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Article: Autologous Blood-Derived Products (ABDPs) for the Treatment of Chronic Wounds.

Fierro, Allegra L / Foley, Carolyn / Lagziel, Tomer / Lantis, John C

2024 Volume 44

Abstract: Autologous blood-derived therapies have emerged as a unique and promising treatment option for chronic wounds. From whole blood clots to spun-down clot constituents, these therapies are highly versatile and tend to have a lower cost profile, allow for ... ...

Abstract	Autologous blood-derived therapies have emerged as a unique and promising treatment option for chronic wounds. From whole blood clots to spun-down clot constituents, these therapies are highly versatile and tend to have a lower cost profile, allow for point-of-service preparation, and inherently carry minimal to no risk of rejection or allergic reaction when compared to many alternative cellular and matrix-like products. Subsequently, a diversity of processing systems, devices, and kits have surfaced on the market for preparing autologous blood-derived products (ABDPs) and many have demonstrated preclinical and clinical efficacy in facilitating chronic wound healing. However, not all ABDPs are created equal, and the lack of standardization among product formulations and cell concentrations as well as varying complexities in preparation protocols has led to unreliable substrate viabilities and overall inconsistent conclusions on efficacy. Additionally, external factors, such as the ease of drawing blood, the health of a patient's blood, and the reimbursement landscape have dissuaded some practitioners from incorporating ABDPs into an algorithm of care for recalcitrant wounds. Here, we attempt to categorize ABDPs into "classes" and examine their efficacy, advantages, and limitations when used as both a primary therapy and an adjunct for treating chronic wounds as well as comment on some potential considerations that may help gear future product development and application.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225512-9
ISSN	1090-3941
ISSN	1090-3941
DOI	10.52198/24.STI.44.WH1752
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Article ; Online: Incisional Release and Fat Grafting for the Surgical Management of Perioral Fibrosis in Scleroderma: A Technical Report and Institutional Review.

Lagziel, Tomer / Kawaji, Qingwen / Hultman, C Scott

Annals of plastic surgery

2023 Volume 90, Issue 6S Suppl 5, Page(s) S495–S498

Abstract: Introduction: Scleroderma (systemic sclerosis [SSc]) is a rare autoimmune, connective tissue disorder. Perioral fibrosis is a local cutaneous complication, negatively impacting functional capabilities and aesthetic satisfaction. Fat grafting has been ... ...

Abstract	Introduction: Scleroderma (systemic sclerosis [SSc]) is a rare autoimmune, connective tissue disorder. Perioral fibrosis is a local cutaneous complication, negatively impacting functional capabilities and aesthetic satisfaction. Fat grafting has been postulated to aid in the management of SSc fibrosis thanks to stem cell enrichment. This technique's success has been demonstrated using different graft origin sites and different injection targets. We aim to demonstrate our SSc patients' success using abdominal fat and perioral target. Methods: We queried our records for patients with preexisting SSc who underwent incisional release and fat grafting for perioral fibrosis from 2018 to 2021. For perioral release, a semisharp cannula was tunneled under the vermilion border into the vermilion and along the skin. For grafting, cannulas were used to infiltrate the fat with a retrograde filling technique in a radial-fanning manner. Their autoimmune diagnosis, anesthetic risk assessment, systemic disease complications, and degree of presenting symptoms were reviewed along with their postoperative outcomes. Results: From 2018 to 2021, 16 patients diagnosed with SSc were treated with incisional release and fat grafting for the management of perioral fibrosis. Of the SSc patients, 8 presented with limited SSc, and 8 presented with diffuse SSc. The mean patient age was 54.31 years. All SSc patients presented with functional symptoms with the most common concern (n = 9) being "decreased mouth opening." Other common complaints were "difficulty eating" (n = 3) or "difficulty drinking" (n = 2). Some patients (n = 11) also presented with cosmetic concerns with "perioral rhytids" being the most common (n = 6). The mean number of systemic complications, at the time of presentation, was 3.06. The mean anesthetic risk assessment was 2.44. The average amount of fat grafted intraoperatively was 14.89 mL. Two patients with SSc required regrafting. For one patient, this was part of the original treatment plan and for the other due to fat resorption. Patients who followed up reported improved functionality and were pleased aesthetically. Conclusions: Patients with perioral fibrosis due to SSc can benefit from autologous fat grafting. Incisional release in combination with fat grafting can enhance procedure outcomes. This technique provides beneficial functional and aesthetic outcomes. Patients with both diffuse and limited disease are appropriate candidates for this procedure.
MeSH term(s)	Humans ; Middle Aged ; Adipose Tissue/transplantation ; Connective Tissue Diseases/complications ; Fibrosis ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/surgery ; Scleroderma, Systemic/diagnosis ; Skin/pathology
Language	English
Publishing date	2023-02-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000003475
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Article ; Online: The Shunt Valve Recession Technique as a Neuroplastic Surgery Adjunct in Complex and High-Risk Shunt Revisions: Technical Note and Case Series.

