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  1. Article ; Online: Random effects models for complex designs.

    Jarrett, R G / Farewell, V T / Herzberg, A M

    Statistical methods in medical research

    2020  Volume 29, Issue 12, Page(s) 3695–3706

    Abstract: ... of treatments applied to columns. In a 2003 publication, Farewell and Herzberg presented an analysis of variance ...

    Abstract Plaid designs are characterised by having one set of treatments applied to rows and another set of treatments applied to columns. In a 2003 publication, Farewell and Herzberg presented an analysis of variance structure for such designs. They presented an example of a study in which medical practitioners, trained in different ways, evaluated a series of videos of patients obtained under a variety of conditions. However, their analysis did not take full account of all error terms. In this paper, a more comprehensive analysis of this study is presented, informed by the recognition that the study can also be regarded as a two-phase design. The development of random effects models is outlined and the potential importance of block-treatment interactions is highlighted. The use of a variety of techniques is shown to lead to a better understanding of the study. Examination of the variance components involved in the expected mean squares is demonstrated to have particular value in identifying appropriate error terms for F-tests derived from an analysis of variance table. A package such as ASReml can also be used provided an appropriate error structure is specified. The methods presented can be applied to the design and analysis of other complex studies in which participants supply multiple measurements under a variety of conditions.
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1136948-6
    ISSN 1477-0334 ; 0962-2802
    ISSN (online) 1477-0334
    ISSN 0962-2802
    DOI 10.1177/0962280220938418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3564: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article: Study design.

    Farewell, Vernon T / Farewell, Daniel M

    Diagnostic histopathology (Oxford, England)

    2016  Volume 22, Issue 7, Page(s) 246–252

    Abstract: A brief survey is provided of common designs for medical studies and important issues in their implementation. The designs discussed include those for laboratory studies, clinical trials, cohort studies, case-control and related studies, and diagnostic ... ...

    Abstract A brief survey is provided of common designs for medical studies and important issues in their implementation. The designs discussed include those for laboratory studies, clinical trials, cohort studies, case-control and related studies, and diagnostic studies.
    Language English
    Publishing date 2016-08-24
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2399849-0
    ISSN 1756-2317
    ISSN 1756-2317
    DOI 10.1016/j.mpdhp.2016.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4110: Show issues Location:
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  3. Article ; Online: Relationship between Chronic Health Conditions and Occupational Burnout in the Early Care and Education Workforce.

    Shreedar, Priyanka / Pangalangan, Julia M L / Puma, Jini E / Farewell, Charlotte V

    Journal of occupational and environmental medicine

    2024  

    Abstract: Objective: The early care and education (ECE) workforce experiences high rates of poor mental and physical health outcomes which impact staff well-being and burnout. This study aimed to assess the relationship between chronic health conditions and ... ...

    Abstract Objective: The early care and education (ECE) workforce experiences high rates of poor mental and physical health outcomes which impact staff well-being and burnout. This study aimed to assess the relationship between chronic health conditions and occupational burnout in ECE Head Start staff working in low-resourced locations.
    Methods: This study administered an 89-item cross-sectional survey to 332 ECE staff employed in 42 Head Start centers in the United States. Staff self-reported on 10 chronic health conditions: arthritis, asthma, cancer, depression, diabetes, heart disease, high blood pressure, insomnia, lung disease, and musculoskeletal disorders.
    Results: We found that multimorbidity of chronic conditions significantly predicted overall burnout (B = 2.39, p < .01), particularly related to emotional exhaustion (B = 2.04, p < .01).
    Conclusions: Workplace interventions targeting emotional exhaustion related to chronic health conditions are recommended to effectively address occupational burnout among ECE staff.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000003102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 155: Show issues Location:
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  4. Article ; Online: Partially hidden multi-state modelling of a prolonged disease state defined by a composite outcome.

    Farewell, Vernon T / Su, Li / Jackson, Christopher

    Lifetime data analysis

    2019  Volume 25, Issue 4, Page(s) 696–711

    Abstract: For rheumatic diseases, Minimal Disease Activity (MDA) is usually defined as a composite outcome which is a function of several individual outcomes describing symptoms or quality of life. There is ever increasing interest in MDA but relatively little has ...

