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Article ; Online: ERMA (TMEM94) is a P-type ATPase transporter for Mg

2024 Volume 84, Issue 7, Page(s) 1321–1337.e11

Abstract: Intracellular ... ...

Abstract	Intracellular Mg
MeSH term(s)	Animals ; Mice ; Humans ; Adenosine Triphosphatases/metabolism ; Membrane Transport Proteins/metabolism ; Endoplasmic Reticulum/genetics ; Endoplasmic Reticulum/metabolism ; Biological Transport ; P-type ATPases/metabolism ; Calcium/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases
Chemical Substances	Adenosine Triphosphatases (EC 3.6.1.-) ; Membrane Transport Proteins ; P-type ATPases (EC 3.6.3.-) ; Calcium (SY7Q814VUP) ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8)
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2024.02.033
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Article: Evaluation of substance P as a biomarker for pain in equine colic.

Gruber, Nina / Gesell-May, Stefan / Scholler, Dominik / Zablotski, Yury / May, Anna

Journal of equine veterinary science

2023 Volume 132, Page(s) 104979

Abstract: ... The aim of this study was to determine if substance P (SP) could be a reliable biomarker to reflect pain ...

Abstract	Equine colic is an important condition associated with acute abdominal pain and one of the leading causes of death in horses. As such, objectively evaluating pain is of interest for attending veterinarians. Pain scales for assessment are present, but no single pain-specific biomarker has been reported. The aim of this study was to determine if substance P (SP) could be a reliable biomarker to reflect pain and serve as a parameter to predict outcome in equine colic. The hypothesis was that horses displaying severe colic signs present with higher values of SP in contrast to those with mild colic signs. Thirty warmblood horses, aged between 3 and 20 years were recruited; evenly distributed (10 horses each) in three colic groups (mild, moderate, severe). To classify the colic signs, the horses were graded by the Equine Acute Abdominal Pain Scale (EAAPS). Clinical examination and EAAPS were performed at arrival in the hospital. Blood samples were collected four times in hourly intervals commencing from arrival. For comparison, already established parameters for prognosticating equine colic (heart rate, serum cortisol, and blood lactate concentration) were also measured. The assumption of increasing SP concentrations along with pain could not be confirmed. SP did not show any association with heart rate, cortisol, lactate, or EAAPS. Whereas the established parameters increased according to the EAAPS, SP remained stable in individual horses regardless of clinical signs, treatment, and disease progression. Consequently, SP was not a reliable parameter to reflect painful conditions or to predict outcome in equine colic.
MeSH term(s)	Animals ; Horses ; Colic/diagnosis ; Colic/veterinary ; Substance P ; Hydrocortisone ; Horse Diseases/diagnosis ; Biomarkers ; Lactic Acid ; Abdominal Pain/diagnosis ; Abdominal Pain/veterinary
Chemical Substances	Substance P (33507-63-0) ; Hydrocortisone (WI4X0X7BPJ) ; Biomarkers ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2102631-2
ISSN	1542-7412 ; 0737-0806
ISSN (online)	1542-7412
ISSN	0737-0806
DOI	10.1016/j.jevs.2023.104979
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Article ; Online: Application of a Bacillus subtilis Whole-Cell Biosensor (P

Kobras, Carolin Martina / Morris, Sali May / Mascher, Thorsten / Gebhard, Susanne

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2601, Page(s) 259–270

Abstract: ... is based on the well-characterized promoter P ...

Abstract	Whole-cell biosensors, based on the visualization of a reporter strain's response to a particular stimulus, are a robust and cost-effective means to monitor defined environmental conditions or the presence of chemical compounds. One specific field in which such biosensors are frequently applied is drug discovery, that is, the screening of large numbers of bacterial or fungal strains for the production of antimicrobial compounds. Here, we describe the application of a luminescence-based Bacillus subtilis biosensor for the discovery of cell wall active substances; this article is an update to our previous chapter published in 2017. The system is based on the well-characterized promoter P
MeSH term(s)	Bacillus subtilis ; Anti-Bacterial Agents/pharmacology ; Cell Wall ; Cell Membrane ; Biosensing Techniques
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-11-14
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2855-3_13
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Article ; Online: Phenotypic spectrum of the recurrent TRPM3 p.(Val837Met) substitution in seven individuals with global developmental delay and hypotonia.

