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Article ; Online: Macitentan in the treatment of pulmonary hypertension in Gaucher‚s disease.

Taylan, Gokay / Aktoz, Meryem / Celik, Mehmet / Yılmaztepe, Mustafa

2020 Volume 23, Issue 2, Page(s) 114–116

MeSH term(s)	Adult ; Diagnosis, Differential ; Endothelin A Receptor Antagonists/administration & dosage ; Endothelin A Receptor Antagonists/therapeutic use ; Female ; Gaucher Disease ; Humans ; Hypertension, Pulmonary/drug therapy ; Pyrimidines/administration & dosage ; Pyrimidines/therapeutic use ; Sulfonamides/administration & dosage ; Sulfonamides/therapeutic use
Chemical Substances	Endothelin A Receptor Antagonists ; Pyrimidines ; Sulfonamides ; macitentan (Z9K9Y9WMVL)
Language	English
Publishing date	2020-02-06
Publishing country	Turkey
Document type	Case Reports
ZDB-ID	2278670-3
ISSN	2149-2271 ; 2149-2263
ISSN (online)	2149-2271
ISSN	2149-2263
DOI	10.14744/AnatolJCardiol.2019.23096
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Article ; Online: The Effect of Pulmonary Sarcoidosis on Cardiac Autonomic Dysfunction

Ali MANAV / Gökay TAYLAN / Meryem AKTOZ

Namık Kemal Tıp Dergisi, Vol 9, Iss 3, Pp 284-

2021 Volume 289

Abstract: Aim:The assessment of heart rate variability (HRV) has been considered as an important non-invasive method to evaluate cardiac autonomic function. Concerning recent evidence on the relationship between impaired autonomic dysfunction and sarcoidosis, we ... ...

Abstract	Aim:The assessment of heart rate variability (HRV) has been considered as an important non-invasive method to evaluate cardiac autonomic function. Concerning recent evidence on the relationship between impaired autonomic dysfunction and sarcoidosis, we aimed to investigate the effect of pulmonary sarcoidosis on cardiac autonomic dysfunction.Materials and Methods:This prospective study comprised of 36 participants, including 18 patients diagnosed with pulmonary sarcoidosis and 18 age-matched healthy volunteers. All participants underwent echocardiographic examination, 12-channel electrocardiography and 24-h Holter monitoring. HRV parameters were determined and compared between the groups.Results:In time domain analyses, RMSDD values significantly decreased in the patient group compared to the control group (p=0.043). The low-frequency power in frequency domain analyses between sarcoidosis patients and controls demonstrated a statistically significant difference (p=0.045). In the correlation analysis, PR duration was negatively correlated with all-time domain and frequency domain parameters as SDNN, SDANN and high-frequency values, which had a statistically significant difference (p=0.009, p=0.003, p=0.047 respectively). Corrected QT (QTc) duration was negatively correlated with all-time domain and frequency domain parameters as well. The low-frequency/high-frequency ratio was positively correlated with QTc duration.Conclusion:The patients with pulmonary sarcoidosis displayed a decrease in all HRV values reflecting diminished parasympathetic tone or blunted cardiac response to vagal modulation. This may cause cardiac outcomes such as atrioventricular conduction abnormalities, proarrhythmic tendency, ventricular arrhythmias and sudden death.
Keywords	heart rate variability ; sarcoidosis ; autonomic dysfunction ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Galenos Yayincilik
Document type	Article ; Online
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Article ; Online: The mitral valve prolapse frequency in healthy females with generalized joint hypermobility: A case-control study.

Özdemir, Hande / Tuna, Filiz / Aktoz, Meryem / Taştekin, Nurettin / Demirbağ Kabayel, Derya

Archives of rheumatology

2021 Volume 36, Issue 3, Page(s) 335–340

Abstract: Objectives: The aim of this study was to investigate the frequency of mitral valve prolapse between healthy females with generalized joint hypermobility and healthy controls.: Patients and methods: This observational, cross-sectional, controlled ... ...

