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  1. Book ; Thesis: CD95 signaling

    Sancho-Martinez, Ignacio

    novel non-apoptotic pathways

    2009  

    Author's details presented by Ignacio Sancho-Martinez
    Subject code 616.994
    Language English
    Size [5], 146 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2009
    HBZ-ID HT016307571
    Database Catalogue ZB MED Medicine, Health

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    2010 E 1685 order for loan Magazin

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  2. Article ; Online: Reprogramming strategies for the establishment of novel human cancer models.

    Sancho-Martinez, Ignacio / Izpisua Belmonte, Juan Carlos

    Cell cycle (Georgetown, Tex.)

    2016  Volume 15, Issue 18, Page(s) 2393–2397

    Abstract: Cancer comprises heterogeneous cells, ranging from highly proliferative immature precursors to more differentiated cell lineages. The emergence of the "cancer stem cell" (CSC) hypothesis that they are the cells responsible for resistance, metastasis and ... ...

    Abstract Cancer comprises heterogeneous cells, ranging from highly proliferative immature precursors to more differentiated cell lineages. The emergence of the "cancer stem cell" (CSC) hypothesis that they are the cells responsible for resistance, metastasis and secondary tumor appearance identifies these populations as novel obligatory targets for the treatment of cancer. CSCs, like their normal tissue-specific stem cell counterparts, are multipotent, partially differentiated, self-sustaining, yet transformed cells. To date, most studies on CSC biology have relied on the use of murine models and primary human material. In spite of much progress, the use of primary material presents several limitations that limit our understanding of the mechanisms underlying CSC formation, the similarities between normal stem cells and CSCs and ultimately, the possibility for developing targeted therapies. Recently, different strategies for controlling cell fate have been applied to the modeling of human cancer initiation and for the generation of human CSC models. Here we will summarize recent developments in the establishment and application of reprogramming strategies for the modeling of human cancer initiation and CSC formation.
    MeSH term(s) Animals ; Carcinogenesis/pathology ; Cellular Reprogramming ; Humans ; Models, Biological ; Mutation/genetics ; Neoplasms/pathology ; Neoplastic Stem Cells/pathology
    Language English
    Publishing date 2016-06-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2016.1196305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5881: Show issues Location:
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  3. Article ; Online: APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation.

    Arnaud, Laurie / Benech, Philippe / Greetham, Louise / Stephan, Delphine / Jimenez, Angélique / Jullien, Nicolas / García-González, Laura / Tsvetkov, Philipp O / Devred, François / Sancho-Martinez, Ignacio / Izpisua Belmonte, Juan Carlos / Baranger, Kévin / Rivera, Santiago / Nivet, Emmanuel

    Cell reports

    2022  Volume 40, Issue 7, Page(s) 111200

    Abstract: Apolipoprotein E4 (APOEε4) is the major allelic risk factor for late-onset sporadic Alzheimer's disease (sAD). Inflammation is increasingly considered as critical in sAD initiation and progression. Identifying brain molecular mechanisms that could bridge ...

