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Article ; Online: Overcoming Barriers and Advancements in Endovascular Robotics: A Review of Systems and Developments.

Morag, Eyal / Cornelis, Francois H / Weisz, Giora / Gandhi, Ripal

Techniques in vascular and interventional radiology

2023 Volume 26, Issue 3, Page(s) 100918

Abstract: Endovascular robots have the potential to revolutionize the field of vascular interventions by enhancing procedural efficiency, accuracy, and standardization. They aim to reduce radiation exposure, as well as physical strain on operators and medical ... ...

Abstract	Endovascular robots have the potential to revolutionize the field of vascular interventions by enhancing procedural efficiency, accuracy, and standardization. They aim to reduce radiation exposure, as well as physical strain on operators and medical staff, while enabling precise navigation of catheters through challenging anatomical structures. However, the widespread adoption of these robots faces barriers, such as real estate constraints, setup time, limited range of compatible tools, and high costs. This paper discusses these barriers and highlights Hansen Medical's Magellan and the Liberty robotic systems as notable examples. New developments will offer cost-effective, intuitive, and disposable approaches to endovascular procedures. Despite challenges, endovascular robots hold promise for improving access to endovascular therapy and transforming patient care in various healthcare settings.
MeSH term(s)	Humans ; Robotics ; Endovascular Procedures/adverse effects ; Catheters
Language	English
Publishing date	2023-10-21
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2170922-1
ISSN	1557-9808 ; 1089-2516
ISSN (online)	1557-9808
ISSN	1089-2516
DOI	10.1016/j.tvir.2023.100918
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Article ; Online: Ultrafast pulse duration measurement method of near-infrared pulses for a broad range of wavelengths using two-photon absorption in a liquid and fluorescent dye solution.

Syed, Rafeeq / Uiterwaal, Cornelis J G J

The Review of scientific instruments

2023 Volume 94, Issue 10

Abstract: A novel characterization method to measure the pulse duration of ultrafast near-IR pulses is introduced, which uses simple tabletop optics, is relatively inexpensive, and is expected to work in a broad wavelength range. Our diagnostic tool quantitatively ...

Abstract	A novel characterization method to measure the pulse duration of ultrafast near-IR pulses is introduced, which uses simple tabletop optics, is relatively inexpensive, and is expected to work in a broad wavelength range. Our diagnostic tool quantitatively characterizes the laser pulse duration of any near-IR wavelength assuming a Gaussian pulse shape with a linear chirp. We negatively prechirp near-IR pulses with a home-built broadband pulse compressor (BPC) and send this prechirped beam through a cell filled with a low-molar solution of a fluorescent dye in a liquid. After two-photon absorption, this dye fluoresces in the visible, and we record this visible signal as a function of the propagation distance in the liquid cell. We calibrate the group velocity dispersion (GVD) of our home-built BPC device against the known GVD of the compressor of our 800 nm laser and confirm this value using geometric considerations. Now knowing the GVD of BPC and the recorded visible signal for various amounts of negative chirp, let us extract the smallest pulse duration of the near-IR pulse from this visible signal. As a useful corollary, our analysis also enables the direct measurement of the GVD for liquids and the indirect measurement of the absorption coefficient for liquids in the near-IR range, in contrast to indirect GVD measurements that rely on methods such as the double derivative of the refractive index.
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0160178
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Article ; Online: Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis.

Rezzani, Rita / Gianò, Marzia / Pinto, Daniela / Rinaldi, Fabio / van Noorden, Cornelis J F / Favero, Gaia

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder, and its etiology is not well understood. It is known that genetic and nongenetic factors determine alterations in several organs, such as the liver, in individuals with this ... ...