    Abstract For rheumatic diseases, Minimal Disease Activity (MDA) is usually defined as a composite outcome which is a function of several individual outcomes describing symptoms or quality of life. There is ever increasing interest in MDA but relatively little has been done to characterise the pattern of MDA over time. Motivated by the aim of improving the modelling of MDA in psoriatic arthritis, the use of a two-state model to estimate characteristics of the MDA process is illustrated when there is particular interest in prolonged periods of MDA. Because not all outcomes necessary to define MDA are measured at all clinic visits, a partially hidden multi-state model with latent states is used. The defining outcomes are modelled as conditionally independent given these latent states, enabling information from all visits, even those with missing data on some variables, to be used. Data from the Toronto Psoriatic Arthritis Clinic are analysed to demonstrate improvements in accuracy and precision from the inclusion of data from visits with incomplete information on MDA. An additional benefit of this model is that it can be extended to incorporate explanatory variables, which allows process characteristics to be compared between groups. In the example, the effect of explanatory variables, modelled through the use of relative risks, is also summarised in a potentially more clinically meaningful manner by comparing times in states, and probabilities of visiting states, between patient groups.
    MeSH term(s) Algorithms ; Data Interpretation, Statistical ; Disease Progression ; Female ; Humans ; Male ; Models, Statistical ; Quality of Life ; Rheumatic Diseases
    Language English
    Publishing date 2019-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1479719-7
    ISSN 1572-9249 ; 1380-7870
    ISSN (online) 1572-9249
    ISSN 1380-7870
    DOI 10.1007/s10985-018-09460-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Medical statistics, Austin Bradford Hill, and a celebration of 40 years of Statistics in Medicine.

    Farewell, Vern / Johnson, Tony

    Statistics in medicine

    2020  Volume 40, Issue 1, Page(s) 17–28

    Language English
    Publishing date 2020-12-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.8832
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1756: Show issues Location:
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  6. Article ; Online: Dirichlet negative multinomial regression for overdispersed correlated count data.

    Farewell, Daniel M / Farewell, Vernon T

    Biostatistics (Oxford, England)

    2012  Volume 14, Issue 2, Page(s) 395–404

    Abstract: A generic random effects formulation for the Dirichlet negative multinomial distribution is developed together with a convenient regression parameterization. A simulation study indicates that, even when somewhat misspecified, regression models based on ... ...

    Abstract A generic random effects formulation for the Dirichlet negative multinomial distribution is developed together with a convenient regression parameterization. A simulation study indicates that, even when somewhat misspecified, regression models based on the Dirichlet negative multinomial distribution have smaller median absolute error than generalized estimating equations, with a particularly pronounced improvement when correlation between observations in a cluster is high. Estimation of explanatory variable effects and sources of variation is illustrated for a study of clinical trial recruitment.
    MeSH term(s) Biostatistics ; Clinical Trials as Topic/statistics & numerical data ; Computer Simulation ; Data Interpretation, Statistical ; Humans ; Linear Models ; Longitudinal Studies ; Models, Statistical ; Patient Selection ; Regression Analysis
    Language English
    Publishing date 2012-12-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2031500-4
    ISSN 1468-4357 ; 1465-4644
    ISSN (online) 1468-4357
    ISSN 1465-4644
    DOI 10.1093/biostatistics/kxs050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6259: Show issues Location:
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  7. Article: Correlated multistate models for multiple processes: an application to renal disease progression in systemic

    O'Keeffe, Aidan G / Su, Li / Farewell, Vernon T

    Journal of the Royal Statistical Society. Series C, Applied statistics

    2018  Volume 67, Issue 4, Page(s) 841–860

    Abstract: Bidirectional changes over time in the estimated glomerular filtration rate and in urine protein content are of interest for the treatment and management of patients ... ...

