricular (LV ... the maximum displacement of the posterior. If an early septal point was not present, anatomical M-mode was ... of posterolateral wall on M-mode images were the appropriate dyssynchrony parameter, and could improve ...

    Abstract Background: To determine an appropriate M-mode method in assessing left ventricular (LV) dyssynchrony in left bundle branch block (LBBB), and to assess feasibility of the method to predict cardiac resynchronization therapy (CRT) responses.
    Methods and results: Fifty-one patients with LBBB were enrolled. Among them 31 patients underwent CRT. In addition to original septal to posterior wall motion delay (SPWMD), first peak-SPWMD was proposed as time of difference between the first septal displacement and the maximum displacement of the posterior. If an early septal point was not present, anatomical M-mode was used to visualize an early septal displacement spreading scan-area until inferoseptal wall. CRT responders were defined as LV end-systolic volume reduction (>15%) at 6 months after CRT. Twenty patients (65%) were identified as CRT responders. First peak-SPWMD in responders was significantly higher than those in nonresponders, although SPWMD did not differ between groups. Strong predicting ability of first peak-SPWMD was revealed (first peak-SPWMD: 80/90/83%; SPWMD: 35/100/58%), and area under the curve in receiver operating characteristic analysis of first peak-SPWMD (0.88) was significantly higher than that of SPWMD (0.61) (p<0.05).
    Conclusion: In patients with LBBB, time differences between early septal and delayed displacement of posterolateral wall on M-mode images were the appropriate dyssynchrony parameter, and could improve the predictive ability for CRT responses.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Bundle-Branch Block/diagnostic imaging ; Bundle-Branch Block/therapy ; Cardiac Resynchronization Therapy ; Echocardiography/methods ; Feasibility Studies ; Female ; Forecasting ; Humans ; Male ; Middle Aged ; Treatment Outcome
    Language English
    Publishing date 2014-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639364-0
    ISSN 1876-4738 ; 0386-2887 ; 0914-5087
    ISSN (online) 1876-4738
    ISSN 0386-2887 ; 0914-5087
    DOI 10.1016/j.jjcc.2013.12.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Late life-threatening arrhythmia in patients with Brugada syndrome: Results from long-term follow-up in a large Japanese cohort.

    Shinohara, Tetsuji / Takagi, Masahiko / Kamakura, Tsukasa / Komatsu, Yuki / Aizawa, Yoshiyasu / Sekiguchi, Yukio / Yokoyama, Yasuhiro / Aihara, Naohiko / Hiraoka, Masayasu / Aonuma, Kazutaka

    Journal of cardiovascular electrophysiology

    2024  Volume 35, Issue 4, Page(s) 701–707

    Abstract: Introduction: Most patients with Brugada syndrome (BrS) are first diagnosed in their 40s, with sudden cardiac death (SCD) often occurring in their 50s. Ventricular fibrillation (VF) may occur in some patients with BrS despite having been asymptomatic ... ...

    Abstract Introduction: Most patients with Brugada syndrome (BrS) are first diagnosed in their 40s, with sudden cardiac death (SCD) often occurring in their 50s. Ventricular fibrillation (VF) may occur in some patients with BrS despite having been asymptomatic for a long period. This study aimed to assess the incidence and risk factors for late life-threatening arrhythmias in patients with BrS.
    Methods: Patients with BrS (n = 523; mean age, 51 ± 13 years; male, n = 497) were enrolled. The risk of late life-threatening arrhythmia was investigated in 225 patients who had experienced no cardiac events (CEs: SCD or ventricular tachyarrhythmia) for at least 10 years after study enrollment. The incidence of CEs during the follow-up period was examined.
    Results: During the follow-up of the 523 patients, 59 (11%) experienced CEs. The annual incidences of CEs were 2.87%, 0.77%, and 0.09% from study enrollment to 3, 3-10, and after 10 years, respectively. Among 225 patients who had experienced no CEs for at least 10 years after enrollment, four patients (1.8%) subsequently experienced CEs. Kaplan-Meier analysis revealed significant differences in the incidence of late CEs between patients with and without a history of symptoms (p = .032). The positive and negative predictive values of late CEs for the programmed electrical stimulation (PES) test were 2.9% and 100%, respectively.
    Conclusion: Our results suggest that patients with BrS who are asymptomatic and have no ventricular tachycardia/VF inducibility by PES are at extremely low risk of experiencing late life-threatening arrhythmias.
    MeSH term(s) Humans ; Male ; Adult ; Middle Aged ; Brugada Syndrome/diagnosis ; Brugada Syndrome/therapy ; Brugada Syndrome/complications ; Follow-Up Studies ; Japan/epidemiology ; Electrocardiography/methods ; Arrhythmias, Cardiac/complications ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/epidemiology ; Ventricular Fibrillation/therapy ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.16205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The R Wave Amplitude in Lead aVL Could Predict Successful Catheter Ablation of Ventricular Arrhythmias Originating below the His Bundle Region of the Right Ventricle.

