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  1. Article ; Online: In utero ventilation induces lung parenchymal and vascular alterations in extremely preterm fetal sheep.

    Azman, Zahrah / Vidinopoulos, Kayla / Somers, Ainsley / Hooper, Stuart B / Zahra, Valerie A / Thiel, Alison M / Galinsky, Robert / Tran, Nhi T / Allison, Beth J / Polglase, Graeme R

    American journal of physiology. Lung cellular and molecular physiology

    2024  Volume 326, Issue 3, Page(s) L330–L343

    Abstract: Extremely preterm infants are often exposed to long durations of mechanical ventilation to facilitate gas exchange, resulting in ventilation-induced lung injury (VILI). New lung protective strategies utilizing noninvasive ventilation or low tidal volumes ...

    Abstract Extremely preterm infants are often exposed to long durations of mechanical ventilation to facilitate gas exchange, resulting in ventilation-induced lung injury (VILI). New lung protective strategies utilizing noninvasive ventilation or low tidal volumes are now common but have not reduced rates of bronchopulmonary dysplasia. We aimed to determine the effect of 24 h of low tidal volume ventilation on the immature lung by ventilating preterm fetal sheep in utero. Preterm fetal sheep at 110 ± 1(SD) days' gestation underwent sterile surgery for instrumentation with a tracheal loop to enable in utero mechanical ventilation (IUV). At 112 ± 1 days' gestation, fetuses received either in utero mechanical ventilation (IUV,
    MeSH term(s) Humans ; Infant, Newborn ; Sheep ; Animals ; Infant, Extremely Premature ; Lung/metabolism ; Fetus/metabolism ; Respiration, Artificial/adverse effects ; Respiration, Artificial/methods ; Ventilator-Induced Lung Injury/metabolism ; Collagen/metabolism ; Pneumonia/pathology ; Surface-Active Agents/metabolism ; RNA, Messenger/metabolism
    Chemical Substances Collagen (9007-34-5) ; Surface-Active Agents ; RNA, Messenger
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00249.2023
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  2. Article: The sensitivity, specificity and predictive values of post mortem computed tomography in detecting liver and splenic injury due to road traffic accident.

    Norzailin, A B / Noor Azman, S / Mohd Helmee, M N / Khairul Anuar, Z

    The Medical journal of Malaysia

    2016  Volume 71, Issue 1, Page(s) 1–7

    Abstract: Objective: The purpose of the study was to determine the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of post mortem computed tomography (PMCT) in detecting liver and splenic injuries due to road traffic ... ...

    Abstract Objective: The purpose of the study was to determine the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of post mortem computed tomography (PMCT) in detecting liver and splenic injuries due to road traffic accidents.
    Material & method: 61 road traffic accidental death cases underwent both PMCT and conventional autopsy. The imaging findings were compared to the conventional autopsy findings.
    Result: The sensitivity, specificity, PPV and NPV for liver injuries in PMCT was 71%, 82%, 68% and 85% while that of splenic injuries was 73%, 80%, 55% and 90% respectively. The accuracy of PMCT scan was 79% for both liver and splenic injuries. There is strong association between lower left ribs fracture and splenic injury (p=0.005) and significant association between positive liver and splenic PMCT finding and intraabdominal fatal injury (p=0.037).
    Conclusion: In conclusion PMCT has high specificity and NPV for liver and splenic injuries; however the sensitivity and PPV are low. The overall accuracy is not high enough to enable PMCT to be used as a replacement for conventional autopsy; however it is a useful complementary examination and has potential to be used as decision making tool for selective internal autopsy.
    MeSH term(s) Accidents, Traffic ; Autopsy ; Cause of Death ; Humans ; Liver/diagnostic imaging ; Liver/injuries ; Sensitivity and Specificity ; Tomography, X-Ray Computed
    Language English
    Publishing date 2016-04-29
    Publishing country Malaysia
    Document type Journal Article
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
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  3. Article ; Online: Global landscape of SARS-CoV-2 genomic surveillance and data sharing.

    Chen, Zhiyuan / Azman, Andrew S / Chen, Xinhua / Zou, Junyi / Tian, Yuyang / Sun, Ruijia / Xu, Xiangyanyu / Wu, Yani / Lu, Wanying / Ge, Shijia / Zhao, Zeyao / Yang, Juan / Leung, Daniel T / Domman, Daryl B / Yu, Hongjie

    Nature genetics

    2022  Volume 54, Issue 4, Page(s) 499–507

    Abstract: Genomic surveillance has shaped our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. We performed a global landscape analysis on SARS-CoV-2 genomic surveillance and genomic data using a collection of country- ... ...

