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Article ; Online: Subjective cancer-related cognitive impairments and salience network connectivity in breast cancer survivors.

Henneghan, Ashley M / Kesler, Shelli R

Journal of cancer survivorship : research and practice

2022 Volume 17, Issue 4, Page(s) 967–973

Abstract: Purpose: Little is known about the neural basis of subjective cancer-related cognitive changes. The purpose of this study was to explore salience network connectivity in relation to subjective executive and memory dysfunction in breast cancer survivors ... ...

Abstract	Purpose: Little is known about the neural basis of subjective cancer-related cognitive changes. The purpose of this study was to explore salience network connectivity in relation to subjective executive and memory dysfunction in breast cancer survivors compared to controls. Methods: A retrospective cross-sectional analysis of neuroimaging, subjective cognitive, clinical, and demographic data in chemotherapy-treated primary breast cancer survivors compared to frequency matched controls was used. Functional connectivity within salience network hubs (anterior cingulate, bilateral insula) was determined using resting state functional MRI. Mann-Whitney U tests were used to evaluate group differences and Spearman's rho correlations were examined among the behavioral measures and salience network connectivity. Results: We included 65 breast cancer survivors and 71 controls. Survivors demonstrated greater subjective executive dysfunction and memory complaints (p < .001) and lower salience network connectivity (p < .05) than controls. Executive functioning correlated with bilateral insula and left anterior cingulate connectivity (rho > - 0.29, p < .05). Distress did not correlate with salience network connectivity. Conclusion: These findings suggest that salience network connectivity may represent a biomarker of subjective cancer-related cognitive changes. Implications for cancer survivors: Subjective cancer-related cognitive changes are common following treatment and associated with objective changes in brain connectivity.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/complications ; Breast Neoplasms/drug therapy ; Cancer Survivors ; Retrospective Studies ; Cross-Sectional Studies ; Brain ; Cognitive Dysfunction/etiology ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2022-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2388888-X
ISSN	1932-2267 ; 1932-2259
ISSN (online)	1932-2267
ISSN	1932-2259
DOI	10.1007/s11764-022-01307-8
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Article ; Online: An Exploratory Analysis of Contributors to Cognitive Functioning Among Sexual and Gender Minority Individuals Who Had COVID-19.

Franco-Rocha, Oscar Y / Lewis, Kimberly A / Kesler, Shelli R / Henneghan, Ashley M

Journal of homosexuality

2024 , Page(s) 1–16

Abstract: Sexual and gender minority (SGM) individuals face mental health disparities. However, research analyzing SGM people's mental health after a COVID-19 diagnosis is scarce. In this secondary analysis of a remote study, we 1) examined associations between ... ...

Abstract	Sexual and gender minority (SGM) individuals face mental health disparities. However, research analyzing SGM people's mental health after a COVID-19 diagnosis is scarce. In this secondary analysis of a remote study, we 1) examined associations between cognitive and psychosocial health and 2) explored differences between these health outcomes among SGM (
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	193138-6
ISSN	1540-3602 ; 0091-8369
ISSN (online)	1540-3602
ISSN	0091-8369
DOI	10.1080/00918369.2024.2309497
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Article: Strength of spatial correlation between gray matter connectivity and patterns of proto-oncogene and neural network construction gene expression is associated with diffuse glioma survival.

Kesler, Shelli R / Harrison, Rebecca A / Schutz, Alexa De La Torre / Michener, Hayley / Bean, Paris / Vallone, Veronica / Prinsloo, Sarah

Frontiers in neurology

2024 Volume 15, Page(s) 1345520

Abstract: Introduction: Like other forms of neuropathology, gliomas appear to spread along neural pathways. Accordingly, our group and others have previously shown that brain network connectivity is highly predictive of glioma survival. In this study, we aimed to ...

Abstract	Introduction: Like other forms of neuropathology, gliomas appear to spread along neural pathways. Accordingly, our group and others have previously shown that brain network connectivity is highly predictive of glioma survival. In this study, we aimed to examine the molecular mechanisms of this relationship via imaging transcriptomics. Methods: We retrospectively obtained presurgical, T1-weighted MRI datasets from 669 adult patients, newly diagnosed with diffuse glioma. We measured brain connectivity using gray matter networks and coregistered these data with a transcriptomic brain atlas to determine the spatial co-localization between brain connectivity and expression patterns for 14 proto-oncogenes and 3 neural network construction genes. Results: We found that all 17 genes were significantly co-localized with brain connectivity ( Discussion: Our findings provide novel insights regarding how gene-brain connectivity interactions may affect glioma survival.
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1345520
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Article ; Online: Behavioral and biologic characteristics of cancer-related cognitive impairment biotypes.

