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Article ; Online: Oxidation of tantalum disulfide (TaS

Takeuchi, Hayate / Urakami, Noriyuki / Hashimoto, Yoshio

2022 Volume 33, Issue 37

Abstract: Ta-based high- ...

Abstract	Ta-based high-
Language	English
Publishing date	2022-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/ac75f9
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Article ; Online: Primary Severe Pulmonary and Tricuspid Valve Regurgitation in an Adult Patient.

Yoshida, Kazuki / Sasaki, Haruka / Takaoka, Hiroyuki / Hashimoto, Rei / Kawasaki, Kenji / Matsumiya, Goro / Matsushita, Kazuyuki / Kobayashi, Yoshio

CASE (Philadelphia, Pa.)

2024 Volume 8, Issue 3Part B, Page(s) 265–272

Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Case Reports
ISSN	2468-6441
ISSN (online)	2468-6441
DOI	10.1016/j.case.2023.12.034
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Article ; Online: AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation.

Urushihara, Yusuke / Hashimoto, Takuma / Fujishima, Yohei / Hosoi, Yoshio

International journal of molecular sciences

2023 Volume 24, Issue 16

Abstract: Most solid tumors contain hypoxic and nutrient-deprived microenvironments. The cancer cells in these microenvironments have been reported to exhibit radioresistance. We have previously reported that nutrient starvation increases the expression and/or ... ...

Abstract	Most solid tumors contain hypoxic and nutrient-deprived microenvironments. The cancer cells in these microenvironments have been reported to exhibit radioresistance. We have previously reported that nutrient starvation increases the expression and/or activity of ATM and DNA-PKcs, which are involved in the repair of DNA double-strand breaks induced by ionizing radiation. In the present study, to elucidate the molecular mechanisms underlying these phenomena, we investigated the roles of AMPK and FOXO3a, which play key roles in the cellular response to nutrient starvation. Nutrient starvation increased clonogenic cell survival after irradiation and increased the activity and/or expression of AMPKα, FOXO3a, ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 in MDA-MB-231 cells. Knockdown of AMPKα using siRNA suppressed the activity and/or expression of FOXO3a, ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 under nutrient starvation. Knockdown of FOXO3a using siRNA suppressed the activity and/or expression of AMPKα, ATM, DNA-PKcs, FOXO3a, Src, EGFR, PDK1, and SOD2 under nutrient starvation. Nutrient starvation decreased the incidence of apoptosis after 8 Gy irradiation. Knockdown of FOXO3a increased the incidence of apoptosis after irradiation under nutrient starvation. AMPK and FOXO3a appear to be key molecules that induce radioresistance under nutrient starvation and may serve as targets for radiosensitization.
MeSH term(s)	Humans ; AMP-Activated Protein Kinases ; Nutrients ; RNA, Small Interfering/genetics ; Starvation ; ErbB Receptors/genetics ; DNA ; Ataxia Telangiectasia Mutated Proteins/genetics
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31) ; RNA, Small Interfering ; ErbB Receptors (EC 2.7.10.1) ; DNA (9007-49-2) ; EGFR protein, human (EC 2.7.10.1) ; ATM protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
Language	English
Publishing date	2023-08-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241612828
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Article ; Online: Reply to letter to the editor by Yoshii.

Nagayama, Yoshio / Ebina, Kosuke / Tsuboi, Hideki / Hirao, Makoto / Hashimoto, Jun / Yoshikawa, Hideki / Okada, Seiji / Nakata, Ken

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2023 Volume 28, Issue 3, Page(s) 717–718

Language	English
Publishing date	2023-03-10
Publishing country	Japan
Document type	Letter ; Comment
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2023.02.023
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Article ; Online: Outcomes of solitary postoperative recurrence of esophageal squamous cell carcinoma diagnosed with FDG-PET/CT and treated with definitive radiation therapy.

Ihara, Hiroki / Yoshio, Kotaro / Tanabe, Shunsuke / Sugiyama, Soichi / Hashimoto, Masashi / Maeda, Naoaki / Akagi, Shinsuke / Takao, Soshi / Noma, Kazuhiro / Hiraki, Takao

Esophagus : official journal of the Japan Esophageal Society

2023 Volume 20, Issue 3, Page(s) 548–556

Abstract: Background: Surgical resection of esophageal cancer is frequently performed to achieve a complete cure. However, the postoperative recurrence rate is 36.8-42.5%, leading to poor prognosis. Radiation therapy has been used to treat recurrences; solitary ... ...