    Abstract Genomic surveillance has shaped our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. We performed a global landscape analysis on SARS-CoV-2 genomic surveillance and genomic data using a collection of country-specific data. Here, we characterize increasing circulation of the Alpha variant in early 2021, subsequently replaced by the Delta variant around May 2021. SARS-CoV-2 genomic surveillance and sequencing availability varied markedly across countries, with 45 countries performing a high level of routine genomic surveillance and 96 countries with a high availability of SARS-CoV-2 sequencing. We also observed a marked heterogeneity of sequencing percentage, sequencing technologies, turnaround time and completeness of released metadata across regions and income groups. A total of 37% of countries with explicit reporting on variants shared less than half of their sequences of variants of concern (VOCs) in public repositories. Our findings indicate an urgent need to increase timely and full sharing of sequences, the standardization of metadata files and support for countries with limited sequencing and bioinformatics capacity.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/genetics ; Genomics ; Humans ; Information Dissemination ; SARS-CoV-2/genetics
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-022-01033-y
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  4. Article: Epidemiology and Factors Affecting Functional Outcome of Distal Radial Fracture in an Urban Tertiary Medical Centre in Malaysia.

    Chao, W Q / Azman, M Z / Rosdi, S A / Tuan-Mustafa, Taw / Tan, Y J / Abdullah, S / Aizuddin, A N

    Malaysian orthopaedic journal

    2021  Volume 15, Issue 3, Page(s) 84–90

    Abstract: ... to AO classification, we grouped our patients into A (extra-articular), B (partial articular) and C ... treatment modalities in Type A fracture (p=0.094), but Type B (p=0.043) and Type C (p=0.007) had better ...

    Abstract Introduction: Distal radial fracture is a commonly encountered fracture. This study aims to study the epidemiology of distal radial fracture and factors affecting the patients' functional outcome one to two years after the injury.
    Materials and methods: This is a retrospective cohort study. The records of patients, fulfilling the radiographical diagnosis of distal radial fracture, and aged 18 and above, who presented to our Emergency Department from 1st January 2018 to 31st December 2018 were retrieved. According to AO classification, we grouped our patients into A (extra-articular), B (partial articular) and C (complete articular). Patients with congenital abnormalities were excluded. Epidemiological data and relevant medical history were obtained and tabulated. A Malaysian language translation of Disability of the Arm, Shoulder and Hand (DASH) questionnaire was used to assess the functional outcome.
    Results: Out of 168 patients' data retrieved, only 110 patients' data were found complete for purposes of this study. The mean DASH score was 13.7 ± 7.87 approximately one to two years post-injury regardless of treatment method. Increasing age was associated with higher DASH score with r=0.407(p<0.001). Several variables had significantly better functional outcome: male gender (p=0.01), Type A fracture configuration (p=0.007) and non-operational treatment (p=0.03). There was no significant difference between treatment modalities in Type A fracture (p=0.094), but Type B (p=0.043) and Type C (p=0.007) had better outcome without surgery. There was no significant difference between different ethnic groups, open or closed fracture and mechanism of injury.
    Conclusion: Better functional outcome after sustaining distal radial fracture was associated with young age, male gender, type A fracture and treated non-operatively. Interestingly, more complex fracture pattern had better functionality were observed without surgery.
    Language English
    Publishing date 2021-12-20
    Publishing country Malaysia
    Document type Journal Article
    ZDB-ID 2621480-5
    ISSN 1985-2533
    ISSN 1985-2533
    DOI 10.5704/MOJ.2111.013
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  5. Article ; Online: Biodegradation of tetracycline under various conditions and effects on microbial community.

    Cetecioglu, Zeynep / Ince, Bahar / Azman, Samet / Ince, Orhan

    Applied biochemistry and biotechnology

    2014  Volume 172, Issue 2, Page(s) 631–640

    Abstract: Five hundred tons of antibiotics are consumed yearly in the world. In this study, the biodegradation characteristics of tetracycline (TET) under nitrate-reducing, sulfate-reducing, and methanogenic conditions were determined by batch tests. Also, effects ...