Mulholland, Michele M / Prinsloo, Sarah / Kvale, Elizabeth / Dula, Adrienne N / Palesh, Oxana / Kesler, Shelli R

Brain imaging and behavior

2023 Volume 17, Issue 3, Page(s) 320–328

Abstract: Psychiatric diagnosis is moving away from symptom-based classification and towards multi-dimensional, biologically-based characterization, or biotyping. We previously identified three biotypes of chemotherapy-related cognitive impairment based on ... ...

Abstract	Psychiatric diagnosis is moving away from symptom-based classification and towards multi-dimensional, biologically-based characterization, or biotyping. We previously identified three biotypes of chemotherapy-related cognitive impairment based on functional brain connectivity. In this follow-up study of 80 chemotherapy-treated breast cancer survivors and 80 non-cancer controls, we evaluated additional factors to help explain biotype expression: neurofunctional stability, brain age, apolipoprotein (APOE) genotype, and psychoneurologic symptoms. We also compared the discriminative ability of a traditional, symptom-based cognitive impairment definition with that of biotypes. We found significant differences in cortical brain age (F = 10.50, p < 0.001), neurofunctional stability (F = 2.83, p = 0.041), APOE e4 genotype (X
MeSH term(s)	Humans ; Follow-Up Studies ; Magnetic Resonance Imaging ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/genetics ; Biological Products ; Apolipoproteins E ; Neoplasms/complications ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy
Chemical Substances	Biological Products ; Apolipoproteins E
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2377165-3
ISSN	1931-7565 ; 1931-7557
ISSN (online)	1931-7565
ISSN	1931-7557
DOI	10.1007/s11682-023-00774-6
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Article: Neuroimaging based biotypes for precision diagnosis and prognosis in cancer-related cognitive impairment.

Kesler, Shelli R / Henneghan, Ashley M / Prinsloo, Sarah / Palesh, Oxana / Wintermark, Max

Frontiers in medicine

2023 Volume 10, Page(s) 1199605

Abstract: Cancer related cognitive impairment (CRCI) is commonly associated with cancer and its treatments, yet the present binary diagnostic approach fails to capture the full spectrum of this syndrome. Cognitive function is highly complex and exists on a ... ...

Abstract	Cancer related cognitive impairment (CRCI) is commonly associated with cancer and its treatments, yet the present binary diagnostic approach fails to capture the full spectrum of this syndrome. Cognitive function is highly complex and exists on a continuum that is poorly characterized by dichotomous categories. Advanced statistical methodologies applied to symptom assessments have demonstrated that there are multiple subclasses of CRCI. However, studies suggest that relying on symptom assessments alone may fail to account for significant differences in the neural mechanisms that underlie a specific cognitive phenotype. Treatment plans that address the specific physiologic mechanisms involved in an individual patient's condition is the heart of precision medicine. In this narrative review, we discuss how biotyping, a precision medicine framework being utilized in other mental disorders, could be applied to CRCI. Specifically, we discuss how neuroimaging can be used to determine biotypes of CRCI, which allow for increased precision in prediction and diagnosis of CRCI
Language	English
Publishing date	2023-08-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1199605
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Article ; Online: Driving among individuals with chronic conditions: A systematic review of applied research using kinematic driving sensors.

Mukherjee, Srijani / McDonald, Anthony D / Kesler, Shelli R / Cuevas, Heather / Swank, Chad / Stevens, Alan / Ferris, Thomas K / Danesh, Valerie

Journal of the American Geriatrics Society

2024 Volume 72, Issue 4, Page(s) 1242–1251

Abstract: Background: Kinematic driving data studies are a novel methodology relevant to health care, but prior studies have considerable variance in their methods, populations, and findings suggesting a need for critical analysis and appraisal for feasibility ... ...