Abstract	Objectives: The aim of this study was to investigate the frequency of mitral valve prolapse between healthy females with generalized joint hypermobility and healthy controls. Patients and methods: This observational, cross-sectional, controlled study included female individuals with generalized joint hypermobility (n=39, mean age: 20.5±1.1 years; range, 19 to 23 years) and healthy controls (n=42, mean age: 20.6±1.2 years; range, 18 to 23 years) between July 2017 and November 2017. The generalized joint hypermobility consisted of women with a Beighton score of ≥4, while the control group consisted of women with a Beighton score of ≤3. Echocardiography was performed to all participants. Mitral valve prolapse was defined as having single or bileaflet prolapse of at least 2 mm beyond the long-axis annular plane with or without mitral leaflet thickening. Results: No significant difference was found in the age, height, body weight, and body mass index between the groups (p>0.05). The median Beighton score was 5 in the generalized joint hypermobility group and 2 in the control group. No mitral valve prolapse was detected in those with generalized joint hypermobility, while non-classical mitral valve prolapse was observed in one participant in the control group, indicating no statistically significant difference between the two groups (p>0.05). Conclusion: Our study results suggest that the frequency of mitral valve prolapse is comparable between the women with generalized joint hypermobility and healthy controls. Based on these results, routine assessment of mitral valve prolapse is not recommended in this population.
Language	English
Publishing date	2021-01-21
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3012972-2
ISSN	2618-6500 ; 2148-5046
ISSN (online)	2618-6500
ISSN	2148-5046
DOI	10.46497/ArchRheumatol.2021.8192
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Article: Brain Natriuretic Peptide Levels in Acute Inferior Myocardial Infarction.

Yildirim, Tarik / Yildirim, Seda Elcim / Aktoz, Meryem / Altun, Armagan

publication RETRACTED

Journal of clinical medicine research

2018 Volume 10, Issue 3, Page(s) 254–259

Abstract: Background: Our objective was to evaluate the relationship between initial serum brain natriuretic peptide (BNP) levels and right ventricular functions in inferior myocardial infarction (MI) with and without right ventricular involvement.: Methods: ... ...

Abstract	Background: Our objective was to evaluate the relationship between initial serum brain natriuretic peptide (BNP) levels and right ventricular functions in inferior myocardial infarction (MI) with and without right ventricular involvement. Methods: The study included 61 patients, who presented with acute inferior MI. Twenty-seven patients had right ventricular involvement. Blood samples for BNP were obtained from each patient on admission. Echocardiographic assessments were performed and recorded during the first 12 h. Right ventricular involvement was determined by electrocardiography, conventional and tissue Doppler echocardiography (TDI). Results: In inferior MI with right ventricular involvement, tricuspid annulus planimetric systolic excursion (TAPSE) and right ventricular fractional area change were lower, and left ventricular E/E' ratio was higher. In the group with BNP levels above 400 pg/mL, left ventricular end-diastolic diameter and left ventricular end-systolic diameter were higher, and left ventricular ejection fraction and TAPSE, indicator of right ventricular systolic function, were lower. The elevated BNP levels were negatively correlated with RSm and TAPSE, while they were positively correlated with the E/E' ratio. The systolic blood pressure and left ventricular end-diastolic diameter during admission were independent predictors of BNP levels. Conclusions: In acute inferior MI, initially increased BNP levels may be valuable in predicting the right ventricle involvement. Higher rates of hypotension, right ventricular dysfunction and increased left ventricle diameters are observed in patients with BNP levels ≥ 400 pg/mL.
Language	English
Publishing date	2018-01-26
Publishing country	Canada
Document type	Journal Article ; Retracted Publication
ZDB-ID	2548987-2
ISSN	1918-3011 ; 1918-3003
ISSN (online)	1918-3011
ISSN	1918-3003
DOI	10.14740/jocmr3324w
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Article ; Online: Non-Sustained Ventricular Tachycardia Episodes Predict Future Hospitalization in ICD Recipients with Heart Failure.

Uçar, Fatih Mehmet / Yilmaztepe, Mustafa Adem / Taylan, Gökay / Aktoz, Meryem

Arquivos brasileiros de cardiologia

2017 Volume 109, Issue 4, Page(s) 284–289

Abstract: Background: Implantable cardioverter-defibrillator (ICD) therapy is well known to reduce mortality in selected patients with heart failure (HF).: Objective: To investigate whether monitored episodes of non-sustained ventricular tachycardia (NSVT) ... ...

