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Article ; Online: PECULIARITIES OF ETHANOL INTOXICATION OF ANIMALS AT APPLICATION OF INTERMITTENT HYPOXIC TRAINING AT THE BEGINNING OF ALCOHOL CONSUMPTION

L.P. Kozak

Медична наука України, Vol 17, Iss 2, Pp 33-

2021 Volume 38

Abstract: Relevance. It was shown a wide therapeutic effects of intermittent hypoxic training (IHT) on the human organism which can increase the organism's resistance to damaging factors by inducing mechanisms of the safety use of energy resources. The objective: ... ...

Abstract	Relevance. It was shown a wide therapeutic effects of intermittent hypoxic training (IHT) on the human organism which can increase the organism's resistance to damaging factors by inducing mechanisms of the safety use of energy resources. The objective: to investigate the protective effect of IHT applied at the beginning of the 30-day alcohol intoxication of rats on the redox processes and the state of the antioxidant system of blood and liver tissues. Materials and methods. The study was performed on white male rats, which were divided into four groups: the first - intact (control); animals of the second group received a 15% ethanol solution for 30 days as the only source of drink; third - animals under IHT; fourth - rats that IHT was applied at the beginning of 30 days alcohol intoxication. The amount of the consumed ethanol was monitored during the experiment. Intermittent hypoxic training was performed in the altitude chamber in the following mode: five 10-min “elevations” to a height of 6 km at a rate of 20 m/sec, intervals between the elevations being 30 min. The activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase), total antioxidant activity (IAOA), as well as the content of lactic and pyruvic acids, malone dialdehyde and diene conjugates were determined. The research materials were homogenates of liver tissues and blood. The process is two-phase, which obviously reflects the stages of alcoholism. Results. It was found that alcohol intoxication of animals adapted to IHT is accompanied by an increase in the activity of superoxide dismutase and glutathione peroxidase in the blood and liver tissue against rats that consumed ethanol as the only source of drink. A tendency to increase IAOA and catalase activity against rats that received ethanol for a long time under these conditions was revealed. Analyzing the process of consumption of ethanol solution by animals, we can conclude that animals have a pronounced craving for alcohol in this model of alcoholization. The ...
Keywords	інтервальне гіпоксичне тренування ; етанол ; гіпоксія ; антиоксидантна система ; Medicine ; R
Subject code	630
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Bogomolets National Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mirror visual feedback as therapeutic modality in unilateral upper extremity complex regional pain syndrome type I: randomized controlled trial.

Machač, Stanislav / Chasáková, Ludmila / Kakawand, Soroush / Kozák, Jiří / Štěpánek, Lubomír / Vejvalka, Jan / Kolář, Pavel / Černý, Rudolf

European journal of physical and rehabilitation medicine

2024 Volume 60, Issue 2, Page(s) 280–291

Abstract: Background: There is growing evidence for the effectiveness of mirror therapy (MT) on pain reduction in patients with type I complex regional pain syndrome (CRPS I).: Aim: To evaluate the efficacy of MT on pain reduction and hand function in subjects ...

Abstract	Background: There is growing evidence for the effectiveness of mirror therapy (MT) on pain reduction in patients with type I complex regional pain syndrome (CRPS I). Aim: To evaluate the efficacy of MT on pain reduction and hand function in subjects with unilateral upper extremity CRPS I. Design: Randomized controlled trial with control group cross-over (half cross-over design). Setting: Subjects with CRPS I were outpatients of a university hospital and cooperating centers. All patients carried out the daily exercise at home. Population: Subjects with unilateral upper extremity CRPS I meeting the Budapest diagnostic criteria. Methods: Subjects were randomly divided into two groups. Group A (N.=13) carried out a ten-minute MT exercise daily, for a total duration of six weeks. Group B (N.=14) acted as a control group for six weeks followed by six weeks of MT with the same characteristics as Group A. Upper extremity active range of motion, strength, dexterity, limb volume, affected-to-unaffected hand temperature difference, and health-related quality of life were evaluated before and after each period. Daily records on the visual analogue scale were used for pain evaluation. Effectiveness was calculated using mixed-effects modelling for between-group comparisons and within-group variability, and identification of significant predictors. Results: Twenty-three females and four males with an average age of 56.1±9.6 years completed the study. Except for the affected-to-unaffected hand temperature difference, both groups consistently demonstrated significant or near-significant improvements in measured parameters after MT period. The improvements were evident upon an intergroup comparison of Group A and the control period of Group B as well as longitudinally within Group B. No significant improvement was found during the control period. Conclusions: Principles focused on mirror visual feedback to the central nervous system can sustain promising therapeutic potential as part of the treatment for pain reduction and hand function in CRPS I patients. Clinical rehabilitation impact: MT can be considered as part of the therapeutic regimen employed for the treatment of CRPS I.
MeSH term(s)	Male ; Female ; Humans ; Middle Aged ; Aged ; Reflex Sympathetic Dystrophy/therapy ; Quality of Life ; Feedback, Sensory ; Treatment Outcome ; Upper Extremity ; Complex Regional Pain Syndromes/therapy ; Pain
Language	English
Publishing date	2024-01-10
Publishing country	Italy
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2426908-6
ISSN	1973-9095 ; 1973-9087
ISSN (online)	1973-9095
ISSN	1973-9087
DOI	10.23736/S1973-9087.23.07625-6
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Article ; Online: Impacts of anthropogenic activities and glacial processes on the distribution of chemical elements in Billefjord, Svalbard, Arctic.

