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Article ; Online: A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder.

Szot, Justin O / Cuny, Hartmut / Martin, Ella Mma / Sheng, Delicia Z / Iyer, Kavitha / Portelli, Stephanie / Nguyen, Vivien / Gereis, Jessica M / Alankarage, Dimuthu / Chitayat, David / Chong, Karen / Wentzensen, Ingrid M / Vincent-Delormé, Catherine / Lermine, Alban / Burkitt-Wright, Emma / Ji, Weizhen / Jeffries, Lauren / Pais, Lynn S / Tan, Tiong Y /

The Journal of clinical investigation

2024 Volume 134, Issue 4

Abstract: Nicotinamide adenine dinucleotide (NAD) is essential for embryonic development. To date, biallelic loss-of-function variants in 3 genes encoding nonredundant enzymes of the NAD de novo synthesis pathway - KYNU, HAAO, and NADSYN1 - have been identified in ...

Abstract	Nicotinamide adenine dinucleotide (NAD) is essential for embryonic development. To date, biallelic loss-of-function variants in 3 genes encoding nonredundant enzymes of the NAD de novo synthesis pathway - KYNU, HAAO, and NADSYN1 - have been identified in humans with congenital malformations defined as congenital NAD deficiency disorder (CNDD). Here, we identified 13 further individuals with biallelic NADSYN1 variants predicted to be damaging, and phenotypes ranging from multiple severe malformations to the complete absence of malformation. Enzymatic assessment of variant deleteriousness in vitro revealed protein domain-specific perturbation, complemented by protein structure modeling in silico. We reproduced NADSYN1-dependent CNDD in mice and assessed various maternal NAD precursor supplementation strategies to prevent adverse pregnancy outcomes. While for Nadsyn1+/- mothers, any B3 vitamer was suitable to raise NAD, preventing embryo loss and malformation, Nadsyn1-/- mothers required supplementation with amidated NAD precursors (nicotinamide or nicotinamide mononucleotide) bypassing their metabolic block. The circulatory NAD metabolome in mice and humans before and after NAD precursor supplementation revealed a consistent metabolic signature with utility for patient identification. Our data collectively improve clinical diagnostics of NADSYN1-dependent CNDD, provide guidance for the therapeutic prevention of CNDD, and suggest an ongoing need to maintain NAD levels via amidated NAD precursor supplementation after birth.
MeSH term(s)	Female ; Pregnancy ; Humans ; Mice ; Animals ; NAD/metabolism ; Niacinamide ; Phenotype ; Metabolome ; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/metabolism
Chemical Substances	NAD (0U46U6E8UK) ; Niacinamide (25X51I8RD4) ; NADSYN1 protein, human (EC 6.3.5.-) ; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor (EC 6.3.5.-)
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI174824
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Article ; Online: CT-based radiomics features in the prediction of thyroid cartilage invasion from laryngeal and hypopharyngeal squamous cell carcinoma.

Guo, Ran / Guo, Jian / Zhang, Lichen / Qu, Xiaoxia / Dai, Shuangfeng / Peng, Ruchen / Chong, Vincent F H / Xian, Junfang

Cancer imaging : the official publication of the International Cancer Imaging Society

2020 Volume 20, Issue 1, Page(s) 81

Abstract: Background: Laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) with thyroid cartilage invasion are considered T4 and need total laryngectomy. However, the accuracy of preoperative diagnosis of thyroid cartilage invasion remains lower. ... ...

