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  1. Article: Principles and Terminology for Host-Microbiome-Drug Interactions.

    Heirali, Alya / Moossavi, Shirin / Arrieta, Marie Claire / Coburn, Bryan

    Open forum infectious diseases

    2023  Volume 10, Issue 5, Page(s) ofad195

    Abstract: Interactions between the microbiome and medical therapies are distinct and bidirectional. The existing term "pharmacomicrobiomics" describes the effects of the microbiome on drug distribution, metabolism, efficacy, and toxicity. We propose that the term " ...

    Abstract Interactions between the microbiome and medical therapies are distinct and bidirectional. The existing term "pharmacomicrobiomics" describes the effects of the microbiome on drug distribution, metabolism, efficacy, and toxicity. We propose that the term "pharmacoecology" be used to describe the effects that drugs and other medical interventions such as probiotics have on microbiome composition and function. We suggest that the terms are complementary but distinct and that both are potentially important when assessing drug safety and efficacy as well as drug-microbiome interactions. As a proof of principle, we describe the ways in which these concepts apply to antimicrobial and non-antimicrobial medications.
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad195
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  2. Article ; Online: A Microbiota-Derived Metabolite Augments Cancer Immunotherapy Responses in Mice.

    Allen-Vercoe, Emma / Coburn, Bryan

    Cancer cell

    2020  Volume 38, Issue 4, Page(s) 452–453

    Abstract: Improving the rate of patient response to immune checkpoint blockade therapy is a current clinical goal. An article published in Science suggests that some members of the gut microbiome may provide a key molecule toward this end. ...

    Abstract Improving the rate of patient response to immune checkpoint blockade therapy is a current clinical goal. An article published in Science suggests that some members of the gut microbiome may provide a key molecule toward this end.
    MeSH term(s) Animals ; Gastrointestinal Microbiome ; Humans ; Immunotherapy ; Inosine ; Mice ; Microbiota ; Neoplasms/therapy
    Chemical Substances Inosine (5A614L51CT)
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2020.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5650: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 104: Show issues

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  3. Article: Patient-derived cancer models: Valuable platforms for anticancer drug testing.

    Genta, Sofia / Coburn, Bryan / Cescon, David W / Spreafico, Anna

    Frontiers in oncology

    2022  Volume 12, Page(s) 976065

    Abstract: Molecularly targeted treatments and immunotherapy are cornerstones in oncology, with demonstrated efficacy across different tumor types. Nevertheless, the overwhelming majority metastatic disease is incurable due to the onset of drug resistance. ... ...

    Abstract Molecularly targeted treatments and immunotherapy are cornerstones in oncology, with demonstrated efficacy across different tumor types. Nevertheless, the overwhelming majority metastatic disease is incurable due to the onset of drug resistance. Preclinical models including genetically engineered mouse models, patient-derived xenografts and two- and three-dimensional cell cultures have emerged as a useful resource to study mechanisms of cancer progression and predict efficacy of anticancer drugs. However, variables including tumor heterogeneity and the complexities of the microenvironment can impair the faithfulness of these platforms. Here, we will discuss advantages and limitations of these preclinical models, their applicability for drug testing and in co-clinical trials and potential strategies to increase their reliability in predicting responsiveness to anticancer medications.
    Language English
    Publishing date 2022-08-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.976065
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  4. Article ; Online: Therapeutic interventions and mechanisms associated with gut microbiota-mediated modulation of immune checkpoint inhibitor responses.

    Wong, Matthew K / Barbulescu, Philip / Coburn, Bryan / Reguera-Nuñez, Elaine

    Microbes and infection

    2021  Volume 23, Issue 6-7, Page(s) 104804

    Abstract: The link between the gut microbiome and responsiveness to immune checkpoint inhibitor (ICI) therapy is now well established. New therapeutic opportunities exploiting this relationship are being developed with the goal of augmenting ICI efficacy. In this ... ...