Souza-Kasprzyk, Juliana / Kozak, Lídia / Niedzielski, Przemyslaw

The Science of the total environment

2023 Volume 909, Page(s) 168534

Abstract: ... of the fjord had the lowest mean concentrations of most elements (18 out of 31; B, Ca, Cu, Cd, K, Li, P, Mg, Mo ...

Abstract	The Arctic region is undergoing rapid and extensive transformations due to global climate change. This study investigated the spatial distribution of 31 chemical elements in eight locations in Billefjord, Svalbard, Arctic, with varying degrees of anthropogenic and glacial influences. The west coast of Billefjord has experienced a greater historical anthropogenic impact, while the east coast has larger glaciers and shows less visible evidence of direct human impact. Over 450 topsoil samples collected in the west (abandoned mining town Pyramiden, and glacial valleys of Elsa, Ferdinand, Sven) and east coast of the fjord (glacial valleys of Ebba, Pollock, Ragnar and nearby the Nordenskiöld glacier). These samples were extracted and analyzed by ICP-OES. The results revealed complex distributions of elements among the locations. Nordenskiöld glacier area, along with other locations in the eastern part of the Billefjord, had significantly higher levels of most elements (20 out of 31; As, B, Ca, Cd, Co, Cr, Cu, K, Li, Mg, Mo, Sb, Se, Sn, Sr, Ti, Tl, U, V, Zr). In contrast, Ferdinand Valley and other locations on the western side of the fjord had the lowest mean concentrations of most elements (18 out of 31; B, Ca, Cu, Cd, K, Li, P, Mg, Mo, Sb, Se, Sn, Sr, Ti, Tl, U, V, Zr). These findings highlight the significant influence of glacial processes on the elemental composition of soils within the region. The meltwater flow originating from glaciers in the sampled valleys contributes to the local element load, while the loss of glacier mass is associated with decreased element concentrations within these valleys. These results underscore the complexity of element distribution in the study area and emphasize the necessity for continuous monitoring efforts in this unique and environmentally sensitive region.
Language	English
Publishing date	2023-11-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.168534
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Article: Potential of Plant-Based Extracts to Alleviate Sorbitol-Induced Osmotic Stress in Cabbage Seedlings.

Pacyga, Katarzyna / Pacyga, Paweł / Boba, Aleksandra / Kozak, Bartosz / Wolko, Łukasz / Kochneva, Yelyzaveta / Michalak, Izabela

Plants (Basel, Switzerland)

2024 Volume 13, Issue 6

Abstract: In light of expected climate change, it is important to seek nature-based solutions that can contribute to the protection of our planet as well as to help overcome the emerging adverse changes. In an agricultural context, increasing plant resistance to ... ...

Abstract	In light of expected climate change, it is important to seek nature-based solutions that can contribute to the protection of our planet as well as to help overcome the emerging adverse changes. In an agricultural context, increasing plant resistance to abiotic stress seems to be crucial. Therefore, the scope of the presented research was focused on the application of botanical extracts that exerted positive effects on model plants growing under controlled laboratory conditions, as well as plants subjected to sorbitol-induced osmotic stress. Foliar spraying increased the length and fresh mass of the shoots (e.g., extracts from
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13060843
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Article: Porovnání připravenosti nemocnic na řešení krizového stavu při hromadném neštěstí v závislosti na indexu lidského rozvoje dané země.

