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  1. Article: Rotors Drift Toward and Stabilize in Low Power Regions in Heterogeneous Models of Atrial Fibrillation.

    Martinez-Mateu, Laura / Saiz, Javier / Berenfeld, Omer

    Computing in cardiology

    2023  Volume 49

    Abstract: Atrial fibrillation (AF) afflicts more than 33 million people worldwide. Success of therapy strategies remains poor and better understanding of the arrhythmia and how to device more effective therapies are needed. The aim of this work is to study the ... ...

    Abstract Atrial fibrillation (AF) afflicts more than 33 million people worldwide. Success of therapy strategies remains poor and better understanding of the arrhythmia and how to device more effective therapies are needed. The aim of this work is to study the role of electric power distributions in rotors and AF dynamics. For this purpose, single cell and tissue simulations were performed to study the effect of ionic currents gradients and fibrosis in rotor's drifting. The root mean square of the ionic (P
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 2325-8861
    ISSN 2325-8861
    DOI 10.22489/cinc.2022.366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: To the Editor- Concerns in multi-electrode and phase mapping of AF.

    Berenfeld, Omer

    Heart rhythm

    2017  Volume 15, Issue 2, Page(s) e3–e4

    MeSH term(s) Atrial Fibrillation/surgery ; Catheter Ablation ; Electrodes ; Pulmonary Veins/surgery
    Language English
    Publishing date 2017-11-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2017.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6278: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: ELUCIDATING THE ROLE OF THE HIS-PURKINJE SYSTEM DURING LONG QT MEDIATED ARRHYTHMIAS.

    Owusu-Mensah, Anthony / Berenfeld, Omer / Audette, Michel

    Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)

    2023  Volume 2023, Page(s) 393–401

    Abstract: Mutation in the hERG gene leading to partial or complete blockade of the rapid delayed rectifier current causes Long QT Type 2 (LQT2) phenotype, the second most common form of Long QT Syndrome. However, the exact involvement of the His-Purkinje System ( ... ...

    Abstract Mutation in the hERG gene leading to partial or complete blockade of the rapid delayed rectifier current causes Long QT Type 2 (LQT2) phenotype, the second most common form of Long QT Syndrome. However, the exact involvement of the His-Purkinje System (HPS) remains elusive. We utilized a finite element model of the rabbit ventricles integrated with a HPS to elucidate the role of HPS during LQT2-mediated arrhythmia. Following the induction of persistent reentry from an ectopic stimulus, we isolated the HPS at different time points. Moreover, we varied the coupling resistance and the number of myocytes at the Purkinje-Myocardial Junctions (PMJs) to ascertain how the junctional parameters altered reentry dynamics. Reentry was terminated with the earliest termination time for reentry coinciding with the earliest time the HPS was isolated. This observation provides evidence of direct involvement of the HPS during LQT2-mediated ventricular arrhythmia. Increasing the coupling resistance or the number of myocytes at the PMJs reduced the percentage of successful retrograde propagation during reentry. Thus, the HPS alters reentry dynamics. Our multi-scale computer modeling outcomes offer important new understandings of probable arrhythmia mechanisms under LQT2 circumstances.
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Major Role of

    Berenfeld, Omer

    Clinical Medicine Insights. Cardiology

    2016  Volume 10, Issue Suppl 1, Page(s) 71–79

    Abstract: Maintenance of paroxysmal atrial fibrillation (AF) by fast rotors in the left atrium (LA) or at the pulmonary veins (PVs) is not fully understood. This review describes the role of the heterogeneous distribution of transmembrane currents in the PVs and ... ...

    Abstract Maintenance of paroxysmal atrial fibrillation (AF) by fast rotors in the left atrium (LA) or at the pulmonary veins (PVs) is not fully understood. This review describes the role of the heterogeneous distribution of transmembrane currents in the PVs and LA junction (PV-LAJ) in the localization of rotors in the PVs. Experimentally observed heterogeneities in
    Language English
    Publishing date 2016-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2575256-X
    ISSN 1179-5468
    ISSN 1179-5468
    DOI 10.4137/CMC.S39773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Atrial Fibrillation: Technologies for Investigation, Monitoring and Treatment, Volume II.

    Berenfeld, Omer / Corino, Valentina / Loewe, Axel / Martínez, Juan Pablo / Rodriguez Matas, Jose F

    Frontiers in physiology

    2023  Volume 14, Page(s) 1209458

    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1209458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Genetic risk factors for drug-induced long QT syndrome: findings from a large real-world case-control study.