Lagziel, Tomer / Lee, Ryan P / Gordon, Chad R / Luciano, Mark / Ben-Shalom, Netanel

The Journal of craniofacial surgery

2024

Abstract: Background and objectives: Ventricular shunting is one of the most common procedures in neurosurgery. However, complications and revisions are frequent. Patients requiring multiple revisions often suffer secondary issues with scalp healing over hardware. ...

Abstract	Background and objectives: Ventricular shunting is one of the most common procedures in neurosurgery. However, complications and revisions are frequent. Patients requiring multiple revisions often suffer secondary issues with scalp healing over hardware. Many common ventricular shunt valves have an obligate thickness that creates a visible protrusion and can potentially cause local tissue ischemia and breakdown in the setting of repeated surgery. The authors present a simple technique for recessing the shunt valve into the underlying bone to alleviate protrusion in high-risk cases. Three example cases utilizing this technique are presented. Methods: The skull directly underlying the planned valve site is uniformly recessed with a cutting burr several millimeters as desired while maintaining the inner cortical bone layer. The valve is fixed with standard cranial plating hardware. Expected outcomes: Three patients are reported who underwent shunt valve recession as an adjunct to their shunt revision with neuroplastic surgery assistance. All patients had undergone multiple prior surgeries that had resulted in thin and high-risk fragile scalp. In 1 patient, the prior valve was eroding through the scalp before the described revision. All patients had satisfactory cosmetic outcomes, and there were no revisions in the 2-month follow-up period. Discussion: Complex and high-risk ventricular shunt patients should be considered for shunt valve recession into the bone to reduce wound-related complications and enhance healing. This is a technically simple, safe, and effective technique to include as a neuroplastic adjunct.
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000009923
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Article ; Online: Skin Substitutes and Autograft Techniques: Temporary and Permanent Coverage Solutions.

Kenny, Elizabeth M / Lagziel, Tomer / Hultman, C Scott / Egro, Francesco M

Clinics in plastic surgery

2023 Volume 51, Issue 2, Page(s) 241–254

Abstract: Coverage of burn wounds is crucial to prevent sequalae including dehydration, wound infection, sepsis, shock, scarring, and contracture. To this end, numerous temporary and permanent options for coverage of burn wounds have been described. Temporary ... ...

Abstract	Coverage of burn wounds is crucial to prevent sequalae including dehydration, wound infection, sepsis, shock, scarring, and contracture. To this end, numerous temporary and permanent options for coverage of burn wounds have been described. Temporary options for burn coverage include synthetic dressings, allografts, and xenografts. Permanent burn coverage can be achieved through skin substitutes, cultured epithelial autograft, ReCell, amnion, and autografting. Here, we aim to summarize the available options for burn coverage, as well as important considerations that must be made when choosing the best reconstructive option for a particular patient.
MeSH term(s)	Humans ; Transplantation, Autologous ; Autografts ; Skin, Artificial ; Transplantation, Homologous ; Bandages ; Skin Transplantation ; Burns/surgery ; Skin
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	193117-9
ISSN	1558-0504 ; 0094-1298
ISSN (online)	1558-0504
ISSN	0094-1298
DOI	10.1016/j.cps.2023.12.001
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Article ; Online: Purpura fulminans from acquired protein C deficiency in the era of COVID-19: a case report.