Lines, Matthew A / Goldenberg, Paula / Wong, Ashley / Srivastava, Siddharth / Bayat, Allan / Hove, Hanne / Karstensen, Helena Gásdal / Anyane-Yeboa, Kwame / Liao, Jun / Jiang, Nan / May, Alison / Guzman, Edwin / Morleo, Manuela / D'Arrigo, Stefano / Ciaccio, Claudia / Pantaleoni, Chiara / Castello, Raffaele / McKee, Shane / Ong, Jinfon /

Zibdeh-Lough, Hana / Tran-Mau-Them, Frederic / Gerasimenko, Anna / Heron, Delphine / Keren, Boris / Margot, Henri / de Sainte Agathe, Jean-Madeleine / Burglen, Lydie / Voets, Thomas / Vriens, Joris / Innes, A Micheil / Dyment, David A

American journal of medical genetics. Part A

2022 Volume 188, Issue 6, Page(s) 1667–1675

Abstract: ... c.2509G>A, p.(Val837Met) has been associated with syndromic intellectual disability and seizures ... identified by exome sequencing, with the recurrent p.(Val837Met) variant and global developmental delay ... for the de novo recurrent substitution p.(Val837Met). In contrast with the initial report, epilepsy was not ...

Abstract	TRPM3 encodes a transient receptor potential cation channel of the melastatin family, expressed in the central nervous system and in peripheral sensory neurons of the dorsal root ganglia. The recurrent substitution in TRPM3: c.2509G>A, p.(Val837Met) has been associated with syndromic intellectual disability and seizures. In this report, we present the clinical and molecular features of seven previously unreported individuals, identified by exome sequencing, with the recurrent p.(Val837Met) variant and global developmental delay. Other shared clinical features included congenital hypotonia, dysmorphic facial features (broad forehead, deep-set eyes, and down turned mouth), exotropia, and musculoskeletal issues (hip dysplasia, hip dislocation, scoliosis). Seizures were observed in two of seven individuals (febrile seizure in one and generalized tonic-clonic seizures with atonic drops in another), and epileptiform activity was observed in an additional two individuals. This report extends the number of affected individuals to 16 who are heterozygous for the de novo recurrent substitution p.(Val837Met). In contrast with the initial report, epilepsy was not a mandatory feature observed in this series. TRPM3 pathogenic variation should be considered in individuals with global developmental delays, moderate-severe intellectual disability with, or without, childhood-onset epilepsy.
MeSH term(s)	Child ; Developmental Disabilities/genetics ; Epilepsy ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases ; Intellectual Disability/genetics ; Muscle Hypotonia/genetics ; Mutation, Missense ; TRPM Cation Channels/genetics ; Whole Exome Sequencing
Chemical Substances	TRPM Cation Channels ; TRPM3 protein, human
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2108614-X
ISSN	1552-4833 ; 0148-7299 ; 1552-4825
ISSN (online)	1552-4833
ISSN	0148-7299 ; 1552-4825
DOI	10.1002/ajmg.a.62673
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Article ; Online: Introduction of medical genomics and clinical informatics integration for p-Health care.

Tong, Li / Wu, Hang / Wang, May D / Wang, Geoffrey

Progress in molecular biology and translational science

2022 Volume 190, Issue 1, Page(s) 1–37

Abstract: Achieving predictive, precise, participatory, preventive, and personalized health (abbreviated as p ... the opportunities in biomedical big data integration that can reshape healthcare toward p-health. ...

