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Article ; Online: The Impact of Pre-Heart Transplantation Blood Transfusion Varies Based on Recipient MELD-XI Score.

Nordan, Taylor / Lee, Hansuh H / Chen, Frederick Y / Couper, Gregory S / Kawabori, Masashi

ASAIO journal (American Society for Artificial Internal Organs : 1992)

2024

Abstract: ... for end-stage liver disease excluding international normalized ratio (MELD-XI) score of 9.4, and propensity score matched ... showed transfusion recipients, MELD-XI ≥9.4, were more likely to experience post-heart transplantation ... With MELD-XI <9.4, there was slight survival detriment among transfusion recipients on univariable analysis ...

Abstract	Prior studies reveal adverse effects of transfusion on cardiac surgery, but little is known of transfusion impact on heart transplantation. First-time, single-organ adult heart transplant recipients between January 1, 2010, and December 31, 2020, were included, stratified above or below a model for end-stage liver disease excluding international normalized ratio (MELD-XI) score of 9.4, and propensity score matched to their nearest neighbor. A 90 day landmark analysis within each cohort was also performed. Unadjusted analysis showed transfusion recipients, MELD-XI ≥9.4, were more likely to experience post-heart transplantation mortality (Hazard Ratio (HR), 1.352 [95% Confidence Interval (CI), 1.239-1.477], p < 0.001), persisting after adjustment for potential confounders (adjusted HR, 1.211 [95% CI, 1.100-1.335], p < 0.001) and after propensity-score matching (HR, 1.174 [95% CI, 1.045-1.319], p = 0.007). Post-transplant length of stay was longer (25.9 vs. 23.2 days, p < 0.001). Post-transplant dialysis was more common (18.7 vs. 15.9%, p = 0.009). There was no survival difference on 90 day landmarked analysis (p = 0.108). With MELD-XI <9.4, there was slight survival detriment among transfusion recipients on univariable analysis (HR, 1.111 [95% CI, 1.001-1.234], p = 0.049) but not on multivariable analysis (adjusted HR, 1.061 [95% CI, 0.952-1.181], p = 0.285). There was similar survival after propensity-score matching (HR, 1.032 [95% CI, 0.903-1.180], p = 0.642) and on landmark analysis (p = 0.581). Ultimately, transfusion was associated with worse post-heart transplantation outcomes among recipients with a MELD-XI ≥9.4.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	759982-1
ISSN	1538-943X ; 0162-1432 ; 1058-2916
ISSN (online)	1538-943X
ISSN	0162-1432 ; 1058-2916
DOI	10.1097/MAT.0000000000002175
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Article ; Online: Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers.

Liu, Tianxing / Hashizume, Kensei / Krieg, Eva / Chen, Huijun / Mukaida, Yuki / Thelen, Kirstin / Friedrichs, Frauke / Willmann, Stefan / Schwers, Stephan / Solms, Alexander / Yu, Rosie

Clinical and translational science

2024 Volume 17, Issue 4, Page(s) e13784

Abstract: The inhibition of coagulation factor XI (FXI) presents an attractive approach for anticoagulation ...

Abstract	The inhibition of coagulation factor XI (FXI) presents an attractive approach for anticoagulation as it is not expected to increase the risk of clinically relevant bleeding and is anticipated to be at least as effective as currently available anticoagulants. Fesomersen is a conjugated antisense oligonucleotide that selectively inhibits the expression of FXI. The article describes three clinical studies that investigated the safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of fesomersen after subcutaneous (s.c.) injection to healthy participants. The studies included participants from diverse ethnic backgrounds (Caucasian, Japanese, and Chinese). Fesomersen demonstrated good safety and tolerability in all three studies. No major bleeding events were observed. After single-dose s.c. injection, fesomersen was rapidly absorbed into the systemic circulation, with maximum fesomersen-equivalent (fesomersen-eq) concentrations (C
MeSH term(s)	Humans ; Dose-Response Relationship, Drug ; Double-Blind Method ; Factor XI ; Healthy Volunteers ; Hemorrhage ; Partial Thromboplastin Time ; East Asian People ; White People
Chemical Substances	Factor XI (9013-55-2)
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2433157-0
ISSN	1752-8062 ; 1752-8054
ISSN (online)	1752-8062
ISSN	1752-8054
DOI	10.1111/cts.13784
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Article: Intraoperative thromboelastography-guided transfusion in a patient with factor XI deficiency: A case report.

