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Book ; Online: Age determinations from northwest Russia, supplementary data to: Larsen, Eiliv; Lyså, Astrid; Demidov, Igor; Funder, Svend; Houmark-Nielsen, Michael; Kjær, Kurt H; Murray, Andrew S (1999): Age and extent of the Scandinavian ice sheet in northwest Russia. Boreas, 28(1), 115-132

Larsen, Eiliv / Demidov, Igor / Funder, Svend / Houmark-Nielsen, Michael / Kjær, Kurt H / Lyså, Astrid / Murray, Andrew S

1999

Abstract: ... migration of the ice divide(s) to the east as ice growth continued. Deglaciation was either by lateral ...

Abstract	The last glacial maximum (LGM) of the Scandinavian ice sheet in the Arkhangelsk region has been identified morphologically as ridges and hummocks in an otherwise flat topography. Stratigraphically the limit is marked by the presence of till above Mikhulinian (last interglacial) sediments inside the ridges and by the absence of till outside the ridges. During the LGM, ice flowed into the region from the north and northwest forming a lobe in the Dvina-Vaga depression. The continuation northward, northeast of Arkhangelsk, is still somewhat uncertain, but evidence suggests that the outer margin of the Scandinavian ice sheet was situated in the Mezen drainage basin. Luminescence and radiocarbon dates suggest that the maximum position was attained after some 17 ka ago, and that deglaciation started close to 15 ka ago. This age for the maximum position is younger than the maximum position in the western peripheral areas of the Scandinavian ice sheet. This may be accounted for by initial ice build-up in the west followed by a successive migration of the ice divide(s) to the east as ice growth continued. Deglaciation was either by lateral retreat or isolation of dead ice masses causing areal downwasting.
Language	English
Dates of publication	1999-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1111/j.1502-3885.1999.tb00209.x
DOI	10.1594/PANGAEA.727408
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Online: Age determination of sediment from Lake Komi, supplementary data to: Mangerud, Jan; Astakhov, Valery I; Murray, Andrew S; Svendsen, John I (2001): The chronology of a large ice-dammed lake and the Barents-Kara ice sheet advances, northern Russia. Global and Planetary Change, QUEEN special issue, 31(1), 321-336

Mangerud, Jan / Astakhov, Valery I / Murray, Andrew S / Svendsen, John I

2001

Abstract: Beach and shoreface sediments deposited in the more than 800-km long ice-dammed Lake Komi in northern European Russia have been investigated and dated. The lake flooded the lowland areas between the Barents-Kara Ice Sheet in the north and the continental ...

Abstract	Beach and shoreface sediments deposited in the more than 800-km long ice-dammed Lake Komi in northern European Russia have been investigated and dated. The lake flooded the lowland areas between the Barents-Kara Ice Sheet in the north and the continental drainage divide in the south. Shoreline facies have been dated by 18 optical stimulated luminescence (OSL) dates, most of which are closely grouped in the range 80-100 ka, with a mean of 88 +/- 3 ka. This implies that that the Barents-Kara Ice Sheet had its Late Pleistocene maximum extension during the Early Weichselian, probably in the cold interval (Rederstall) between the Brørup and Odderade interstadials of western Europe, correlated with marine isotope stage 5b. This is in strong contrast to the Scandinavian and North American ice sheets, which had their maxima in isotope stage 2, about 20 ka. Field and air photo interpretations suggest that Lake Komi was dammed by the ice advance, which formed the Harbei-Harmon-Sopkay Moraines. These has earlier been correlated with the Markhida moraine across the Pechora River Valley and its western extension. However, OSL dates on fluvial sediments below the Markhida moraine have yielded ages as young as 60 ka. This suggests that the Russian mainland was inundated by two major ice sheet advances from the Barents-Kara seas after the last interglacial: one during the Early Weichselian (about 90 ka) that dammed Lake Komi and one during the Middle Weichselian (about 60 ka). Normal fluvial drainage prevailed during the Late Weichselian, when the ice front was located offshore.
Language	English
Dates of publication	2001-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1016/S0921-8181(01)00127-8
DOI	10.1594/PANGAEA.728846
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book: Measuring the global burden of disease

Eyal, Nir M. / Hurst-Majno, Samia / Murray, Christopher J.L. / Schroeder, S. Andrew / Wikler, Daniel

philosophical dimensions

(Population level bioethics series)