Burget, F / DouŠa, P / Kloub, M / KozÁk, T / Pleva, L / Rogalewicz, V

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

2021 Volume 87, Issue 6, Page(s) 438–446

Abstract: PURPOSE OF THE STUDY This thesis presents the very current topic of general hospital preparedness to deal with crisis situations in mass casualty incidents. MATERIAL AND METHODS The key part of the work consists in a questionnaire survey of 26 foreign ... ...

Title translation	Comparison of Hospital Preparedness to Deal with Crisis Situations in Mass Casualty Incidents According to the UN Human Development Index.
Abstract	PURPOSE OF THE STUDY This thesis presents the very current topic of general hospital preparedness to deal with crisis situations in mass casualty incidents. MATERIAL AND METHODS The key part of the work consists in a questionnaire survey of 26 foreign and domestic respondents, which provides a very good description of this issue in various countries of the world. The group is divided into health facilities in developed and developing countries of the world according to the UN Human Development Index. Another sub-group consists of hospitals in areas with a higher frequency of terrorist attacks and a separate group is formed by 5 hospitals in the Czech Republic. Based on the results of the questionnaire survey, the preparedness of hospitals for dealing with mass casualty incidents is compared in both the groups according to the advancement of the country and also in the subgroup of hospitals in the Czech Republic and in countries with frequent terrorist attacks. The maximum achievable score evaluating the hospital readiness is 20 points. The data obtained by the questionnaire survey is evaluated using statistical methods. RESULTS Higher preparedness of hospitals was found in developed countries, with a hospital preparedness score of 12.9 points compared with 5.9 points in developing countries' hospitals. Hospitals in the Czech Republic show a similar readiness for mass casualties as the other hospitals in developed countries, with the mean score of 12.2 points. Hospitals in countries with a higher number of terrorist attacks did not show a higher readiness to deal with crisis situations associated with mass casualties - the mean score of 9.4 points. DISCUSSION The following discussions and evaluations, together with personal experience and thorough knowledge of real-life solutions, became the basis for recommendations of triage procedures, organization of surgery and traumatology departments and material equipment of medical facilities in the Czech Republic. CONCLUSIONS By applying the results of the habilitation thesis it is possible to achieve an optimal solution and increase the reliability in the preparedness of hospitals in dealing with crisis situations, especially to eliminate the discrepancy between theory and practice. Key words: mass casualty incidents, triage, hospital preparedness, disaster management response.
MeSH term(s)	Czech Republic ; Disaster Planning ; Hospitals ; Humans ; Mass Casualty Incidents ; Reproducibility of Results ; United Nations
Language	Czech
Publishing date	2021-01-06
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	418889-5
ISSN	0001-5415
ISSN	0001-5415
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Article ; Online: Development and assessment of an epidemiologic dashboard for surveillance of Varroa destructor in Ontario apiaries.

Sobkowich, K E / Berke, O / Bernardo, T M / Pearl, D L / Kozak, P

Preventive veterinary medicine

2023 Volume 212, Page(s) 105853

Abstract: Varroosis (caused by the Varroa destructor mite) is a key health issue for honey bees in North America. Because these mites can exist in reservoirs of feral honey bee colonies, eradication is impossible, and instead efforts are made to maintain mites ... ...

Abstract	Varroosis (caused by the Varroa destructor mite) is a key health issue for honey bees in North America. Because these mites can exist in reservoirs of feral honey bee colonies, eradication is impossible, and instead efforts are made to maintain mites below a critical threshold. Monitoring for Varroa mites within a population is key for allocating resources and targeting interventions but surveillance can be difficult and/or expensive. This project aims to reflect on the success of data dashboards developed throughout the 2019-coronavirus pandemic and showcase how these methods can improve surveillance of Varroa mite infestations in Ontario, Canada. Dashboards provide a consistent source of information and epidemiologic metrics through data visualizations, and mobilize data otherwise bound to tables and intermittent reports. In the present work, an interactive dashboard for the surveillance of Varroa mite infestations across the province is proposed. This dashboard was developed using routine ministry inspection data to depict the spatio-temporal distribution of mites across a five-year data collection period. Through interactive figures and plots, able to be disaggregated to a specific region and time frame, this dashboard will allow for members of the beekeeping community to monitor provincial mite levels throughout the season. Seven criteria found to be common across highly actionable COVID-19 dashboards were used in a beta testing stage of development to assess the quality of the dashboard, and critically reflect on its strengths and weaknesses. Furthermore, future directions for surveillance dashboards are explored, including integration with citizen science data collection to develop a comprehensive province-wide surveillance system. The outcome of this project is a functional dashboard proof-of-concept for population-level monitoring of Varroa mites and a model for future tools designed for other species and diseases.
MeSH term(s)	Bees ; Animals ; Varroidae ; Ontario/epidemiology ; COVID-19/epidemiology ; COVID-19/veterinary ; Mite Infestations/veterinary ; Beekeeping
Language	English
Publishing date	2023-01-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	43399-8
ISSN	1873-1716 ; 0167-5877
ISSN (online)	1873-1716
ISSN	0167-5877
DOI	10.1016/j.prevetmed.2023.105853
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Article ; Online: Chemical element distribution in Arctic soils: Assessing vertical, spatial, animal and anthropogenic influences in Elsa and Ebba Valleys, Spitsbergen, Svalbard.