    Abstract The link between the gut microbiome and responsiveness to immune checkpoint inhibitor (ICI) therapy is now well established. New therapeutic opportunities exploiting this relationship are being developed with the goal of augmenting ICI efficacy. In this review, we summarize the foundational research establishing these interactions and discuss the mechanisms and novel therapeutic options associated with this gut microbiome-ICI connection.
    MeSH term(s) Animals ; Gastrointestinal Microbiome/drug effects ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-02-27
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2021.104804
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5014: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The microbiome and cancer for clinicians.

    Picardo, Sarah L / Coburn, Bryan / Hansen, Aaron R

    Critical reviews in oncology/hematology

    2019  Volume 141, Page(s) 1–12

    Abstract: The human microbiome is an emerging target in cancer development and therapeutics. It may be directly oncogenic, through promotion of mucosal inflammation or systemic dysregulation, or may alter anti-cancer immunity/therapy. Microorganisms within, ... ...

    Abstract The human microbiome is an emerging target in cancer development and therapeutics. It may be directly oncogenic, through promotion of mucosal inflammation or systemic dysregulation, or may alter anti-cancer immunity/therapy. Microorganisms within, adjacent to and distant from tumors may affect cancer progression, and interactions and differences between these populations can influence the course of disease. Here we review the microbiome as it pertains to cancer for clinicians. The microbiota of cancers including colorectal, pancreas, breast and prostate are discussed. We examine "omics" technologies, microbiota associated with tumor tissue and tumor-site fluids such as feces and urine, as well as indirect effects of the gut microbiome. We describe roles of the microbiome in immunotherapy, and how it can be modulated to improve cancer therapeutics. While research is still at an early stage, there is potential to exploit the microbiome, as modulation may increase efficacy of treatments, reduce toxicities and prevent carcinogenesis.
    MeSH term(s) Carcinogenesis ; Female ; Gastrointestinal Microbiome/immunology ; Gastrointestinal Microbiome/physiology ; Humans ; Immunity/physiology ; Immunologic Factors/therapeutic use ; Immunotherapy ; Male ; Microbiota/immunology ; Microbiota/physiology ; Neoplasms/immunology ; Neoplasms/microbiology ; Neoplasms/therapy
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2019-06-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2019.06.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1931: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A microbial consortium alters intestinal

    Rooney, Ashley M / Cochrane, Kyla / Fedsin, Stephanie / Yao, Samantha / Anwer, Shaista / Dehmiwal, Satyender / Hota, Susy / Poutanen, Susan / Allen-Vercoe, Emma / Coburn, Bryan

    mBio

    2023  Volume 14, Issue 4, Page(s) e0348222

    Abstract: Intestinal colonization with pathogens and antimicrobial-resistant organisms (AROs) is associated with increased risk of infection. Fecal microbiota transplant (FMT) has successfully been used to cure ... ...

    Abstract Intestinal colonization with pathogens and antimicrobial-resistant organisms (AROs) is associated with increased risk of infection. Fecal microbiota transplant (FMT) has successfully been used to cure recurrent
    MeSH term(s) Humans ; Microbial Consortia ; Anti-Bacterial Agents/pharmacology ; Clostridioides difficile ; Gastrointestinal Microbiome ; Drug Resistance, Bacterial ; Fecal Microbiota Transplantation ; Clostridium Infections/therapy ; Clostridium Infections/microbiology ; Feces/microbiology ; Microbiota ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03482-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The human microbiome.

    Coburn, Bryan / Guttman, David S

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2015  Volume 187, Issue 11, Page(s) 825

    MeSH term(s) Bacterial Infections/microbiology ; Bacterial Infections/physiopathology ; Diet ; Exercise/physiology ; Health Status ; Humans ; Immunocompetence/immunology ; Life Style ; Microbiota/immunology ; Microbiota/physiology ; Probiotics/administration & dosage ; Risk Factors ; Sensitivity and Specificity
    Language English
    Publishing date 2015-05-19
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.141072
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.136: Show issues Location:
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  8. Article ; Online: Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1.