2020

Author's details	edited by Nir Eyal, Samia A. Hurst, Christopher J.L. Murray, S. Andrew Schroeder, and Daniel Wikler
Series title	Population level bioethics series
Language	English
Size	x, 328 Seiten
Publisher	Oxford University Press
Publishing place	Oxford
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT020476531
ISBN	978-0-19-008254-3 ; 9780190082574 ; 0-19-008254-2 ; 0190082577
Database	Catalogue ZB MED Medicine, Health

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2020 A 976	available for loan (reading room)	Lesesaal EG

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Article ; Online: Extending the reach of homology by using successive computational filters to find yeast pheromone genes.

Srikant, Sriram / Gaudet, Rachelle / Murray, Andrew W

Current biology : CB

2023 Volume 33, Issue 19, Page(s) 4098–4110.e3

Abstract: ... in Saccharomyces cerevisiae) or C-terminally farnesylated (e.g., a-factor in S. cerevisiae). Peptide pheromones have been ...

Abstract	The mating of fungi depends on pheromones that mediate communication between two mating types. Most species use short peptides as pheromones, which are either unmodified (e.g., α-factor in Saccharomyces cerevisiae) or C-terminally farnesylated (e.g., a-factor in S. cerevisiae). Peptide pheromones have been found by genetics or biochemistry in a small number of fungi, but their short sequences and modest conservation make it impossible to detect homologous sequences in most species. To overcome this problem, we used a four-step computational pipeline to identify candidate a-factor genes in sequenced genomes of the Saccharomycotina, the fungal clade that contains most of the yeasts: we require that candidate genes have a C-terminal prenylation motif, are shorter than 100 amino acids long, and contain a proteolytic-processing motif upstream of the potential mature pheromone sequence and that closely related species contain highly conserved homologs of the potential mature pheromone sequence. Additional manual curation exploits the observation that many species carry more than one a-factor gene, encoding identical or nearly identical pheromones. From 332 Saccharomycotina genomes, we identified strong candidate pheromone genes in 241 genomes, covering 13 clades that are each separated from each other by at least 100 million years, the time required for evolution to remove detectable sequence homology among small pheromone genes. For one small clade, the Yarrowia, we demonstrated that our algorithm found the a-factor genes: deleting all four related genes in the a-mating type of Yarrowia lipolytica prevents mating.
MeSH term(s)	Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Pheromones/metabolism ; Peptides/metabolism ; Ascomycota/metabolism ; Genes, Fungal ; Mating Factor/genetics ; Mating Factor/metabolism
Chemical Substances	Pheromones ; Peptides ; Mating Factor (61194-02-3)
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.08.039
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Article ; Online: O blood type is not associated with worse coagulopathy or outcome in exsanguinating trauma.

Gwin, J Cole / Rangnekar, Niyati / Murray, Glenn P / Byerly, Saskya / Fleming, Andrew M / Easterday, Thomas S / Kerwin, Andrew J / Howley, Isaac W

American journal of surgery

2024

Abstract: Background: Despite improving understanding of trauma-induced coagulopathy (TIC), mortality and morbidity due to exsanguinating trauma remain high. Increased complications due to hemorrhage have been reported in blood group O, possibly due to reduced ... ...

Abstract	Background: Despite improving understanding of trauma-induced coagulopathy (TIC), mortality and morbidity due to exsanguinating trauma remain high. Increased complications due to hemorrhage have been reported in blood group O, possibly due to reduced levels of von Willebrand factor (vWF). Methods: An urban level 1 adult trauma center registry was retrospectively queried. Patients receiving ≥6 units of pRBC within 4 h of presentation were included. Patient demographics, admission labs and outcomes were obtained. Univariate and multiple logistic regression analyses were performed. Results: 562 patients were identified. There were no significant differences in demographics, admission labs, or outcome between different ABO groups. After adjustment, Type A patients were more likely to be hypocoagulable compared to Type O patients (p = 0.014). No mortality differences were seen between ABO types in multiple regression analysis. Conclusions: No outcome or mortality differences were seen between ABO types, therefore factors other than vWF expression should be considered to explain coagulopathy in trauma patients.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2024.03.021
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Article ; Online: Hospital Facility Prices Declined As A Result Of Oregon's Hospital Payment Cap.