Abstract	Achieving predictive, precise, participatory, preventive, and personalized health (abbreviated as p-Health) requires comprehensive evaluations of an individual's conditions captured by various measurement technologies. Since the 1950s, analysis of care providers' and physicians' notes and measurement data by computers to improve healthcare delivery has been termed clinical informatics. Since the 2010s, wide adoptions of Electronic Health Records (EHRs) have greatly improved clinical informatics development with fast growing pervasive wearable technologies that continuously capture the human physiological profile in-clinic (EHRs) and out-of-clinic (PHRs or Personal Health Records) to bolster mobile health (mHealth). In addition, after the Human Genome Project in the 1990s, medical genomics has emerged to capture the high-throughput molecular profile of a person. As a result, integrated data analytics is becoming one of the fast-growing areas under Biomedical Big Data to improve human healthcare outcomes. In this chapter, we first introduce the scope of data integration and review applications, data sources, and tools for clinical informatics and medical genomics. We then describe the data integration analytics at the raw data level, feature level, and decision level with case studies, and the opportunity for research and translation using advanced artificial intelligence (AI), such as deep learning. Lastly, we summarize the opportunities in biomedical big data integration that can reshape healthcare toward p-health.
MeSH term(s)	Artificial Intelligence ; Delivery of Health Care ; Genomics ; Humans ; Medical Informatics ; Precision Medicine
Language	English
Publishing date	2022-07-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2471995-X
ISSN	1878-0814 ; 0079-6603 ; 1877-1173
ISSN (online)	1878-0814
ISSN	0079-6603 ; 1877-1173
DOI	10.1016/bs.pmbts.2022.05.002
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Article ; Online: Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults.

Oo, Swe Mar / Htut, Min Thar / Htun, Ye Win / Mon, Aye Aye / Kyaw, May Pyone

Journal of the ASEAN Federation of Endocrine Societies

2022 Volume 38, Issue 1, Page(s) 6–12

Abstract: ... mitochondrial biogenesis in exercising tissues. Selenoprotein P (SELENOP) is the antioxidant hepatokine ... between selenoprotein P and mitochondrial dynamics in humans has not yet been reported. While reduction ... of plasma selenoprotein P becomes an attractive therapeutic target for metabolic diseases, the role ...

Abstract	Objective: Physical exercise can provide many health benefits in humans. Exercise-induced reactive oxygen species (ROS) formation and its downstream signaling cascades are reported to induce mitochondrial biogenesis in exercising tissues. Selenoprotein P (SELENOP) is the antioxidant hepatokine whose hypersecretion is associated with various metabolic diseases. It was reported to impair exercise-induced reactive oxygen species signaling and inhibit subsequent mitochondrial biogenesis in mice. However, the relationship between selenoprotein P and mitochondrial dynamics in humans has not yet been reported. While reduction of plasma selenoprotein P becomes an attractive therapeutic target for metabolic diseases, the role of regular exercise in this regard is still unknown. This study aimed to analyze the influence of regular habitual exercise on plasma selenoprotein P levels and its association with leucocyte mitochondrial DNA copy number in healthy young adults. Methodology: Plasma selenoprotein P levels and leucocyte mitochondrial DNA copy numbers were compared in 44 regularly exercising subjects and 44 non-exercising controls, and the correlation between the two parameters was analyzed. Plasma selenoprotein P levels were measured by Enzyme-linked Immunosorbent Assay, and leucocyte mitochondrial DNA copy numbers were measured using the qPCR method. Results: The regular-exercise group had lower plasma selenoprotein P levels with higher leucocyte mitochondrial DNA copy numbers than the non-exercise group. There was a tendency of negative correlation between the two variables in our studied population. Conclusion: Regular habitual exercise has a beneficial effect on reducing plasma selenoprotein P levels while raising mitochondrial DNA copy numbers.
MeSH term(s)	Humans ; Young Adult ; DNA, Mitochondrial/genetics ; Leukocytes/metabolism ; Mitochondria/genetics ; Reactive Oxygen Species/metabolism ; Selenoprotein P/genetics
Chemical Substances	DNA, Mitochondrial ; Reactive Oxygen Species ; Selenoprotein P
Language	English
Publishing date	2022-04-30
Publishing country	Philippines
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2893162-2
ISSN	2308-118X ; 0857-1074
ISSN (online)	2308-118X
ISSN	0857-1074
DOI	10.15605/jafes.037.S4
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Article: Evaluation of Substance P as a New Stress Parameter in Horses in a Stress Model Involving Four Different Stress Levels.