Rostami, Sohayla / Martinez, Stephanie L / Kawaji, Qingwen / Lagziel, Tomer / Hultman, Charles S / Caffrey, Julie

International journal of dermatology

2023 Volume 62, Issue 6, Page(s) 835–836

MeSH term(s)	Humans ; Protein C Deficiency/complications ; Protein C Deficiency/diagnosis ; Purpura Fulminans/diagnosis ; Purpura Fulminans/etiology ; COVID-19/complications
Language	English
Publishing date	2023-05-10
Publishing country	England
Document type	Letter
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.16643
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Article ; Online: The impact of different co-morbidities on clinical outcomes and resource utilization in critically ill burn and surgical patients: A population-based analysis of social determinants of health.

Lagziel, Tomer / Quiroga, Luis H / Ross, Emily / Khoo, Kimberly H / Shamoun, Feras / Asif, Mohammed / Caffrey, Julie A / Hultman, C Scott

Burns : journal of the International Society for Burn Injuries

2024 Volume 50, Issue 4, Page(s) 823–828

Abstract: Background: This study aims to establish the significance of social determinants of health and prevalent co-morbidities on multiple indicators for quality of care in patients admitted to the Burn and Surgical Intensive Care Unit (ICU).: Methods: We ... ...

Abstract	Background: This study aims to establish the significance of social determinants of health and prevalent co-morbidities on multiple indicators for quality of care in patients admitted to the Burn and Surgical Intensive Care Unit (ICU). Methods: We performed a retrospective analysis of population group data for patients admitted at the Burn and Surgical ICU from January 1, 2016, to November 18, 2019. The primary outcomes were length of hospital stay (LOS), mortality, 30-day readmission, and hospital charges. Pearson's chi-square test for categorical variables and t-test for continuous variables were used to compare population health groups. Results: We analyzed a total of 487 burn and 510 surgical patients. When comparing ICU patients, we observed significantly higher mean hospital charges and length of stay (LOS) in BICU v. SICU patients with a history of mental health ($93,259.40 v. $50,503.36, p = 0.013 and 16.28 v. 9.16 days, p = 0.0085), end-stage-renal-disease (ESRD) ($653,871.05 v. $75,746.35, p = 0.0047 and 96.15 v. 17.53 days, p = 0.0104), sepsis ($267,979.60 v. $99,154.41, p = <0.001 and 39.1 v. 18.42 days, p = 0.0043), and venous thromboembolism (VTE) ($757,740.50 v. $117,816.40, p = <0.001 and 93.11 v. 20.21 days, p = 0.002). Also, higher mortality was observed in burn patients with ESRD, ST-Elevation Myocardial Infarction (STEMI), sepsis, VTE, and diabetes mellitus. 30-day-readmissions were greater among burn patients with a history of mental health, drug dependence, heart failure, and diabetes mellitus. Conclusions: Our study provides new insights into the variability of outcomes between burn patients treated in different critical care settings, underlining the influence of comorbidities on these outcomes. By comparing burn patients in the BICU with those in the SICU, we aim to highlight how differences in patient backgrounds, including the quality of care received, contribute to these outcomes. This comparison underscores the need for tailored healthcare strategies that consider the unique challenges faced by each patient group, aiming to mitigate disparities in health outcomes and healthcare spending. Further research to develop relevant and timely interventions that can improve these outcomes.
MeSH term(s)	Humans ; Burns/epidemiology ; Burns/economics ; Burns/therapy ; Male ; Female ; Middle Aged ; Comorbidity ; Retrospective Studies ; Length of Stay/statistics & numerical data ; Social Determinants of Health/statistics & numerical data ; Critical Illness/epidemiology ; Adult ; Aged ; Patient Readmission/statistics & numerical data ; Hospital Charges/statistics & numerical data ; Intensive Care Units/statistics & numerical data ; Kidney Failure, Chronic/epidemiology ; Mental Disorders/epidemiology ; Venous Thromboembolism/epidemiology ; Sepsis/epidemiology ; Diabetes Mellitus/epidemiology ; Heart Failure/epidemiology ; Hospital Mortality
Language	English
Publishing date	2024-03-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2024.03.003
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Article ; Online: Mind your media.

