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  1. Article ; Online: ESR Essentials: Imaging in colorectal cancer-practice recommendations by ESGAR.

    Caruso, Damiano / Polici, Michela / Bellini, Davide / Laghi, Andrea

    European radiology

    2024  

    Abstract: Colorectal cancer (CRC) is a significant global health concern. Diagnostic imaging, using different modalities, has a pivotal role in CRC, from early detection (i.e., screening) to follow-up. The role of imaging in CRC screening depends on each country's ...

    Abstract Colorectal cancer (CRC) is a significant global health concern. Diagnostic imaging, using different modalities, has a pivotal role in CRC, from early detection (i.e., screening) to follow-up. The role of imaging in CRC screening depends on each country's approach: if an organized screening program is in place, the role of CT colonography (CTC) is limited to the study of either individuals with a positive stool test unwilling/unable to undergo colonoscopy (CC) or in patients with incomplete CC. Although CC is the most common modality to diagnose CRC, CRC can be also incidentally detected during a routine abdominal imaging examination or at the emergency room in patients presenting with intestinal occlusion/subocclusion or perforation. Staging is a crucial aspect of CRC management, guiding treatment decisions and providing valuable prognostic information. An accurate local staging is mandatory in both rectal and colon cancer to drive the appropriate therapeutic workflow. Important limitations of US, CT, and MR in N-staging can be partially solved by FDG PET/CT. Distant staging is usually managed by CT, with MR and FDG PET/CT which can be used as problem-solving techniques. Follow-up is performed according to the general recommendations of the oncological societies. CLINICAL RELEVANCE STATEMENT: It is essential to summarize each phase of colorectal cancer workup, differentiating the management for colon and rectal cancer supported by the main international guidelines and literature data, with the aim to inform the community on the best practice imaging in colorectal cancer. KEY POINTS: • Colorectal cancer is a prevalent disease that lends itself to imaging at each stage of detection and management. • Various imaging modalities can be used as adjuncts to, or in place of, direct visualization methods of screening and are necessary for evaluating metastatic disease. • Reevaluation of follow-up strategies should be considered depending on patients' individual risk of recurrence.
    Language English
    Publishing date 2024-02-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-024-10645-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial for Special Issue on Imaging Biomarker in Oncology.

    Polici, Michela / Laghi, Andrea / Caruso, Damiano

    Cancers

    2023  Volume 15, Issue 4

    Abstract: Imaging biomarkers are the expression of quantitative imaging and have become central in the management of cancers, proving consistent and objective information to outline an appropriate workflow for oncologic patients [ ... ]. ...

    Abstract Imaging biomarkers are the expression of quantitative imaging and have become central in the management of cancers, proving consistent and objective information to outline an appropriate workflow for oncologic patients [...].
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial for "Pre-Treatment T2-WI Based Radiomics Features for Prediction of Locally Advanced Rectal Cancer Non-Response to Neoadjuvant Chemoradiotherapy: A Preliminary Study".

    Zerunian, Marta / Laghi, Andrea / Caruso, Damiano

    Cancers

    2023  Volume 15, Issue 3

    Abstract: Colorectal cancer still represents the third most frequent cancer in the world; around one-third of cancers are located in the rectum, with important differences in terms of diagnosis, treatment management, and survival compared to colon cancer [ ... ]. ...

    Abstract Colorectal cancer still represents the third most frequent cancer in the world; around one-third of cancers are located in the rectum, with important differences in terms of diagnosis, treatment management, and survival compared to colon cancer [...].
    Language English
    Publishing date 2023-01-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Comment on Gassenmaier et al. Accelerated T2-Weighted TSE Imaging of the Prostate Using Deep Learning Image Reconstruction: A Prospective Comparison with Standard T2-Weighted TSE Imaging.

    Pucciarelli, Francesco / Laghi, Andrea / Caruso, Damiano

    Cancers

    2023  Volume 15, Issue 2

    Abstract: Magnetic resonance imaging (MRI) plays a central role in oncology without using ionizing radiation or radioactive markers [ ... ]. ...

    Abstract Magnetic resonance imaging (MRI) plays a central role in oncology without using ionizing radiation or radioactive markers [...].
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15020370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Radiomics in Oncology III

    Marta Zerunian / Andrea Laghi / Damiano Caruso

    Diagnostics, Vol 13, Iss 1, p

    2023  Volume 149

    Abstract: In recent years, radiomics has been among the most impactful topics in the research field of quantitative imaging [.] ...

