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  1. Article ; Online: An appreciative inquiry and inventory of Indigenous food sovereignty initiatives within the western U.S.

    Ashley Babcock / Rachael Budowle

    Journal of Agriculture, Food Systems, and Community Development, Vol 11, Iss

    2022  Volume 2

    Abstract: Indigenous food sovereignty is informed by—and is a framework and movement that supports—all the various means through which Indigenous peo­ple are revitalizing and reclaiming their traditional foodways. These efforts incorporate established values, pro­ ... ...

    Abstract Indigenous food sovereignty is informed by—and is a framework and movement that supports—all the various means through which Indigenous peo­ple are revitalizing and reclaiming their traditional foodways. These efforts incorporate established values, pro­cesses, and outcomes, including rela­tionality, self-determination, decolonization, and wellbeing. Through appreciative inquiry, this re­search inven­tories Indigenous food sovereignty initiatives in the western United States and identi­fies their common themes and key features. A systematic search of scholarly and popular sources yielded a database of 123 initiatives that vary by type, land base, and geo­graphic location. Three themes emerged across ini­tiatives. First, concrete strategies include growing and food production, harvesting and food acquisi­tion, food preparation, and distribution and ex­change. Second, cultural revitalization occurs through community develop­ment, youth and young adult education, other forms of education, and regenerating cultural iden­tity through tradi­tions. Finally, initiative founda­tions include advo­cacy, policy, and environmental stewardship; fund­ing mechanisms; and partner­ships with non-Indigenous actors. Across themes, individual initia­tives include numerous intercon­nected food sover­eignty efforts and demonstrate the adaptive capaci­ties of Indigenous people. This research compiles and aims to respectfully celebrate the myriad ways Indigenous people in the western U.S. are revitaliz­ing their foodways as part of a larger movement toward Indigenous food sovereignty.
    Keywords Indigenous Food Sovereignty ; Appreciative Inquiry ; Systematic Search ; Inventory ; Interconnection ; Adaptability ; Agriculture ; S ; Technology ; T ; Home economics ; TX1-1110 ; Nutrition. Foods and food supply ; TX341-641 ; Geography. Anthropology. Recreation ; G ; Recreation. Leisure ; GV1-1860 ; Human ecology. Anthropogeography ; GF1-900 ; Environmental sciences ; GE1-350 ; Social Sciences ; H ; Communities. Classes. Races ; HT51-1595 ; Urban groups. The city. Urban sociology ; HT101-395 ; Regional planning ; HT390-395
    Subject code 390
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Thomas A. Lyson Center for Civic Agriculture and Food Systems
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Vascular Endothelial Growth Factor-C Treatment Enhances Cerebrospinal Fluid Outflow during Toxoplasma gondii Brain Infection but Does Not Improve Cerebral Edema.

    Kovacs, Michael A / Babcock, Isaac W / Royo Marco, Ana / Sibley, Lydia A / Kelly, Abigail G / Harris, Tajie H

    The American journal of pathology

    2023  Volume 194, Issue 2, Page(s) 225–237

    Abstract: ... that C57BL/6 mice develop vasogenic edema 4 to 5 weeks after infection with T. gondii. Tracer experiments ... a decreased rate in CSF outflow in T. gondii-infected mice. Next, mice were treated ... lymphatic outflow in mice infected with T. gondii, this effect does not lead to increased clearance of edema ...