Lagziel, Shoval / Gottlieb, Eyal / Shlomi, Tomer

Nature metabolism

2020 Volume 2, Issue 12, Page(s) 1369–1372

MeSH term(s)	Animals ; Cell Line, Tumor ; Cells, Cultured ; Culture Media ; Humans ; Neoplasms/metabolism
Chemical Substances	Culture Media
Language	English
Publishing date	2020-12-17
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2522-5812
ISSN (online)	2522-5812
DOI	10.1038/s42255-020-00299-y
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Article ; Online: The Added Value of Bronchoalveolar Lavage for Pulmonary Tuberculosis Diagnosis in High-Risk Hospitalized Patients with Negative Sputum Samples.

Freund, Ophir / Hadad, Yitzhac / Lagziel, Tomer / Friedman Regev, Inbal / Kleinhendler, Eyal / Unterman, Avraham / Bar-Shai, Amir / Perluk, Tal Moshe

Advances in respiratory medicine

2023 Volume 92, Issue 1, Page(s) 15–24

Abstract: Hospitalized patients with a high suspicion of pulmonary tuberculosis (HS-PTB) are isolated until a definite diagnosis can be determined. If doubt remains after negative sputum samples, bronchoscopy with bronchoalveolar lavage (BAL) is often sought. ... ...

Abstract	Hospitalized patients with a high suspicion of pulmonary tuberculosis (HS-PTB) are isolated until a definite diagnosis can be determined. If doubt remains after negative sputum samples, bronchoscopy with bronchoalveolar lavage (BAL) is often sought. Still, evidence of the added value of BAL in this patient population is scarce. To address this issue, we included consecutive HS-PTB patients with negative sputum samples who underwent BAL between 2017 and 2018. Chest X-rays (CXR) and CT scans were evaluated by a chest radiologist blind to the final diagnosis. Independent predictors for PTB were assessed by multivariate regression, using all positive PTB patients between 2017 and 2019 (by sputum or BAL) as a control group (
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Male ; Mycobacterium tuberculosis ; Sputum ; Bronchoalveolar Lavage Fluid ; Sensitivity and Specificity ; Tuberculosis, Pulmonary/diagnostic imaging ; Bronchoalveolar Lavage ; Dimercaprol
Chemical Substances	Dimercaprol (0CPP32S55X)
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2893877-X
ISSN	2543-6031 ; 2451-4934
ISSN (online)	2543-6031
ISSN	2451-4934
DOI	10.3390/arm92010003
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Article: Revitalizing Hands: A Comprehensive Review of Anatomy and Treatment Options for Hand Rejuvenation.

Har-Shai, Lior / Ofek, Sar-El / Lagziel, Tomer / Pikkel, Yoav Y / Duek, Ori S / Ad-El, Dean D / Shay, Tamir

Cureus

2023 Volume 15, Issue 2, Page(s) e35573

Abstract: Dorsal hand rejuvenation is gaining popularity as a solitary procedure and adjunct to face and neck rejuvenation treatments. As the hands age, the skin loses elasticity and becomes more translucent, the veins, joints, and tendons appear more prominent, ... ...

Abstract	Dorsal hand rejuvenation is gaining popularity as a solitary procedure and adjunct to face and neck rejuvenation treatments. As the hands age, the skin loses elasticity and becomes more translucent, the veins, joints, and tendons appear more prominent, and the bones become more noticeable. These changes are due to intrinsic and extrinsic factors. Current treatment methods include the injection of dermal fillers and autologous fat grafting. Anatomic studies to ensure the successful implementation of rejuvenation procedures identified three separate fascial layers in the dorsum, from superficial to deep. More recent re-evaluations revealed a less distinct, inseparable, sponge-like fascial layer. All authors agree that the superficial dermal layer is probably the optimal location for the injection of volumizing materials because it is free of anatomical structures. Many methods for harvesting, preparing, and injecting fat grafts to the dorsum of the hand have been described in the past three decades. Both filler and fat-graft procedures are performed on an ambulatory basis under local anesthesia. Good results with low postoperative and long-term complication rates and high patient satisfaction have been reported.
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.35573
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Article ; Online: Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches.

Lagziel, Shoval / Lee, Won Dong / Shlomi, Tomer

BMC biology

2019 Volume 17, Issue 1, Page(s) 51

MeSH term(s)	Acclimatization ; Humans ; Metabolic Flux Analysis ; Metabolic Networks and Pathways ; Models, Biological ; Neoplasms/metabolism
Language	English
Publishing date	2019-07-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1741-7007
ISSN (online)	1741-7007
DOI	10.1186/s12915-019-0669-x
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