Guo, Wen-Juan / Chen, Wei-Yun / Yu, Xue-Rong / Shen, Le / Huang, Yu-Guang

World journal of clinical cases

2022 Volume 10, Issue 1, Page(s) 242–248

Abstract: Background: Factor XI (FXI) deficiency, also known as hemophilia C, is a rare bleeding disorder ...

Abstract	Background: Factor XI (FXI) deficiency, also known as hemophilia C, is a rare bleeding disorder of unpredictable severity that correlates poorly with FXI coagulation activity. This often poses great challenges in perioperative hemostatic management. Thromboelastography (TEG) is a method for testing blood coagulation using a viscoelastic hemostatic assay of whole blood to assess the overall coagulation status. Here, we present the successful application of intraoperative TEG monitoring in an FXI-deficient patient as an individualized blood transfusion strategy. Case summary: A 21-year-old male patient with FXI deficiency was scheduled to undergo reconstructive surgery for macrodactyly of the left foot under general anesthesia. To minimize his bleeding risk, he was scheduled to receive fresh frozen plasma (FFP) as an empirical prophylactic FXI replacement at a dose of 15-20 mL/kg body weight (900-1200 mL) before surgery. Subsequent FFP transfusion was to be adjusted according to surgical need. Instead, TEG assessment was used at the beginning and toward the end of his surgery. According to intraoperative TEG results, the normalization of coagulation function was achieved with an infusion of only 800 mL FFP, and blood loss was minimal. The patient showed an uneventful postoperative course and was discharged on postoperative day 8. Conclusion: TEG can be readily applied in the intraoperative period to individualize transfusion needs in patients with rare inherited coagulopathy.
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i1.242
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Article ; Online: Successful use of peritoneal dialysis after abdominal surgery in a patient with factor XI deficiency: A case report.

Li, Xueying / Chen, Ming / Wang, Yong / Zhou, Xuelei / Wang, Min / Zou, Lihua

Seminars in dialysis

2023 Volume 36, Issue 2, Page(s) 178–182

Abstract: Factor XI (FXI) deficiency is a rare bleeding disorder of unpredictable severity that correlates ...

Abstract	Factor XI (FXI) deficiency is a rare bleeding disorder of unpredictable severity that correlates poorly with FXI coagulation activity and that poses great challenges for perioperative hemostatic management and the dialysis methods potentially available to new end-stage renal disease (ESRD) patients. We describe an individual with both ESRD and severe FXI deficiency, who successfully underwent peritoneal dialysis (PD) after emergency abdominal surgery. In the traditional concept, recent abdominal surgery is a contraindication to PD, especially for patients with bleeding risk. However, this case report highlights that PD can still be an possible option for patients with FXI deficiency who have just undergone abdominal surgery; laparoscopic PD catheter placement offers a chance to establish PD access in patients traditionally viewed as noncandidates for this method. Careful perioperative management and fresh frozen plasma transfusion ensure successful surgery. This case should be of help to clinicians and patients considering PD in similar situations.
MeSH term(s)	Humans ; Factor XI Deficiency ; Factor XI ; Blood Component Transfusion ; Renal Dialysis ; Plasma ; Peritoneal Dialysis ; Kidney Failure, Chronic
Chemical Substances	Factor XI (9013-55-2)
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	1028193-9
ISSN	1525-139X ; 0894-0959
ISSN (online)	1525-139X
ISSN	0894-0959
DOI	10.1111/sdi.13136
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Article ; Online: The Spatial Pattern and Influencing Factors of Traffic Dominance in Xi’an Metropolitan Area

Julin Li / Tongsheng Li / Bingchen Zhu / Yilin Wang / Xieyang Chen / Ruikuan Liu

Land, Vol 12, Iss 1146, p

2023 Volume 1146

Abstract: ... the Xi’an metropolitan area as an exemplar and the town as the basic unit, this paper employs this model ... relatively high in the main urban area of Xi’an city or along and on both sides of the high-speed railways ... km of Xi’an city, especially in the main urban area of Xi’an city; (3) the integrated traffic ...