    Abstract Cerebral edema frequently develops in the setting of brain infection and can contribute to elevated intracranial pressure, a medical emergency. How excess fluid is cleared from the brain is not well understood. Previous studies have shown that interstitial fluid is transported out of the brain along perivascular channels that collect into the cerebrospinal fluid (CSF)-filled subarachnoid space. CSF is then removed from the central nervous system through venous and lymphatic routes. The current study tested the hypothesis that increasing lymphatic drainage of CSF would promote clearance of cerebral edema fluid during infection with the neurotropic parasite Toxoplasma gondii. Fluorescent microscopy and magnetic resonance imaging was used to show that C57BL/6 mice develop vasogenic edema 4 to 5 weeks after infection with T. gondii. Tracer experiments were used to evaluate how brain infection affects meningeal lymphatic function, which demonstrated a decreased rate in CSF outflow in T. gondii-infected mice. Next, mice were treated with a vascular endothelial growth factor (VEGF)-C-expressing viral vector, which induced meningeal lymphangiogenesis and improved CSF outflow in chronically infected mice. No difference in cerebral edema was observed between mice that received VEGF-C and those that rececived sham treatment. Therefore, although VEGF-C treatment can improve lymphatic outflow in mice infected with T. gondii, this effect does not lead to increased clearance of edema fluid from the brains of these mice.
    MeSH term(s) Animals ; Mice ; Brain/pathology ; Brain Edema/parasitology ; Brain Edema/therapy ; Mice, Inbred C57BL ; Toxoplasma ; Toxoplasmosis/complications ; Toxoplasmosis/therapy ; Vascular Endothelial Growth Factor C/therapeutic use
    Chemical Substances Vascular Endothelial Growth Factor C
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2023.11.008
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  3. Article ; Online: Clinically significant findings in a decade-long retrospective study of prenatal chromosomal microarray testing.

    Olayiwola, Joie O / Marhabaie, Mohammad / Koboldt, Daniel / Matthews, Theodora / Siemon, Amy / Mouhlas, Danielle / Porter, Taylor / Kyle, George / Myers, Cortlandt / Mei, Hui / Hou, Ying-Chen Claire / Babcock, Melanie / Hunter, Jesse / Schieffer, Kathleen M / Akkari, Yassmine / Reshmi, Shalini / Cottrell, Catherine / Mathew, Mariam T / Leung, Marco L

    Molecular genetics & genomic medicine

    2024  Volume 12, Issue 3, Page(s) e2349

    Abstract: Background: Chromosomal microarray (CMA) is commonly utilized in the obstetrics setting. CMA is recommended when one or more fetal structural abnormalities is identified. CMA is also commonly used to determine genetic etiologies for miscarriages, fetal ... ...

    Abstract Background: Chromosomal microarray (CMA) is commonly utilized in the obstetrics setting. CMA is recommended when one or more fetal structural abnormalities is identified. CMA is also commonly used to determine genetic etiologies for miscarriages, fetal demise, and confirming positive prenatal cell-free DNA screening results.
    Methods: In this study, we retrospectively examined 523 prenatal and 319 products-of-conception (POC) CMA cases tested at Nationwide Children's Hospital from 2011 to 2020. We reviewed the referral indications, the diagnostic yield, and the reported copy number variants (CNV) findings.
    Results: In our cohort, the diagnostic yield of clinically significant CNV findings for prenatal testing was 7.8% (n = 41/523) compared to POC testing (16.3%, n = 52/319). Abnormal ultrasound findings were the most common indication present in 81% of prenatal samples. Intrauterine fetal demise was the common indication identified in POC samples. The most common pathogenic finding observed in all samples was isolated trisomy 21, detected in seven samples.
    Conclusion: Our CMA study supports the clinical utility of prenatal CMA for clinical management and identifying genetic etiology in POC arrays. In addition, it provides insight to the spectrum of prenatal and POC CMA results as detected in an academic hospital clinical laboratory setting that serves as a reference laboratory.
    MeSH term(s) Female ; Humans ; Pregnancy ; Chromosome Disorders/diagnosis ; Chromosome Disorders/genetics ; Down Syndrome ; Fetal Death ; Prenatal Diagnosis/methods ; Retrospective Studies
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2734884-2
    ISSN 2324-9269 ; 2324-9269
    ISSN (online) 2324-9269
    ISSN 2324-9269
    DOI 10.1002/mgg3.2349
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  4. Article ; Online: Verification of High-Rate Vertical Loading Laboratory Skeletal Fractures by Comparison with Theater Injury Patterns.

    Danelson, K A / Polich, J G / Barnes, D R / Bullock, G S / Scott, A T / Halvorson, J J / O'Gara, T / Pilson, H T / Babcock, S / Birkedal, J / McAllister, B / Loftis, K L

    Annals of biomedical engineering

    2021  Volume 49, Issue 11, Page(s) 3080–3090

    Abstract: For the current study, an existing theater injury data set was compared to component and whole body experiments meant to replicate the theater high rate vertical loading environment. The theater injury data set was derived from real world events that ... ...