Murray, Roslyn C / Brown, Zach Y / Miller, Sarah / Norton, Edward C / Ryan, Andrew M

Health affairs (Project Hope)

2024 Volume 43, Issue 3, Page(s) 424–432

Abstract: ... on hospital facility prices for Oregon's state employee plan enrollees. We found that the cap was not ...

Abstract	Hospital prices for commercially insured people are high and vary widely, prompting states to seek ways to control hospital price growth. In October 2019, the Oregon state employee health insurance plan instituted a cap on hospital payments. Using 2014-21 data from the Oregon All Payer All Claims Reporting Program database, we performed a difference-in-differences analysis to test the impact of the cap on hospital facility prices for Oregon's state employee plan enrollees. We found that the cap was not associated with a significant reduction in inpatient facility prices across the post period (-$901.9 per admission) but was associated with a significant reduction in the second year after implementation (-$2,774.20). The cap was associated with a significant reduction in outpatient facility prices over the course of the first twenty-seven months of the policy (-$130.50 per procedure). We estimated $107.5 million (or 4 percent of total plan spending) in savings to the state employee plan during the first two years. The hospital payment cap successfully reduced hospital prices for enrollees in that plan.
MeSH term(s)	Humans ; Oregon ; Hospitals ; Hospitalization ; Databases, Factual ; Income
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	632712-6
ISSN	1544-5208 ; 0278-2715
ISSN (online)	1544-5208
ISSN	0278-2715
DOI	10.1377/hlthaff.2023.01021
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Article ; Online: Epidemiology of musculoskeletal injury in professional and amateur golfers: a systematic review and meta-analysis.

Williamson, Thomas R / Kay, Robert S / Robinson, Patrick G / Murray, Andrew D / Clement, Nicholas D

British journal of sports medicine

2024

Abstract: Objective: To determine the prevalence and incidence of musculoskeletal injury in amateur and professional golfers, and to identify common injury sites and factors associated with increased injury frequency.: Design: Systematic epidemiological review ...

Abstract	Objective: To determine the prevalence and incidence of musculoskeletal injury in amateur and professional golfers, and to identify common injury sites and factors associated with increased injury frequency. Design: Systematic epidemiological review and meta-analysis. Data sources: PubMed (Medline), Embase, the Cochrane Library and SPORTDiscus were searched in September 2023. Eligibility criteria: Studies published in the English language reporting the incidence or prevalence of musculoskeletal injuries in golfers at all anatomical sites. Results: 20 studies (9221 golfers, 71.9% male, 28.1% female) were included, with mean age 46.8 years. Lifetime injury prevalence was significantly greater in professional golfers (73.5% (95% CI: 47.3% to 93.0%)) than amateur golfers (56.6% (95% CI: 47.4% to 65.5%); relative risk (RR)=1.50, p<0.001). Professional golfers had a significantly greater lifetime prevalence of hand and wrist (RR=3.33, p<0.001) and lower back injury (RR=3.05, p<0.001). Soft tissue injuries were most common, and diagnoses were typically non-specific. Injury frequency was not associated with age or sex. Two studies reported a greater injury risk in amateur golfers playing more than three and four rounds per week. Conclusion: Over half of golfers are at risk of sustaining a musculoskeletal injury during their lifetime. Risks and patterns of injury differ between professional and amateur golfers, with professionals significantly more likely to develop lower back, and hand and wrist injuries. A recent international consensus statement on the reporting of injury and illness in golf should aid consistency in future research assessing the epidemiology of specific diagnoses, informing golf injury prevention and management strategies. Prospero registration number: CRD42023408738.
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	600592-5
ISSN	1473-0480 ; 0306-3674
ISSN (online)	1473-0480
ISSN	0306-3674
DOI	10.1136/bjsports-2023-107324
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Article: Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation.

O'Brien, Katie A / Murray, Andrew J / Simonson, Tatum S

Life (Basel, Switzerland)

2022 Volume 12, Issue 3

Abstract: Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen ( ... ...

Abstract	Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O
Language	English
Publishing date	2022-03-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12030437
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mapping quality improvement education initiatives to Standards for QUality Improvement Reporting Excellence (SQUIRE) guidelines.

