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  1. Article ; Online: Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death.

    Castedo, Maria / Lafarge, Antoine / Kroemer, Guido

    Cell stress

    2023  Volume 7, Issue 1, Page(s) 1–6

    Abstract: The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson's disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of ... ...

    Abstract The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson's disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhibition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging.
    Language English
    Publishing date 2023-01-23
    Publishing country Austria
    Document type Journal Article
    ISSN 2523-0204
    ISSN (online) 2523-0204
    DOI 10.15698/cst2023.01.275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Severe hemophagocytic lymphohistiocytosis in kidney transplant recipient: the etiology is on the tip of the tongue!

    Vasseur, Margot / Valade, Sandrine / Suner, Ludovic / Lafarge, Antoine

    Intensive care medicine

    2022  Volume 48, Issue 9, Page(s) 1237–1238

    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Lymphohistiocytosis, Hemophagocytic/etiology ; Tongue ; Transplant Recipients
    Language English
    Publishing date 2022-06-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06757-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
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  3. Article: The positive impact of COVID-19 on critical care: from unprecedented challenges to transformative changes, from the perspective of young intensivists.

    Hermann, Bertrand / Benghanem, Sarah / Jouan, Youenn / Lafarge, Antoine / Beurton, Alexandra

    Annals of intensive care

    2023  Volume 13, Issue 1, Page(s) 28

    Abstract: Over the past 2 years, SARS-CoV-2 infection has resulted in numerous hospitalizations and deaths worldwide. As young intensivists, we have been at the forefront of the fight against the COVID-19 pandemic and it has been an intense learning experience ... ...

    Abstract Over the past 2 years, SARS-CoV-2 infection has resulted in numerous hospitalizations and deaths worldwide. As young intensivists, we have been at the forefront of the fight against the COVID-19 pandemic and it has been an intense learning experience affecting all aspects of our specialty. Critical care was put forward as a priority and managed to adapt to the influx of patients and the growing demand for beds, financial and material resources, thereby highlighting its flexibility and central role in the healthcare system. Intensivists assumed an essential and unprecedented role in public life, which was important when claiming for indispensable material and human investments. Physicians and researchers around the world worked hand-in-hand to advance research and better manage this disease by integrating a rapidly growing body of evidence into guidelines. Our daily ethical practices and communication with families were challenged by the massive influx of patients and restricted visitation policies, forcing us to improve our collaboration with other specialties and innovate with new communication channels. However, the picture was not all bright, and some of these achievements are already fading over time despite the ongoing pandemic and hospital crisis. In addition, the pandemic has demonstrated the need to improve the working conditions and well-being of critical care workers to cope with the current shortage of human resources. Despite the gloomy atmosphere, we remain optimistic. In this ten-key points review, we outline our vision on how to capitalize on the lasting impact of the pandemic to face future challenges and foster transformative changes of critical care for the better.
    Language English
    Publishing date 2023-04-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-023-01118-9
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  4. Article ; Online: Acute Kidney Injury in Cancer Immunotherapy Recipients.

    Joseph, Adrien / Lafarge, Antoine / Azoulay, Elie / Zafrani, Lara

    Cells

    2022  Volume 11, Issue 24

    Abstract: Cancer immunotherapy has now entered clinical practice and has reshaped the standard of care for many cancer patients. With these new strategies, specific toxicities have emerged, and renal side effects have been described. In this review, we will ... ...

    Abstract Cancer immunotherapy has now entered clinical practice and has reshaped the standard of care for many cancer patients. With these new strategies, specific toxicities have emerged, and renal side effects have been described. In this review, we will describe the causes of acute kidney injury in CAR T cell, immune checkpoint inhibitors and other cancer immuno-therapy recipients. CAR T cell therapy and bispecific T cell engaging antibodies can lead to acute kidney injury as a consequence of cytokine release syndrome, tumor lysis syndrome, sepsis or specific CAR T cell infiltration. Immune checkpoint blockade most often results in acute tubular interstitial nephritis, but glomerular diseases have also been described. Although the pathophysiology remains mostly elusive, we will describe the mechanisms of renal damage in these contexts, its prognosis and treatment. As the place of immunotherapy in the anti-cancer armamentarium is exponentially increasing, close collaboration between nephrologists and oncologists is of utmost importance to provide the best standard of care for these patients.
    Language English
    Publishing date 2022-12-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11243991
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  5. Article ; Online: PARP1 inhibition elicits immune responses against non-small cell lung cancer.

