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Article ; Online: Invited Perspective: How Far Have We Come? Revisiting a 2009 Report on Occupational Cancer Research Recommendations.

Purdue, Mark P / Ward, Mary H

2023 Volume 131, Issue 10, Page(s) 101303

Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP13883
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Article ; Online: Associations of per- and polyfluoroalkyl substances and nonalcoholic fatty liver disease in the United States adult population, 2003-2018.

Momo, Harry D / Alvarez, Christian S / Purdue, Mark P / Graubard, Barry I / McGlynn, Katherine A

Environmental epidemiology (Philadelphia, Pa.)

2024 Volume 8, Issue 1, Page(s) e284

Abstract: Background: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide and a leading cause of liver-related mortality. Prior studies have linked per- and polyfluoroalkyl substances (PFAS) exposure to liver dysfunction and ... ...

Abstract	Background: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide and a leading cause of liver-related mortality. Prior studies have linked per- and polyfluoroalkyl substances (PFAS) exposure to liver dysfunction and alterations in metabolic pathways, but the extent of a PFAS-NAFLD relationship is unclear. Thus, the aim of the current study was to examine whether there were associations between PFAS exposures and NAFLD in the US adult population over a 16-year period. Methods: Data from 10,234 persons who participated in the National Health and Nutrition Examination Survey between 2003 and 2018 were analyzed. Odds ratios and 95% confidence intervals were calculated using multivariable logistic regression for the associations between PFAS and NAFLD, defined by the Hepatic Steatosis Index (NAFLD-HSI), the Fatty Liver Index (NAFLD-FLI), and by Transient Elastography with Controlled Attenuation Parameter (NAFLD-TE-CAP). Results: Overall, there was a significant inverse association between total PFAS and NAFLD-HSI ( Conclusions: The current study found no evidence of a positive association between the most common PFAS and NAFLD in the US population.
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ISSN	2474-7882
ISSN (online)	2474-7882
DOI	10.1097/EE9.0000000000000284
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Article ; Online: Blood lead levels and lung cancer mortality: An updated analysis of NHANES II and III.

Rhee, Jongeun / Graubard, Barry I / Purdue, Mark P

Cancer medicine

2021 Volume 10, Issue 12, Page(s) 4066–4074

Abstract: ... CI 0.7, 10.0 for ≥20.0 µg/dl vs. <10.0 µg/dl, P ...

Abstract	Previous analyses within the National Health and Nutrition Examination Survey (NHANES) II and III cycles suggested an association between blood lead levels (BLLs) and lung cancer mortality, although the evidence was limited by small case numbers. To clarify this relationship, we conducted updated analyses of 4,182 and 15,629 participants in NHANES II and III, respectively, (extending follow-up 20 and 8 years) aged ≥20 with BLL measurements and mortality follow-up through 2014. We fit multivariable Cox models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) relating BLLs and lung cancer with adjustment for smoking and other factors. We did not observe an overall association between BLLs and lung cancer after adjustment for smoking (both surveys) and serum cotinine and environmental tobacco smoke exposure (NHANES III), although suggestive associations were observed among women (NHANES II: HR 2.7, 95% CI 0.7, 10.0 for ≥20.0 µg/dl vs. <10.0 µg/dl, P
MeSH term(s)	Adult ; Confidence Intervals ; Cotinine/blood ; Ex-Smokers ; Female ; Humans ; Lead/blood ; Lung Neoplasms/blood ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Nutrition Surveys/statistics & numerical data ; Proportional Hazards Models ; Sex Factors ; Smokers ; Smoking/blood ; Tobacco Smoke Pollution/adverse effects
Chemical Substances	Tobacco Smoke Pollution ; Lead (2P299V784P) ; Cotinine (K5161X06LL)
Language	English
Publishing date	2021-05-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.3943
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Article ; Online: Coffee consumption and risk of renal cancer: a meta-analysis of cohort evidence.

Rhee, Jongeun / Lim, Rachel K / Purdue, Mark P

Cancer causes & control : CCC

2021 Volume 33, Issue 1, Page(s) 101–108

Abstract: Purpose: There is increasing evidence that coffee consumption is related to reduced risks for some cancers, but the evidence for renal cancer is inconclusive. Therefore, we conducted a meta-analysis to summarize the cohort evidence of this relationship.! ...