Abstract	Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder, and its etiology is not well understood. It is known that genetic and nongenetic factors determine alterations in several organs, such as the liver, in individuals with this disorder. The aims of the present study were to analyze morphological and biological alterations in the liver of an autistic mouse model, BTBR T + Itpr3tf/J (BTBR) mice, and to identify therapeutic strategies for alleviating hepatic impairments using melatonin administration. We studied hepatic cytoarchitecture, oxidative stress, inflammation and ferroptosis in BTBR mice and used C57BL6/J mice as healthy control subjects. The mice were divided into four groups and then treated and not treated with melatonin, respectively. BTBR mice showed (a) a retarded development of livers and (b) iron accumulation and elevated oxidative stress and inflammation. We demonstrated that the expression of ferroptosis markers, the transcription factor nuclear factor erythroid-related factor 2 (NFR2), was upregulated, and the Kelch-like ECH-associated protein 1 (KEAP1) was downregulated in BTBR mice. Then, we evaluated the effects of melatonin on the hepatic alterations of BTBR mice; melatonin has a positive effect on liver cytoarchitecture and metabolic functions.
MeSH term(s)	Humans ; Animals ; Mice ; Autistic Disorder/drug therapy ; Autistic Disorder/genetics ; Kelch-Like ECH-Associated Protein 1 ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Autism Spectrum Disorder/drug therapy ; Autism Spectrum Disorder/genetics ; Ferroptosis ; NF-E2-Related Factor 2/genetics ; Liver ; Inflammation/drug therapy ; Oxidative Stress ; Disease Models, Animal ; Mice, Inbred C57BL
Chemical Substances	Kelch-Like ECH-Associated Protein 1 ; Melatonin (JL5DK93RCL) ; NF-E2-Related Factor 2
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021086
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Article: Damage Functions and the Social Cost of Carbon: Addressing Uncertainty in Estimating the Economic Consequences of Mitigating Climate Change

Russell, Alyssa R. / van Kooten, G. Cornelis / Izett, Jonathan G. / Eiswerth, Mark E.

Environmental management. 2022 May, v. 69, no. 5

2022

Abstract: Mitigating the effects of human-induced climate change requires the reduction of greenhouse gases. Policymakers must balance the need for mitigation with the need to sustain and develop the economy. To make informed decisions regarding mitigation ... ...

Abstract	Mitigating the effects of human-induced climate change requires the reduction of greenhouse gases. Policymakers must balance the need for mitigation with the need to sustain and develop the economy. To make informed decisions regarding mitigation strategies, policymakers rely on estimates of the social cost of carbon (SCC), which represents the marginal damage from increased emissions; the SCC must be greater than the marginal abatement cost for mitigation to be economically desirable. To determine the SCC, damage functions translate projections of carbon and temperature into economic losses. We examine the impact that four damage functions commonly employed in the literature have on the SCC. Rather than using an economic growth model, we convert the CO₂ pathways from the Representative Concentration Pathways (RCPs) into temperature projections using a three-layer, energy balance model and subsequently estimate damages under each RCP using the damage functions. We estimate marginal damages for 2020–2100, finding significant variability in SCC estimates between damage functions. Despite the uncertainty in choosing a specific damage function, comparing the SCC estimates to estimates of marginal abatement costs from the Shared Socioeconomic Pathways (SSPs) indicates that reducing emissions beyond RCP6.0 is economically beneficial under all scenarios. Reducing emissions beyond RCP4.5 is also likely to be economically desirable under certain damage functions and SSP scenarios. However, future work must resolve the uncertainty surrounding the form of damage function and the SSP estimates of marginal abatement costs to better estimate the economic impacts of climate change and the benefits of mitigating it.
Keywords	carbon ; carbon dioxide ; climate change ; econometric models ; energy balance ; environmental management ; greenhouses ; marginal abatement cost ; temperature ; uncertainty
Language	English
Dates of publication	2022-05
Size	p. 919-936.
Publishing place	Springer US
Document type	Article
ZDB-ID	1478932-2
ISSN	1432-1009 ; 0364-152X
ISSN (online)	1432-1009
ISSN	0364-152X
DOI	10.1007/s00267-022-01608-9
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Article ; Online: The Aryl Hydrocarbon Receptor in Energy Balance

Nathaniel G. Girer / Craig R. Tomlinson / Cornelis J. Elferink

International Journal of Molecular Sciences, Vol 22, Iss 49, p

The Road from Dioxin-Induced Wasting Syndrome to Combating Obesity with Ahr Ligands

2021 Volume 49

Abstract: The aryl hydrocarbon receptor (AHR) has been studied for over 40 years, yet our understanding of this ligand-activated transcription factor remains incomplete. Each year, novel findings continually force us to rethink the role of the AHR in mammalian ... ...

