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  1. Article ; Online: How did life become cellular?

    Goldman, Aaron D

    Proceedings. Biological sciences

    2023  Volume 290, Issue 1992, Page(s) 20222327

    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2022.2327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1364: Show issues Location:
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  2. Article ; Online: Drug-induced resistance: nipping it in the 'budding'.

    Goldman, Aaron

    Oncotarget

    2018  Volume 9, Issue 89, Page(s) 35873–35874

    Language English
    Publishing date 2018-11-13
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.26328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A simplified approach for the surgical treatment of hip and knee periprosthetic joint infections.

    Sanderson, Galen / Olsen, Aaron / Nabet, Austin / Goldman, Ashton

    Journal of orthopaedics

    2023  Volume 47, Page(s) 58–62

    Language English
    Publishing date 2023-11-11
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2240839-3
    ISSN 0972-978X
    ISSN 0972-978X
    DOI 10.1016/j.jor.2023.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Very early evolution from the perspective of microbial ecology

    Goldman, Aaron D. / Kaçar, Betül

    Environmental Microbiology. 2023 Jan., v. 25, no. 1 p.5-10

    2023  

    Abstract: The universal ancestor at the root of the species tree of life depicts a population of organisms with a surprising degree of complexity, posessing genomes and translation systems much like that of microbial life today. As the first life forms were most ... ...

    Abstract The universal ancestor at the root of the species tree of life depicts a population of organisms with a surprising degree of complexity, posessing genomes and translation systems much like that of microbial life today. As the first life forms were most likely to have been simple replicators, considerable evolutionary change must have taken place prior to the last universal common ancestor. It is often assumed that the lack of earlier branches on the tree of life is due to a prevalence of random horizontal gene transfer that obscured the delineations between lineages and hindered their divergence. Therefore, principles of microbial evolution and ecology may give us some insight into these early stages in the history of life. Here, we synthesize the current understanding of organismal and genome evolution from the perspective of microbial ecology and apply these evolutionary principles to the earliest stages of life on Earth. We focus especially on broad evolutionary modes pertaining to horizontal gene transfer, pangenome structure, and microbial mat communities.
    Keywords ancestry ; evolution ; genome ; horizontal gene transfer ; microbial ecology ; microbiology
    Language English
    Dates of publication 2023-01
    Size p. 5-10.
    Publishing place John Wiley & Sons, Inc.
    Document type Article ; Online
    Note EDITORIAL
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.16144
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Very early evolution from the perspective of microbial ecology.

    Goldman, Aaron D / Kaçar, Betül

    Environmental microbiology

    2022  Volume 25, Issue 1, Page(s) 5–10

    Abstract: The universal ancestor at the root of the species tree of life depicts a population of organisms with a surprising degree of complexity, posessing genomes and translation systems much like that of microbial life today. As the first life forms were most ... ...

    Abstract The universal ancestor at the root of the species tree of life depicts a population of organisms with a surprising degree of complexity, posessing genomes and translation systems much like that of microbial life today. As the first life forms were most likely to have been simple replicators, considerable evolutionary change must have taken place prior to the last universal common ancestor. It is often assumed that the lack of earlier branches on the tree of life is due to a prevalence of random horizontal gene transfer that obscured the delineations between lineages and hindered their divergence. Therefore, principles of microbial evolution and ecology may give us some insight into these early stages in the history of life. Here, we synthesize the current understanding of organismal and genome evolution from the perspective of microbial ecology and apply these evolutionary principles to the earliest stages of life on Earth. We focus especially on broad evolutionary modes pertaining to horizontal gene transfer, pangenome structure, and microbial mat communities.
    MeSH term(s) Evolution, Molecular ; Genome ; Ecology ; Gene Transfer, Horizontal ; Microbiota ; Phylogeny ; Biological Evolution
    Language English
    Publishing date 2022-08-09
    Publishing country England
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.16144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Journal of Molecular Evolution Turns 50.