Abstract	Purpose: There is increasing evidence that coffee consumption is related to reduced risks for some cancers, but the evidence for renal cancer is inconclusive. Therefore, we conducted a meta-analysis to summarize the cohort evidence of this relationship. Methods: A literature search was performed in PubMed and Embase through February 2021. Meta-analyses using a random effects model were conducted for reported relative risk estimates (RRs) relating coffee intake and renal cancer incidence or mortality. We also performed a two-stage random effects exposure-response meta-analysis. Between-study heterogeneity was assessed. Results: In a meta-analysis of the ten identified cohort studies, we found a summary RR of 0.88 [95% confidence interval (CI) 0.78-0.99] relating the highest vs. the lowest category of coffee intake and renal cancer, with no significant between-study heterogeneity observed (I Conclusions: Our findings from this meta-analysis of the published cohort evidence are suggestive of an inverse association between coffee consumption and renal cancer risk.
MeSH term(s)	Coffee/adverse effects ; Cohort Studies ; Humans ; Incidence ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/etiology ; Risk Factors
Chemical Substances	Coffee
Language	English
Publishing date	2021-10-22
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-021-01506-1
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Article ; Online: Nested Case-Control Studies Investigating Serum Perfluorooctanoate and Perfluorooctane Sulfonate Levels and Pancreatic Ductal Adenocarcinoma in Two Cohorts.

Zhang, Ting / Fu, Sheng / Yu, Kai / Albanes, Demetrius / Moore, Steven C / Purdue, Mark P / Stolzenberg-Solomon, Rachael Z

Environmental health perspectives

2023 Volume 131, Issue 10, Page(s) 107702

MeSH term(s)	Humans ; Fluorocarbons ; Caprylates ; Case-Control Studies ; Adenocarcinoma ; Alkanesulfonic Acids ; Pancreatic Neoplasms/epidemiology
Chemical Substances	perfluorooctane (6P60ZBK0QL) ; perfluorooctanoic acid (947VD76D3L) ; Fluorocarbons ; Caprylates ; Alkanesulfonic Acids
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP13208
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Article ; Online: Trichloroethylene and cancer.

Purdue, Mark P

Journal of the National Cancer Institute

2013 Volume 105, Issue 12, Page(s) 844–846

MeSH term(s)	Female ; Humans ; Male ; Neoplasms/chemically induced ; Neoplasms/epidemiology ; Occupational Diseases/chemically induced ; Occupational Diseases/epidemiology ; Solvents/poisoning ; Trichloroethylene/poisoning
Chemical Substances	Solvents ; Trichloroethylene (290YE8AR51)
Language	English
Publishing date	2013-05-30
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Intramural ; Comment
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djt131
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Article ; Online: Improve the model of disease subtype heterogeneity by leveraging external summary data.

Fu, Sheng / Purdue, Mark P / Zhang, Han / Qin, Jing / Song, Lei / Berndt, Sonja I / Yu, Kai

PLoS computational biology

2023 Volume 19, Issue 7, Page(s) e1011236

Abstract: Researchers are often interested in understanding the disease subtype heterogeneity by testing whether a risk exposure has the same level of effect on different disease subtypes. The polytomous logistic regression (PLR) model provides a flexible tool for ...

Abstract	Researchers are often interested in understanding the disease subtype heterogeneity by testing whether a risk exposure has the same level of effect on different disease subtypes. The polytomous logistic regression (PLR) model provides a flexible tool for such an evaluation. Disease subtype heterogeneity can also be investigated with a case-only study that uses a case-case comparison procedure to directly assess the difference between risk effects on two disease subtypes. Motivated by a large consortium project on the genetic basis of non-Hodgkin lymphoma (NHL) subtypes, we develop PolyGIM, a procedure to fit the PLR model by integrating individual-level data with summary data extracted from multiple studies under different designs. The summary data consist of coefficient estimates from working logistic regression models established by external studies. Examples of the working model include the case-case comparison model and the case-control comparison model, which compares the control group with a subtype group or a broad disease group formed by merging several subtypes. PolyGIM efficiently evaluates risk effects and provides a powerful test for disease subtype heterogeneity in situations when only summary data, instead of individual-level data, is available from external studies due to various informatics and privacy constraints. We investigate the theoretic properties of PolyGIM and use simulation studies to demonstrate its advantages. Using data from eight genome-wide association studies within the NHL consortium, we apply it to study the effect of the polygenic risk score defined by a lymphoid malignancy on the risks of four NHL subtypes. These results show that PolyGIM can be a valuable tool for pooling data from multiple sources for a more coherent evaluation of disease subtype heterogeneity.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Computer Simulation ; Logistic Models ; Lymphoma, Non-Hodgkin/genetics ; Multifactorial Inheritance
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1011236
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Article ; Online: Clearing the Air: Summarizing the Smoking-related Relative Risks of Bladder and Kidney Cancer.