Abstract	Metropolitan areas shoulder the crucial task of regional and even national economic development. Analyzing the spatial patterns and influencing factors of metropolitan traffic dominance can provide a scientific basis for the optimization of its transportation and industrial layout, which is conducive to the development of its economy. Previous studies on traffic dominance paid little attention to metropolitan areas and even less so to study these areas from the perspective of town units, even though these are the basic units that narrow the gap between urban and rural areas and thus achieve regional economic integration. The traffic dominance model can comprehensively and wholly reflect regional traffic conditions, due to its multidimensional characteristics (including traffic network density, traffic arterial influence and accessibility). Consequently, taking the Xi’an metropolitan area as an exemplar and the town as the basic unit, this paper employs this model and other methods to study the spatial pattern and influencing factors of its traffic dominance. The results show the following: (1) the traffic network density, traffic arterial influence and accessibility had different distribution patterns; however, they were the same in that their superiorities were relatively high in the main urban area of Xi’an city or along and on both sides of the high-speed railways (HSRs), whereas relatively low in the peripheral areas; (2) the integrated traffic dominance consistently displayed a “point-axis” pattern, with greater superiority in the east–west axis areas within 30 km of Xi’an city, especially in the main urban area of Xi’an city; (3) the integrated traffic dominance between towns had stable agglomeration correlation in the global areas and formed three major modes in the local areas: high–high, low–low and low–high aggregation. High–high mode was concentrated in the main urban areas of Xi’an and Xianyang city, low–low mode was mainly distributed in the Weibei hilly and gully areas and the Qinling mountain ...
Keywords	traffic dominance ; traffic network density ; traffic arterial influence ; accessibility ; spatial pattern ; influencing factor ; Agriculture ; S
Subject code	380
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring the Relationship between Land Use and Congestion Source in Xi’an

Duo Wang / Hong Chen / Chenguang Li / Enze Liu

Sustainability, Vol 15, Iss 9328, p

A Multisource Data Analysis Approach

2023 Volume 9328

Abstract: ... parcels in the Second Ring Road of Xi’an, China. The study combines cell-phone data, POI data, and ...

Abstract	Traffic congestion is a critical problem in urban areas, and understanding the relationship between land use and congestion source is crucial for traffic management and urban planning. This study investigates the relationship between land-use characteristics and congestion pattern features of source parcels in the Second Ring Road of Xi’an, China. The study combines cell-phone data, POI data, and land-use data for the empirical analysis, and uses a spatial clustering approach to identify congested road sections and trace them back to source parcels. The correlations between building factors and congestion patterns are explored using the XGBoost algorithm. The results reveal that residential land and residential population density have the strongest impact on congestion clusters, followed by lands used for science and education and the density of the working population. The study also shows that a small number of specific parcels are responsible for the majority of network congestion. These findings have important implications for urban planners and transportation managers in developing targeted strategies to alleviate traffic congestion during peak periods.
Keywords	human mobility ; congestion source analysis ; land use ; cell-phone data ; machine learning ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	380
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Tests of $CP$ symmetry in the entangled $\Xi^0-\bar{\Xi}^0$ Pairs

BESIII Collaboration / Ablikim, M. / Achasov, M. N. / Adlarson, P. / Ai, X. C. / Aliberti, R. / Amoroso, A. / An, M. R. / An, Q. / Bai, Y. / Bakina, O. / Balossino, I. / Ban, Y. / Batozskaya, V. / Begzsuren, K. / Berger, N. / Berlowski, M. / Bertani, M. / Bettoni, D. /