Abstract	Background: Implantable cardioverter-defibrillator (ICD) therapy is well known to reduce mortality in selected patients with heart failure (HF). Objective: To investigate whether monitored episodes of non-sustained ventricular tachycardia (NSVT) might predict future HF hospitalizations in ICD recipients with HF. Methods: We examined 104 ICD recipients (mean age: 60 ± 10.1 years, 80.8 % male) with HF who were referred to our outpatient clinic for device follow-up. After device interrogation, patients were divided into NSVT positive and negative groups. The primary endpoint was the rate of hospitalization within the next 6 months after initial ICD evaluation. Results: Device evaluation demonstrated at least one episode of monitored NSVT in 50 out of 104 patients. As expected, no device therapy (shock or anti-tachycardia) was needed for such episodes. At 6 months, 24 patients were hospitalized due to acute decompensated HF. Hospitalization rate was significantly lower in the NSVT negative as compared with positive groups (38% versus 62%; adjusted hazard ratio [HR] 0.166 95% CI 0.056 to 0.492; p = 0.01). Conclusions: Monitored NSVT bouts in ICD recordings may serve as a predictor of future HF hospitalizations in ICD recipients with HF suggesting optimization of therapeutic modalities in these patients along with a close supervision in the clinical setting.
MeSH term(s)	Aged ; Defibrillators, Implantable ; Female ; Heart Failure/physiopathology ; Heart Failure/therapy ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Monitoring, Physiologic ; Proportional Hazards Models ; Prospective Studies ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Sensitivity and Specificity ; Statistics, Nonparametric ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/physiopathology ; Tachycardia, Ventricular/therapy ; Time Factors
Language	English
Publishing date	2017-10-04
Publishing country	Brazil
Document type	Journal Article ; Observational Study
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.5935/abc.20170141
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Zs.A 548: Show issues

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Article ; Online: Consensus paper on the evaluation and treatment of resistant hypertension by the Turkish Society of Cardiology.

Sahinarslan, Asife / Gazi, Emine / Aktoz, Meryem / Ozkan, Cigdem / Ulusal Okyay, Gülay / Ucar Elalmis, Ozgul / Belen, Erdal / Bitigen, Reviewers Atila / Derici, Ulver / Bascil Tutuncu, Neslihan / Yildirir, Aylin

Anatolian journal of cardiology

2020 Volume 24, Issue 3, Page(s) 137–152

MeSH term(s)	Cardiology ; Humans ; Hypertension/therapy ; Societies, Medical ; Turkey
Language	English
Publishing date	2020-09-01
Publishing country	Turkey
Document type	Consensus Development Conference ; Journal Article
ZDB-ID	2278670-3
ISSN	2149-2271 ; 2149-2271
ISSN (online)	2149-2271
ISSN	2149-2271
DOI	10.14744/AnatolJCardiol.2020.74154
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Article ; Online: Long-term Results of One Cycle of Remote Ischemic Preconditioning Applied Before Elective Percutaneous Coronary Intervention

Mustafa Yılmaztepe / Gökay Taylan / Fatih Mehmet Uçar / Uğur Özkan / Meryem Aktoz / Hanefi Yekta Gürlertop

Koşuyolu Heart Journal, Vol 21, Iss 2, Pp 143-

2018 Volume 148

Abstract: Introduction: Myocardial injury after percutaneous coronary intervention (PCI) is seen frequently. Ischemia/reperfusion injury, side branch occlusion and distal embolization of atherothrombotic debris are the main causes of myocardial injury. Remote ... ...

Abstract	Introduction: Myocardial injury after percutaneous coronary intervention (PCI) is seen frequently. Ischemia/reperfusion injury, side branch occlusion and distal embolization of atherothrombotic debris are the main causes of myocardial injury. Remote ischemic preconditioning (RIPC) is a promising technique for protection from ischemia/reperfusion injury, but sufficient data of long-term clinical outcomes is not available. In this study we planned to investigate the effect of one cycle of RIPC on major cardiovascular events one year after elective PCI. Patients and Methods: 102 patients, undergoing elective PCI, with normal baseline cTroponin-I (cTn-I) values, were randomized equally into two groups. Five minutes of ischemic preconditioning was applied before the intervention to the preconditioning group, by inflating blood pressure cuff up-to 200 mmHg on non-dominant arm. After 1 year, the clinical outcomes of these patients (angina, heart failure, death, myocardial infarction, repeat revascularization) were questioned. Results: From a total of 102 patients, 90 could be reached after an year. The mean duration of follow-up was 432 vs. 423.5 days (p= 0.793). Post-PCI 16th hour cTn-I was insignificantly lower in the preconditioning arm (0.079 μg/L vs. 0.069 μg/L, p= 0.074). The incidence of cTn-I elevation 5 fold above the URL (> 0.115 μg/L) was lower in the preconditioning group; however, it was also insignificant (24.4% vs. 13.3%, p= 0.301). Death, MI or repeat revascularization rates did not differ between the groups. Conclusion: One cycle of RIPC had no effect on major cardiovascular events (MACE) after elective PCI.
Keywords	Remote ischemic preconditioning ; percutaneous coronary intervention ; Medicine ; R ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
Subject code	610
Language	English
Publishing date	2018-08-01T00:00:00Z
Publisher	Bilimsel Tip Yayinevi
Document type	Article ; Online
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Article ; Online: Wellens' syndrome: the electrocardiographic finding that is seen as unimportant.