    Abstract Five hundred tons of antibiotics are consumed yearly in the world. In this study, the biodegradation characteristics of tetracycline (TET) under nitrate-reducing, sulfate-reducing, and methanogenic conditions were determined by batch tests. Also, effects of TET on mixed microbial cultures were revealed by microbiological analysis. In this scope, gas generation and composition, dissolved organic carbon, and electron acceptor concentrations were monitored during 120 days. Additionally, changes on quantities of specific microbial groups were determined by Q-PCR. TET showed non-biodegradable behavior under nitrate- and sulfate-reducing conditions, whereas slightly biodegradable behavior under methanogenic conditions approximately 46 % degradation. The effects of TET on the abundance of mixed culture varied according to taxonomic units. Sulfate-reducing bacteria were inhibited by TET, while archaeal, bacterial, and methanogenic populations were not affected significantly.
    MeSH term(s) Archaea/metabolism ; Bacteria/metabolism ; Batch Cell Culture Techniques ; Biodegradation, Environmental ; Methane/metabolism ; Microbiota ; Nitrates/metabolism ; Oxidation-Reduction ; Reproducibility of Results ; Sulfates/metabolism ; Tetracycline/metabolism
    Chemical Substances Nitrates ; Sulfates ; Tetracycline (F8VB5M810T) ; Methane (OP0UW79H66)
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-013-0559-6
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  6. Article ; Online: Comparison of COVID-19 Pandemic Waves in 10 Countries in Southern Africa, 2020-2021.

    Smith-Sreen, Joshua / Miller, Bridget / Kabaghe, Alinune N / Kim, Evelyn / Wadonda-Kabondo, Nellie / Frawley, Alean / Labuda, Sarah / Manuel, Eusébio / Frietas, Helga / Mwale, Anne C / Segolodi, Tebogo / Harvey, Pauline / Seitio-Kgokgwe, Onalenna / Vergara, Alfredo E / Gudo, Eduardo S / Dziuban, Eric J / Shoopala, Naemi / Hines, Jonas Z / Agolory, Simon /
    Kapina, Muzala / Sinyange, Nyambe / Melchior, Michael / Mirkovic, Kelsey / Mahomva, Agnes / Modhi, Surbhi / Salyer, Stephanie / Azman, Andrew S / McLean, Catherine / Riek, Lul P / Asiimwe, Fred / Adler, Michelle / Mazibuko, Sikhatele / Okello, Velephi / Auld, Andrew F

    Emerging infectious diseases

    2022  Volume 28, Issue 13, Page(s) 93–104

    Abstract: ... variant (B.1.351) drove the second wave and Delta (B.1.617.2) the third. Stringent implementation ...

    Abstract We used publicly available data to describe epidemiology, genomic surveillance, and public health and social measures from the first 3 COVID-19 pandemic waves in southern Africa during April 6, 2020-September 19, 2021. South Africa detected regional waves on average 7.2 weeks before other countries. Average testing volume 244 tests/million/day) increased across waves and was highest in upper-middle-income countries. Across the 3 waves, average reported regional incidence increased (17.4, 51.9, 123.3 cases/1 million population/day), as did positivity of diagnostic tests (8.8%, 12.2%, 14.5%); mortality (0.3, 1.5, 2.7 deaths/1 million populaiton/day); and case-fatality ratios (1.9%, 2.1%, 2.5%). Beta variant (B.1.351) drove the second wave and Delta (B.1.617.2) the third. Stringent implementation of safety measures declined across waves. As of September 19, 2021, completed vaccination coverage remained low (8.1% of total population). Our findings highlight opportunities for strengthening surveillance, health systems, and access to realistically available therapeutics, and scaling up risk-based vaccination.
    Language English
    Publishing date 2022-12-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2813.220228
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  7. Article: Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress.

    Azman, Khairunnuur Fairuz / Zakaria, Rahimah / AbdAziz, CheBadariah / Othman, Zahiruddin / Al-Rahbi, Badriya

    Noise & health

    2015  Volume 17, Issue 75, Page(s) 83–89

    Abstract: Recent evidence has exhibited dietary influence on the manifestation of different types of behavior induced by stressor tasks. The present study examined the effects of Tualang honey supplement administered with the goal of preventing or attenuating the ... ...