    Abstract For the current study, an existing theater injury data set was compared to component and whole body experiments meant to replicate the theater high rate vertical loading environment. The theater injury data set was derived from real world events that were within the design range of the Warrior Injury Assessment Manikin. A qualitative and quantitative assessment of the whole body fracture patterns was developed to determine whether the laboratory loading was correctly representing the resulting injuries seen in theater Underbody Blast (UBB) events. Results indicated that most of the experimental test fracture patterns were similar to the theater injuries for Abbreviated Injury Scale body regions of interest (lower extremities, pelvis, and spine); however, some of the body regions had higher similarity scores compared to others. Whole body fracture distribution was less similar than the component tests because of differences in injury distributions. The lower extremity whole body similarity was lower than spine and pelvis similarity. This analysis was able to identify some experimental tests that might not represent theater loading. In conclusion, this analysis confirmed that some laboratory testing produced skeletal injury patterns that are seen in comparable theater UBB events.
    MeSH term(s) Blast Injuries ; Explosions ; Fractures, Bone ; Humans ; Laboratories ; Lower Extremity/injuries ; Manikins ; Operating Rooms ; Pelvis/injuries ; Reproducibility of Results ; Spinal Injuries
    Language English
    Publishing date 2021-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185984-5
    ISSN 1573-9686 ; 0191-5649 ; 0090-6964
    ISSN (online) 1573-9686
    ISSN 0191-5649 ; 0090-6964
    DOI 10.1007/s10439-021-02873-1
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: A G1528C Hadha knock-in mouse model recapitulates aspects of human clinical phenotypes for long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency.

    Gaston, Garen / Babcock, Shannon / Ryals, Renee / Elizondo, Gabriela / DeVine, Tiffany / Wafai, Dahlia / Packwood, William / Holden, Sarah / Raber, Jacob / Lindner, Jonathan R / Pennesi, Mark E / Harding, Cary O / Gillingham, Melanie B

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 890

    Abstract: ... FAOD) caused by a pathogenic variant, c.1528 G > C, in HADHA encoding the alpha subunit ...

    Abstract Long chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) is a fatty acid oxidation disorder (FAOD) caused by a pathogenic variant, c.1528 G > C, in HADHA encoding the alpha subunit of trifunctional protein (TFPα). Individuals with LCHADD develop chorioretinopathy and peripheral neuropathy not observed in other FAODs in addition to the more ubiquitous symptoms of hypoketotic hypoglycemia, rhabdomyolysis and cardiomyopathy. We report a CRISPR/Cas9 generated knock-in murine model of G1528C in Hadha that recapitulates aspects of the human LCHADD phenotype. Homozygous pups are less numerous than expected from Mendelian probability, but survivors exhibit similar viability with wildtype (WT) littermates. Tissues of LCHADD homozygotes express TFPα protein, but LCHADD mice oxidize less fat and accumulate plasma 3-hydroxyacylcarnitines compared to WT mice. LCHADD mice exhibit lower ketones with fasting, exhaust earlier during treadmill exercise and develop a dilated cardiomyopathy compared to WT mice. In addition, LCHADD mice exhibit decreased visual performance, decreased cone function, and disruption of retinal pigment epithelium. Neurological function is affected, with impaired motor function during wire hang test and reduced open field activity. The G1528C knock-in mouse exhibits a phenotype similar to that observed in human patients; this model will be useful to explore pathophysiology and treatments for LCHADD in the future.
    MeSH term(s) Humans ; Animals ; Mice ; Disease Models, Animal ; Cardiomyopathies/genetics ; Lipid Metabolism, Inborn Errors/genetics ; Rhabdomyolysis/genetics ; Mitochondrial Trifunctional Protein, alpha Subunit
    Chemical Substances Hadha protein, mouse (EC 4.2.1.17) ; Mitochondrial Trifunctional Protein, alpha Subunit (EC 1.1.1.211)
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05268-1
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  6. Article ; Online: High Salt Intake Augments Blood Pressure Responses During Submaximal Aerobic Exercise.

    Babcock, Matthew C / Robinson, Austin T / Migdal, Kamila U / Watso, Joseph C / Martens, Christopher R / Edwards, David G / Pescatello, Linda S / Farquhar, William B

    Journal of the American Heart Association

    2020  Volume 9, Issue 10, Page(s) e015633

    Abstract: Background High sodium ( ... ...