Abstract	Background: Surgical resection of esophageal cancer is frequently performed to achieve a complete cure. However, the postoperative recurrence rate is 36.8-42.5%, leading to poor prognosis. Radiation therapy has been used to treat recurrences; solitary recurrence has been proposed as a prognostic factor for radiation therapy, though its significance is unclear. Methods: We examined 27 patients who underwent definitive radiation therapy for single or multiple postoperative recurrences of esophageal squamous cell carcinoma between May 2015 and April 2021. Results: The 1-, 2-, and 3-year overall survival rates were 85.2%, 62.6%, and 47.3%, respectively, and solitary recurrence was the only significant factor associated with overall survival (P = 0.003). The 1-, 2-, and 3-year overall survival rates in patients with solitary recurrence were 91.7%, 80.2%, and 80.2%, respectively, and in patients with multiple recurrences they were 80.0%, 50.3%, and 25.1%, respectively. Multivariate analysis also showed solitary recurrence as a significant factor for overall survival. Conclusions: When diagnosed with
MeSH term(s)	Humans ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography/methods ; Esophageal Squamous Cell Carcinoma/diagnosis ; Esophageal Squamous Cell Carcinoma/radiotherapy ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/radiotherapy ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/radiotherapy ; Carcinoma, Squamous Cell/surgery ; Retrospective Studies ; Positron-Emission Tomography ; Recurrence
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-04-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2133367-1
ISSN	1612-9067 ; 1612-9059
ISSN (online)	1612-9067
ISSN	1612-9059
DOI	10.1007/s10388-023-01000-4
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Article ; Online: Histopathological significance of connective tissue disease-associated interstitial lung disease in transbronchial lung cryobiopsy specimens.

Katsuragawa, Hiroyuki / Sumiyoshi, Shinji / Ikegami, Naoya / Hashimoto, Seishu / Hajiro, Takashi / Taguchi, Yoshio / Kobashi, Yoichiro / Haga, Hironori / Yoshizawa, Akihiko

Pathology, research and practice

2024 Volume 254, Page(s) 155078

Abstract: Differentiating between idiopathic interstitial pneumonia (IIP) and secondary interstitial pneumonia, particularly connective tissue disease-associated interstitial lung disease (CTD-ILD), can be challenging histopathologically, and there may be ... ...

Abstract	Differentiating between idiopathic interstitial pneumonia (IIP) and secondary interstitial pneumonia, particularly connective tissue disease-associated interstitial lung disease (CTD-ILD), can be challenging histopathologically, and there may be discrepancies among pathologists. While surgical lung biopsy has traditionally been considered the gold standard for diagnosing interstitial pneumonia, the usefulness of transbronchial lung cryobiopsy (TBLC) has been reported. If TBLC could effectively distinguish between primary and secondary diseases, it would provide a less invasive option for patients. The aim of this study was to identify specific pathologic findings in TBLC specimens that could assist in distinguishing CTD-ILD from IIP. A total of 93 underwent TBLC at Tenri Hospital between 2018 and 2022. We retrospectively reviewed cases of CTD-ILD exhibiting a nonspecific interstitial pneumonia (NSIP) pattern (CTD-NSIP) and cases of NSIP with an unknown etiology (NSIP-UE), as determined through multidisciplinary discussion. Nineteen patients with CTD-NSIP and 26 patients with NSIP-UE were included in the study for clinicopathological analysis. The CTD-NSIP group had a significantly higher proportion of female patients compared to the NSIP-UE group (79% vs. 31%; p = 0.002). The presence of both fresh and old intraluminal fibrosis within the same TBLC specimen was significantly more frequent in CTD-NSIP group than in the NSIP-UE group (p = 0.023). The presence of an NSIP pattern with co-existing fresh and old intraluminal fibrosis in TBLC specimens raised suspicion for CTD-ILD.
MeSH term(s)	Humans ; Female ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/pathology ; Retrospective Studies ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/pathology ; Lung/pathology ; Connective Tissue Diseases/complications ; Connective Tissue Diseases/diagnosis ; Connective Tissue Diseases/pathology ; Biopsy ; Fibrosis
Language	English
Publishing date	2024-01-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.155078
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Article ; Online: Significance of the cribriform morphology area ratio for biochemical recurrence in Gleason score 4 + 4 prostate cancer patients following robot-assisted radical prostatectomy.