Abstract	Background: Laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) with thyroid cartilage invasion are considered T4 and need total laryngectomy. However, the accuracy of preoperative diagnosis of thyroid cartilage invasion remains lower. Therefore, the purpose of this study was to assess the potential of computed tomography (CT)-based radiomics features in the prediction of thyroid cartilage invasion from LHSCC. Methods: A total of 265 patients with pathologically proven LHSCC were enrolled in this retrospective study (86 with thyroid cartilage invasion and 179 without invasion). Two head and neck radiologists evaluated the thyroid cartilage invasion on CT images. Radiomics features were extracted from venous phase contrast-enhanced CT images. The least absolute shrinkage and selection operator (LASSO) and logistic regression (LR) method were used for dimension reduction and model construction. In addition, the support vector machine-based synthetic minority oversampling (SVMSMOTE) algorithm was adopted to balance the dataset and a new LR-SVMSMOTE model was constructed. The performance of the radiologist and the two models were evaluated with receiver operating characteristic (ROC) curves and compared using the DeLong test. Results: The areas under the ROC curves (AUCs) in the prediction of thyroid cartilage invasion from LHSCC for the LR-SVMSMOTE model, LR model, and radiologist were 0.905 [95% confidence interval (CI): 0.863 to 0.937)], 0.876 (95%CI: 0.830 to 0.913), and 0.721 (95%CI: 0.663-0.774), respectively. The AUCs of both models were higher than that of the radiologist assessment (all P < 0.001). There was no significant difference in predictive performance between the LR-SVMSMOTE and LR models (P = 0.05). Conclusions: Models based on CT radiomic features can improve the accuracy of predicting thyroid cartilage invasion from LHSCC and provide a new potentially noninvasive method for preoperative prediction of thyroid cartilage invasion from LHSCC.
MeSH term(s)	Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/pathology ; Female ; Humans ; Hypopharyngeal Neoplasms/diagnostic imaging ; Hypopharyngeal Neoplasms/pathology ; Laryngeal Neoplasms/diagnostic imaging ; Laryngeal Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Invasiveness ; Thyroid Cartilage/diagnostic imaging ; Thyroid Cartilage/pathology ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/secondary ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2020-11-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2104862-9
ISSN	1470-7330 ; 1470-7330
ISSN (online)	1470-7330
ISSN	1470-7330
DOI	10.1186/s40644-020-00359-2
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Article ; Online: CT-based radiomics features in the prediction of thyroid cartilage invasion from laryngeal and hypopharyngeal squamous cell carcinoma

Ran Guo / Jian Guo / Lichen Zhang / Xiaoxia Qu / Shuangfeng Dai / Ruchen Peng / Vincent F. H. Chong / Junfang Xian

Cancer Imaging, Vol 20, Iss 1, Pp 1-

2020 Volume 11

Abstract: Abstract Background Laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) with thyroid cartilage invasion are considered T4 and need total laryngectomy. However, the accuracy of preoperative diagnosis of thyroid cartilage invasion remains lower. ... ...

Abstract	Abstract Background Laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) with thyroid cartilage invasion are considered T4 and need total laryngectomy. However, the accuracy of preoperative diagnosis of thyroid cartilage invasion remains lower. Therefore, the purpose of this study was to assess the potential of computed tomography (CT)-based radiomics features in the prediction of thyroid cartilage invasion from LHSCC. Methods A total of 265 patients with pathologically proven LHSCC were enrolled in this retrospective study (86 with thyroid cartilage invasion and 179 without invasion). Two head and neck radiologists evaluated the thyroid cartilage invasion on CT images. Radiomics features were extracted from venous phase contrast-enhanced CT images. The least absolute shrinkage and selection operator (LASSO) and logistic regression (LR) method were used for dimension reduction and model construction. In addition, the support vector machine-based synthetic minority oversampling (SVMSMOTE) algorithm was adopted to balance the dataset and a new LR-SVMSMOTE model was constructed. The performance of the radiologist and the two models were evaluated with receiver operating characteristic (ROC) curves and compared using the DeLong test. Results The areas under the ROC curves (AUCs) in the prediction of thyroid cartilage invasion from LHSCC for the LR-SVMSMOTE model, LR model, and radiologist were 0.905 [95% confidence interval (CI): 0.863 to 0.937)], 0.876 (95%CI: 0.830 to 0.913), and 0.721 (95%CI: 0.663–0.774), respectively. The AUCs of both models were higher than that of the radiologist assessment (all P < 0.001). There was no significant difference in predictive performance between the LR-SVMSMOTE and LR models (P = 0.05). Conclusions Models based on CT radiomic features can improve the accuracy of predicting thyroid cartilage invasion from LHSCC and provide a new potentially noninvasive method for preoperative prediction of thyroid cartilage invasion from LHSCC.
Keywords	Radiomics ; Larynx ; Hypopharynx ; Squamous cell carcinoma ; Thyroid cartilage ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	616
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Tumour volume measurement in head and neck cancer.