    Abstract Background High sodium (Na
    MeSH term(s) Adult ; Arterial Pressure ; Biomarkers/blood ; Brachial Artery/physiopathology ; Delaware ; Double-Blind Method ; Endothelium, Vascular/physiopathology ; Exercise ; Female ; Humans ; Male ; Natriuresis ; Norepinephrine/blood ; Sodium Chloride, Dietary/adverse effects ; Time Factors ; Vasodilation ; Young Adult
    Chemical Substances Biomarkers ; Sodium Chloride, Dietary ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.015633
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  7. Article ; Online: CO Guest Interactions in SDB-Based Metal-Organic Frameworks: A Solid-State Nuclear Magnetic Resonance Investigation.

    Wong, Y T Angel / Babcock, Troy K / Chen, Shoushun / Lucier, Bryan E G / Huang, Yining

    Langmuir : the ACS journal of surfaces and colloids

    2018  Volume 34, Issue 51, Page(s) 15640–15649

    Abstract: Metal-organic frameworks (MOFs) are promising materials for greener carbon monoxide (CO) capture and separation processes. SDB-based (SDB = 4, ... ...

    Abstract Metal-organic frameworks (MOFs) are promising materials for greener carbon monoxide (CO) capture and separation processes. SDB-based (SDB = 4,4
    Language English
    Publishing date 2018-12-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.8b02205
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  8. Article ; Online: Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.

    Lee, Chang Seok / Jung, Sung Yun / Yee, Rachel Sue Zhen / Agha, Nadia H / Hong, Jin / Chang, Ting / Babcock, Lyle W / Fleischman, Jorie D / Clayton, Benjamin / Hanna, Amy D / Ward, Christopher S / Lanza, Denise / Hurley, Ayrea E / Zhang, Pumin / Wehrens, Xander H T / Lagor, William R / Rodney, George G / Hamilton, Susan L

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 942

    Abstract: Here we show that striated muscle preferentially expressed protein kinase α (Spegα) maintains cardiac function in hearts with Spegβ deficiency. Speg is required for stability of excitation-contraction coupling (ECC) complexes and interacts with esterase ... ...

    Abstract Here we show that striated muscle preferentially expressed protein kinase α (Spegα) maintains cardiac function in hearts with Spegβ deficiency. Speg is required for stability of excitation-contraction coupling (ECC) complexes and interacts with esterase D (Esd), Cardiomyopathy-Associated Protein 5 (Cmya5), and Fibronectin Type III and SPRY Domain Containing 2 (Fsd2) in cardiac and skeletal muscle. Mice with a sequence encoding a V5/HA tag inserted into the first exon of the Speg gene (HA-Speg mice) display a >90% decrease in Spegβ but Spegα is expressed at ~50% of normal levels. Mice deficient in both Spegα and Speg β (Speg KO mice) develop a severe dilated cardiomyopathy and muscle weakness and atrophy, but HA-Speg mice display mild muscle weakness with no cardiac involvement. Spegα in HA-Speg mice suppresses Ca
    MeSH term(s) Animals ; Mice ; Cardiomyopathy, Dilated ; Exons ; Heart ; Immunoprecipitation ; Muscle Weakness ; Muscle Proteins ; Myosin-Light-Chain Kinase ; Intracellular Signaling Peptides and Proteins
    Chemical Substances Speg protein, mouse (EC 2.7.11.1) ; Muscle Proteins ; Myosin-Light-Chain Kinase (EC 2.7.11.18) ; Cmya5 protein, mouse ; Intracellular Signaling Peptides and Proteins
    Language English
    Publishing date 2023-09-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05330-y
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  9. Article ; Online: IMOVE: Protocol for a randomized, controlled 2x2 factorial trial of improvisational movement and social engagement interventions in older adults with early Alzheimer's disease.

    Hugenschmidt, Christina E / Ip, Edward H / Laurita-Spanglet, Jessie / Babcock, Phyllis / Morgan, Ashley R / Fanning, Jason T / King, Kamryn / Thomas, Jantira T / Soriano, Christina T

    Contemporary clinical trials communications

    2023  Volume 32, Page(s) 101073

    Abstract: ... neuropsychiatric symptoms (e.g., apathy, depression), altered gait, and poor balance that further diminish ...