Lamont, Scott / Murray, Andrew / Tetik, Emine / Yeo, Jiaming / Blair, Bianca

Journal of clinical nursing

2023 Volume 32, Issue 15-16, Page(s) 5126–5134

Abstract: ... within Kirkpatrick's four levels of training evaluation model. The SQUIRE checklist was also applied in line ... to evaluation frameworks in n = 133 projects to position within Kirkpatrick's four levels of training evaluation ...

Abstract	Aims and objectives: To explore the rigour of nurse-led quality improvement projects involving education, training or continuing professional development, and examine evaluation frameworks contained within. Background: Healthcare organisations invest significantly in quality improvement in the pursuit of cost-effective, safe, evidence-based and person-centred care. Consequently, efforts to examine the success of investment in quality improvement activities are prominent, against a backdrop of rising healthcare expenditure, reforms, consumer expectations and feedback. Design: A qualitative document analysis of quality improvement projects located in a local health district repository was undertaken. Methods: N = 3004 projects were screened against inclusion criteria, with n = 160 projects remaining for analysis. Projects were mapped to an adapted version of the Standards for QUality Improvement Reporting Excellence (SQUIRE), specifically the education extension (SQUIRE-EDU). Additionally, project evaluation frameworks were positioned within Kirkpatrick's four levels of training evaluation model. The SQUIRE checklist was also applied in line with EQUATOR guidelines. Results: Of n = 60 completed projects assessed against four broad SQUIRE-EDU categories and relevant criteria, n = 36 were assessed not to have met any categories, n = 14 projects met one category, n = 8 projects met two categories, and n = 2 projects met three categories. None of the completed projects met all four SQUIRE-EDU categories. There was insufficient documentation relating to evaluation frameworks in n = 133 projects to position within Kirkpatrick's four levels of training evaluation. Conclusions: Scientific rigour should underpin all quality improvement efforts. We recommend that SQUIRE international consensus guidelines (full or abridged) should guide both the design and reporting of all local quality improvement efforts. Relevance to clinical practice: To be of value to the expansion of evidence-based practice, quality improvement platforms should be designed to reflect the structural logic, rigour and reporting recommendations being advocated in consensus reporting guidelines. This may require investment in training and development programs, and identification of governance and support systems. No Patient or Public Contribution, as the study was retrospective in nature and involved a health service repository of quality improvement projects accessible to health service staff only.
MeSH term(s)	Humans ; Quality Improvement ; Retrospective Studies ; Educational Status ; Delivery of Health Care ; Consensus
Language	English
Publishing date	2023-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1159483-4
ISSN	1365-2702 ; 0962-1067 ; 1752-9816
ISSN (online)	1365-2702
ISSN	0962-1067 ; 1752-9816
DOI	10.1111/jocn.16610
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Article ; Online: Value-Based Payment Models In The Commercial Insurance Sector: A Systematic Review.

Milad, Marina A / Murray, Roslyn C / Navathe, Amol S / Ryan, Andrew M

Health affairs (Project Hope)

2022 Volume 41, Issue 4, Page(s) 540–548

Abstract: Value-based payment models are a prominent strategy in health reform. Although Medicare payment models have been extensively evaluated, much less is known about value-based payment models in the commercial insurance sector. We performed the first ... ...

Abstract	Value-based payment models are a prominent strategy in health reform. Although Medicare payment models have been extensively evaluated, much less is known about value-based payment models in the commercial insurance sector. We performed the first systematic review of the quality, spending, and utilization effects of commercial models, extracting results from fifty-nine studies. Forty-one of these studies evaluated outcomes. More studies had positive results for quality outcomes (81 percent of studies) than for spending (56 percent) and utilization (58 percent). Less rigorous studies were more likely to find positive results. Given the mixed nature of the findings, commercial insurers should identify ways to strengthen value-based payment programs or leverage other strategies to improve health care value.
MeSH term(s)	Aged ; Delivery of Health Care ; Health Care Reform ; Humans ; Medicare ; United States
Language	English
Publishing date	2022-04-04
Publishing country	United States
Document type	Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	632712-6
ISSN	1544-5208 ; 0278-2715
ISSN (online)	1544-5208
ISSN	0278-2715
DOI	10.1377/hlthaff.2021.01020
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