Tatli, Ersan / Aktoz, Meryem

Cardiology journal

2009 Volume 16, Issue 1, Page(s) 73–75

Abstract: Wellens' syndrome is a pattern of electrocardiography T-wave changes associated with critical proximal left anterior descending artery lesion. Patients with Wellens' syndrome are at high risk of the development of extensive myocardial infarction of the ... ...

Abstract	Wellens' syndrome is a pattern of electrocardiography T-wave changes associated with critical proximal left anterior descending artery lesion. Patients with Wellens' syndrome are at high risk of the development of extensive myocardial infarction of the anterior wall and death. Thus, it is vital that this finding is recognized promptly. We present a patient with Wellens' syndrome in this article.
MeSH term(s)	Action Potentials ; Angina Pectoris/etiology ; Angina Pectoris/physiopathology ; Angioplasty, Balloon, Coronary/instrumentation ; Coronary Angiography ; Coronary Stenosis/complications ; Coronary Stenosis/diagnosis ; Coronary Stenosis/physiopathology ; Coronary Stenosis/therapy ; Electrocardiography ; Heart Conduction System/physiopathology ; Humans ; Male ; Middle Aged ; Stents ; Syndrome ; Treatment Outcome
Language	English
Publishing date	2009
Publishing country	Poland
Document type	Case Reports ; Journal Article
ZDB-ID	2488680-4
ISSN	1897-5593 ; 1897-5593
ISSN (online)	1897-5593
ISSN	1897-5593
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Zs.A 6770: Show issues

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Article ; Online: Effects of Gender on Electrocardiography in Subjects with Shortened Ventricular Depolarization (QRS).

Aydin, Fatih / Aktoz, Meryem / Altun, Armagan / Gursul, Erdal / Aksit, Ercan

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

2015 Volume 21, Issue 3, Page(s) 272–279

Abstract: Background: Distinctions between electrocardiograms of female and male subjects have been recognized for many years. Due to these differences, arrhythmias in each gender have a tendency to differ. In our study, we aimed to compare electrocardiography ... ...

Abstract	Background: Distinctions between electrocardiograms of female and male subjects have been recognized for many years. Due to these differences, arrhythmias in each gender have a tendency to differ. In our study, we aimed to compare electrocardiography intervals between men and women with short QRS durations. Methods: Subjects with a QRS interval of ≤80 ms were included in the study. Patients were grouped by gender and the parameters were compared. Patients with diseases that might affect QRS interval and/or who were on medications were excluded. The electrocardiogram intervals of the subjects were measured, Holter monitors were placed, and parameters of time-based heart rate variation were analyzed. Results: A total of 100 patients (55% female) were included in the study. According to statistical analysis, no significant difference between the genders was observed in the heart rate or in the parameters, such as QT, JT, JTp, and TpTe intervals or heart rate-corrected QTc, JTc, JTpc, and TpTec intervals, which affect repolarization and are known to be arrhythmia precursors by shortening or elongation. No statistically significant difference was found between the two groups for the parameters of heart rate variability time measures (SDNN, SDANN, rMSSD, and pNN50). Conclusion: We observed that when the QRS interval gets shorter, repolarization differences between the genders disappear. New studies are required on this subject.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Electrocardiography ; Female ; Heart Conduction System/physiology ; Heart Rate/physiology ; Humans ; Male ; Middle Aged ; Sex Factors ; Ventricular Function/physiology
Chemical Substances	Biomarkers
Language	English
Publishing date	2015-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1325530-7
ISSN	1542-474X ; 1082-720X
ISSN (online)	1542-474X
ISSN	1082-720X
DOI	10.1111/anec.12296
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Zs.A 4953: Show issues

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Article ; Online: Parachute mitral valve abnormality and bicuspid aortic valve in an asymptomatic adult patient.

Erdogan, Okan / Aktoz, Meryem

The Canadian journal of cardiology

2008 Volume 24, Issue 8, Page(s) e57

MeSH term(s)	Aortic Valve/abnormalities ; Aortic Valve/diagnostic imaging ; Chordae Tendineae/abnormalities ; Echocardiography, Transesophageal ; Humans ; Male ; Middle Aged ; Mitral Valve/abnormalities ; Mitral Valve/diagnostic imaging ; Mitral Valve Insufficiency/diagnostic imaging
Language	English
Publishing date	2008-08-07
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/s0828-282x(08)70660-3
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