Purdue, Mark P / Silverman, Debra T

European urology

2016 Volume 70, Issue 3, Page(s) 467–468

Abstract: This Platinum Priority editorial discusses the strengths and limitations of a recent meta-analysis summarizing the published smoking-related relative risks for bladder cancer and kidney cancer. ...

Abstract	This Platinum Priority editorial discusses the strengths and limitations of a recent meta-analysis summarizing the published smoking-related relative risks for bladder cancer and kidney cancer.
MeSH term(s)	Carcinogenesis ; Humans ; Incidence ; Kidney Neoplasms ; Risk ; Smoke ; Smoking ; Nicotiana ; Urinary Bladder Neoplasms
Chemical Substances	Smoke
Language	English
Publishing date	2016-04-27
Publishing country	Switzerland
Document type	Editorial ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2016.04.009
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article ; Online: Body mass index and risk of progression from monoclonal gammopathy of undetermined significance to multiple myeloma: Results from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.

Chang, Vicky C / Khan, Ali A / Huang, Wen-Yi / Katki, Hormuzd A / Purdue, Mark P / Landgren, Ola / Hofmann, Jonathan N

Blood cancer journal

2022 Volume 12, Issue 4, Page(s) 51

MeSH term(s)	Body Mass Index ; Clinical Trials as Topic ; Colorectal Neoplasms ; Early Detection of Cancer ; Female ; Humans ; Lung ; Male ; Monoclonal Gammopathy of Undetermined Significance/diagnosis ; Monoclonal Gammopathy of Undetermined Significance/epidemiology ; Multiple Myeloma/diagnosis ; Multiple Myeloma/epidemiology ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/epidemiology ; Prostate
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Letter
ZDB-ID	2600560-8
ISSN	2044-5385 ; 2044-5385
ISSN (online)	2044-5385
ISSN	2044-5385
DOI	10.1038/s41408-022-00642-4
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Article ; Online: Inflammatory markers in women with reported benign gynecologic pathology: an analysis of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.

King, Lauren A / Wentzensen, Nicolas / Purdue, Mark P / Katki, Hormuzd A / Pinto, Ligia A / Trabert, Britton

Annals of epidemiology

2021 Volume 68, Page(s) 1–8

Abstract: ... ovarian cysts were associated with increased PAI-1 (OR [95% CI] 6.24 [2.53-15.39], P <.001) and TGF-β1 (3.79 [1 ... 62-8.86], P =.002) and decreased BCA-1 (0.38 [0.19-0.73], P =.004). Uterine fibroids were associated ... with decreased CXCL11 (0.37 [0.22-0.63], P <.001) and VEGFR3 (0.40 [0.24-0.65], P <.001). Endometriosis was ...

Abstract	Background: Associations between benign gynecologic pathologies and circulating inflammatory markers are unknown. Our goal was to evaluate self-reported history of benign gynecologic pathology and subsequent alterations in systemic inflammation. Methods: Using nested case-control studies from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, study-specific associations between self-reported history of benign ovarian cysts, uterine fibroids, and endometriosis with inflammatory marker concentrations were evaluated using logistic regression and combined using meta-analysis. Inflammatory markers associated with individual benign pathologies were mutually adjusted for one another to evaluate independent associations. Results: Compared to women without a self-reported history of the pathology evaluated, benign ovarian cysts were associated with increased PAI-1 (OR [95% CI] 6.24 [2.53-15.39], P <.001) and TGF-β1 (3.79 [1.62-8.86], P =.002) and decreased BCA-1 (0.38 [0.19-0.73], P =.004). Uterine fibroids were associated with decreased CXCL11 (0.37 [0.22-0.63], P <.001) and VEGFR3 (0.40 [0.24-0.65], P <.001). Endometriosis was associated with increased SIL-4R (4.75 [1.84-12.26], P =.001). Conclusions: Self-reported history of benign gynecologic pathologies were associated with alterations in inflammatory markers that have been previously linked to cancer risk. Understanding interactions between benign gynecologic pathologies and the systemic immune system may help inform disease risk later in life.
MeSH term(s)	Clinical Trials as Topic ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Early Detection of Cancer ; Female ; Humans ; Logistic Models ; Lung ; Male ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/epidemiology ; Prostate
Language	English
Publishing date	2021-12-11
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Intramural
ZDB-ID	1074355-8
ISSN	1873-2585 ; 1047-2797
ISSN (online)	1873-2585
ISSN	1047-2797
DOI	10.1016/j.annepidem.2021.12.003
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