    Nodera, Minoru / Igarashi, Miyako / Hasegawa, Kanae / Aonuma, Kazutaka / Nogami, Akihiko / Tada, Hiroshi

    International heart journal

    2023  Volume 64, Issue 4, Page(s) 614–622

    Abstract: Radiofrequency catheter ablation (RFCA) to treat ventricular arrhythmias (VAs) originating below the His bundle (HB) region of the right ventricular (RV) septum could impair the atrioventricular node conduction. This study aimed to clarify the parameters ...

    Abstract Radiofrequency catheter ablation (RFCA) to treat ventricular arrhythmias (VAs) originating below the His bundle (HB) region of the right ventricular (RV) septum could impair the atrioventricular node conduction. This study aimed to clarify the parameters of the 12-lead electrocardiography that predict successful RFCA of VAs originating from this region. This study included 20 consecutive patients (13 men; mean age, 68 ± 7 years) with monomorphic VAs in whom the earliest ventricular activation during the VA was below the HB region of the RV septum. According to the ablation results, the patients were divided into two groups: successful ablation (S-group; n = 10) and failed ablation groups (F-group; n = 10). The electrocardiographic parameters during the VAs and RFCA results were assessed. The R wave amplitudes in leads aVL (P = 0.001) and I (P = 0.010) in the S-group were both smaller than those in the F-group. In addition, the S-group had smaller negative deflection amplitudes in leads III (P = 0.002) and aVF (P = 0.003) than the F-group. According to the receiver operating characteristic curve analysis, the most useful electrocardiographic parameter for predicting successful ablation was the R wave amplitude in lead aVL (area under the curve, 0.895; P < 0.001); a cutoff value of < 1.3 mV predicted a successful RFCA with the highest accuracy (sensitivity, 90%; specificity, 80%; positive predictive value, 82%; negative predictive value, 89%). The R wave amplitude in lead aVL was the most useful parameter for predicting a successful RFCA to treat VAs originating below the HB region of the RV septum.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Heart Ventricles ; Bundle of His/surgery ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/surgery ; Arrhythmias, Cardiac ; Electrocardiography/methods ; Catheter Ablation/methods ; Treatment Outcome
    Language English
    Publishing date 2023-07-14
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2187806-7
    ISSN 1349-3299 ; 1349-2365
    ISSN (online) 1349-3299
    ISSN 1349-2365
    DOI 10.1536/ihj.23-054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Magnetocardiographic risk stratification in patients with Brugada-pattern ST-elevation.

    Yoshida, Kentaro / Inaba, Takeshi / Horigome, Hitoshi / Nogami, Akihiko / Aonuma, Kazutaka / Ieda, Masaki

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

    2023  Volume 67, Issue 1, Page(s) 35–37

    MeSH term(s) Humans ; Magnetocardiography ; ST Elevation Myocardial Infarction ; Arrhythmias, Cardiac ; Ventricular Fibrillation ; Risk Assessment ; Electrocardiography ; Brugada Syndrome/diagnosis
    Language English
    Publishing date 2023-09-11
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1329179-8
    ISSN 1572-8595 ; 1383-875X
    ISSN (online) 1572-8595
    ISSN 1383-875X
    DOI 10.1007/s10840-023-01641-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Performance of using opposing homozygotes for paternity testing in Japanese Black cattle.

    Komiya, Ryota / Ogawa, Shinichiro / Aonuma, Tatsuya / Satoh, Masahiro

    Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie

    2021  Volume 139, Issue 1, Page(s) 113–124

    Abstract: Genome-wide single nucleotide polymorphism (SNP) markers in Japanese Black cattle enable genomic prediction and verifying parent-offspring relationships. We assessed the performance of opposing homozygotes (OH) for paternity testing in Japanese Black ... ...