Chong, Vincent F H

Cancer imaging : the official publication of the International Cancer Imaging Society

2007 Volume 7 Spec No A, Page(s) S47–9

Abstract: Tumour volume is a significant prognostic factor in the treatment of malignant head and neck tumours. Studies of laryngeal and pharyngeal tumours have shown tumour volume to be an important predictor for tumour recurrence. Some studies (for instance ... ...

Abstract	Tumour volume is a significant prognostic factor in the treatment of malignant head and neck tumours. Studies of laryngeal and pharyngeal tumours have shown tumour volume to be an important predictor for tumour recurrence. Some studies (for instance nasopharyngeal carcinoma) have shown through multivariate modelling that tumour volume is a dominant covariate that overwhelms T stage, N stage and stage group. The results of these studies have prompted several investigators to suggest the inclusion of tumour volume as an additional prognostic factor in future revisions of the TNM staging system. This paper briefly reviews the TNM system as a staging tool, the measurement of tumour volume and how tumour volume could possibly be incorporated in the system or used as an additional prognostic factor.
MeSH term(s)	Diagnosis, Computer-Assisted ; Diagnostic Imaging ; Head and Neck Neoplasms/pathology ; Humans ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Predictive Value of Tests ; Prognosis
Language	English
Publishing date	2007-10-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2104862-9
ISSN	1470-7330 ; 1470-7330
ISSN (online)	1470-7330
ISSN	1470-7330
DOI	10.1102/1470-7330.2007.9002
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Article ; Online: Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization.

Gormley, Mark / Dudding, Tom / Kachuri, Linda / Burrows, Kimberley / Chong, Amanda H W / Martin, Richard M / Thomas, Steven J / Tyrrell, Jessica / Ness, Andrew R / Brennan, Paul / Munafò, Marcus R / Pring, Miranda / Boccia, Stefania / Olshan, Andrew F / Diergaarde, Brenda / Hung, Rayjean J / Liu, Geoffrey / Tajara, Eloiza H / Severino, Patricia /

Toporcov, Tatiana N / Lacko, Martin / Waterboer, Tim / Brenner, Nicole / Smith, George Davey / Vincent, Emma E / Richmond, Rebecca C

BMC medicine

2022 Volume 20, Issue 1, Page(s) 40

Abstract: Background: Human papilloma virus infection is known to influence oropharyngeal cancer (OPC) risk, likely via sexual transmission. However, sexual behaviour has been correlated with other risk factors including smoking and alcohol, meaning independent ... ...