Abstract	The aryl hydrocarbon receptor (AHR) has been studied for over 40 years, yet our understanding of this ligand-activated transcription factor remains incomplete. Each year, novel findings continually force us to rethink the role of the AHR in mammalian biology. The AHR has historically been studied within the context of potent activation via AHR agonist 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD), with a focus on how the AHR mediates TCDD toxicity. Research has subsequently revealed that the AHR is actively involved in distinct physiological processes ranging from the development of the liver and reproductive organs, to immune system function and wound healing. More recently, the AHR was implicated in the regulation of energy metabolism and is currently being investigated as a potential therapeutic target for obesity. In this review, we re-trace the steps through which the early toxicological studies of TCDD led to the conceptual framework for the AHR as a potential therapeutic target in metabolic disease. We additionally discuss the key discoveries that have been made concerning the role of the AHR in energy metabolism, as well as the current and future directions of the field.
Keywords	aryl hydrocarbon receptor ; energy metabolism ; obesity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of exercise training on heart rate variability in individuals with lower extremity arterial disease and claudication: A systematic review.

Marçal, Isabela R / Abreu, Raphael M / Cornelis, Nils / Leicht, Anthony S / Forjaz, Claudia L M / Cucato, Gabriel / Brenner, Ingrid / Novakovic, Marko / Ritti-Dias, Raphael / Ciolac, Emmanuel G / Cornelissen, Véronique A

Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing

2023 Volume 41, Issue 4, Page(s) 226–234

Abstract: ... IC, assessing ≥ 4 wk of exercise interventions, and reporting at least one HRV measure (e.g., time or ...

Abstract	Purpose: To perform a systematic review of studies assessing the effects of regular exercise on heart rate variability (HRV) in individuals with lower extremity arterial disease (LEAD) and symptoms of claudication. Methods: A systematic search in the electronic databases MEDLINE, Embase, and Scielo, was conducted and updated on January 21, 2023. Randomized clinical trials investigating patients with LEAD and IC, assessing ≥ 4 wk of exercise interventions, and reporting at least one HRV measure (e.g., time or frequency domains) at baseline and follow-up were included. Two reviewers independently screened studies for inclusion, performed data extraction, and quality assessment of included studies. Results: Data from 7 trials were included (i.e., 5 walking, 1 resistance, and 1 isometric handgrip training), totaling 327 patients (66% males; range: 61 - 68 yr; ankle brachial index: 0.4 - 0.7). Following exercise training, three studies investigating walking training reported an increase in parasympathetic modulation indices and/or a decrease in sympathetic modulation indices (n = 2) as well as an increase in non-linear indices (n = 1). Conclusion: The current evidence is weak, and larger randomized controlled trials are needed to confirm the efficacy of exercise training in improving HRV. Additionally, the high divergence in the methodology of studies indicated the need for standard tools to improve the quality of HRV measurements in exercise trials. It is recommended to use standard procedures in future trials investigating HRV.
MeSH term(s)	Male ; Humans ; Female ; Heart Rate/physiology ; Exercise Therapy/methods ; Hand Strength ; Exercise/physiology ; Intermittent Claudication/therapy ; Lower Extremity
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1083367-5
ISSN	1532-6578 ; 1062-0303
ISSN (online)	1532-6578
ISSN	1062-0303
DOI	10.1016/j.jvn.2023.09.002
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Article ; Online: Damage Functions and the Social Cost of Carbon: Addressing Uncertainty in Estimating the Economic Consequences of Mitigating Climate Change.