Scholler, Dominik / Zablotski, Yury / May, Anna

Animals : an open access journal from MDPI

2023 Volume 13, Issue 7

Abstract: ... horses were used to establish reference values for plasma substance P (SP) concentrations. Moreover, 16 ...

Abstract	Stress has a significant impact on equine welfare. There are some studies on the stress response in horses ridden with tight nosebands, but little is known about other stress parameters than cortisol, which potentially could address an emotional component. In this study, blood samples of a total of 74 warmblood horses were used to establish reference values for plasma substance P (SP) concentrations. Moreover, 16 of these warmblood horses were included in a stress model. Four different stress levels (level 1: horses ridden with loose noseband, level 2: tight noseband, level 3: loose noseband and overground endoscope, level 4: tight noseband and overground endoscope) were applied to evaluate SP as a potential stress parameter in horses. Blood samples were taken at rest (t0) and directly after inducing stress (noseband tightening, insertion of endoscope; t1), as well as after 20 min of riding at all gaits (t2). A ridden horse ethogram was applied and showed that horses in the tight noseband group resorted to other stress-related behavioral issues than horses with loose nosebands. Serum cortisol showed a linear increase concurrent with the increase in stress levels with a significant difference between level 1 and level 4 (
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13071142
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Article ; Online: Sensitive monitoring of NAD(P)H levels within cancer cells using mitochondria-targeted near-infrared cyanine dyes with optimized electron-withdrawing acceptors.

Arachchige, Dilka Liyana / Dwivedi, Sushil K / Waters, May / Jaeger, Sophia / Peters, Joe / Tucker, Daniel R / Geborkoff, Micaela / Werner, Thomas / Luck, Rudy L / Godugu, Bhaskar / Liu, Haiying

Journal of materials chemistry. B

2024 Volume 12, Issue 2, Page(s) 448–465

Abstract: ... groups, enabling the sensing of NAD(P)H. Probes A and B exhibit absorptions and emissions in the near ... employed to monitor NAD(P)H levels in glycolysis and specific mitochondrial targeting. Furthermore, it has been used ... to assess the influence of lactate and pyruvate on the levels of NAD(P)H, to explore how hypoxia ...

Abstract	A series of near-infrared fluorescent probes, labeled A to E, were developed by combining electron-rich thiophene and 3,4-ethylenedioxythiophene bridges with 3-quinolinium and various electron deficient groups, enabling the sensing of NAD(P)H. Probes A and B exhibit absorptions and emissions in the near-infrared range, offering advantages such as minimal interference from autofluorescence, negligible photo impairment in cells and tissues, and exceptional tissue penetration. These probes show negligible fluorescence when NADH is not present, and their absorption maxima are at 438 nm and 470 nm, respectively. In contrast, probes C-E feature absorption maxima at 450, 334 and 581 nm, respectively. Added NADH triggers the transformation of the electron-deficient 3-quinolinium units into electron-rich 1,4-dihydroquinoline units resulting in fluorescence responses which were established at 748, 730, 575, 625 and 661 for probes AH-EH, respectively, at detection limits of 0.15 μM and 0.07 μM for probes A and B, respectively. Optimized geometries based on theoretical calculations reveal non-planar geometries for probes A-E due to twisting of the 3-quinolinium and benzothiazolium units bonded to the central thiophene group, which all attain planarity upon addition of hydride resulting in absorption and fluorescence in the near-IR region for probes AH and BH in contrast to probes CH-EH which depict fluorescence in the visible range. Probe A has been successfully employed to monitor NAD(P)H levels in glycolysis and specific mitochondrial targeting. Furthermore, it has been used to assess the influence of lactate and pyruvate on the levels of NAD(P)H, to explore how hypoxia in cancer cells can elevate levels of NAD(P)H, and to visualize changes in levels of NAD(P)H under hypoxic conditions with CoCl
MeSH term(s)	Animals ; NAD/metabolism ; Cisplatin ; Drosophila melanogaster/metabolism ; Electrons ; Mitochondria/metabolism ; Fluorescent Dyes/metabolism ; Pyruvic Acid/metabolism ; Thiophenes ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Neoplasms/metabolism
Chemical Substances	NAD (0U46U6E8UK) ; Cisplatin (Q20Q21Q62J) ; Fluorescent Dyes ; Pyruvic Acid (8558G7RUTR) ; Thiophenes
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb02124f
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Article: Disseminating Metaproteomic Informatics Capabilities and Knowledge Using the Galaxy-P Framework.

