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  1. Article ; Online: UK medical students graduating early to work during the COVID-19 pandemic.

    Sharif, Shazia P

    Psychological medicine

    2020  Volume 51, Issue 11, Page(s) 1951

    MeSH term(s) COVID-19 ; Humans ; Pandemics ; SARS-CoV-2 ; Students, Medical ; United Kingdom/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291720001488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19, masks and communication in the operating theatre: the importance of face value.

    Sharif, Shazia P / Blagrove, Elisabeth

    Psychological medicine

    2020  , Page(s) 1

    Keywords covid19
    Language English
    Publishing date 2020-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291720003669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: UK medical students graduating early to work during the COVID-19 pandemic

    Sharif, Shazia P.

    Psychological Medicine

    2020  , Page(s) 1–1

    Keywords Applied Psychology ; Psychiatry and Mental health ; covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/s0033291720001488
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: COVID-19, masks and communication in the operating theatre

    Sharif, Shazia P. / Blagrove, Elisabeth

    Psychological Medicine

    the importance of face value

    2020  , Page(s) 1–1

    Keywords Applied Psychology ; Psychiatry and Mental health ; covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/s0033291720003669
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  7. Article ; Online: C-reactive protein/albumin ratio is a prognostic indicator for predicting surgical intervention and mortality in neonates with necrotizing enterocolitis.

    Mohd Amin, Amir T / Zaki, Rafdzah A / Friedmacher, Florian / Sharif, Shazia P

    Pediatric surgery international

    2021  Volume 37, Issue 7, Page(s) 881–886

    Abstract: ... 63-0.79); p < 0.0001] and mortality [AUC 0.66 (95% CI 0.54-0.77); p = 0.0150], respectively ...

    Abstract Purpose: The role of hypoalbuminemia and raised C-reactive protein (CRP) levels in predicting critical prognosis has been described extensively in adult literature. However, there are limited studies in pediatrics, particularly neonates. The CRP/albumin (CRP/ALB) ratio is often associated with higher mortality, organ failure and prolonged hospital stay. We hypothesized that the serum CRP/ALB ratio has a prognostic value in predicting surgery and mortality in neonates with necrotizing enterocolitis (NEC).
    Methods: Retrospective review of all neonates with clinical and radiological evidence of non-perforated NEC that were treated in a tertiary-level referral hospital between 2009 and 2018. General patient demographics, laboratory parameters and outcomes were recorded. Receiver operating characteristics analysis was performed to evaluated optimal cut-offs and area under the curve (AUC) with 95% confidence intervals (CI).
    Results: A total of 191 neonates were identified. Of these, 103 (53.9%) were born at ≤ 28 weeks of gestation and 101 (52.9%) had a birth weight of ≤ 1000 g. Eighty-four (44.0%) patients underwent surgical intervention for NEC. The overall survival rate was 161/191 (84.3%). A CRP/ALB ratio of ≥ 3 on day 2 of NEC diagnosis was associated with a statistically significant higher likelihood for surgery [AUC 0.71 (95% CI 0.63-0.79); p < 0.0001] and mortality [AUC 0.66 (95% CI 0.54-0.77); p = 0.0150], respectively.
    Conclusions: A CRP/ALB ratio of ≥ 3 on day 2 is indicative of a critical pathway in neonates with radiologically confirmed, non-perforated NEC. This could be used as an additional criterion to guide parental counselling in NEC for surgical intervention and mortality.
    Language English
    Publishing date 2021-03-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632773-4
    ISSN 1437-9813 ; 0179-0358
    ISSN (online) 1437-9813
    ISSN 0179-0358
    DOI 10.1007/s00383-021-04879-1
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    Zs.A 2138: Show issues Location:
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  8. Article ; Online: Management of post appendicectomy intra-abdominal collections: A volumetric cut off for drainage?

    Bough, Georgina M / Singh, Rashmi R / Johnson, Bethan / Soorasangaram, Mathanki / Mahbubani, Krishnaa T / Joshi, Ashwini / Sharif, Shazia P

    Journal of pediatric surgery

    2021  Volume 57, Issue 2, Page(s) 245–249

    Abstract: ... management: maximum diameter (p = 0.028), volume (p = 0.002), and surface area (p = 0.001). Collections ... vs 6/11; p < 0.0001).: Discussion: Not all post appendicectomy IACs require drainage ...

    Abstract Background: Intra-abdominal collections (IAC) are a common complication following appendicectomy, one of the most commonly performed emergency abdominal procedures in childhood. The option to drain a collection is frequently available but not always required.
    Aim: The aim of this study was to compare the outcomes of medically and procedurally-managed post appendicectomy IACs and suggest a method of standardising the need for intervention.
    Methods: A single centre, retrospective review of children aged ≤ 16 years presenting between 2014 and 2019 was performed. Patient demographics, management, and outcome data were collected. IAC volume and surface area were calculated assuming a prolate spheroid or true ellipsoid depending on the number of dimensions reported.
    Results: 60 patients (18%) of 334 patients developed an IAC post appendicectomy. Medical management was undertaken in 44 (73%), drainage in 12 (20%), and surgical washout in 4 (7%). Collection size was associated with failure of medical management: maximum diameter (p = 0.028), volume (p = 0.002), and surface area (p = 0.001). Collections with a volume of 2 ml/kg were significantly less likely to fail medical management than larger collections (0/33 vs 6/11; p < 0.0001).
    Discussion: Not all post appendicectomy IACs require drainage. The relationship between collection volume and need for drainage is more closely assessed using a volume calculation rather than a single dimension measurement, particularly when adjusted for weight of the child. A cut off of 2 ml/kg appears to be a good objective measure for intervention and provides a communication tool for discussion amongst the multidisciplinary team. Prospectively collected multicentre data on this subject would be timely.
    Level of evidence: III.
    MeSH term(s) Abdominal Muscles ; Adolescent ; Appendectomy ; Appendicitis/surgery ; Child ; Drainage ; Humans ; Retrospective Studies
    Language English
    Publishing date 2021-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2021.10.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 607: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Low serum albumin concentration predicts the need for surgical intervention in neonates with necrotizing enterocolitis.