    Abstract Apolipoprotein E4 (APOEε4) is the major allelic risk factor for late-onset sporadic Alzheimer's disease (sAD). Inflammation is increasingly considered as critical in sAD initiation and progression. Identifying brain molecular mechanisms that could bridge these two risk factors remain unelucidated. Leveraging induced pluripotent stem cell (iPSC)-based strategies, we demonstrate that APOE controls inflammation in human astrocytes by regulating Transgelin 3 (TAGLN3) expression and, ultimately, nuclear factor κB (NF-κB) activation. We uncover that APOE4 specifically downregulates TAGLN3, involving histone deacetylases activity, which results in low-grade chronic inflammation and hyperactivated inflammatory responses. We show that APOE4 exerts a dominant negative effect to prime astrocytes toward a pro-inflammatory state that is pharmacologically reversible by TAGLN3 supplementation. We further confirm that TAGLN3 is downregulated in the brain of patients with sAD. Our findings highlight the APOE-TAGLN3-NF-κB axis regulating neuroinflammation in human astrocytes and reveal TAGLN3 as a molecular target to modulate neuroinflammation, as well as a potential biomarker for AD.
    MeSH term(s) Alzheimer Disease/metabolism ; Apolipoprotein E3/metabolism ; Apolipoprotein E4/metabolism ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; Astrocytes/metabolism ; Humans ; Inflammation/metabolism ; NF-kappa B/metabolism ; Nerve Tissue Proteins/metabolism
    Chemical Substances ApoE protein, human ; Apolipoprotein E3 ; Apolipoprotein E4 ; Apolipoproteins E ; NF-kappa B ; Nerve Tissue Proteins ; TAGLN3 protein, human
    Language English
    Publishing date 2022-07-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.111200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Alginate Improves the Chondrogenic Capacity of 3D PCL Scaffolds In Vitro: A Histological Approach.

    Milián, Lara / Oliver-Ferrándiz, María / Peregrín, Ignacio / Sancho-Tello, María / Martín-de-Llano, José Javier / Martínez-Ramos, Cristina / Carda, Carmen / Mata, Manuel

    Current issues in molecular biology

    2024  Volume 46, Issue 4, Page(s) 3563–3578

    Abstract: Polycaprolactone (PCL) scaffolds have demonstrated an effectiveness in articular cartilage regeneration due to their biomechanical properties. On the other hand, alginate hydrogels generate a 3D environment with great chondrogenic potential. Our aim is ... ...

    Abstract Polycaprolactone (PCL) scaffolds have demonstrated an effectiveness in articular cartilage regeneration due to their biomechanical properties. On the other hand, alginate hydrogels generate a 3D environment with great chondrogenic potential. Our aim is to generate a mixed PCL/alginate scaffold that combines the chondrogenic properties of the two biomaterials. Porous PCL scaffolds were manufactured using a modified salt-leaching method and embedded in a culture medium or alginate in the presence or absence of chondrocytes. The chondrogenic capacity was studied in vitro. Type II collagen and aggrecan were measured by immunofluorescence, cell morphology by F-actin fluorescence staining and gene expression of
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb46040223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5122: Show issues Location:
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  5. Article ; Online: Understanding the molecular mechanisms of reprogramming.

    Krause, Marie N / Sancho-Martinez, Ignacio / Izpisua Belmonte, Juan Carlos

    Biochemical and biophysical research communications

    2016  Volume 473, Issue 3, Page(s) 693–697

    Abstract: Despite the profound and rapid advancements in reprogramming technologies since the generation of the first induced pluripotent stem cells (iPSCs) in 2006[1], the molecular basics of the process and its implications are still not fully understood. Recent ...

    Abstract Despite the profound and rapid advancements in reprogramming technologies since the generation of the first induced pluripotent stem cells (iPSCs) in 2006[1], the molecular basics of the process and its implications are still not fully understood. Recent work has suggested that a subset of TFs, so called "Pioneer TFs", play an important role during the stochastic phase of iPSC reprogramming [2-6]. Pioneer TFs activities differ from conventional transcription factors in their mechanism of action. They bind directly to condensed chromatin and elicit a series of chromatin remodeling events that lead to opening of the chromatin. Chromatin decondensation by pioneer factors progressively occurs during cell division and in turn exposes specific gene promoters in the DNA to which TFs can now directly bind to promoters that are readily accessible[2, 6]. Here, we will summarize recent advancements on our understanding of the molecular mechanisms underlying reprogramming to iPSC as well as the implications that pioneer Transcription Factor activities might play during different lineage conversion processes.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Lineage ; Cellular Reprogramming ; Chromatin/chemistry ; Embryonic Stem Cells/cytology ; Epigenesis, Genetic ; Gene Expression Regulation ; Humans ; Induced Pluripotent Stem Cells/cytology ; Regenerative Medicine/methods ; Transcription Factors/metabolism
    Chemical Substances Chromatin ; Transcription Factors
    Language English
    Publishing date 2016--06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2015.11.120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 116: Show issues Location:
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  6. Article ; Online: Stem cells: Surf the waves of reprogramming.