Abstract	Background: Human papilloma virus infection is known to influence oropharyngeal cancer (OPC) risk, likely via sexual transmission. However, sexual behaviour has been correlated with other risk factors including smoking and alcohol, meaning independent effects are difficult to establish. We aimed to evaluate the causal effect of sexual behaviour on the risk of OPC using Mendelian randomization (MR). Methods: Genetic variants robustly associated with age at first sex (AFS) and the number of sexual partners (NSP) were used to perform both univariable and multivariable MR analyses with summary data on 2641 OPC cases and 6585 controls, obtained from the largest available genome-wide association studies (GWAS). Given the potential for genetic pleiotropy, we performed a number of sensitivity analyses: (i) MR methods to account for horizontal pleiotropy, (ii) MR of sexual behaviours on positive (cervical cancer and seropositivity for Chlamydia trachomatis) and negative control outcomes (lung and oral cancer), (iii) Causal Analysis Using Summary Effect estimates (CAUSE), to account for correlated and uncorrelated horizontal pleiotropic effects, (iv) multivariable MR analysis to account for the effects of smoking, alcohol, risk tolerance and educational attainment. Results: In univariable MR, we found evidence supportive of an effect of both later AFS (IVW OR = 0.4, 95%CI (0.3, 0.7), per standard deviation (SD), p = < 0.001) and increasing NSP (IVW OR = 2.2, 95%CI (1.3, 3.8) per SD, p = < 0.001) on OPC risk. These effects were largely robust to sensitivity analyses accounting for horizontal pleiotropy. However, negative control analysis suggested potential violation of the core MR assumptions and subsequent CAUSE analysis implicated pleiotropy of the genetic instruments used to proxy sexual behaviours. Finally, there was some attenuation of the univariable MR results in the multivariable models (AFS IVW OR = 0.7, 95%CI (0.4, 1.2), p = 0.21; NSP IVW OR = 0.9, 95%CI (0.5 1.7), p = 0.76). Conclusions: Despite using genetic variants strongly related sexual behaviour traits in large-scale GWAS, we found evidence for correlated pleiotropy. This emphasizes a need for multivariable approaches and the triangulation of evidence when performing MR of complex behavioural traits.
MeSH term(s)	Genome-Wide Association Study ; Humans ; Mendelian Randomization Analysis/methods ; Oropharyngeal Neoplasms/epidemiology ; Oropharyngeal Neoplasms/genetics ; Polymorphism, Single Nucleotide ; Sexual Behavior ; Smoking/adverse effects ; Smoking/epidemiology
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-022-02233-3
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Article ; Online: Thyroid nodules: risk stratification for malignancy with ultrasound and guided biopsy.

Anil, Gopinathan / Hegde, Amogh / Chong, F H Vincent

Cancer imaging : the official publication of the International Cancer Imaging Society

2011 Volume 11, Page(s) 209–223

Abstract: Replacing palpating fingers with an ultrasound (US) probe has resulted in an epidemic of thyroid nodules. Despite the high prevalence of thyroid nodules in the general population, thyroid malignancy is rare. Although no imaging modality can accurately ... ...

Abstract	Replacing palpating fingers with an ultrasound (US) probe has resulted in an epidemic of thyroid nodules. Despite the high prevalence of thyroid nodules in the general population, thyroid malignancy is rare. Although no imaging modality can accurately predict the nature of every nodule, high-resolution US is the most sensitive, easily available and cost-effective diagnostic test available to detect thyroid nodules, measure their dimensions and identify their structure. The presence of calcifications, irregular spiculated outline, hypoechogenicity in a solid nodule, chaotic intranodular vascularity and an elongated shape are well-known US features of malignancy in thyroid nodules. Cervical lymph node metastasis and extrathyroidal extension of a thyroid nodule are highly specific for malignancy but seen infrequently. Spongiform nodules, purely or predominantly cystic nodules, nodules with well-defined hypoechoic halo and echogenic as well as isoechoic nodules are usually benign. None of the US characteristics have 100% accuracy in detecting or excluding malignancy. Fine-needle biopsy is currently the best triage test for pre-operative evaluation of a thyroid nodule. There is no significant difference in the risk for malignancy between palpable and non-palpable nodules and size is not a reliable indicator for their malignant potential. The best tool for risk stratification for malignancy in thyroid nodules is US and guided biopsy of nodules with suspicious imaging features. This is especially relevant in patients with multinodular goitre.
MeSH term(s)	Biopsy, Fine-Needle/methods ; Diagnosis, Differential ; Humans ; Risk Assessment/methods ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/pathology ; Ultrasonography, Interventional
Language	English
Publishing date	2011-12-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2104862-9
ISSN	1470-7330 ; 1470-7330
ISSN (online)	1470-7330
ISSN	1470-7330
DOI	10.1102/1470-7330.2011.0030
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Article ; Online: Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor.