    Abstract Genome-wide single nucleotide polymorphism (SNP) markers in Japanese Black cattle enable genomic prediction and verifying parent-offspring relationships. We assessed the performance of opposing homozygotes (OH) for paternity testing in Japanese Black cattle, using SNP genotype information of 50 sires and 3,420 fattened animals, 1,945 of which were fathered by the 50 genotyped sires. The number of OH was counted for each sire-progeny pair in 28,764 SNPs with minor allele frequencies of ≥0.05 in this population. Across all pairs of animals, the number of OH tended to increase as the pedigree-based coefficient of relationship decreased. With a threshold of 288 (1% of SNPs) for paternity testing, most sire-progeny pairs were detected as true relationships. The frequency of Mendelian inconsistencies was 2.4%, reflecting the high accuracy of pedigree information in Japanese Black cattle population. The results indicate the utility of OH for paternity testing in Japanese Black cattle.
    MeSH term(s) Animals ; Cattle/genetics ; Gene Frequency ; Genotype ; Homozygote ; Paternity ; Pedigree ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2021-09-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631363-2
    ISSN 1439-0388 ; 0044-3581 ; 0931-2668 ; 1742-4488
    ISSN (online) 1439-0388
    ISSN 0044-3581 ; 0931-2668 ; 1742-4488
    DOI 10.1111/jbg.12649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Anticancer effects of OK-432 (2). Anticancer actions of M phi activated by OK-432].

    Saito, M / Aonuma, E / Noda, T / Nakadate, I / Nanjo, M / Ebina, T / Ishida, N

    Gan to kagaku ryoho. Cancer & chemotherapy

    1983  Volume 10, Issue 5, Page(s) 1363–1371

    Abstract: Mouse spleen cells (DDI, BALB/c, 10 weeks old), either pretreated in vitro with 100 u/ml of OK-432-induced IFN gamma for 18 hr or obtained from mice 24 or 48 hr after iv injection of OK-432 (100 micrograms/mouse), were examined for their antitumor effect ...

    Abstract Mouse spleen cells (DDI, BALB/c, 10 weeks old), either pretreated in vitro with 100 u/ml of OK-432-induced IFN gamma for 18 hr or obtained from mice 24 or 48 hr after iv injection of OK-432 (100 micrograms/mouse), were examined for their antitumor effect by Winn assay against Meth-A tumor cells in BALB/c mice. Both of these spleen cells preparations clearly inhibited the growth of admixed Meth-A cells. In order to determine the effector subpopulation, these spleen cells were treated with either anti-Thy-1 monoclonal antibody plus complement, anti-asialo GM1 serum plus complement or in combination of adherence on plastic plates followed by Sephadex G-10 column treatment. As a result, the effector activity in Winn assay was lost only after the removal of macrophages through plastic plate adherence and Sephadex G-10 column treatment, but not after anti-Thy-1 or anti-asialo GM1 treatment, with either spleen cell populations. Moreover, after anti-Thy-1 treatment, the effector activity of spleen cells increased, suggesting the presence of suppressor T cells in these spleen cell populations. The growth of Meth-A cells was not only inhibited by these activated macrophages in Winn assay but also by adoptive transfer of OK-432-induced cytotoxic spleen macrophages, intralegionally 4 days after the implantation of 1 X 10(6) Meth-A cells. In conclusion, the effector cells which appeared in mouse spleens after iv injection of OK-432 were found to be cytotoxic macrophages, which inhibited the growth of Meth-A cells, both in vitro and in vivo. IFN gamma induced by OK-432 in mouse spleen cell cultures produced the same cytotoxic macrophages when added to the spleen cell cultures, at a dose as low as 100 u/ml. All of our evidence suggests that the systemic action of OK-432 can be explained by the effect of IFN gamma induction.
    MeSH term(s) Animals ; Biological Products/pharmacology ; Cell Division/drug effects ; Cytotoxicity, Immunologic ; Interferon Inducers/pharmacology ; Macrophages/drug effects ; Macrophages/immunology ; Mice ; Mice, Inbred BALB C ; Picibanil/pharmacology ; Sarcoma, Experimental/immunology
    Chemical Substances Biological Products ; Interferon Inducers ; Picibanil (39325-01-4)
    Language Japanese
    Publishing date 1983-05
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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  7. Article: Electrical, structural, and autonomic atrial remodeling underlies atrial fibrillation in inflammatory atrial cardiomyopathy.