Shimodaira, Kenji / Inoue, Rie / Hashimoto, Takeshi / Satake, Naoya / Shishido, Toshihide / Namiki, Kazunori / Harada, Kazuharu / Nagao, Toshitaka / Ohno, Yoshio

Cancer medicine

2024 Volume 13, Issue 5, Page(s) e7086

Abstract: Background: In prostate cancer, histological cribriform patterns are categorized as Gleason pattern 4, and recent studies have indicated that their size and percentage are associated with the risk of biochemical recurrence (BCR). However, these studies ... ...

Abstract	Background: In prostate cancer, histological cribriform patterns are categorized as Gleason pattern 4, and recent studies have indicated that their size and percentage are associated with the risk of biochemical recurrence (BCR). However, these studies included a mixture of cases with various Gleason scores (GSs). We therefore examined the prognostic value of the area and percentage of cribriform patterns in patients with GS 4 + 4 prostate cancer. Methods: We investigated 108 patients with GS 4 + 4 prostate cancer who underwent robot-assisted radical prostatectomy (RARP). After digitally scanning the hematoxylin and eosin-stained slides, we measured the area of the entire cancer and cribriform patterns. Predictive factors for BCR were explored using log-rank test and Cox proportional hazard model analyses. Results: Sixty-seven (62.0%) patients had a cribriform pattern in RARP specimens, and 32 (29.6%) experienced BCR. The median total cancer area, cribriform pattern area, and percentage of cribriform pattern area (% cribriform) were 427.70 mm Conclusions: An increased % cribriform value was associated with BCR in patients with GS 4 + 4 prostate cancer following RARP.
MeSH term(s)	Male ; Humans ; Neoplasm Grading ; Prostate-Specific Antigen ; Robotics ; Prostatic Neoplasms/pathology ; Prostatectomy ; Neoplasm Recurrence, Local/pathology
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.7086
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Article: Effects of Subjective Social Status and Self-Esteem in the Association Between Childhood Abuse and Adulthood Anxiety.

Endo, Misaki / Ono, Miki / Deguchi, Ayaka / Iwata, Yoshio / Tamada, Yu / Masuya, Jiro / Tanabe, Hajime / Hashimoto, Naoki / Inoue, Takeshi / Honyashiki, Mina

Neuropsychiatric disease and treatment

2024 Volume 20, Page(s) 877–884

Abstract: Background: Subjective social status influences anxiety, but at present, the mechanism is not fully understood. It has been reported that negative childhood experiences, such as abuse, can influence depressive symptoms through subjective social status ... ...

Abstract	Background: Subjective social status influences anxiety, but at present, the mechanism is not fully understood. It has been reported that negative childhood experiences, such as abuse, can influence depressive symptoms through subjective social status and personality traits, such as self-esteem. A similar mechanism is presumed to underlie anxiety symptoms in adulthood. Therefore, we hypothesized that subjective social status and self-esteem are intermediate factors in the indirect effects of childhood abuse on state anxiety in adulthood, and analyzed the indirect effects via these factors using a path analysis. Subjects and methods: Child Abuse and Trauma Scale, Subjective Social Status, Rosenberg Self-Esteem Scale, and State-Trait Anxiety Inventory Form Y questionnaires were administered in a self-report format to 404 adult volunteers from January 2014 to August 2014. In addition, a path analysis was conducted to determine whether subjective social status and self-esteem are associated with the indirect effects of childhood abuse on anxiety symptoms in adulthood. Results: Childhood abuse did not directly affect state anxiety in adulthood, but affected state anxiety via subjective social status and self-esteem. Subjective social status affected state anxiety via self-esteem. This model explained 25.2% of the variation in state anxiety in adult volunteers. Conclusion: The present study demonstrated that childhood abuse affects anxiety in adulthood through subjective social status and self-esteem. Therefore, interventions that enhance subjective social status and self-esteem for adults who experienced childhood abuse may help reduce their anxiety.
Language	English
Publishing date	2024-04-16
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S440616
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Article ; Online: Comparison of Postoperative Stress Urinary Incontinence between Anteroposterior Dissection and Modified Gilling Method in Holmium Laser Enucleation of the Prostate.

Shishido, Toshihide / Hirasawa, Yosuke / Kashima, Takeshi / Hashimoto, Takeshi / Satake, Naoya / Hayashi, Kenjiro / Aizawa, Taku / Harada, Kazuharu / Taguri, Masataka / Ohno, Yoshio

Urology journal

2024 Volume 21, Issue 2, Page(s) 133–139

Abstract: Purpose: Few studies have evaluated the usefulness of anteroposterior dissection holmium laser enucleation of the prostate (HoLEP). Thus, this study investigated the incidence of stress urinary incontinence (SUI) after HoLEP and usefulness of ... ...