Chong, Pek Y / Shotwell, J Brad / Miller, John / Price, Daniel J / Maynard, Andy / Voitenleitner, Christian / Mathis, Amanda / Williams, Shawn / Pouliot, Jeffrey J / Creech, Katrina / Wang, Feng / Fang, Jing / Zhang, Huichang / Tai, Vincent W-F / Turner, Elizabeth / Kahler, Kirsten M / Crosby, Renae / Peat, Andrew J

Journal of medicinal chemistry

2019 Volume 62, Issue 7, Page(s) 3254–3267

Abstract: ... Unfortunately, facile benzylic oxidation resulted in a short plasma half-life (5 h) in human volunteers, and ... within the binding pocket. In clinical studies, 49 displayed a 60-63 h half-life and a robust decrease in viral RNA ...

Abstract	We previously described the discovery of GSK5852 (1), a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV), in which an N-benzyl boronic acid was essential for potent antiviral activity. Unfortunately, facile benzylic oxidation resulted in a short plasma half-life (5 h) in human volunteers, and a backup program was initiated to remove metabolic liabilities associated with 1. Herein, we describe second-generation NS5B inhibitors including GSK8175 (49), a sulfonamide- N-benzoxaborole analog with low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons. An X-ray structure of NS5B protein cocrystallized with 49 revealed unique protein-inhibitor interactions mediated by an extensive network of ordered water molecules and the first evidence of boronate complex formation within the binding pocket. In clinical studies, 49 displayed a 60-63 h half-life and a robust decrease in viral RNA levels in HCV-infected patients, thereby validating our hypothesis that reducing benzylic oxidation would improve human pharmacokinetics and lower efficacious doses relative to 1.
MeSH term(s)	Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Boronic Acids/chemistry ; Boronic Acids/pharmacokinetics ; Boronic Acids/pharmacology ; Crystallography, X-Ray ; Dogs ; Drug Design ; Half-Life ; Hepacivirus/drug effects ; Humans ; Macaca fascicularis ; Mice ; Molecular Structure ; Nucleic Acid Synthesis Inhibitors/chemistry ; Nucleic Acid Synthesis Inhibitors/pharmacokinetics ; Nucleic Acid Synthesis Inhibitors/pharmacology ; Rats
Chemical Substances	Antiviral Agents ; Boronic Acids ; GSK8175 ; Nucleic Acid Synthesis Inhibitors
Language	English
Publishing date	2019-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.8b01719
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Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: A follow-up longitudinal survey on a cohort of undergraduate medical students' attitudes towards radiology.

Teo, Lynette L S / Choo, Yun Song / Ong, Ching Ching / Han, Thazin / Chong, Vincent F H / Quek, Swee Tian

Annals of the Academy of Medicine, Singapore

2014 Volume 44, Issue 1, Page(s) 29–31

MeSH term(s)	Attitude ; Education, Medical, Undergraduate ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Radiology ; Students, Medical ; Surveys and Questionnaires
Language	English
Publishing date	2014-12-01
Publishing country	Singapore
Document type	Letter
ZDB-ID	604527-3
ISSN	0304-4602
ISSN	0304-4602
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Zs.B 2420: Show issues

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Article ; Online: Investigating the effect of sexual behaviour on oropharyngeal cancer risk

Mark Gormley / Tom Dudding / Linda Kachuri / Kimberley Burrows / Amanda H. W. Chong / Richard M. Martin / Steven J. Thomas / Jessica Tyrrell / Andrew R. Ness / Paul Brennan / Marcus R. Munafò / Miranda Pring / Stefania Boccia / Andrew F. Olshan / Brenda Diergaarde / Rayjean J. Hung / Geoffrey Liu / Eloiza H. Tajara / Patricia Severino /

Tatiana N. Toporcov / Martin Lacko / Tim Waterboer / Nicole Brenner / George Davey Smith / Emma E. Vincent / Rebecca C. Richmond

BMC Medicine, Vol 20, Iss 1, Pp 1-

a methodological assessment of Mendelian randomization

2022 Volume 18

Abstract: Abstract Background Human papilloma virus infection is known to influence oropharyngeal cancer (OPC) risk, likely via sexual transmission. However, sexual behaviour has been correlated with other risk factors including smoking and alcohol, meaning ... ...

