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  1. Article: Insights into the Use of Point-of-Care Ultrasound for Diagnosing Obstructive Sleep Apnea.

    Kalkanis, Alexandros / Testelmans, Dries / Papadopoulos, Dimitrios / Van den Driessche, Annelies / Buyse, Bertien

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 13

    Abstract: Obstructive sleep apnea (OSA) is a sleeping disorder caused by complete or partial disturbance of breathing during the night. Existing screening methods include questionnaire-based evaluations which are time-consuming, vary in specificity, and are not ... ...

    Abstract Obstructive sleep apnea (OSA) is a sleeping disorder caused by complete or partial disturbance of breathing during the night. Existing screening methods include questionnaire-based evaluations which are time-consuming, vary in specificity, and are not globally adopted. Point-of-care ultrasound (PoCUS), on the other hand, is a painless, inexpensive, portable, and useful tool that has already been introduced for the evaluation of upper airways by anesthetists. PoCUS could also serve as a potential screening tool for the diagnosis of OSA by measuring different airway parameters, including retropalatal pharynx transverse diameter, tongue base thickness, distance between lingual arteries, lateral parapharyngeal wall thickness, palatine tonsil volume, and some non-airway parameters like carotid intima-media thickness, mesenteric fat thickness, and diaphragm characteristics. This study reviewed previously reported studies to highlight the importance of PoCUS as a potential screening tool for OSA.
    Language English
    Publishing date 2023-07-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13132262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Improving protein therapeutic development through cloud-based data integration.

    Van Den Driessche, George A / Bailey, Devin / Anderson, Evan O / Tarselli, Michael A / Blackwell, Len

    SLAS technology

    2023  Volume 28, Issue 5, Page(s) 293–301

    Abstract: Pharma 4.0 is a digital evolution of the pharmaceutical industry that automates scientists' traditional workflows with the implementation of modern technologies like cloud pipelines, artificial intelligence, robotic platforms, and augmented reality. Lab ... ...

    Abstract Pharma 4.0 is a digital evolution of the pharmaceutical industry that automates scientists' traditional workflows with the implementation of modern technologies like cloud pipelines, artificial intelligence, robotic platforms, and augmented reality. Lab data capture (LDC) is an essential strategy for initiating Pharma 4.0 that aggregates and harmonizes siloed lab data from analytical instruments, reporting systems, and operational platforms. This publication describes the execution of LDC within a quantitative PCR (qPCR) workflow using the Tetra Data Platform (TDP). We selected this workflow because the qPCR instrument, the ViiA7, generates discrete file-based data that documents execution of individual assays for quantifying residual DNA throughout biologics process development and product profiling. TDP executes LDC through the deployment of file scanning software agents, scanning and ingestion processes, and a cloud-based parsing pipeline that harmonizes source data. Web applications were developed to query, visualize, and interpret harmonized qPCR data for automated experiment data processing and process control charting from the TDP platform. Our implementation of LDC enables analytical researchers to harness FAIR (Findable, Accessible, Interoperable, Reproducible) data practices across the organization and establishes a "compliance-by-code" culture in development labs.
    Language English
    Publishing date 2023-07-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2900310-6
    ISSN 2472-6311 ; 2472-6303
    ISSN (online) 2472-6311
    ISSN 2472-6303
    DOI 10.1016/j.slast.2023.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: From Corrosion Casting to Virtual Dissection: Contrast-Enhanced Vascular Imaging using Hafnium Oxide Nanocrystals.

    Goossens, Eline / Deblock, Loren / Caboor, Lisa / Eynden, Dietger Van den / Josipovic, Iván / Isaacura, Pablo Reyes / Maksimova, Elizaveta / Van Impe, Matthias / Bonnin, Anne / Segers, Patrick / Cornillie, Pieter / Boone, Matthieu N / Van Driessche, Isabel / De Spiegelaere, Ward / De Roo, Jonathan / Sips, Patrick / De Buysser, Klaartje

    Small methods

    2024  , Page(s) e2301499

    Abstract: Vascular corrosion casting is a method used to visualize the three dimensional (3D) anatomy and branching pattern of blood vessels. A polymer resin is injected in the vascular system and, after curing, the surrounding tissue is removed. The latter often ... ...