    Lopez-Medina, Ana I / Campos-Staffico, Alessandra M / A Chahal, Choudhary Anwar / Volkers, Isabella / Jacoby, Juliet P / Berenfeld, Omer / Luzum, Jasmine A

    Pharmacogenomics

    2024  Volume 25, Issue 3, Page(s) 117–131

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Potassium Channels, Voltage-Gated/genetics ; Potassium Channels, Voltage-Gated/adverse effects ; Case-Control Studies ; Long QT Syndrome/chemically induced ; Long QT Syndrome/genetics ; Risk Factors
    Chemical Substances Potassium Channels, Voltage-Gated
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2023-0229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Editorial: Atrial Fibrillation: Technology for Diagnosis, Monitoring, and Treatment.

    Berenfeld, Omer / Corino, Valentina D A / Loewe, Axel / Martínez, Juan Pablo / Rodriguez Matas, Jose F

    Frontiers in physiology

    2022  Volume 13, Page(s) 848096

    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.848096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: TIME- AND FREQUENCY-BASED INDEPENDENT EVALUATION OF QRST CANCELLATION TECHNIQUES FOR SINGLE-LEAD ELECTROCARDIOGRAMS DURING ATRIAL FIBRILLATION.

    Price, Nicholas F / Berenfeld, Omer / Devabhaktuni, Vijay / Deo, Makarand

    Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)

    2022  Volume 2022, Page(s) 294–304

    Abstract: With the increased prevalence of atrial fibrillation (AF) - a rhythm disturbance in heart's top chambers - there is growing interest in accurate non-invasive diagnosis of atrial activity to improve its therapy. A key component in non-invasive analysis of ...

    Abstract With the increased prevalence of atrial fibrillation (AF) - a rhythm disturbance in heart's top chambers - there is growing interest in accurate non-invasive diagnosis of atrial activity to improve its therapy. A key component in non-invasive analysis of atrial activity is a successful removal of the ventricular QRST complexes from electrocardiograms (ECGs). In this study, we have developed a new approach for an objective and physiologically-based evaluation of QRST cancellation methods based on comparisons with the power spectra of the AF. Three commonly used QRST cancellation methods were evaluated; namely, average beat subtraction, singular value cancellation, and principal component analysis. These methods were evaluated in time and frequency domains using a set of synthesized ECGs preserving the atrial-specific temporal and spectral properties. It was observed that the ABS method provided the best estimation when QRST morphological variability is low, while PCA produces an overall best estimate when a large QRST morphological variability is present.
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article
    DOI 10.23919/annsim55834.2022.9859334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Optical Mapping.

    Berenfeld, Omer / Efimov, Igor

    Cardiac electrophysiology clinics

    2019  Volume 11, Issue 3, Page(s) 495–510

    Abstract: Optical mapping of electrical activity in the heart is based on voltage-sensitive and lipophilic fluorescence dyes. Optical signals recorded from cardiac cells correlate well with their transmembrane potentials. High spatiotemporal resolution, wide field ...

    Abstract Optical mapping of electrical activity in the heart is based on voltage-sensitive and lipophilic fluorescence dyes. Optical signals recorded from cardiac cells correlate well with their transmembrane potentials. High spatiotemporal resolution, wide field mapping, and high sensitivity to transmembrane potential enable detailed characterization of action potential initiation and propagation. Optical mapping is used to study complex patterns of excitation propagation, including propagation across the sinoatrial and atrioventricular nodes and during atrial and ventricular arrhythmias.Optical mapping is used to study the role of reentrant activity in atrial and ventricular fibrillation.
    MeSH term(s) Action Potentials/physiology ; Animals ; Arrhythmias, Cardiac/diagnostic imaging ; Arrhythmias, Cardiac/physiopathology ; Cardiac Imaging Techniques ; Electrophysiologic Techniques, Cardiac ; Fluorescent Dyes ; Heart Conduction System/diagnostic imaging ; Heart Conduction System/physiology ; Humans ; Mice ; Optical Imaging ; Rabbits
    Chemical Substances Fluorescent Dyes
    Language English
    Publishing date 2019-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1877-9190
    ISSN (online) 1877-9190
    DOI 10.1016/j.ccep.2019.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Artificial intelligence analysis of the impact of fibrosis in arrhythmogenesis and drug response.

    Sánchez de la Nava, Ana María / Gómez-Cid, Lidia / Domínguez-Sobrino, Alonso / Fernández-Avilés, Francisco / Berenfeld, Omer / Atienza, Felipe

    Frontiers in physiology

    2022  Volume 13, Page(s) 1025430

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.1025430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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