Abstract	Purpose: Few studies have evaluated the usefulness of anteroposterior dissection holmium laser enucleation of the prostate (HoLEP). Thus, this study investigated the incidence of stress urinary incontinence (SUI) after HoLEP and usefulness of anteroposterior dissection HoLEP in preventing postoperative SUI. Materials and methods: In total, 288 patients who underwent HoLEP performed by a single experienced surgeon between May 2014 and September 2021 were enrolled. Furthermore, 134 patients underwent retrograde dissection using the modified Gilling method (surgery 1) and 154 patients underwent anteroposterior dissection HoLEP (surgery 2). The risk factors for SUI, as well as the rates of SUI improvement for the two surgical procedures, were evaluated. Results: Postoperative SUI was observed in 58 (20.1%) of 288 patients, of whom, 48 (82.8%) recovered continence within 6 months. Ten patients (17.2%) required more than 6 months to recover continence. SUI incidence 1 month after HoLEP was 29.9% (40/134 patients) for surgery 1 and 11.7% (18/154 patients) for surgery 2; a statistically significant difference was observed between the two groups (odds ratio [OR], 0.311; 95% confidence interval [CI], 0.168-0.575; p < 0.001). In addition, surgery 2 was significantly associated with early recovery from SUI compared with surgery 1 (stratified hazard ratio, 0.782; 95% CI, 0.615------0.995; p < 0.001). The multivariable analysis demonstrated that only surgical procedure (OR, 0.350; 95%CI, 0.168-0.732; p=0.005) was an independent predictor of SUI.- Conclusion: We reaffirmed that anteroposterior dissection HoLEP is a useful procedure for reducing the risk of postoperative SUI and early recovery of urinary continence.
MeSH term(s)	Male ; Humans ; Prostate ; Urinary Incontinence, Stress/etiology ; Urinary Incontinence, Stress/surgery ; Lasers, Solid-State/therapeutic use ; Prostatic Hyperplasia/surgery ; Prostatic Hyperplasia/complications ; Transurethral Resection of Prostate/adverse effects ; Laser Therapy/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2024-03-24
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2251940-3
ISSN	1735-546X ; 1735-1308
ISSN (online)	1735-546X
ISSN	1735-1308
DOI	10.22037/uj.v20i.7746
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Article ; Online: C16, a PKR inhibitor, suppresses cell proliferation by regulating the cell cycle via p21 in colorectal cancer.

Hashimoto, Yu / Tokumoto, Yoshio / Watanabe, Takao / Ogi, Yusuke / Sugishita, Hiroki / Akita, Satoshi / Niida, Kazuki / Hayashi, Mirai / Okada, Masaya / Shiraishi, Kana / Tange, Kazuhiro / Tomida, Hideomi / Yamamoto, Yasunori / Takeshita, Eiji / Ikeda, Yoshio / Oshikiri, Taro / Hiasa, Yoichi

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9029

Abstract: Double-stranded RNA-activated protein kinase R (PKR) is highly expressed in colorectal cancer (CRC). However, the role of PKR in CRC remains unclear. The aim of this study was to clarify whether C16 (a PKR inhibitor) exhibits antitumor effects and to ... ...

Abstract	Double-stranded RNA-activated protein kinase R (PKR) is highly expressed in colorectal cancer (CRC). However, the role of PKR in CRC remains unclear. The aim of this study was to clarify whether C16 (a PKR inhibitor) exhibits antitumor effects and to identify its target pathway in CRC. We evaluated the effects of C16 on CRC cell lines using the MTS assay. Enrichment analysis was performed to identify the target pathway of C16. The cell cycle was analyzed using flow cytometry. Finally, we used immunohistochemistry to examine human CRC specimens. C16 suppressed the proliferation of CRC cells. Gene Ontology (GO) analysis revealed that the cell cycle-related GO category was substantially enriched in CRC cells treated with C16. C16 treatment resulted in G1 arrest and increased p21 protein and mRNA expression. Moreover, p21 expression was associated with CRC development as observed using immunohistochemical analysis of human CRC tissues. C16 upregulates p21 expression in CRC cells to regulate cell cycle and suppress tumor growth. Thus, PKR inhibitors may serve as a new treatment option for patients with CRC.
MeSH term(s)	Humans ; Protein Kinase Inhibitors/pharmacology ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Cell Cycle ; Cell Proliferation ; Cell Division ; Cell Line, Tumor ; Apoptosis ; Gene Expression Regulation, Neoplastic
Chemical Substances	Protein Kinase Inhibitors
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59671-7
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