Russell, Alyssa R / van Kooten, G Cornelis / Izett, Jonathan G / Eiswerth, Mark E

Environmental management

2022 Volume 69, Issue 5, Page(s) 919–936

Abstract	Mitigating the effects of human-induced climate change requires the reduction of greenhouse gases. Policymakers must balance the need for mitigation with the need to sustain and develop the economy. To make informed decisions regarding mitigation strategies, policymakers rely on estimates of the social cost of carbon (SCC), which represents the marginal damage from increased emissions; the SCC must be greater than the marginal abatement cost for mitigation to be economically desirable. To determine the SCC, damage functions translate projections of carbon and temperature into economic losses. We examine the impact that four damage functions commonly employed in the literature have on the SCC. Rather than using an economic growth model, we convert the CO
MeSH term(s)	Carbon ; Climate Change ; Greenhouse Gases ; Humans ; Models, Economic ; Uncertainty
Chemical Substances	Greenhouse Gases ; Carbon (7440-44-0)
Language	English
Publishing date	2022-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1478932-2
ISSN	1432-1009 ; 0364-152X
ISSN (online)	1432-1009
ISSN	0364-152X
DOI	10.1007/s00267-022-01608-9
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Article ; Online: Determinants of workload-related clinician stress levels in general hospital consultation liaison psychiatry services during the COVID-19 pandemic in England and Ireland. Short report.

van der Feltz-Cornelis, Christina M / Sweetman, Jennifer / Lee, William / Doherty, Anne M / Dineen, Peter / Meinlschmidt, Gunther / Vitinius, Frank / Fazekas, Christian / Huber, Christian G / Schaefert, Rainer / Stein, Barbara

Journal of psychosomatic research

2023 Volume 177, Page(s) 111584

Abstract: ... and workload-related stress levels as reported by CLP staff: r(22) = 0.41, p = 0.045, R: Conclusion ...

Abstract	Objective: To explore workload-related stress levels experienced by consultation liaison psychiatry (CLP) staff in England and Ireland, and factors relevant to such a burden, during the COVID-19 pandemic. Methods: Data were obtained for England and Ireland from a European survey among CLP services in general hospitals spread via CLP networks (11th June - 3rd October 2021). The heads of respective CLP services in general hospitals responded on behalf of each service, on 100 CLP hospital staff in total. Dependent variable: workload-related stress levels in CLP services due to COVID-19 (0-10 point scale). Independent variables: hospital size, CLP service size, degree of hospital involvement in COVID-19-related care, and the number of support options available to hospital staff. Spearman's rho correlation analyses were performed. Results: There was a significant association between the hospital's involvement in COVID-19-related care and workload-related stress levels as reported by CLP staff: r(22) = 0.41, p = 0.045, R Conclusion: Our findings suggest that perceived workload-related stress levels of CLP staff during the COVID-19 pandemic can be an indicator of COVID-19 involvement of the hospitals. Staff support seemed not to alleviate work stress in the context of the pandemic. Healthcare policies should improve working conditions for CLP hospital staff that play an essential role from a population health perspective. Rigorous measures may be needed to ensure mental healthcare provision remains tenable and sustainable in the long term.
MeSH term(s)	Humans ; Hospitals, General ; Mental Health Services ; Pandemics ; Ireland/epidemiology ; Workload ; COVID-19/epidemiology ; Psychiatry ; England ; Referral and Consultation
Language	English
Publishing date	2023-12-30
Publishing country	England
Document type	Journal Article
ZDB-ID	80166-5
ISSN	1879-1360 ; 0022-3999
ISSN (online)	1879-1360
ISSN	0022-3999
DOI	10.1016/j.jpsychores.2023.111584
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Article ; Online: Impact of colorectal cancer screening on survival after metachronous metastasis.

Hamers, Patricia A H / Vink, Geraldine R / Elferink, Marloes A G / Moons, Leon M G / Punt, Cornelis J A / May, Anne M / Koopman, Miriam

European journal of cancer (Oxford, England : 1990)

2023 Volume 196, Page(s) 113429

Abstract: Background: An increasing proportion of colorectal cancer (CRC) cases in Europe are detected by screening with faecal immunochemical testing (FIT). Previous studies showed that population screening with FIT leads to a decrease in CRC incidence and to ... ...