Bianchi, F. / Bianco, E. / Bortone, A. / Boyko, I. / Briere, R. A. / Brueggemann, A. / Cai, H. / Cai, X. / Calcaterra, A. / Cao, G. F. / Cao, N. / Cetin, S. A. / Chang, J. F. / Chang, T. T. / Chang, W. L. / Che, G. R. / Chelkov, G. / Chen, C. / Chen, Chao / Chen, G. / Chen, H. S. / Chen, M. L. / Chen, S. J. / Chen, S. M. / Chen, T. / Chen, X. R. / Chen, X. T. / Chen, Y. B. / Chen, Y. Q. / Chen, Z. J. / Cheng, W. S. / Choi, S. K. / Chu, X. / Cibinetto, G. / Coen, S. C. / Cossio, F. / Cui, J. J. / Dai, H. L. / Dai, J. P. / Dbeyssi, A. / de Boer, R. E. / Dedovich, D. / Deng, Z. Y. / Denig, A. / Denysenko, I. / Destefanis, M. / De Mori, F. / Ding, B. / Ding, X. X. / Ding, Y. / Dong, J. / Dong, L. Y. / Dong, M. Y. / Dong, X. / Du, M. C. / Du, S. X. / Duan, Z. H. / Egorov, P. / Fan, Y. L. / Fang, J. / Fang, S. S. / Fang, W. X. / Fang, Y. / Farinelli, R. / Fava, L. / Feldbauer, F. / Felici, G. / Feng, C. Q. / Feng, J. H. / Fischer, K / Fritsch, M. / Fritzsch, C. / Fu, C. D. / Fu, J. L. / Fu, Y. W. / Gao, H. / Gao, Y. N. / Gao, Yang / Garbolino, S. / Garzia, I. / Ge, P. T. / Ge, Z. W. / Geng, C. / Gersabeck, E. M. / Gilman, A / Goetzen, K. / Gong, L. / Gong, W. X. / Gradl, W. / Gramigna, S. / Greco, M. / Gu, M. H. / Gu, Y. T. / Guan, C. Y / Guan, Z. L. / Guo, A. Q. / Guo, L. B. / Guo, M. J. / Guo, R. P. / Guo, Y. P. / Guskov, A. / Han, T. T. / Han, W. Y. / Hao, X. Q. / Harris, F. A. / He, K. K. / He, K. L. / Heinsius, F. H. H. / Heinz, C. H. / Heng, Y. K. / Herold, C. / Holtmann, T. / Hong, P. C. / Hou, G. Y. / Hou, X. T. / Hou, Y. R. / Hou, Z. L. / Hu, H. M. / Hu, J. F. / Hu, T. / Hu, Y. / Huang, G. S. / Huang, K. X. / Huang, L. Q. / Huang, X. T. / Huang, Y. P. / Hussain, T. / Hüsken, N / Imoehl, W. / Irshad, M. / Jackson, J. / Jaeger, S. / Janchiv, S. / Jeong, J. H. / Ji, Q. / Ji, Q. P. / Ji, X. B. / Ji, X. L. / Ji, Y. Y. / Jia, X. Q. / Jia, Z. K. / Jiang, P. C. / Jiang, S. S. / Jiang, T. J. / Jiang, X. S. / Jiang, Y. / Jiao, J. B. / Jiao, Z. / Jin, S. / Jin, Y. / Jing, M. Q. / Johansson, T. / K., X. / Kabana, S. / Kalantar-Nayestanaki, N. / Kang, X. L. / Kang, X. S. / Kappert, R. / Kavatsyuk, M. / Ke, B. C. / Khoukaz, A. / Kiuchi, R. / Kliemt, R. / Kolcu, O. B. / Kopf, B. / Kuessner, M. K. / Kupsc, A. / Kühn, W. / Lane, J. J. / Larin, P. / Lavania, A. / Lavezzi, L. / Lei, T. T. / Lei, Z. H. / Leithoff, H. / Lellmann, M. / Lenz, T. / Li, C. / Li, C. H. / Li, Cheng / Li, D. M. / Li, F. / Li, G. / Li, H. / Li, H. B. / Li, H. J. / Li, H. N. / Li, Hui / Li, J. R. / Li, J. S. / Li, J. W. / Li, K. L. / Li, Ke / Li, L. J / Li, L. K. / Li, Lei / Li, M. H. / Li, P. R. / Li, Q. X. / Li, S. X. / Li, T. / Li, W. D. / Li, W. G. / Li, X. H. / Li, X. L. / Li, Xiaoyu / Li, Y. G. / Li, Z. J. / Li, Z. X. / Liang, C. / Liang, H. / Liang, Y. F. / Liang, Y. T. / Liao, G. R. / Liao, L. Z. / Libby, J. / Limphirat, A. / Lin, D. X. / Lin, T. / Liu, B. J. / Liu, B. X. / Liu, C. / Liu, C. X. / Liu, F. 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L. / Ouyang, Q. / Pacetti, S. / Pan, X. / Pan, Y. / Pathak, A. / Patteri, P. / Pei, Y. P. / Pelizaeus, M. / Peng, H. P. / Peters, K. / Ping, J. L. / Ping, R. G. / Plura, S. / Pogodin, S. / Prasad, V. / Qi, F. Z. / Qi, H. / Qi, H. R. / Qi, M. / Qi, T. Y. / Qian, S. / Qian, W. B. / Qiao, C. F. / Qin, J. J. / Qin, L. Q. / Qin, X. P. / Qin, X. S. / Qin, Z. H. / Qiu, J. F. / Qu, S. Q. / Redmer, C. F. / Ren, K. J. / Rivetti, A. / Rodin, V. / Rolo, M. / Rong, G. / Rosner, Ch. / Ruan, S. N. / Salone, N. / Sarantsev, A. / Schelhaas, Y. / Schoenning, K. / Scodeggio, M. / Shan, K. Y. / Shan, W. / Shan, X. Y. / Shangguan, J. F. / Shao, L. G. / Shao, M. / Shen, C. P. / Shen, H. F. / Shen, W. H. / Shen, X. Y. / Shi, B. A. / Shi, H. C. / Shi, J. L. / Shi, J. Y. / Shi, Q. Q. / Shi, R. S. / Shi, X. / Song, J. J. / Song, T. Z. / Song, W. M. / Song, Y. J. / Song, Y. X. / Sosio, S. / Spataro, S. / Stieler, F. / Su, Y. J. / Sun, G. B. / Sun, G. X. / Sun, H. / Sun, H. K. / Sun, J. 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Q. / Zhang, J. W. / Zhang, J. X. / Zhang, J. Y. / Zhang, J. Z. / Zhang, Jianyu / Zhang, Jiawei / Zhang, L. M. / Zhang, L. Q. / Zhang, Lei / Zhang, P. / Zhang, Q. Y. / Zhang, Shuihan / Zhang, Shulei / Zhang, X. D. / Zhang, X. M. / Zhang, X. Y. / Zhang, Y. / Zhang, Y. T. / Zhang, Y. H. / Zhang, Yan / Zhang, Yao / Zhang, Z. H. / Zhang, Z. L. / Zhang, Z. Y. / Zhao, G. / Zhao, J. / Zhao, J. Y. / Zhao, J. Z. / Zhao, Lei / Zhao, Ling / Zhao, M. G. / Zhao, S. J. / Zhao, Y. B. / Zhao, Y. X. / Zhao, Z. G. / Zhemchugov, A. / Zheng, B. / Zheng, J. P. / Zheng, W. J. / Zheng, Y. H. / Zhong, B. / Zhong, X. / Zhou, H. / Zhou, L. P. / Zhou, X. / Zhou, X. K. / Zhou, X. R. / Zhou, X. Y. / Zhou, Y. Z. / Zhu, J. / Zhu, K. / Zhu, K. J. / Zhu, L. / Zhu, L. X. / Zhu, S. H. / Zhu, S. Q. / Zhu, T. J. / Zhu, W. J. / Zhu, Y. C. / Zhu, Z. A. / Zou, J. H. / Zu, J.