    Juncheng, Pan / Lafarge, Antoine / Kroemer, Guido / Castedo, Maria

    Oncoimmunology

    2022  Volume 11, Issue 1, Page(s) 2111915

    Abstract: High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical ... ...

    Abstract High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation now demonstrates that PARP1 inhibition in cancer cells mediates strong immunostimulatory effects.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Humans ; Immunity ; Lung Neoplasms/drug therapy ; Poly (ADP-Ribose) Polymerase-1 ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Poly(ADP-ribose) Polymerases/therapeutic use
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors ; PARP1 protein, human (EC 2.4.2.30) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30)
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2022.2111915
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  6. Article ; Online: Severe Community-Acquired Pneumonia in Immunocompromised Patients.

    Chean, Dara / Windsor, Camille / Lafarge, Antoine / Dupont, Thibault / Nakaa, Sabrine / Whiting, Livia / Joseph, Adrien / Lemiale, Virginie / Azoulay, Elie

    Seminars in respiratory and critical care medicine

    2024  Volume 45, Issue 2, Page(s) 255–265

    Abstract: Due to higher survival rates with good quality of life, related to new treatments in the fields of oncology, hematology, and transplantation, the number of immunocompromised patients is increasing. But these patients are at high risk of intensive care ... ...

    Abstract Due to higher survival rates with good quality of life, related to new treatments in the fields of oncology, hematology, and transplantation, the number of immunocompromised patients is increasing. But these patients are at high risk of intensive care unit admission because of numerous complications. Acute respiratory failure due to severe community-acquired pneumonia is one of the leading causes of admission. In this setting, the need for invasive mechanical ventilation is up to 60%, associated with a high hospital mortality rate of around 40 to 50%. A wide range of pathogens according to the reason of immunosuppression is associated with severe pneumonia in those patients: documented bacterial pneumonia represents a third of cases, viral and fungal pneumonia both account for up to 15% of cases. For patients with an undetermined etiology despite comprehensive diagnostic workup, the hospital mortality rate is very high. Thus, a standardized diagnosis strategy should be defined to increase the diagnosis rate and prescribe the appropriate treatment. This review focuses on the benefit-to-risk ratio of invasive or noninvasive strategies, in the era of omics, for the management of critically ill immunocompromised patients with severe pneumonia in terms of diagnosis and oxygenation.
    MeSH term(s) Humans ; Noninvasive Ventilation ; Quality of Life ; Pneumonia ; Respiration, Artificial ; Pneumonia, Bacterial ; Immunocompromised Host ; Community-Acquired Infections/therapy ; Intensive Care Units
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1778137
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1555: Show issues Location:
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  7. Article ; Online: PTSD Symptoms Among Family Members of Patients With ARDS Caused by COVID-19 After 12 Months.

    Kentish-Barnes, Nancy / Resche-Rigon, Matthieu / Lafarge, Antoine / Souppart, Virginie / Renet, Anne / Pochard, Frédéric / Azoulay, Elie

    JAMA

    2023  Volume 330, Issue 14, Page(s) 1383–1385

    MeSH term(s) Humans ; COVID-19/complications ; Family/psychology ; Quality of Life ; Respiratory Distress Syndrome/etiology ; Stress Disorders, Post-Traumatic/psychology
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.15879
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    Ua VI Zs.88: Show issues Location:
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  8. Article ; Online: Increased Rice Susceptibility to Rice Blast Is Related to Post-Flowering Nitrogen Assimilation Efficiency.

    Frontini, Mathias / Morel, Jean-Benoit / Gravot, Antoine / Lafarge, Tanguy / Ballini, Elsa

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 11

    Abstract: Reducing nitrogen leaching and nitrous oxide emissions with the goal of more sustainability in agriculture implies better identification and characterization of the different patterns in nitrogen use efficiency by crops. However, a change in the ability ... ...