    Abstract Vascular corrosion casting is a method used to visualize the three dimensional (3D) anatomy and branching pattern of blood vessels. A polymer resin is injected in the vascular system and, after curing, the surrounding tissue is removed. The latter often deforms or even fractures the fragile cast. Here, a method is proposed that does not require corrosion, and is based on in situ micro computed tomography (micro-CT) scans. To overcome the lack of CT contrast between the polymer cast and the animals' surrounding soft tissue, hafnium oxide nanocrystals (HfO
    Language English
    Publishing date 2024-01-10
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202301499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: A framework for studying transients in marine metapopulations

    Harrington, Peter D. / Lewis, Mark A. / Driessche, P. van den

    2021  

    Abstract: Transient dynamics can often differ drastically from the asymptotic dynamics of systems. In this paper we provide a unifying framework for analysing transient dynamics in marine metapopulations, from the choice of norms to the addition of stage structure. ...

    Abstract Transient dynamics can often differ drastically from the asymptotic dynamics of systems. In this paper we provide a unifying framework for analysing transient dynamics in marine metapopulations, from the choice of norms to the addition of stage structure. We use the $\ell_1$ norm, because of its biological interpretation, to extend the transient metrics of reactivity and attenuation to marine metapopulations, and use examples to compare these metrics under the more commonly used $\ell_2$ norm. We then connect the reactivity and attenuation of marine metapopulations to the source-sink distribution of habitat patches and demonstrate how to meaningfully measure reactivity when metapopulations are stage-structured.

    Comment: 34 pages, 11 figures
    Keywords Quantitative Biology - Populations and Evolution ; Mathematics - Dynamical Systems ; 92D25 ; 92D40 ; 34A30 ; 34C11
    Publishing date 2021-03-17
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A general theory for target reproduction numbers with applications to ecology and epidemiology.

    Lewis, Mark A / Shuai, Zhisheng / van den Driessche, P

    Journal of mathematical biology

    2019  Volume 78, Issue 7, Page(s) 2317–2339

    Abstract: A general framework for threshold parameters in population dynamics is developed using the concept of target reproduction numbers. This framework identifies reproduction numbers and other threshold parameters in the literature in terms of their roles in ... ...

    Abstract A general framework for threshold parameters in population dynamics is developed using the concept of target reproduction numbers. This framework identifies reproduction numbers and other threshold parameters in the literature in terms of their roles in population control. The framework is applied to the analysis of single and multiple control strategies in ecology and epidemiology, and this provides new biological insights.
    MeSH term(s) Algorithms ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/prevention & control ; Computer Simulation ; Ecosystem ; Humans ; Matricaria/growth & development ; Models, Theoretical ; Population Dynamics ; Reproduction
    Language English
    Publishing date 2019-03-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 187101-8
    ISSN 1432-1416 ; 0303-6812
    ISSN (online) 1432-1416
    ISSN 0303-6812
    DOI 10.1007/s00285-019-01345-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lower Attentional Skills predict increased exploratory foraging patterns.

    Van den Driessche, Charlotte / Chevrier, Françoise / Cleeremans, Axel / Sackur, Jérôme

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 10948

    Abstract: When engaged in a search task, one needs to arbitrate between exploring and exploiting the environment to optimize the outcome. Many intrinsic, task and environmental factors are known to influence the exploration/exploitation balance. Here, in a non ... ...

    Abstract When engaged in a search task, one needs to arbitrate between exploring and exploiting the environment to optimize the outcome. Many intrinsic, task and environmental factors are known to influence the exploration/exploitation balance. Here, in a non clinical population, we show that the level of inattention (assessed as a trait) is one such factor: children with higher scores on an ADHD (Attention Deficit/Hyperactivity Disorder) questionnaire exhibited longer transitions between consecutively retrieved items, in both a visual and a semantic search task. These more frequent exploration behaviours were associated with differential performance patterns: children with higher levels of ADHD traits performed better in semantic search, while their performance was unaffected in visual search. Our results contribute to the growing literature suggesting that ADHD should not be simply conceived as a pure deficit of attention, but also as a specific cognitive strategy that may prove beneficial in some contexts.
    MeSH term(s) Attention ; Attention Deficit Disorder with Hyperactivity/psychology ; Child ; Cognition ; Exploratory Behavior ; Female ; Humans ; Male ; Semantics
    Language English
    Publishing date 2019-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-46761-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Superinfection and the evolution of an initial asymptomatic stage.

    Saad-Roy, Chadi M / Grenfell, Bryan T / Levin, Simon A / Pellis, Lorenzo / Stage, Helena B / van den Driessche, P / Wingreen, Ned S

    Royal Society open science

    2021  Volume 8, Issue 1, Page(s) 202212

    Abstract: Pathogens have evolved a variety of life-history strategies. An important strategy consists of successful transmission by an infected host before the appearance of symptoms, that is, while the host is still partially or fully asymptomatic. During this ... ...