    Abstract Recent evidence has exhibited dietary influence on the manifestation of different types of behavior induced by stressor tasks. The present study examined the effects of Tualang honey supplement administered with the goal of preventing or attenuating the occurrence of stress-related behaviors in male rats subjected to noise stress. Forty-eight adult male rats were randomly divided into the following four groups: i) nonstressed with vehicle, ii) nonstressed with Tualang honey, iii) stressed with vehicle, and iv) stressed with honey. The supplement was given once daily via oral gavage at 0.2 g/kg body weight. Two types of behavioral tests were performed, namely, the novel object recognition test to evaluate working memory and the forced swimming test to evaluate depressive-like behavior. Data were analyzed by a two-way analysis of variance (ANOVA) using IBM SPSS 18.0. It was observed that the rats subjected to noise stress expressed higher levels of depressive-like behavior and lower memory functions compared to the unexposed control rats. In addition, our results indicated that the supplementation regimen successfully counteracted the effects of noise stress. The forced swimming test indicated that climbing and swimming times were significantly increased and immobility times significantly decreased in honey-supplemented rats, thereby demonstrating an antidepressant-like effect. Furthermore, cognitive function was shown to be intensely affected by noise stress, but the effects were counteracted by the honey supplement. These findings suggest that subchronic exposure to noise stress induces depressive-like behavior and reduces cognitive functions, and that these effects can be attenuated by Tualang honey supplementation. This warrants further studies to examine the role of Tulang honey in mediating such effects.
    MeSH term(s) Animals ; Behavior, Animal ; Depression ; Honey ; Male ; Memory ; Memory, Short-Term ; Noise ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological
    Language English
    Publishing date 2015-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 1482372-x
    ISSN 1998-4030 ; 1463-1741
    ISSN (online) 1998-4030
    ISSN 1463-1741
    DOI 10.4103/1463-1741.153388
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  8. Article: Two cases of deletion 5p syndrome: one with paternal involvement and another with atypical presentation.

    Azman, B Z / Akhir, S M / Zilfalil, B A / Ankathil, R

    Singapore medical journal

    2008  Volume 49, Issue 4, Page(s) e98–e100

    Abstract: We report two cases of deletion 5p or cri du chat syndrome (CdCS) with different presentations and risks of transmission: one case with paternal chromosome 5 involvement and another, a de novo case with atypical clinical presentation. Cytogenetic ... ...

    Abstract We report two cases of deletion 5p or cri du chat syndrome (CdCS) with different presentations and risks of transmission: one case with paternal chromosome 5 involvement and another, a de novo case with atypical clinical presentation. Cytogenetic analysis was performed on the two cases and their parents. GTG-banded karyotype analysis of Cases 1 and 2 revealed abnormal 46,XY,del(5)(p13-15) male karyotypes. For Case 1, the mother showed normal female karyotype while the father showed an abnormal karyotype involving a balanced translocation 46,XY,t(5;10)(p13;p15). For Case 2, however, both parents showed a normal karyotype pattern. In Case 1, the clinical features, particularly the distinct facial phenotype in combination with a characteristic cat-like cry and hypotonia, aided in the diagnosis at birth and the karyotype analysis was resolutive. The boy in Case 2 presented with atypical clinical features. Even though this patient had multiple syndromic features, the typical high pitched cat-like cry was not prominent. Instead, the patient manifested persistent stridor (from day three of life), which might have prevented the clinician from suspecting CdCS at birth. However, when this patient was presented at seven months of age for cytogenetic analysis, a confirmatory diagnosis of CdCS was established. For children with congenital abnormalities, an early clinical diagnosis confirmed through cytogenetic and molecular investigations, is important for providing personalised diagnostic and prognostic evaluation, and also for genetic counselling on the reproductive risk, particularly for patients with parental chromosome translocation involvement.
    MeSH term(s) Chromosomes, Human, Pair 5/genetics ; Cri-du-Chat Syndrome/diagnosis ; Cri-du-Chat Syndrome/genetics ; Gene Deletion ; Genetic Carrier Screening ; Humans ; Infant ; Infant, Newborn ; Karyotyping ; Male ; Pedigree ; Respiratory Sounds ; Telomerase/genetics ; Translocation, Genetic
    Chemical Substances TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2008-04
    Publishing country Singapore
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
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  9. Article: The foundation of NCVD PCI Registry: the Malaysia's first multi-centre interventional cardiology project.

    Liew, H B / Rosli, M A / Wan Azman, W A / Robaayah, Z / Sim, K H

    The Medical journal of Malaysia

    2008  Volume 63 Suppl C, Page(s) 41–44

    Abstract: The National Cardiovascular Database for Percutaneous Coronary Intervention (NCVD PCI) Registry is the first multicentre interventional cardiology project, involving the main cardiac centres in the country. The ultimate goal of NCVD PCI is to provide a ... ...

    Abstract The National Cardiovascular Database for Percutaneous Coronary Intervention (NCVD PCI) Registry is the first multicentre interventional cardiology project, involving the main cardiac centres in the country. The ultimate goal of NCVD PCI is to provide a contemporary appraisal of PCI in Malaysia. This article introduces the foundation, the aims, methodology, database collection and preliminary results of the first six-month database.
    MeSH term(s) Aged ; Aged, 80 and over ; Angioplasty, Balloon, Coronary/statistics & numerical data ; Cooperative Behavior ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/therapy ; Databases, Factual ; Female ; Humans ; Malaysia/epidemiology ; Male ; Middle Aged ; Multicenter Studies as Topic ; Program Development/methods ; Registries/statistics & numerical data
    Language English
    Publishing date 2008-09
    Publishing country Malaysia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
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  10. Article ; Online: Tropical and subtropical Asia's valued tree species under threat.