    Abstract In recent years, radiomics has been among the most impactful topics in the research field of quantitative imaging [.]
    Keywords n/a ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Senotherapeutics to Counteract Senescent Cells Are Prominent Topics in the Context of Anti-Ageing Strategies.

    Calabrò, Anna / Accardi, Giulia / Aiello, Anna / Caruso, Calogero / Galimberti, Damiano / Candore, Giuseppina

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Cellular senescence is implicated in ageing and associated with a broad spectrum of age-related diseases. Importantly, a cell can initiate the senescence program irrespective of the organism's age. Various stress signals, including those defined as ... ...

    Abstract Cellular senescence is implicated in ageing and associated with a broad spectrum of age-related diseases. Importantly, a cell can initiate the senescence program irrespective of the organism's age. Various stress signals, including those defined as ageing hallmarks and alterations leading to cancer development, oncogene activation, or loss of cancer-suppressive functions, can trigger cellular senescence. The primary outcome of these alterations is the activation of nuclear factor (NF)-κB, thereby inducing the senescence-associated secretory phenotype (SASP). Proinflammatory cytokines and chemokines, components of this phenotype, contribute to chronic systemic sterile inflammation, commonly referred to as inflamm-ageing. This inflammation is linked to age-related diseases (ARDs), frailty, and increased mortality in older individuals. Additionally, senescent cells (SCs) accumulate in multiple tissues with age and are believed to underlie the organism functional decline, as demonstrated by models. An escalating effort has been dedicated to identify senotherapeutics that selectively target SCs by inducing apoptosis; these drugs are termed senolytics. Concurrently, small molecules that suppress senescent phenotypes without causing cell death are known as senomorphics. Both natural and synthetic senotherapeutics, along with immunotherapies employing immune cell-mediated clearance of SCs, currently represent the most promising strategies to combat ageing and ARDs. Indeed, it is fascinating to observe that information regarding the immune reaction to SCs indicates that regulation by specific lymphocyte subsets, elevated in the oldest centenarians, plays a role in attaining extreme longevity. Regardless, the application of methods already utilized in cancer treatment, such as CAR cells and monoclonal antibodies, broadens the spectrum of potential approaches to be utilized.
    MeSH term(s) Humans ; Aged, 80 and over ; Aged ; Senotherapeutics ; Aging/metabolism ; Cellular Senescence ; Inflammation/metabolism ; Respiratory Distress Syndrome
    Chemical Substances Senotherapeutics
    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Liver Magnetic Resonance Elastography: Focus on Methodology, Technique, and Feasibility.

    Zerunian, Marta / Masci, Benedetta / Caruso, Damiano / Pucciarelli, Francesco / Polici, Michela / Nardacci, Stefano / De Santis, Domenico / Iannicelli, Elsa / Laghi, Andrea

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Magnetic resonance elastography (MRE) is an imaging technique that combines low-frequency mechanical vibrations with magnetic resonance imaging to create visual maps and quantify liver parenchyma stiffness. As in recent years, diffuse liver diseases have ...

    Abstract Magnetic resonance elastography (MRE) is an imaging technique that combines low-frequency mechanical vibrations with magnetic resonance imaging to create visual maps and quantify liver parenchyma stiffness. As in recent years, diffuse liver diseases have become highly prevalent worldwide and could lead to a chronic condition with different stages of fibrosis. There is a strong necessity for a non-invasive, highly accurate, and standardised quantitative assessment to evaluate and manage patients with different stages of fibrosis from diagnosis to follow-up, as the actual reference standard for the diagnosis and staging of liver fibrosis is biopsy, an invasive method with possible peri-procedural complications and sampling errors. MRE could quantitatively evaluate liver stiffness, as it is a rapid and repeatable method with high specificity and sensitivity. MRE is based on the propagation of mechanical shear waves through the liver tissue that are directly proportional to the organ's stiffness, expressed in kilopascals (kPa). To obtain a valid assessment of the real hepatic stiffness values, it is mandatory to obtain a high-quality examination. To understand the pearls and pitfalls of MRE, in this review, we describe our experience after one year of performing MRE from indications and patient preparation to acquisition, quality control, and image analysis.
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14040379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation.

    Arrivi, Giulia / Specchia, Monia / Pilozzi, Emanuela / Rinzivillo, Maria / Caruso, Damiano / Santangeli, Curzio / Prosperi, Daniela / Ascolese, Anna Maria / Panzuto, Francesco / Mazzuca, Federica

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: Background: The ocular involvement of neuroendocrine neoplasms (NENs) is uncommon and mainly represented by metastases from gastrointestinal and lung neuroendocrine tumors. Primary orbital NENs are even less common and their diagnostic and therapeutic ... ...