Abstract	Background: Kinematic driving data studies are a novel methodology relevant to health care, but prior studies have considerable variance in their methods, populations, and findings suggesting a need for critical analysis and appraisal for feasibility and methodological guidelines. Methods: We assessed kinematic driving studies of adults with chronic conditions for study feasibility, characteristics, and key findings, to generate recommendations for future study designs, and to identify promising directions for applications of kinematic driving data. PRISMA was used to guide the review and searches included PubMed, CINAHL, and Compendex. Of 379 abstract/titles screened, 49 full-text articles were reviewed, and 29 articles met inclusion criteria of analyzing trip-level kinematic driving data from adult drivers with chronic conditions. Results: The predominant chronic conditions studied were Alzheimer's disease and related Dementias, obstructive sleep apnea, and diabetes mellitus. Study objectives included feasibility testing of kinematic driving data collection in the context of chronic conditions, comparisons of simulation with real-world kinematic driving behavior, assessments of driving behavior effects associated with chronic conditions, and prognostication or disease classification drawn from kinematic driving data. Across the studies, there was no consensus on devices, measures, or sampling parameters; however, studies showed evidence that driving behavior could reliably differentiate between adults with chronic conditions and healthy controls. Conclusions: Vehicle sensors can provide driver-specific measures relevant to clinical assessment and interventions. Using kinematic driving data to assess and address driving measures of individuals with multiple chronic conditions is positioned to amplify a functional outcome measure that matters to patients.
MeSH term(s)	Humans ; Biomechanical Phenomena ; Outcome Assessment, Health Care ; Alzheimer Disease ; Research ; Chronic Disease
Language	English
Publishing date	2024-01-20
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.18738
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Article ; Online: Clinical, psychosocial, and sociodemographic factors of sexual and gender minority groups with cancer: A systematic review.

Franco-Rocha, Oscar Y / Wheldon, Christopher W / Trainum, Katie / Kesler, Shelli R / Henneghan, Ashley M

European journal of oncology nursing : the official journal of European Oncology Nursing Society

2023 Volume 64, Page(s) 102343

Abstract: Purpose: Psychosocial health varies depending on demographic and clinical factors and the social context in which individuals grow and live. Sexual and gender minority (SGM) populations experience health disparities due to systemic factors that ... ...

Abstract	Purpose: Psychosocial health varies depending on demographic and clinical factors and the social context in which individuals grow and live. Sexual and gender minority (SGM) populations experience health disparities due to systemic factors that privilege cisgender and heterosexual identities. We reviewed the literature on the psychosocial, sociodemographic, and clinical factors in SGM groups with cancer and described the associations among these factors. Methods: We conducted a systematic review according to Fink's methodology and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines in the PubMed, PsycInfo, Cumulative Index of Nursing and Allied Health Literature, and LGBTQ+ Life databases. Quantitative articles published in English or Spanish were included. Grey literature and studies with participants in hospice care were excluded. The quality of the publications was assessed with the Joanna Briggs Institute criticalappraisal tools. Results: The review included 25 publications. In SGM groups, systemic cancer treatment was associated with worse psychosocial outcomes; and older age, employment, and higher income were associated with better psychosocial outcomes. Conclusions: SGM groups with cancer are different from their heterosexual cisgender peers in sociodemographic, psychosocial, and clinical factors. Clinical and sociodemographic factors are associated with psychosocial outcomes among SGM individuals with cancer.
MeSH term(s)	Humans ; Sociodemographic Factors ; Sexual Behavior/psychology ; Gender Identity ; Sexual and Gender Minorities ; Heterosexuality ; Neoplasms/therapy
Language	English
Publishing date	2023-05-01
Publishing country	Scotland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2017117-1
ISSN	1532-2122 ; 1462-3889
ISSN (online)	1532-2122
ISSN	1462-3889
DOI	10.1016/j.ejon.2023.102343
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Article: Cognitive Impairment in Non-critical, Mild-to-Moderate COVID-19 Survivors.

Henneghan, Ashley M / Lewis, Kimberly A / Gill, Eliana / Kesler, Shelli R

Frontiers in psychology

2022 Volume 13, Page(s) 770459

Abstract: Importance: Previous studies of post-acute COVID-19 syndrome have focused on critical cases with severe disease. However, most cases are mild to moderate in disease severity.: Objective: We aimed to examine cognitive outcomes in cases of non-critical, ...

Abstract	Importance: Previous studies of post-acute COVID-19 syndrome have focused on critical cases with severe disease. However, most cases are mild to moderate in disease severity. Objective: We aimed to examine cognitive outcomes in cases of non-critical, mild-to-moderate COVID-19. Design, Setting, and Participants: In this cross-sectional study, we enrolled 72 adults aged 22 to 65 years in Central Texas who had non-critical, mild-to-moderate COVID-19 infection between 13 January 2021 and 20 April 2021. Main outcomes and measures: We remotely administered cognitive-behavioral testing to determine the frequency of cognitive impairment and examine demographic, clinical, and psychosocial contributors to impairment. Results: The frequency of objective cognitive impairment was 40%. The largest number of participants (24%) showed impairment on a measure of executive functioning. Attention and processing speed was more impaired in males ( Conclusion and relevance: Mild or moderate COVID-19 infection may be associated with cognitive impairments, especially in the domain of executive functioning. A subgroup of younger individuals may be more vulnerable to cognitive and psychosocial effects of COVID-19. Highlights: Question: How frequent is cognitive impairment among non-critical, mild-to-moderate COVID-19 survivors? Findings: In this cross-sectional study of 72 adults, 40% demonstrated cognitive impairment, particularly in executive function. Meaning: Neurologic sequelae, such as cognitive impairment, may be common following COVID-19 infection.
Language	English
Publishing date	2022-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.770459
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Article: Identifying Themes for Assessing Cancer-Related Cognitive Impairment: Topic Modeling and Qualitative Content Analysis of Public Online Comments.