Souza-Kasprzyk, Juliana / Tkachenko, Yana / Kozak, Lídia / Niedzielski, Przemyslaw

Chemosphere

2023 Volume 340, Page(s) 139862

Abstract: The Arctic region is threatened by climate change and pollution caused by human activities which potentially influence the elemental concentrations available to and from the biota. To better understand this delicate balance, it is crucial to investigate ... ...

Abstract	The Arctic region is threatened by climate change and pollution caused by human activities which potentially influence the elemental concentrations available to and from the biota. To better understand this delicate balance, it is crucial to investigate the role of several factors. Therefore, we quantified the level of 43 chemical elements in soils from Elsa and Ebba Valleys, Petunia Bay, Spitsbergen, a region that has experienced lasting environmental impacts from historical mining activities. We evaluated the a) vertical sampling influence by examining the variation in element distribution between the soil upper and deeper layers, b) animal influence by verifying the role of native animals, particularly vertebrates, in introducing thought faeces elements to the soil and c) anthropogenic influence by studying the spatial geographical differences in element distribution based on the degree of human pressure between the valleys. Our analysis also includes data on soil organic matter (SOM) and mineral composition. Both valleys exhibited similar mineralogical composition, but Elsa Valley had higher concentrations of most analyzed elements compared to Ebba Valley. Despite the contribution of vertebrate feaces, no increase in element concentrations was observed in the animal-influenced soils. The sampled soil layers had similar chemical element profiles for most elements. SOM content tended to be higher in superficial soils and showed a strong positive correlation with most quantified elements. The higher concentrations in Elsa Valley reflect its past mining and mineral exploration, making this area more significantly impacted than Ebba Valley. Surprisingly, vertebrate animals do not appear to influence the concentrations of chemical elements or organic matter in soils. Our findings provide valuable insights into the legacy of past mining activities and mechanisms driving environmental change in the Arctic.
MeSH term(s)	Animals ; Humans ; Soil ; Svalbard ; Environment ; Benzylidene Compounds
Chemical Substances	Soil ; N-(4-ethoxybenzylidene)-4-butylaniline (29743-08-6) ; Benzylidene Compounds
Language	English
Publishing date	2023-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139862
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Article ; Online: From varicose veins to venous thromboembolic events.

Poredos, Pavel / Kozak, Matija / Antignani, Pier L / Jezovnik, Mateja K

International angiology : a journal of the International Union of Angiology

2023 Volume 42, Issue 3, Page(s) 254–259

Abstract: Varicose veins (VVs) mostly represent benign disease. However, in some cases, they can lead to serious complications including deep venous thrombosis (DVT) and pulmonary embolism (PE). Besides deteriorated blood flow caused by VVs inflammation is most ... ...