    Abstract Reducing nitrogen leaching and nitrous oxide emissions with the goal of more sustainability in agriculture implies better identification and characterization of the different patterns in nitrogen use efficiency by crops. However, a change in the ability of varieties to use nitrogen resources could also change the access to nutrient resources for a foliar pathogen such as rice blast and lead to an increase in the susceptibility of these varieties. This study focuses on the pre- and post-floral biomass accumulation and nitrogen uptake and utilization of ten temperate japonica rice genotypes grown in controlled conditions, and the relationship of these traits with molecular markers and susceptibility to rice blast disease. After flowering, the ten varieties displayed diversity in nitrogen uptake and remobilization. Surprisingly, post-floral nitrogen uptake was correlated with higher susceptibility to rice blast, particularly in plants fertilized with nitrogen. This increase in susceptibility is associated with a particular metabolite profile in the upper leavers of these varieties.
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8111217
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  9. Article ; Online: Psychometric properties of a Creole version of Medical Outcome Study - Short Form 36 among type II diabetes patients on Reunion Island.

    Soulaimana, Ibtissame / Bruneau, Léa / Tisseaux, Antoine / Safieddine, Maissa / Debussche, Xavier / Lafarge, Sophie / Falissard, Bruno / Ferdynus, Cyril / Huiart, Laetitia

    Frontiers in public health

    2023  Volume 11, Page(s) 1186153

    Abstract: Introduction: Health quality of life assessment is particularly important to measure the impact of chronic diseases. The aims of this study were to provide a cross-culturally adapted Creole-translation of the Medical Outcome Study Short-Form 36 (SF-36) ... ...

    Abstract Introduction: Health quality of life assessment is particularly important to measure the impact of chronic diseases. The aims of this study were to provide a cross-culturally adapted Creole-translation of the Medical Outcome Study Short-Form 36 (SF-36) and to assess psychometric performance of the Creole and French versions of the SF-36 among patients with type II diabetes in Reunion Island.
    Materials and methods: The Creole translation and cross-cultural adaptation processes were based on the International Quality Of Life Assessment (IQOLA) methods. Internal consistency, test-retest reliability, convergent and discriminant validity using Multi-Trait-Multi-Method analysis and structural validity using exploratory factor analysis of the SF-36 for both versions were performed.
    Results: In the Creole version of the SF-36, Cronbach's alpha exceeded 0.70 for all subscales except general health. In the French SF-36, Cronbach's alpha exceeded 0.70 on all subscales except general health and bodily pain. In the Creole SF-36, intraclass correlation coefficient (ICC) for reproducibility was suboptimal. Multi-trait multi-method analysis showed that item-scale correlation exceeded 0.4 for all items except two general health items of the Creole SF-36 and one of the French SF-36. Factor analysis of 2 versions showed that the physical functioning, vitality, and mental health were each divided into two subscales.
    Discussion: Overall, our findings provided evidence that the SF-36 is adapted to Reunion Island in both Creole and French versions. However, further research could be conducted to investigate French-Creole differences in perceived health status and a cultural adaptation of the French version will be considered.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2 ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Reunion
    Language English
    Publishing date 2023-08-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1186153
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  10. Article ; Online: Two different patterns of lymphocyte alterations in critically ill COVID-19 patients.

    Lafarge, Antoine / Martin, Jean-Edouard / Longval, Thomas / Dupont, Thibault / De Jong, Audrey / Azoulay, Elie

    Internal and emergency medicine

    2021  Volume 16, Issue 5, Page(s) 1411–1414

    MeSH term(s) Aged ; COVID-19/blood ; COVID-19/complications ; COVID-19/physiopathology ; Critical Illness/epidemiology ; Critical Illness/mortality ; Female ; Humans ; Lymphocytes/microbiology ; Lymphopenia/diagnosis ; Lymphopenia/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2021-01-01
    Publishing country Italy
    Document type Letter
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02575-x
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    Zs.A 6673: Show issues Location:
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