    Abstract Bidirectional changes over time in the estimated glomerular filtration rate and in urine protein content are of interest for the treatment and management of patients with
    Language English
    Publishing date 2018-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1482300-7
    ISSN 1467-9876 ; 0035-9254
    ISSN (online) 1467-9876
    ISSN 0035-9254
    DOI 10.1111/rssc.12257
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  8. Article ; Online: NICE Guidelines: management of colorectal cancer metastases.

    Baum, M / Fallowfield, L / Farewell, V / Macbeth, F / Treasure, T

    The British journal of surgery

    2020  Volume 107, Issue 9, Page(s) e357

    MeSH term(s) Colorectal Neoplasms/therapy ; Humans ; Liver Neoplasms ; Lung ; Peritoneum
    Language English
    Publishing date 2020-07-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11789
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.66: Show issues Location:
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  9. Article: Clustered multistate models with observation level random effects, mover-stayer effects and dynamic covariates: modelling transition intensities and sojourn times in a study of psoriatic arthritis.

    Yiu, Sean / Farewell, Vernon T / Tom, Brian D M

    Journal of the Royal Statistical Society. Series C, Applied statistics

    2017  Volume 67, Issue 2, Page(s) 481–500

    Abstract: In psoriatic arthritis, it is important to understand the joint activity (represented by swelling and pain) and damage processes because both are related to severe physical disability. The paper aims to provide a comprehensive investigation into both ... ...

    Abstract In psoriatic arthritis, it is important to understand the joint activity (represented by swelling and pain) and damage processes because both are related to severe physical disability. The paper aims to provide a comprehensive investigation into both processes occurring over time, in particular their relationship, by specifying a joint multistate model at the individual hand joint level, which also accounts for many of their important features. As there are multiple hand joints, such an analysis will be based on the use of clustered multistate models. Here we consider an observation level random-effects structure with dynamic covariates and allow for the possibility that a subpopulation of patients is at minimal risk of damage. Such an analysis is found to provide further understanding of the activity-damage relationship beyond that provided by previous analyses. Consideration is also given to the modelling of mean sojourn times and jump probabilities. In particular, a novel model parameterization which allows easily interpretable covariate effects to act on these quantities is proposed.
    Language English
    Publishing date 2017-07-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1482300-7
    ISSN 1467-9876 ; 0035-9254
    ISSN (online) 1467-9876
    ISSN 0035-9254
    DOI 10.1111/rssc.12235
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  10. Article: Exploring the existence of a stayer population with mover-stayer counting process models: application to joint damage in psoriatic arthritis.

    Yiu, Sean / Farewell, Vernon T / Tom, Brian D M

    Journal of the Royal Statistical Society. Series C, Applied statistics

    2017  Volume 66, Issue 4, Page(s) 669–690

    Abstract: Many psoriatic arthritis patients do not progress to permanent joint damage in any of the 28 hand joints, even under prolonged follow-up. This has led several researchers to fit models that estimate the proportion of stayers (those who do not have the ... ...

    Abstract Many psoriatic arthritis patients do not progress to permanent joint damage in any of the 28 hand joints, even under prolonged follow-up. This has led several researchers to fit models that estimate the proportion of stayers (those who do not have the propensity to experience the event of interest) and to characterize the rate of developing damaged joints in the movers (those who have the propensity to experience the event of interest). However, when fitted to the same data, the paper demonstrates that the choice of model for the movers can lead to widely varying conclusions on a stayer population, thus implying that, if interest lies in a stayer population, a single analysis should not generally be adopted. The aim of the paper is to provide greater understanding regarding estimation of a stayer population by comparing the inferences, performance and features of multiple fitted models to real and simulated data sets. The models for the movers are based on Poisson processes with patient level random effects and/or dynamic covariates, which are used to induce within-patient correlation, and observation level random effects are used to account for time varying unobserved heterogeneity. The gamma, inverse Gaussian and compound Poisson distributions are considered for the random effects.
    Language English
    Publishing date 2017-07-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1482300-7
    ISSN 1467-9876 ; 0035-9254
    ISSN (online) 1467-9876
    ISSN 0035-9254
    DOI 10.1111/rssc.12187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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