Kesler, Shelli R / Henneghan, Ashley M / Thurman, Whitney / Rao, Vikram

JMIR cancer

2022 Volume 8, Issue 2, Page(s) e34828

Abstract: Background: Cancer-related cognitive impairment (CRCI) is a common and significant adverse effect of cancer and its therapies. However, its definition and assessment remain difficult due to limitations of currently available measurement tools.: ... ...

Abstract	Background: Cancer-related cognitive impairment (CRCI) is a common and significant adverse effect of cancer and its therapies. However, its definition and assessment remain difficult due to limitations of currently available measurement tools. Objective: This study aims to evaluate qualitative themes related to the cognitive effects of cancer to help guide development of assessments that are more specific than what is currently available. Methods: We applied topic modeling and inductive qualitative content analysis to 145 public online comments related to cognitive effects of cancer. Results: Topic modeling revealed 2 latent topics that we interpreted as representing internal and external factors related to cognitive effects. These findings lead us to hypothesize regarding the potential contribution of locus of control to CRCI. Content analysis suggested several major themes including symptoms, emotional/psychological impacts, coping, "chemobrain" is real, change over time, and function. There was some conceptual overlap between the 2 methods regarding internal and external factors related to patient experiences of cognitive effects. Conclusions: Our findings indicate that coping mechanisms and locus of control may be important themes to include in assessments of CRCI. Future directions in this field include prospective acquisition of free-text responses to guide development of assessments that are more sensitive and specific to cognitive function in patients with cancer.
Language	English
Publishing date	2022-05-25
Publishing country	Canada
Document type	Journal Article
ISSN	2369-1999
ISSN	2369-1999
DOI	10.2196/34828
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Article ; Online: The association of genetic polymorphisms with neuroconnectivity in breast cancer patients.

Harrison, Rebecca A / Rao, Vikram / Kesler, Shelli R

Scientific reports

2021 Volume 11, Issue 1, Page(s) 6169

Abstract: Genetic polymorphisms in select genes, including APOE (apolipoprotein E), COMT (Catechol-O-Methyltransferase), MDR1 (multi-drug resistance 1), BDNF (brain derived neurotrophic factor), and GST (glutathione-S-transferase), have been associated with ... ...

Abstract	Genetic polymorphisms in select genes, including APOE (apolipoprotein E), COMT (Catechol-O-Methyltransferase), MDR1 (multi-drug resistance 1), BDNF (brain derived neurotrophic factor), and GST (glutathione-S-transferase), have been associated with vulnerability to cognitive impairment. In this study, we evaluated the relationship of these genetic variants to measures of brain health in patients with breast cancer, including neurocognitive testing and functional connectome analysis. Women with breast cancer (n = 83) and female healthy controls (n = 53) were evaluated. They underwent resting-state functional MRI scans and neurocognitive testing. Polymerase chain reaction (PCR) was performed on saliva samples to identify single nucleotide polymorphisms (SNPs) in candidate genes: APOE, COMT, MDR1, BDNF, and GST. Breast cancer patients treated with chemotherapy had slower processing speed (p = 0.04) and poorer reported executive function (p < 0.0001) than healthy controls. Those chemotherapy-treated patients that were APOE e4 carriers had significantly slower processing speed. A greater number of risk-related alleles was associated with poorer connectivity in the regions of the left cuneus and left calcarine. While breast cancer patients that are APOE e4 carriers may have a select vulnerability to processing speed impairments, other risk-related alleles were not found to influence cognitive test performance in this population. Conversely, regions of impaired functional connectivity appeared to be related to risk-related genetic polymorphisms in breast cancer patients. This suggests that a cancer patient's SNPs in candidate genes may influence the risk of neurotoxicity. Further study evaluating the impact of genotype on biomarkers of brain health in cancer survivors is warranted.
MeSH term(s)	Adult ; Aged ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Cognitive Dysfunction/genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Middle Aged ; Polymorphism, Single Nucleotide
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2021-03-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-85768-4
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