    Sancho-Martinez, Ignacio / Izpisua Belmonte, Juan Carlos

    Nature

    2013  Volume 493, Issue 7432, Page(s) 310–311

    MeSH term(s) Cellular Reprogramming ; Humans ; Single-Cell Analysis ; Stem Cells/cytology ; Stem Cells/metabolism
    Language English
    Publishing date 2013-01-16
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/493310b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  7. Article ; Online: RE: stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy.

    Krause, Marie N / Sancho-Martinez, Ignacio / Izpisua Belmonte, Juan Carlos

    Journal of the National Cancer Institute

    2015  Volume 107, Issue 1, Page(s) 368

    MeSH term(s) Animals ; Brain Neoplasms/therapy ; Female ; Glioblastoma/therapy ; Humans ; Mesenchymal Stromal Cells/virology ; Oncolytic Virotherapy/methods ; Simplexvirus
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Comment ; Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/dju368
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  8. Article ; Online: Will SCNT-ESCs be better than iPSCs for personalized regenerative medicine?

    Sancho-Martinez, Ignacio / Izpisua Belmonte, Juan Carlos

    Cell stem cell

    2013  Volume 13, Issue 2, Page(s) 141–142

    MeSH term(s) Cell Differentiation ; Cellular Reprogramming ; Embryonic Stem Cells/cytology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Nuclear Transfer Techniques ; Precision Medicine ; Regenerative Medicine ; Stem Cell Transplantation/adverse effects
    Language English
    Publishing date 2013-08-01
    Publishing country United States
    Document type Letter
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2013.07.013
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    Zs.A 6589: Show issues Location:
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  9. Article ; Online: Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation.

    Sancho-Martinez, Ignacio / Ocampo, Alejandro / Izpisua Belmonte, Juan Carlos

    Current opinion in genetics & development

    2014  Volume 28, Page(s) 57–63

    Abstract: The generation of human induced pluripotent stem cells (iPS) has raised enormous expectations within the biomedical community due to their potential vast implications in regenerative and personalized medicine. However, reprogramming to iPS is still not ... ...

    Abstract The generation of human induced pluripotent stem cells (iPS) has raised enormous expectations within the biomedical community due to their potential vast implications in regenerative and personalized medicine. However, reprogramming to iPS is still not fully comprehended. Difficulties found in ascribing specific molecular patterns to pluripotent cells (PSCs), and inherent inter-line and intra-line variability between different PSCs need to be resolved. Additionally, and despite multiple assumptions, it remains unclear whether the current in vitro culturing conditions for the maintenance and differentiation of PSCs do indeed recapitulate the developmental processes observed in vivo. As a consequence, basic questions such as what is the actual nature of PSCs remain unanswered and different theories have emerged in regards to the identity of these valuable cell population. Here we discuss on the published theories for defining PSC identity, the implications that the different postulated models have for the reprogramming field as well as speculate on potential future directions that might be opened once a precise knowledge on the nature of PSCs is accomplished.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Lineage ; Cellular Reprogramming ; Humans ; Pluripotent Stem Cells/cytology
    Language English
    Publishing date 2014-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2014.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Heart regeneration: a tale of cell reprogramming.

    Aguirre, Aitor / Sancho-Martinez, Ignacio / Izpisua Belmonte, Juan Carlos

    Circulation research

    2013  Volume 113, Issue 10, Page(s) 1109–1111

    MeSH term(s) Animals ; Cell Transdifferentiation ; Cellular Reprogramming ; Heart/physiology ; Myocardium/cytology ; Regeneration/physiology ; Zebrafish/physiology
    Language English
    Publishing date 2013-10-25
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.113.302519
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