Abstract	Abstract Background Human papilloma virus infection is known to influence oropharyngeal cancer (OPC) risk, likely via sexual transmission. However, sexual behaviour has been correlated with other risk factors including smoking and alcohol, meaning independent effects are difficult to establish. We aimed to evaluate the causal effect of sexual behaviour on the risk of OPC using Mendelian randomization (MR). Methods Genetic variants robustly associated with age at first sex (AFS) and the number of sexual partners (NSP) were used to perform both univariable and multivariable MR analyses with summary data on 2641 OPC cases and 6585 controls, obtained from the largest available genome-wide association studies (GWAS). Given the potential for genetic pleiotropy, we performed a number of sensitivity analyses: (i) MR methods to account for horizontal pleiotropy, (ii) MR of sexual behaviours on positive (cervical cancer and seropositivity for Chlamydia trachomatis) and negative control outcomes (lung and oral cancer), (iii) Causal Analysis Using Summary Effect estimates (CAUSE), to account for correlated and uncorrelated horizontal pleiotropic effects, (iv) multivariable MR analysis to account for the effects of smoking, alcohol, risk tolerance and educational attainment. Results In univariable MR, we found evidence supportive of an effect of both later AFS (IVW OR = 0.4, 95%CI (0.3, 0.7), per standard deviation (SD), p = < 0.001) and increasing NSP (IVW OR = 2.2, 95%CI (1.3, 3.8) per SD, p = < 0.001) on OPC risk. These effects were largely robust to sensitivity analyses accounting for horizontal pleiotropy. However, negative control analysis suggested potential violation of the core MR assumptions and subsequent CAUSE analysis implicated pleiotropy of the genetic instruments used to proxy sexual behaviours. Finally, there was some attenuation of the univariable MR results in the multivariable models (AFS IVW OR = 0.7, 95%CI (0.4, 1.2), p = 0.21; NSP IVW OR = 0.9, 95%CI (0.5 1.7), p = 0.76). Conclusions Despite ...
Keywords	Sexual behaviour ; Oropharyngeal cancer ; Head and neck cancer ; Mendelian randomization ; Medicine ; R
Subject code	150
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Imaging of carcinoma of the external auditory canal: a pictorial essay.

Ong, Cheng K / Pua, Uei / Chong, Vincent F H

Cancer imaging : the official publication of the International Cancer Imaging Society

2008 Volume 8, Page(s) 191–198

Abstract: Carcinoma of the external auditory canal presents a challenge in management, largely due to limited experience in treating this rare disease and the lack of a universally accepted staging system. Prognosis is most dependent on the extent of local disease ...

Abstract	Carcinoma of the external auditory canal presents a challenge in management, largely due to limited experience in treating this rare disease and the lack of a universally accepted staging system. Prognosis is most dependent on the extent of local disease at presentation, while resection margin status is also a strong determinant of survival in post-operative patients. The intent of this pictorial essay is to review the pattern of tumour spread and highlight the value of imaging, particularly magnetic resonance imaging in pre-operative tumour mapping.
MeSH term(s)	Ear Canal/diagnostic imaging ; Ear Canal/pathology ; Ear Canal/surgery ; Ear Neoplasms/diagnostic imaging ; Ear Neoplasms/mortality ; Ear Neoplasms/pathology ; Ear Neoplasms/surgery ; Humans ; Magnetic Resonance Imaging/methods ; Neoplasm Staging/methods ; Prognosis ; Survival Rate ; Tomography, X-Ray Computed
Language	English
Publishing date	2008-10-20
Publishing country	England
Document type	Journal Article
ISSN	1470-7330
ISSN (online)	1470-7330
DOI	10.1102/1470-7330.2008.0031
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