    Abstract Pathogens have evolved a variety of life-history strategies. An important strategy consists of successful transmission by an infected host before the appearance of symptoms, that is, while the host is still partially or fully asymptomatic. During this initial stage of infection, it is possible for another pathogen to superinfect an already infected host and replace the previously infecting pathogen. Here, we study the effect of superinfection during the first stage of an infection on the evolutionary dynamics of the degree to which the host is asymptomatic (host latency) in that same stage. We find that superinfection can lead to major differences in evolutionary behaviour. Most strikingly, the duration of immunity following infection can significantly influence pathogen evolutionary dynamics, whereas without superinfection the outcomes are independent of host immunity. For example, changes in host immunity can drive evolutionary transitions from a fully symptomatic to a fully asymptomatic first infection stage. Additionally, if superinfection relative to susceptible infection is strong enough, evolution can lead to a unique strategy of latency that corresponds to a local fitness minimum, and is therefore invasible by nearby mutants. Thus, this strategy is a branching point, and can lead to coexistence of pathogens with different latencies. Furthermore, in this new framework with superinfection, we also find that there can exist two interior singular strategies. Overall, new evolutionary outcomes can cascade from superinfection.
    Language English
    Publishing date 2021-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.202212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evolution of an asymptomatic first stage of infection in a heterogeneous population.

    Saad-Roy, Chadi M / Grenfell, Bryan T / Levin, Simon A / van den Driessche, P / Wingreen, Ned S

    Journal of the Royal Society, Interface

    2021  Volume 18, Issue 179, Page(s) 20210175

    Abstract: Pathogens evolve different life-history strategies, which depend in part on differences in their host populations. A central feature of hosts is their population structure (e.g. spatial). Additionally, hosts themselves can exhibit different degrees of ... ...

    Abstract Pathogens evolve different life-history strategies, which depend in part on differences in their host populations. A central feature of hosts is their population structure (e.g. spatial). Additionally, hosts themselves can exhibit different degrees of symptoms when newly infected; this latency is a key life-history property of pathogens. With an evolutionary-epidemiological model, we examine the role of population structure on the evolutionary dynamics of latency. We focus on specific power-law-like formulations for transmission and progression from the first infectious stage as a function of latency, assuming that the across-group to within-group transmission ratio increases if hosts are less symptomatic. We find that simple population heterogeneity can lead to local evolutionarily stable strategies (ESSs) at zero and infinite latency in situations where a unique ESS exists in the corresponding homogeneous case. Furthermore, there can exist more than one interior evolutionarily singular strategy. We find that this diversity of outcomes is due to the (possibly slight) advantage of across-group transmission for pathogens that produce fewer symptoms in a first infectious stage. Thus, our work reveals that allowing individuals without symptoms to travel can have important unintended evolutionary effects and is thus fundamentally problematic in view of the evolutionary dynamics of latency.
    MeSH term(s) Biological Evolution ; Humans ; Models, Biological
    Language English
    Publishing date 2021-06-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2156283-0
    ISSN 1742-5662 ; 1742-5689
    ISSN (online) 1742-5662
    ISSN 1742-5689
    DOI 10.1098/rsif.2021.0175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Targeting the Nonmevalonate Pathway in Burkholderia cenocepacia Increases Susceptibility to Certain β-Lactam Antibiotics.

    Sass, Andrea / Everaert, Annelien / Van Acker, Heleen / Van den Driessche, Freija / Coenye, Tom

    Antimicrobial agents and chemotherapy

    2018  Volume 62, Issue 5

    Abstract: The nonmevalonate pathway is the sole pathway for isoprenoid biosynthesis ... ...

    Abstract The nonmevalonate pathway is the sole pathway for isoprenoid biosynthesis in
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Burkholderia cenocepacia/drug effects ; Burkholderia cenocepacia/genetics ; Burkholderia cenocepacia/metabolism ; Burkholderia cepacia/drug effects ; Burkholderia cepacia/metabolism ; Microbial Sensitivity Tests ; Monobactams/pharmacology ; Plasmids/genetics ; beta-Lactams/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Monobactams ; beta-Lactams
    Language English
    Publishing date 2018-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.02607-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Erratum to: Extending the type reproduction number to infectious disease control targeting contacts between types.

    Shuai, Zhisheng / Heesterbeek, J A P / van den Driessche, P

    Journal of mathematical biology

    2015  Volume 71, Issue 1, Page(s) 255–257

    Language English
    Publishing date 2015-07
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 187101-8
    ISSN 1432-1416 ; 0303-6812
    ISSN (online) 1432-1416
    ISSN 0303-6812
    DOI 10.1007/s00285-015-0858-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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