    Abstract Background: The ocular involvement of neuroendocrine neoplasms (NENs) is uncommon and mainly represented by metastases from gastrointestinal and lung neuroendocrine tumors. Primary orbital NENs are even less common and their diagnostic and therapeutic management is a challenge.
    Methods: A systematic review of the literature was conducted from 1966 to September 2023 on PubMed to identify articles on orbital NENs and to summarize their clinical-pathological features, diagnosis and therapeutic management. Furthermore, we presented a case of a locally advanced retro-orbital primary neuroendocrine tumor that was referred to the certified Center of Excellence of Sant'Andrea Hospital, La Sapienza University of Rome, Italy.
    Results: The final analysis included 63 records on orbital NENs and 11 records focused on primary orbital NENs. The localization was mostly unilateral and in the right orbit; proptosis or exophthalmos represented the initial symptoms. The diagnostic work-up and therapeutic management was discussed and a diagnostic algorithm for the suspicion of primary orbital NENs was proposed.
    Conclusions: A multidisciplinary approach is required for the management of primary orbital NENs, emphasizing the importance of early referral to dedicated centers for prompt differential diagnosis, tailored treatment, and an improved quality of life and survival.
    Language English
    Publishing date 2024-02-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Management decisions of an Academic Radiology Department during COVID-19 pandemic: the important support of a business analytics software.

    Laghi, Andrea / Tamburi, Virginia / Polici, Michela / Anibaldi, Paolo / Marcolongo, Adriano / Caruso, Damiano

    European radiology

    2022  Volume 32, Issue 10, Page(s) 7048–7055

    Abstract: Objectives: To analyze the response in the management of both radiological emergencies and continuity of care in oncologic/fragile patients of a radiology department of Sant'Andrea Academic Hospital in Rome supported by a dedicated business analytics ... ...

    Abstract Objectives: To analyze the response in the management of both radiological emergencies and continuity of care in oncologic/fragile patients of a radiology department of Sant'Andrea Academic Hospital in Rome supported by a dedicated business analytics software during the COVID-19 pandemic.
    Methods: Imaging volumes and workflows for 2019 and 2020 were analyzed. Information was collected from the hospital data warehouse and evaluated using a business analytics software, aggregated both per week and per quarter, stratified by patient service location (emergency department, inpatients, outpatients) and imaging modality. For emergency radiology subunit, radiologist workload, machine workload, and turnaround times (TATs) were also analyzed.
    Results: Total imaging volume in 2020 decreased by 21.5% compared to that in 2019 (p < .001); CT in outpatients increased by 11.7% (p < .005). Median global TAT and median code-blue global TAT were not statistically significantly different between 2019 and 2020 and between the first and the second pandemic waves in 2020 (all p > .09). Radiologist workload decreased by 24.7% (p < .001) during the first pandemic wave in 2020 compared with the same weeks of 2019 and showed no statistically significant difference during the second pandemic wave, compared with the same weeks of 2019 (p = 0.19).
    Conclusions: Despite the reduction of total imaging volume due to the COVID-19 pandemic in 2020 compared to 2019, management decisions supported by a dedicated business analytics software allowed to increase the number of CT in fragile/oncologic outpatients without significantly affecting emergency radiology TATs, and emergency radiologist workload.
    Key points: • During the COVID-19 pandemic, management decisions supported by business analytics software guaranteed efficiency of emergency and preservation of fragile/oncologic patient continuity of care. • Real-time data monitoring using business analytics software is essential for appropriate management decisions in a department of radiology. • Business analytics should be gradually introduced in all healthcare institutions to identify strong and weak points in workflow taking correct decisions.
    MeSH term(s) COVID-19 ; Emergency Service, Hospital ; Humans ; Pandemics ; Radiology ; Radiology Department, Hospital ; Software
    Language English
    Publishing date 2022-04-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-022-08709-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: How new technologies could impact on radiology diagnosis and assessment of pancreatic lesions: Future perspectives.

    Laghi, Andrea / Zerunian, Marta / Caruso, Damiano

    Endoscopic ultrasound

    2018  Volume 7, Issue 5, Page(s) 310–313

    Language English
    Publishing date 2018-10-02
    Publishing country China
    Document type Journal Article
    ZDB-ID 2998317-4
    ISSN 2226-7190 ; 2303-9027
    ISSN (online) 2226-7190
    ISSN 2303-9027
    DOI 10.4103/eus.eus_47_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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