    Gaisberger, Hannes / Fremout, Tobias / Kettle, Chris J / Vinceti, Barbara / Kemalasari, Della / Kanchanarak, Tania / Thomas, Evert / Serra-Diaz, Josep M / Svenning, Jens-Christian / Slik, Ferry / Eiadthong, Wichan / Palanisamy, Kandasamy / Ravikanth, Gudasalamani / Bodos, Vilma / Sang, Julia / Warrier, Rekha R / Wee, Alison K S / Elloran, Christian / Ramos, Lawrence Tolentino /
    Henry, Matieu / Hossain, Md Akhter / Theilade, Ida / Laegaard, Simon / Bandara, K M A / Weerasinghe, Dimantha Panduka / Changtragoon, Suchitra / Yuskianti, Vivi / Wilkie, Peter / Nghia, Nguyen Hoang / Elliott, Stephen / Pakkad, Greuk / Tiansawat, Pimonrat / Maycock, Colin / Bounithiphonh, Chaloun / Mohamed, Rozi / Nazre, M / Siddiqui, Baktiar Nur / Lee, Soon-Leong / Lee, Chai-Ting / Zakaria, Nurul Farhanah / Hartvig, Ida / Lehmann, Lutz / David, Dzaeman B Dzulkifli / Lillesø, Jens-Peter Barnekow / Phourin, Chhang / Yongqi, Zheng / Ping, Huang / Volkaert, Hugo A / Graudal, Lars / Hamidi, Arief / Thea, So / Sreng, Sineath / Boshier, David / Tolentino, Enrique / Ratnam, Wickneswari / Aung, Mu Mu / Galante, Michael / Isa, Siti Fatimah Md / Dung, Nguyen Quoc / Hoa, Tran Thi / Le, Tran Chan / Miah, Md Danesh / Zuhry, Abdul Lateef Mohd / Alawathugoda, Deepani / Azman, Amelia / Pushpakumara, Gamini / Sumedi, Nur / Siregar, Iskandar Z / Nak, Hong Kyung / Linsky, Jean / Barstow, Megan / Koh, Lian Pin / Jalonen, Riina

    Conservation biology : the journal of the Society for Conservation Biology

    2022  Volume 36, Issue 3, Page(s) e13873

    Abstract: Tree diversity in Asia's tropical and subtropical forests is central to nature-based solutions. Species vulnerability to multiple threats, which affect provision of ecosystem services, is poorly understood. We conducted a region-wide, spatially explicit ... ...

    Abstract Tree diversity in Asia's tropical and subtropical forests is central to nature-based solutions. Species vulnerability to multiple threats, which affect provision of ecosystem services, is poorly understood. We conducted a region-wide, spatially explicit assessment of the vulnerability of 63 socioeconomically important tree species to overexploitation, fire, overgrazing, habitat conversion, and climate change. Trees were selected for assessment from national priority lists, and selections were validated by an expert network representing 20 countries. We used Maxent suitability modeling to predict species distribution ranges, freely accessible spatial data sets to map threat exposures, and functional traits to estimate threat sensitivities. Species-specific vulnerability maps were created as the product of exposure maps and sensitivity estimates. Based on vulnerability to current threats and climate change, we identified priority areas for conservation and restoration. Overall, 74% of the most important areas for conservation of these trees fell outside protected areas, and all species were severely threatened across an average of 47% of their native ranges. The most imminent threats were overexploitation and habitat conversion; populations were severely threatened by these factors in an average of 24% and 16% of their ranges, respectively. Our model predicted limited overall climate change impacts, although some study species were likely to lose over 15% of their habitat by 2050 due to climate change. We pinpointed specific natural areas in Borneo rain forests as hotspots for in situ conservation of forest genetic resources, more than 82% of which fell outside designated protected areas. We also identified degraded areas in Western Ghats, Indochina dry forests, and Sumatran rain forests as hotspots for restoration, where planting or assisted natural regeneration will help conserve these species, and croplands in southern India and Thailand as potentially important agroforestry options. Our results highlight the need for regionally coordinated action for effective conservation and restoration.
    MeSH term(s) Climate Change ; Conservation of Natural Resources ; Ecosystem ; Forests ; Thailand ; Trees
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 58735-7
    ISSN 1523-1739 ; 0888-8892
    ISSN (online) 1523-1739
    ISSN 0888-8892
    DOI 10.1111/cobi.13873
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