    Abstract Background: In addition to cognitive impairment, people with Alzheimer's disease (PWAD) experience neuropsychiatric symptoms (e.g., apathy, depression), altered gait, and poor balance that further diminish their quality of life (QoL). Here, we describe a unique, randomized, controlled trial to test the hypothesis that both movement and social engagement aspects of a group dance intervention alter the connectivity of key brain networks involved in motor and social-emotional functioning and lead to improved QoL in PWAD.
    Methods: IMOVE (NCT03333837) was a single-center, randomized, controlled 2x2 factorial trial that assigned PWAD/caregiver dyads to one of 4 study conditions (Movement Group, Movement Alone, Social Group, or Usual Care control). The Movement Group participated in twice-weekly group improvisational dance (IMPROVment® Method) classes for 12 weeks. The Movement Alone intervention captured the same dance movement and auditory stimuli as the group class without social interaction, and the Social Group used improvisational party games to recapitulate the fun and playfulness of the Movement Group without the movement. The primary outcome was change in QoL among PWAD. Key secondary outcomes were functional brain network measures assessed using graph-theory analysis of resting-state functional magnetic resonance imaging scans, as well as neuropsychiatric symptoms, gait, and balance.
    Results: A total of 111 dyads were randomized; 89 completed the study, despite interruption and modification of the protocol due to COVID-19 restrictions (see companion paper by Fanning et al.). The data are being analyzed and will be submitted for publication in 2023.
    Language English
    Publishing date 2023-01-24
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2451-8654
    ISSN (online) 2451-8654
    DOI 10.1016/j.conctc.2023.101073
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  10. Article ; Online: Prediction of Persistent Postconcussion Symptoms in Youth Using a Neuroimaging Decision Rule.

    Faris, Gregory / Byczkowski, Terri / Ho, Mona / Babcock, Lynn

    Academic pediatrics

    2016  Volume 16, Issue 4, Page(s) 336–342

    Abstract: Objective: To evaluate the ability of risk strata generated by a neuroimaging rule, developed to assess risk of clinically important traumatic brain injury (ciTBI), to predict postconcussive symptoms in youth with an acute mild traumatic brain injury.!## ...

    Abstract Objective: To evaluate the ability of risk strata generated by a neuroimaging rule, developed to assess risk of clinically important traumatic brain injury (ciTBI), to predict postconcussive symptoms in youth with an acute mild traumatic brain injury.
    Methods: We performed a prospective cohort study of youth aged 5 to 17 years presenting to an emergency department (ED) within 24 hours of mild traumatic brain injury. Risk strata (very low, intermediate, and at risk) of ciTBI were determined in ED by criteria set forth by the neuroimaging rule. Postconcussive symptoms were assessed using the Health and Behavior Inventory (HBI) in the ED and at 1, 2, and 4 weeks after injury. General linear models were used to examine the relationship between the HBI score at 1 week and risk strata. Repeated measures analysis was used to measure change in HBI over time.
    Results: Of the 120 participants, 46 were categorized by the Pediatric Emergency Care Applied Research Network (PECARN) rule as very low risk, 39 as intermediate risk, and 35 as at risk for ciTBI. Adjusted mean HBI scores (95% confidence intervals) at 1 week were 18.0 (13.9, 22.2) for at risk, 13.8 (9.9, 17.6) for intermediate risk, and 17.1 (13.4, 20.8) for very low risk. Risk strata were not significantly associated with the adjusted HBI score at 1 week (P = .17). While adjusted HBI scores declined significantly over time (P < .0001), the trajectories of the HBI score over time did not differ significantly by risk strata (P = .68).
    Conclusions: Risk of ciTBI as determined by factors within a neuroimaging rule alone is insufficient to predict children with persistent postconcussive symptoms.
    MeSH term(s) Adolescent ; Brain Concussion/diagnosis ; Emergency Service, Hospital ; Humans ; Neuroimaging ; Post-Concussion Syndrome/diagnosis ; Prospective Studies
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2483385-X
    ISSN 1876-2867 ; 1876-2859
    ISSN (online) 1876-2867
    ISSN 1876-2859
    DOI 10.1016/j.acap.2015.10.007
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