Abstract	Varicose veins (VVs) mostly represent benign disease. However, in some cases, they can lead to serious complications including deep venous thrombosis (DVT) and pulmonary embolism (PE). Besides deteriorated blood flow caused by VVs inflammation is most probably a common denominator of VVs and DVT, which promotes a procoagulant state and thrombus formation also in deep veins. Patients with VVs have increased levels of interleukins, the most specific inflammatory markers of vascular wall inflammation that promote coagulation. The studies showed that VVs may increase the risk for DVT. However, the evidence of the risk and incidence of DVT in patients with VVs and without additional risk factors is poor. The increased risk is associated with previous venous thromboembolism (VTE), malignancy, estrogen use, pregnancy and postpartum, hospitalization in the last 6 months, age, and obesity. Varicose veins represent also an increased risk for VTE during long-term immobilization and long air travel or road trip. Further, superficial venous thrombosis is related to an increased risk for DVT, particularly if the thrombus in the superficial vein extends close to the saphenofemoral or femoropopliteal junction. Increased risk for DVT is increased during and after invasive treatment of VVs. Thromboprophylaxis after invasive procedures is recommended in subjects older than 60 years and those with another thrombophilic state.
MeSH term(s)	Pregnancy ; Female ; Humans ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control ; Anticoagulants/therapeutic use ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology ; Varicose Veins/drug therapy ; Pulmonary Embolism/etiology ; Pulmonary Embolism/complications ; Thrombosis/complications ; Risk Factors ; Inflammation/drug therapy
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-02-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604910-2
ISSN	1827-1839 ; 0392-9590
ISSN (online)	1827-1839
ISSN	0392-9590
DOI	10.23736/S0392-9590.23.04948-9
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Article ; Online: Targeting motor cortex high-excitability states defined by functional connectivity with real-time EEG-TMS.

Vetter, David Emanuel / Zrenner, Christoph / Belardinelli, Paolo / Mutanen, Tuomas Petteri / Kozák, Gábor / Marzetti, Laura / Ziemann, Ulf

NeuroImage

2023 Volume 284, Page(s) 120427

Abstract: We tested previous post-hoc findings indicating a relationship between functional connectivity (FC) in the motor network and corticospinal excitability (CsE), in a real-time EEG-TMS experiment in healthy participants. We hypothesized that high FC between ...

Abstract	We tested previous post-hoc findings indicating a relationship between functional connectivity (FC) in the motor network and corticospinal excitability (CsE), in a real-time EEG-TMS experiment in healthy participants. We hypothesized that high FC between left and right motor cortex predicts high CsE. FC was quantified in real-time by single-trial phase-locking value (stPLV), and TMS single pulses were delivered based on the current FC. CsE was indexed by motor-evoked potential (MEP) amplitude in a hand muscle. Possible confounding factors (pre-stimulus μ-power and phase, interstimulus interval) were evaluated post hoc. MEPs were significantly larger during high FC compared to low FC. Post hoc analysis revealed that the FC condition showed a significant interaction with μ-power in the stimulated hemisphere. Further, inter-stimulus interval (ISI) interacted with high vs. low FC conditions. In summary, FC was confirmed to be predictive of CsE, but should not be considered in isolation from μ-power and ISI. Moreover, FC was complementary to μ-phase in predicting CsE. Motor network FC is another marker of real-time accessible CsE beyond previously established markers, in particular phase and power of the μ rhythm, and may help define a more robust composite biomarker of high/low excitability states of human motor cortex.
MeSH term(s)	Humans ; Motor Cortex/physiology ; Electroencephalography ; Transcranial Magnetic Stimulation ; Muscle, Skeletal/physiology ; Evoked Potentials, Motor/physiology
Language	English
Publishing date	2023-11-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2023.120427
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Article: The Improved Quality of Gluten-Free Bread Due to the Use of Flaxseed Oil Cake: A Comprehensive Study Evaluating Nutritional Value, Technological Properties, and Sensory Quality.

Oliveira, Daniela / Starowicz, Małgorzata / Ostaszyk, Anita / Łopusiewicz, Łukasz / Ferreira, Isabel M P L V O / Pinto, Edgar / Krupa-Kozak, Urszula

Foods (Basel, Switzerland)

2023 Volume 12, Issue 23

Abstract: The development of gluten-free bakery products, the quality of which is comparable to the quality of regular wheat-based products, remains a technological challenge. In this study, flaxseed oil cake (FOC), a by-product of flaxseed oil extraction and a ... ...

Abstract	The development of gluten-free bakery products, the quality of which is comparable to the quality of regular wheat-based products, remains a technological challenge. In this study, flaxseed oil cake (FOC), a by-product of flaxseed oil extraction and a source of nutritional and functional compounds, was used as an ingredient in the experimental bread formulation as partial replacement of starches (5%, 15%, and 30%). The gluten-free breads (GFBs) were evaluated for technological parameters, nutritional value, and sensory quality. Compared with the control, all FOC-enhanced GFBs were significantly (
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12234320
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