    Murakata, Yoshiko / Yamagami, Fumi / Murakoshi, Nobuyuki / Xu, DongZhu / Song, Zhonghu / Li, Siqi / Okabe, Yuta / Aonuma, Kazuhiro / Yuan, ZiXun / Mori, Haruka / Aonuma, Kazutaka / Tajiri, Kazuko / Ieda, Masaki

    Frontiers in cardiovascular medicine

    2023  Volume 9, Page(s) 1075358

    Abstract: Background: There is growing evidence indicating a close relationship between inflammation and atrial fibrillation (AF). Although underlying inflammatory atrial cardiomyopathy may contribute to the development of AF, the arrhythmogenic remodeling caused ...

    Abstract Background: There is growing evidence indicating a close relationship between inflammation and atrial fibrillation (AF). Although underlying inflammatory atrial cardiomyopathy may contribute to the development of AF, the arrhythmogenic remodeling caused by atrial inflammation has not been elucidated in detail. Herein, we examined electrical, structural, and autonomic changes in the atria in a mouse model of autoimmune myocarditis.
    Methods: BALB/c mice were immunized with cardiac myosin peptide (MyHC-α
    Results: The mice immunized with MyHC-α
    Conclusion: Inflammatory atrial cardiomyopathy promotes susceptibility to AF via arrhythmogenic electrical, structural, and autonomic remodeling of the atria.
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1075358
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  8. Article ; Online: An accidental sheath insertion into the internal thoracic artery during the subclavian vein puncture: bailed out by the sandwich coiling strategy.

    Kuroki, Kenji / Igarashi, Miyako / Aonuma, Kazutaka / Ieda, Masaki

    European heart journal. Case reports

    2020  Volume 4, Issue 5, Page(s) 1–2

    Language English
    Publishing date 2020-08-16
    Publishing country England
    Document type Journal Article
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytaa278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Termination of long-duration ventricular fibrillation by catheter ablation.

    Hasegawa, Tomoaki / Nogami, Akihiko / Aonuma, Kazutaka / Ieda, Masaki

    HeartRhythm case reports

    2020  Volume 6, Issue 12, Page(s) 955–959

    Language English
    Publishing date 2020-10-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2020.10.002
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  10. Article ; Online: Immediate pharmacotherapy intensification after cardiac resynchronization therapy: incidence, characteristics, and impact.

    Ogawa, Kojiro / Yamasaki, Hiro / Aonuma, Kazutaka / Otani, Masafumi / Hattori, Ai / Baba, Masako / Yoshida, Kentaro / Igarashi, Miyako / Nishina, Hidetaka / Suzuki, Kou / Nogami, Akihiko / Ieda, Masaki

    ESC heart failure

    2024  

    Abstract: ... 47.8 ± 24.7 mL/min/1.73 m: Conclusions: Immediate intensification of HF medication was achieved ...

    Abstract Aims: Cardiac resynchronization therapy (CRT) is an established treatment for drug-refractory heart failure (HF) in patients with left bundle branch block (LBBB). Acute haemodynamic improvement after CRT implantation may enable the intensification of HF medication soon thereafter. Immediate pharmacotherapy intensification (IPI) after CRT implantation achieves a synergetic effect, possibly leading to a better prognosis. This study aimed to explore the incidence, characteristics, and impact of IPI on real-world outcomes among CRT recipients with a history of hospitalization for acute HF.
    Methods and results: This multicentre retrospective study enrolled CRT recipients with LBBB morphology, a QRS width ≥120 ms, a left ventricular ejection fraction ≤35%, and New York Heart Association II-IV HF symptoms. All patients had previous HF hospitalizations within the previous year and received guideline-directed medical therapy before CRT implantation. Patient baseline characteristics, including HF medication, were collected. IPI was defined as the intensification of beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and mineralocorticoid receptor antagonists within 30 days of CRT implantation. The primary endpoint was all-cause death or first hospitalization for HF; the secondary endpoint was all-cause death. We enrolled 194 patients (75% male; mean age, 65 ± 13 years; 78% with non-ischaemic cardiomyopathy). One hundred five (54%) patients received IPI. Patients who received IPI exhibited a significantly shorter QRS duration (159 ± 26 vs. 171 ± 32 ms; P = 0.004), higher estimated glomerular filtration rate (55.2 ± 20.0 vs. 47.8 ± 24.7 mL/min/1.73 m
    Conclusions: Immediate intensification of HF medication was achieved in 54% of CRT recipients and was significantly higher in patients without excessive QRS prolongation, preserved renal function, and dilated cardiomyopathy than others. In patients with LBBB morphology and QRS ≥ 120 ms, IPI was associated with a significantly better prognosis and fewer HF hospitalizations after CRT implantation than others.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14737
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