Blank, Clemens / Easterly, Caleb / Gruening, Bjoern / Johnson, James / Kolmeder, Carolin A / Kumar, Praveen / May, Damon / Mehta, Subina / Mesuere, Bart / Brown, Zachary / Elias, Joshua E / Hervey, W Judson / McGowan, Thomas / Muth, Thilo / Nunn, Brook / Rudney, Joel / Tanca, Alessandro / Griffin, Timothy J / Jagtap, Pratik D

Proteomes

2018 Volume 6, Issue 1

Abstract: ... for proteomics platform (Galaxy-P) offers an open source, web-based bioinformatics platform for disseminating ... analysis. Much of the software available via the Galaxy-P platform was selected, packaged and deployed ...

Abstract	The impact of microbial communities, also known as the microbiome, on human health and the environment is receiving increased attention. Studying translated gene products (proteins) and comparing metaproteomic profiles may elucidate how microbiomes respond to specific environmental stimuli, and interact with host organisms. Characterizing proteins expressed by a complex microbiome and interpreting their functional signature requires sophisticated informatics tools and workflows tailored to metaproteomics. Additionally, there is a need to disseminate these informatics resources to researchers undertaking metaproteomic studies, who could use them to make new and important discoveries in microbiome research. The Galaxy for proteomics platform (Galaxy-P) offers an open source, web-based bioinformatics platform for disseminating metaproteomics software and workflows. Within this platform, we have developed easily-accessible and documented metaproteomic software tools and workflows aimed at training researchers in their operation and disseminating the tools for more widespread use. The modular workflows encompass the core requirements of metaproteomic informatics: (a) database generation; (b) peptide spectral matching; (c) taxonomic analysis and (d) functional analysis. Much of the software available via the Galaxy-P platform was selected, packaged and deployed through an online metaproteomics "Contribution Fest" undertaken by a unique consortium of expert software developers and users from the metaproteomics research community, who have co-authored this manuscript. These resources are documented on GitHub and freely available through the Galaxy Toolshed, as well as a publicly accessible metaproteomics gateway Galaxy instance. These documented workflows are well suited for the training of novice metaproteomics researchers, through online resources such as the Galaxy Training Network, as well as hands-on training workshops. Here, we describe the metaproteomics tools available within these Galaxy-based resources, as well as the process by which they were selected and implemented in our community-based work. We hope this description will increase access to and utilization of metaproteomics tools, as well as offer a framework for continued community-based development and dissemination of cutting edge metaproteomics software.
Language	English
Publishing date	2018-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720995-7
ISSN	2227-7382
ISSN	2227-7382
DOI	10.3390/proteomes6010007
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Article: Near-infrared Absorption and Emission Probes with Optimal Connection Bridges for Live Monitoring of NAD(P)H Dynamics in Living Systems.

Dwivedi, Sushil K / Arachchige, Dilka Liyana / Waters, May / Jaeger, Sophia / Mahmoud, Mohamed / Olowolagba, Adenike Mary / Tucker, Daniel R / Geborkoff, Micaela R / Werner, Thomas / Luck, Rudy L / Godugu, Bhaskar / Liu, Haiying

Sensors and actuators. B, Chemical

2023 Volume 402

Abstract: Two NAD(P)H-biosensing probes consisting of 1,3,3-trimethyl-3H-indolium and 3-quinolinium acceptors ...

Abstract	Two NAD(P)H-biosensing probes consisting of 1,3,3-trimethyl-3H-indolium and 3-quinolinium acceptors, linked by thiophene,
Language	English
Publishing date	2023-11-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1021505-0
ISSN	0925-4005
ISSN	0925-4005
DOI	10.1016/j.snb.2023.135073
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