    Pang, Juan / Raka, Fitore / Heirali, Alya Abbas / Shao, Weijuan / Liu, Dinghui / Gu, Jianqiu / Feng, Jia Nuo / Mineo, Chieko / Shaul, Philip W / Qian, Xiaoxian / Coburn, Bryan / Adeli, Khosrow / Ling, Wenhua / Jin, Tianru

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2656

    Abstract: Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I) in high-fat ... ...

    Abstract Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I) in high-fat diet (HFD)-challenged male mice inhibits chylomicron secretion, associated with reduced expression of jejunal but not hepatic scavenger receptor class B type 1 (SR-B1). Intestinal mucosa-specific SR-B1
    MeSH term(s) Male ; Animals ; Mice ; Humans ; Chylomicrons ; Resveratrol/pharmacology ; Caco-2 Cells ; Polyphenols ; Receptors, Scavenger
    Chemical Substances Chylomicrons ; Resveratrol (Q369O8926L) ; Polyphenols ; Receptors, Scavenger
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38259-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Treatment Success Following Standard Antibiotic Treatment for Bacterial Vaginosis Is Not Associated With Pretreatment Genital Immune or Microbial Parameters.

    Armstrong, Eric / Hemmerling, Anke / Joag, Vineet / Huibner, Sanja / Kulikova, Maria / Crawford, Emily / Castañeda, Gloria R / Anzala, Omu / Obila, Onyango / Shahabi, Kamnoosh / Ravel, Jacques / Coburn, Bryan / Cohen, Craig R / Kaul, Rupert

    Open forum infectious diseases

    2023  Volume 10, Issue 1, Page(s) ofad007

    Abstract: Background: Bacterial vaginosis (BV) is a proinflammatory genital condition associated with adverse reproductive health outcomes, including increased HIV incidence. However, BV recurrence rates are high after standard antibiotic treatment. While the ... ...

    Abstract Background: Bacterial vaginosis (BV) is a proinflammatory genital condition associated with adverse reproductive health outcomes, including increased HIV incidence. However, BV recurrence rates are high after standard antibiotic treatment. While the composition of the vaginal microbiota before BV treatment may be linked to BV recurrence, it is unclear whether the preceding genital immune milieu is predictive of treatment success.
    Methods: Here we assessed whether baseline vaginal soluble immune factors or the composition of the vaginal microbiota predicted treatment success 1 month after metronidazole treatment in 2 separate cohorts of women with BV, 1 in the United States and 1 in Kenya; samples within 48 hours of BV treatment were also available for the US cohort.
    Results: Neither soluble immune factors nor the composition of the vaginal microbiota before BV treatment was associated with treatment response in either cohort. In the US cohort, although the absolute abundances of key vaginal bacterial taxa pretreatment were not associated with treatment response, participants with sustained BV clearance had a more pronounced reduction in the absolute abundance of
    Conclusions: Pretreatment immune and microbial parameters were not predictive of BV treatment success in these clinical cohorts.
    Language English
    Publishing date 2023-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad007
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  10. Article ; Online: Optimizing Empiric Antibiotic Selection in Sepsis: Turning Probabilities Into Practice.

    MacFadden, Derek R / Daneman, Nick / Coburn, Bryan

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2017  Volume 66, Issue 3, Page(s) 479

    MeSH term(s) Anti-Bacterial Agents ; Bacteremia ; Cefepime ; Gram-Negative Bacteria ; Humans ; Meropenem ; Probability ; Sepsis/microbiology ; Tazobactam
    Chemical Substances Anti-Bacterial Agents ; Cefepime (807PW4VQE3) ; Meropenem (FV9J3JU8B1) ; Tazobactam (SE10G96M8W)
    Language English
    Publishing date 2017-11-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/cix775
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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