    Sharif, Shazia P / Friedmacher, Florian / Amin, Amir / Zaki, Rafdzah A / Hird, Michael F / Khashu, Minesh / Phelps, Simon R

    Journal of pediatric surgery

    2020  Volume 55, Issue 12, Page(s) 2625–2629

    Abstract: ... compared to 64 (48.5%) cases that responded well to medical treatment (18.3 ± 3.7 g/L vs. 26.0 ± 2.0 g/L; P ... for surgery (OR 3.41; P = 0.019) with a positive predictive value of 71.4%.: Conclusions: An SA ...

    Abstract Purpose: To investigate whether serum albumin (SA) concentration can predict the need for surgical intervention in neonates with necrotizing enterocolitis (NEC).
    Methods: Retrospective review of all cases with NEC Bell's stage 2 and 3 that were treated in a single center between 2009 and 2015. Data on patient demographics, clinical parameters, laboratory findings and surgical status were recorded. Receiver operating characteristics analysis was used to evaluate optimal cutoffs and predictive values.
    Results: Overall, 151 neonates with NEC were identified. Of these, 132 (87.4%) had confirmed NEC Bell's stage 2. The median gestational age was 28.4 (range, 23.1-39.0) weeks and 69 (52.3%) had a birth weight of ≤1000 g. Sixty-eight (51.5%) underwent surgery, showing a sustained reduction in SA over time with significantly lower median SA levels compared to 64 (48.5%) cases that responded well to medical treatment (18.3 ± 3.7 g/L vs. 26.0 ± 2.0 g/L; P < 0.001). SA concentration of ≤20 g/L on day 2 of NEC diagnosis was a significant predictor for surgery (OR 3.41; P = 0.019) with a positive predictive value of 71.4%.
    Conclusions: An SA concentration of ≤20 g/L on day 2 of the NEC disease process is associated with a higher likelihood for surgical intervention in neonates with NEC Bell's stage 2. SA, in combination with other clinical parameters and serological markers, may be a useful predictive tool for surgery in NEC.
    Level of evidence: II.
    MeSH term(s) Enterocolitis, Necrotizing/surgery ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases ; Retrospective Studies ; Serum Albumin
    Chemical Substances Serum Albumin
    Language English
    Publishing date 2020-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2020.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 607: Show issues Location:
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  10. Article ; Online: Meta-analysis of calcineurin-inhibitor-sparing regimens in kidney transplantation.

    Sharif, Adnan / Shabir, Shazia / Chand, Sourabh / Cockwell, Paul / Ball, Simon / Borrows, Richard

    Journal of the American Society of Nephrology : JASN

    2011  Volume 22, Issue 11, Page(s) 2107–2118

    Abstract: ... with mycophenolate, decreased the odds of overall graft failure (OR 0.61; 95% CI 0.39-0.96; P = 0.03). Similarly ... the odds of graft failure (OR 0.73; 95% CI 0.58-0.92; P = 0.009). Conversely, the use of inhibitors ... OR 1.43; 95% CI 1.08-1.90; P = 0.01). Calcineurin-inhibitor-sparing strategies are associated ...

    Abstract Calcineurin-inhibitor-sparing strategies in kidney transplantation may spare patients the adverse effects of these drugs, but the efficacy of these strategies is unknown. Here, we conduct a meta-analysis to assess outcomes associated with reducing calcineurin inhibitor exposure from the time of transplantation. We search Medline, Embase, and Cochrane Register of Controlled Trials for randomized controlled trials published between 1966 and 2010 that compared de novo calcineurin-inhibitor-sparing regimens to calcineurin-inhibitor-based regimens. In this analysis, we include 56 studies comprising data from 11337 renal transplant recipients. Use of the contemporary agents belatacept or tofacitinib, in combination with mycophenolate, decreased the odds of overall graft failure (OR 0.61; 95% CI 0.39-0.96; P = 0.03). Similarly, minimization of calcineurin inhibitors in combination with various induction and adjunctive agents reduces the odds of graft failure (OR 0.73; 95% CI 0.58-0.92; P = 0.009). Conversely, the use of inhibitors of mammalian target of rapamycin (mTOR), in combination with mycophenolate, increases the odds of graft failure (OR 1.43; 95% CI 1.08-1.90; P = 0.01). Calcineurin-inhibitor-sparing strategies are associated with less delayed graft function (OR 0.89; 95% CI 0.80-0.98; P = 0.02), improved graft function, and less new-onset diabetes. The more contemporary protocols did not seem to increase rates of acute rejection. In conclusion, this meta-analysis suggests that reducing exposure to calcineurin inhibitors immediately after kidney transplantation may improve clinical outcomes.
    MeSH term(s) Calcineurin Inhibitors ; Graft Rejection/drug therapy ; Graft Survival/drug effects ; Graft Survival/immunology ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation
    Chemical Substances Calcineurin Inhibitors ; Immunosuppressive Agents
    Language English
    Publishing date 2011-09-23
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2010111160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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