2023

Abstract: The $J/\psi \to \Xi^0 \bar{\Xi}^{0}$ process and subsequent decays are investigated using $(10087 ... of $\Xi^0$ and $\bar{\Xi}^0$ are measured with greatly improved precision over previous measurements to be ... alpha_{\Xi} = -0.3750 \pm 0.0034 \pm 0.0016$, $\bar{\alpha}_{\Xi} = 0.3790 \pm 0.0034 \pm 0.0021$, $\phi ...

Abstract	The $J/\psi \to \Xi^0 \bar{\Xi}^{0}$ process and subsequent decays are investigated using $(10087 \pm 44)\times 10^6$ $J/\psi$ events collected at the BESIII experiment. The decay parameters of $\Xi^0$ and $\bar{\Xi}^0$ are measured with greatly improved precision over previous measurements to be $\alpha_{\Xi} = -0.3750 \pm 0.0034 \pm 0.0016$, $\bar{\alpha}_{\Xi} = 0.3790 \pm 0.0034 \pm 0.0021$, $\phi_{\Xi} = 0.0051 \pm 0.0096 \pm 0.0018$~rad, $\bar{\phi}_{\Xi} = -0.0053 \pm 0.0097 \pm 0.0019$~rad, where the first and the second uncertainties are statistical and systematic, respectively. From these measurements, precise $CP$ symmetry tests in $\Xi^0$ decay are performed, and $A^{\Xi}_{CP} = (-5.4 \pm 6.5 \pm 3.1) \times 10^{-3}$ and $\Delta\phi^{\Xi}_{CP} = (-0.1 \pm 6.9 \pm 0.9) \times 10^{-3}$~rad are consistent with $CP$ conservation. The sequential decay also enables a separation of weak and strong phase differences, which are found for the first time to be $\xi_{P}-\xi_{S} = (0.0 \pm 1.7 \pm 0.2) \times 10^{-2}$~rad and $\delta_{P}-\delta_{S} = (-1.3 \pm 1.7 \pm 0.4)\times 10^{-2}$~rad, respectively. In addition, we measure the $\Lambda$ decay parameters and test $CP$ symmetry in $\Lambda$ decays.
Keywords	High Energy Physics - Experiment
Subject code	612
Publishing date	2023-05-16
Publishing country	us
Document type	Book ; Online
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Article: The association between the MELD-XI score and heart failure in patients with acute myocardial infarction after coronary artery stenting-a retrospective study.