    Goldman, Aaron D / Liberles, David A

    Journal of molecular evolution

    2021  Volume 89, Issue 3, Page(s) 119–121

    MeSH term(s) Amino Acid Sequence ; Evolution, Molecular ; Protein Structure, Secondary
    Language English
    Publishing date 2021-02-23
    Publishing country Germany
    Document type Editorial
    ZDB-ID 120148-7
    ISSN 1432-1432 ; 0022-2844
    ISSN (online) 1432-1432
    ISSN 0022-2844
    DOI 10.1007/s00239-021-10000-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1129: Show issues Location:
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  7. Article ; Online: On the role of memory in misinformation corrections: Repeated exposure, correction durability, and source credibility.

    Kemp, Paige L / Goldman, Aaron C / Wahlheim, Christopher N

    Current opinion in psychology

    2023  Volume 56, Page(s) 101783

    Abstract: Misinformation can negatively affect cognition, beliefs, and behavior, and thus contribute to societal disruption. Correcting misinformation can counteract these effects by updating memory and beliefs. In this selective review, we highlight recent ... ...

    Abstract Misinformation can negatively affect cognition, beliefs, and behavior, and thus contribute to societal disruption. Correcting misinformation can counteract these effects by updating memory and beliefs. In this selective review, we highlight recent perspectives on and evidence for the role of memory in the efficacy of correction methods. Two theoretical accounts propose that repeating misinformation can impair or improve correction efficacy to the extent that familiarity or integrative encoding prevails. We summarize evidence that recollection of corrections can counteract potential interference from misinformation repetitions on memory and belief updating. The efficacy of such updating also declines over time, especially when misinformation sources are not remembered. We call for more research on the role of memory in everyday misinformation corrections to better understand interactions among these processes.
    MeSH term(s) Humans ; Communication ; Mental Recall ; Recognition, Psychology ; Cognition
    Language English
    Publishing date 2023-12-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2831565-0
    ISSN 2352-2518 ; 2352-250X ; 2352-250X
    ISSN (online) 2352-2518 ; 2352-250X
    ISSN 2352-250X
    DOI 10.1016/j.copsyc.2023.101783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cofactors are Remnants of Life's Origin and Early Evolution.

    Goldman, Aaron D / Kacar, Betul

    Journal of molecular evolution

    2021  Volume 89, Issue 3, Page(s) 127–133

    Abstract: The RNA World is one of the most widely accepted hypotheses explaining the origin of the genetic system used by all organisms today. It proposes that the tripartite system of DNA, RNA, and proteins was preceded by one consisting solely of RNA, which both ...

    Abstract The RNA World is one of the most widely accepted hypotheses explaining the origin of the genetic system used by all organisms today. It proposes that the tripartite system of DNA, RNA, and proteins was preceded by one consisting solely of RNA, which both stored genetic information and performed the molecular functions encoded by that genetic information. Current research into a potential RNA World revolves around the catalytic properties of RNA-based enzymes, or ribozymes. Well before the discovery of ribozymes, Harold White proposed that evidence for a precursor RNA world could be found within modern proteins in the form of coenzymes, the majority of which contain nucleobases or nucleoside moieties, such as Coenzyme A and S-adenosyl methionine, or are themselves nucleotides, such as ATP and NADH (a dinucleotide). These coenzymes, White suggested, had been the catalytic active sites of ancient ribozymes, which transitioned to their current forms after the surrounding ribozyme scaffolds had been replaced by protein apoenzymes during the evolution of translation. Since its proposal four decades ago, this groundbreaking hypothesis has garnered support from several different research disciplines and motivated similar hypotheses about other classes of cofactors, most notably iron-sulfur cluster cofactors as remnants of the geochemical setting of the origin of life. Evidence from prebiotic geochemistry, ribozyme biochemistry, and evolutionary biology, increasingly supports these hypotheses. Certain coenzymes and cofactors may bridge modern biology with the past and can thus provide insights into the elusive and poorly-recorded period of the origin and early evolution of life.
    MeSH term(s) Coenzymes ; Evolution, Molecular ; Nucleotides ; Origin of Life ; Proteins/genetics ; RNA/genetics ; RNA, Catalytic/genetics
    Chemical Substances Coenzymes ; Nucleotides ; Proteins ; RNA, Catalytic ; RNA (63231-63-0)
    Language English
    Publishing date 2021-02-06
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120148-7
    ISSN 1432-1432 ; 0022-2844
    ISSN (online) 1432-1432
    ISSN 0022-2844
    DOI 10.1007/s00239-020-09988-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1129: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: The very early evolution of protein translocation across membranes.