Abstract	Background: An increasing proportion of colorectal cancer (CRC) cases in Europe are detected by screening with faecal immunochemical testing (FIT). Previous studies showed that population screening with FIT leads to a decrease in CRC incidence and to detection at an earlier stage. However, approximately twenty percent of patients with CRC without metastases at initial diagnosis still develop metachronous metastases. We investigated the association between detection mode of the primary tumor and overall survival (OS) after metachronous metastasis in patients with CRC. Methods: Nationwide registry-based data was obtained of 794 patients who developed metachronous metastases after being diagnosed with stage I-III CRC between January and June 2015. With multivariable Cox PH regression modelling, we analyzed the (causal) association between detection mode of the primary tumor (FIT screen-detected versus non-screen-detected) and OS after metachronous metastasis while adjusting for potential confounders. Results: Median OS and five-year OS after metachronous metastasis were significantly higher for patients with screen-detected (n = 152) vs. non-screen-detected primary tumors (n = 642): 38.3 vs. 19.2 months, and 35.4% vs. 18.8%, respectively, p < 0.0001). After adjustment for potential confounders, the association between detection mode and OS after metachronous metastasis remained significant (HR 0.70 [95% CI 0.56-0.89]). Conclusions: Screen-detection of the primary tumor was independently associated with longer OS after metachronous metastasis. This may support the clinical utility of the population screening program and it shows the prognostic value of detection mode of the primary tumor once metachronous metastasis is diagnosed.
MeSH term(s)	Humans ; Early Detection of Cancer ; Colorectal Neoplasms/pathology ; Prognosis ; Europe ; Retrospective Studies
Language	English
Publishing date	2023-11-12
Publishing country	England
Document type	Journal Article
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2023.113429
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Article ; Online: Introducing a novice surgeon to an experienced robotic gynaecological oncology team: An observational cohort study on the impact of a structured curriculum on outcomes of cervical cancer surgery.

Baeten, Ilse G T / Hoogendam, Jacob P / Schreuder, Henk W R / Jürgenliemk-Schulz, Ina M / Gerestein, Cornelis G / Zweemer, Ronald P

Gynecologic oncology

2023 Volume 178, Page(s) 153–160

Abstract: Objective: To evaluate the effect on patient outcomes when introducing a novice robotic surgeon, trained in accordance with a structured learning curriculum, to an experienced robotic surgery team treating cervical cancer patients.: Methods: Patients ...

Abstract	Objective: To evaluate the effect on patient outcomes when introducing a novice robotic surgeon, trained in accordance with a structured learning curriculum, to an experienced robotic surgery team treating cervical cancer patients. Methods: Patients with early-stage cervical cancer who were treated with primary robot-assisted surgery between 2007 and 2019 were retrospectively included. In addition to the 165 patients included in a former analysis, we included a further 61 consecutively treated patients and divided all 226 patients over three groups: early learning phase of 61 procedures without structured training (group 1), experienced phase of 104 procedures (group 2), and the 61 procedures during introduction of a novice with structured training (group 3). Risk-adjusted cumulative sum (RA-CUSUM) analysis was performed to assess the learning curve effect. Patient outcomes between the groups were compared. Results: Based on RA-CUSUM analysis, no learning curve effect was observed for group 3. Regarding surgical outcomes, mean operation time in group 3 was significantly shorter than group 1 (p < 0.001) and similar to group 2 (p = 0.96). Proportions of intraoperative and postoperative adverse events in group 3 were not significantly different from the experienced group (group 2). Regarding oncological outcomes, the 5-year disease-free survival, disease-specific survival, and overall survival in group 3 were not significantly different from the experienced group. Conclusions: Introducing a novice robotic surgeon, who was trained in accordance with a structured learning curriculum, resulted in similar patient outcomes as by experienced surgeons suggesting novices can progress through a learning phase without compromising outcomes of cervical cancer patients.
MeSH term(s)	Female ; Humans ; Robotic Surgical Procedures/methods ; Retrospective Studies ; Uterine Cervical Neoplasms/surgery ; Uterine Cervical Neoplasms/etiology ; Cohort Studies ; Surgeons ; Learning Curve ; Curriculum ; Laparoscopy/methods
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2023.10.008
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