Chen, Difang / Lu, Mei / Fu, Zhaoming / Ding, Kejun / Liang, Peng

Journal of thoracic disease

2023 Volume 15, Issue 5, Page(s) 2721–2728

Abstract: ... MELD-XI score may help to more accurately evaluate the cardiac function in patients with heart failure ... This study was conducted to examine the predictive value of MELD-XI score in patients with acute ... from January 2018 to January 2021 was retrospectively collected. According to the MELD-XI score on admission ...

Abstract	Background: The model for end-stage liver disease (MELD) score is a marker used to evaluate end-stage liver disease in patients with liver failure and is suggested to be valuable in evaluating heart diseases such as heart failure. Because patients with heart failure and myocardial infarction often use anticoagulants, there is an impact on the international normalized ratio (INR). Therefore, removing the INR from MELD score to form MELD-XI score may help to more accurately evaluate the cardiac function in patients with heart failure. This study was conducted to examine the predictive value of MELD-XI score in patients with acute myocardial infarction after coronary artery stenting, as there is a lack of literature in this area. Methods: The data of 318 patients with acute myocardial infarction admitted to The People's Hospital of Dazu from January 2018 to January 2021 was retrospectively collected. According to the MELD-XI score on admission, the patients were divided into a high-MELD-XI score group (n=159) and a low-MELD-XI score group (n=159). The patients were followed up for 1 year after surgery to observe the long-term prognosis and the long-term prognosis of the 2 groups was compared. Results: Compared with that in the low-MELD-XI score group, the left ventricular ejection fraction in the high-MELD-XI score group was significantly reduced (51.61%±7.66% Conclusions: MELD-XI could evaluate the cardiac function of patients with acute myocardial infarction after coronary artery stenting, which was valuable in predicting the prognosis.
Language	English
Publishing date	2023-05-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-562
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Article ; Online: Detection and Gene Mutation Analysis of Three Variations in Two Unrelated Chinese Hereditary Coagulation Factor XI Deficiency Families.

Yang, Ting / Zhu, Jin / Chen, Xiuhua / Wang, Fengping / Zheng, Xiaoyan / Cheng, Xiaoli

Acta haematologica

2022 Volume 145, Issue 6, Page(s) 611–618

Abstract: ... Chinese families with coagulation factor XI deficiency, and their possible pathogenesis was elucidated ...

Abstract	Introduction: Three variations including a novel F11 gene variation were detected in two unrelated Chinese families with coagulation factor XI deficiency, and their possible pathogenesis was elucidated. Methods: The genomic DNA of the probands' pedigrees was extracted, and all exons and flanking sequences of F11 gene were subjected to PCR amplification and Sanger sequencing. ClustalX-2.1-win, Mutation Taster, and Swiss-Pdb Viewer software were used to analyze the conservation and impact of the variations on protein function and structure. Results: DNA sequencing showed that the proband one had p.Gly350Glu and p.Trp501stop complex heterozygous variations, while the proband two took p.Pro338Leu and p.Trp501stop compound heterozygous variations. Conservation, structural, and functional analysis of variant amino acids indicated that these three variations were harmful and probably affected the structure and function of the variable protein. Conclusions: Three variations including p.Pro338Leu, p.Gly350Glu, and p.Trp501stop responsible for the reduction of the FXI activities were herein detected. Notably, the p.Pro338Leu variation was discovered for the first time in the world. Furthermore, the p.Gly350Glu was first reported in China.
MeSH term(s)	Humans ; Factor XI/genetics ; Factor XI Deficiency/diagnosis ; Factor XI Deficiency/genetics ; Heterozygote ; Pedigree ; Mutation
Chemical Substances	Factor XI (9013-55-2)
Language	English
Publishing date	2022-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	80008-9
ISSN	1421-9662 ; 0001-5792
ISSN (online)	1421-9662
ISSN	0001-5792
DOI	10.1159/000526043
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Article ; Online: Transvaginal single-hole laparoscopic (V-NOTES) total hysterectomy assisted by the Da Vinci Xi system: A case report.

Dapeng, Sun / Jie, Chen / Pu, Xu / Jing, Liu

Asian journal of surgery

2022 Volume 45, Issue 7, Page(s) 1505–1506

MeSH term(s)	Female ; Humans ; Hysterectomy ; Laparoscopy ; Robotic Surgical Procedures
Language	English
Publishing date	2022-03-17
Publishing country	China
Document type	Case Reports
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.03.013
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