    Harris, A J / Goldman, Aaron David

    PLoS computational biology

    2021  Volume 17, Issue 3, Page(s) e1008623

    Abstract: In this study, we used a computational approach to investigate the early evolutionary history of a system of proteins that, together, embed and translocate other proteins across cell membranes. Cell membranes comprise the basis for cellularity, which is ... ...

    Abstract In this study, we used a computational approach to investigate the early evolutionary history of a system of proteins that, together, embed and translocate other proteins across cell membranes. Cell membranes comprise the basis for cellularity, which is an ancient, fundamental organizing principle shared by all organisms and a key innovation in the evolution of life on Earth. Two related requirements for cellularity are that organisms are able to both embed proteins into membranes and translocate proteins across membranes. One system that accomplishes these tasks is the signal recognition particle (SRP) system, in which the core protein components are the paralogs, FtsY and Ffh. Complementary to the SRP system is the Sec translocation channel, in which the primary channel-forming protein is SecY. We performed phylogenetic analyses that strongly supported prior inferences that FtsY, Ffh, and SecY were all present by the time of the last universal common ancestor of life, the LUCA, and that the ancestor of FtsY and Ffh existed before the LUCA. Further, we combined ancestral sequence reconstruction and protein structure and function prediction to show that the LUCA had an SRP system and Sec translocation channel that were similar to those of extant organisms. We also show that the ancestor of Ffh and FtsY that predated the LUCA was more similar to FtsY than Ffh but could still have comprised a rudimentary protein translocation system on its own. Duplication of the ancestor of FtsY and Ffh facilitated the specialization of FtsY as a membrane bound receptor and Ffh as a cytoplasmic protein that could bind nascent proteins with specific membrane-targeting signal sequences. Finally, we analyzed amino acid frequencies in our ancestral sequence reconstructions to infer that the ancestral Ffh/FtsY protein likely arose prior to or just after the completion of the canonical genetic code. Taken together, our results offer a window into the very early evolutionary history of cellularity.
    MeSH term(s) Bacterial Proteins ; Cell Membrane/chemistry ; Cell Membrane/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins ; Evolution, Molecular ; Models, Biological ; Phylogeny ; Protein Transport/genetics ; Protein Transport/physiology ; Receptors, Cytoplasmic and Nuclear ; SEC Translocation Channels ; Signal Recognition Particle
    Chemical Substances Bacterial Proteins ; Escherichia coli Proteins ; Ffh protein, E coli ; FtsY protein, Bacteria ; Receptors, Cytoplasmic and Nuclear ; SEC Translocation Channels ; SecY protein, E coli ; Signal Recognition Particle
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1008623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Continued Overreliance On Involuntary Commitment: The Need For A Less Restrictive Alternative.

    Goldman, Aaron

    The Journal of legal medicine

    2015  Volume 36, Issue 2, Page(s) 233–251

    MeSH term(s) Commitment of Mentally Ill/legislation & jurisprudence ; Humans ; United States
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article ; Legal Cases
    ZDB-ID 604915-1
    ISSN 1521-057X ; 0194-7648
    ISSN (online) 1521-057X
    ISSN 0194-7648
    DOI 10.1080/01947648.2015.1121075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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