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Article ; Online: Letter to the Editor Regarding "A Report of Outcomes After Orthotopic Liver Transplant With Allografts From Heparin Antibody-Positive Donors".

To, Catherine / Allison, Teresa A

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2023 Volume 21, Issue 4, Page(s) 382–383

MeSH term(s)	Humans ; Liver Transplantation/adverse effects ; Heparin ; Tissue Donors ; Antibodies ; Allografts ; Retrospective Studies ; Graft Survival
Chemical Substances	Heparin (9005-49-6) ; Antibodies
Language	English
Publishing date	2023-04-21
Publishing country	Turkey
Document type	Letter
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2022.0218
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Zs.A 6632: Show issues

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Article ; Online: Healthcare utilization in Canadian children and young adults with asthma during the COVID-19 pandemic.

To, Teresa / Zhang, Kimball / Terebessy, Emilie / Zhu, Jingqin / Licskai, Christopher

PloS one

2023 Volume 18, Issue 1, Page(s) e0280362

Abstract: Literature is limited regarding the COVID-19 pandemic's impact on health services use in younger Canadian populations with asthma. We utilized health administrative databases from January 2019-December 2021 for a population-based cross-sectional study to ...

Abstract	Literature is limited regarding the COVID-19 pandemic's impact on health services use in younger Canadian populations with asthma. We utilized health administrative databases from January 2019-December 2021 for a population-based cross-sectional study to identify Ontario residents 0-25 years old with physician-diagnosed asthma and calculate rates of healthcare use. Multivariable negative binomial regression analysis was used to adjust for confounders. We included 716,690 children and young adults ≤25 years. There was a sharp increase of ICS and SABA prescription rates at the start of the pandemic (March 2020) of 61.7% and 54.6%, respectively. Monthly virtual physician visit rates increased from zero to 0.23 per 100 asthma population during the pandemic. After adjusting for potential confounders, rate ratios (RR) with 95% confidence intervals (CI) showed that the pandemic was associated with significant decrease in hospital admissions (RR = 0.21, 95% CI: 0.18-0.24), emergency department visits (RR = 0.35, 95% CI: 0.34-0.37), and physician visits (RR = 0.61, 95% CI: 0.60-0.61). ICS and SABA prescriptions filled also significantly decreased during the pandemic (RR = 0.58, 95% CI: 0.57-0.60 and RR = 0.47, 95% CI: 0.46-0.48, respectively). This Canadian population-based asthma study demonstrated a dramatic decline in physician and emergency department visits, hospitalizations, and medication prescriptions filled during the COVID-19 pandemic. An extensive evaluation of the factors contributing to an 80% reduction in the risk of hospitalization may inform post-pandemic asthma management.
MeSH term(s)	Humans ; Child ; Young Adult ; Infant, Newborn ; Infant ; Child, Preschool ; Adolescent ; Adult ; Pandemics ; Cross-Sectional Studies ; COVID-19/epidemiology ; Asthma/drug therapy ; Asthma/epidemiology ; Hospitalization ; Emergency Service, Hospital ; Patient Acceptance of Health Care ; Ontario/epidemiology
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0280362
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Article ; Online: Reply.

Finkelstein, Yaron / To, Teresa

The Journal of pediatrics

2019 Volume 212, Page(s) 248–249

MeSH term(s)	Acetates ; Asthma ; Case-Control Studies ; Child ; Humans ; Quinolines
Chemical Substances	Acetates ; Quinolines ; montelukast (MHM278SD3E)
Language	English
Publishing date	2019-06-11
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2019.05.022
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Um IV Zs.116: Show issues

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Article ; Online: Mortality of Pediatric Surgical Lung Biopsies in Ontario, Canada, 2000-2019.

Wee, Wallace B / Shapera, Shane / To, Teresa / Chiu, Priscilla P L / Dell, Sharon D / Fisher, Jolene H

Annals of the American Thoracic Society

2024 Volume 21, Issue 5, Page(s) 767–773

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Ontario/epidemiology ; Male ; Female ; Child ; Biopsy/statistics & numerical data ; Child, Preschool ; Adolescent ; Infant ; Risk Factors ; Lung Diseases/pathology ; Lung Diseases/mortality ; Lung Diseases/surgery ; Lung/pathology ; Lung/surgery ; Infant, Newborn ; Logistic Models ; Retrospective Studies
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202304-306OC
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Zs.A 5828: Show issues

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Article ; Online: Epidemiology of paediatric out-of-hospital cardiac arrest in Ontario, Canada.

Tijssen, Janice A / McClean, Marisha / Lam, Melody / Le, Britney / To, Teresa

Resuscitation plus

2023 Volume 15, Page(s) 100442

Abstract: Background: There are no Canadian epidemiological studies of Paediatric Out-of-Hospital Cardiac Arrest (POHCA) for ≥20 years. Understanding the epidemiology of POHCA is key to prevention, education, and management strategies.: Methods: We applied a ... ...

Abstract	Background: There are no Canadian epidemiological studies of Paediatric Out-of-Hospital Cardiac Arrest (POHCA) for ≥20 years. Understanding the epidemiology of POHCA is key to prevention, education, and management strategies. Methods: We applied a validated algorithm to hospital administrative databases to describe paediatric (age 1 day to ≤18 years) atraumatic OHCA in Ontario from 2004-2020. Results: The cohort included 1,839 paediatric patients with atraumatic POHCA occurring at a median (IQR) age of 2 (0-12) years with 721 (39.2%) POHCA events in <1-year-olds. Males accounted for 71.1% ( Conclusions: This is the largest Canadian POHCA cohort and the first to describe its incidence, comorbidities, and sociodemographic characteristics. We found an increase in annual crude incidence, POHCA mostly occurred in healthy children, and survival was similar to other cohorts. There were more than double the number of POHCA events in children living in the lowest income quintile neighborhoods compared to the highest. Most children presented to non-academic hospitals first.
Language	English
Publishing date	2023-08-05
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2023.100442
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Article ; Online: Health Inequity and Time From Pediatric Stroke Onset to Arrival.

Pai, Akshat M / To, Teresa / deVeber, Gabrielle A / Nichol, Daniel / Kassner, Andrea / Ertl-Wagner, Birgit / Rafay, Mubeen F / Dlamini, Nomazulu

Stroke

2024 Volume 55, Issue 5, Page(s) 1299–1307

Abstract: Background: Time from stroke onset to hospital arrival determines treatment and impacts outcome. Structural, socioeconomic, and environmental factors are associated with health inequity and onset-to-arrival in adult stroke. We aimed to assess the ... ...

Abstract	Background: Time from stroke onset to hospital arrival determines treatment and impacts outcome. Structural, socioeconomic, and environmental factors are associated with health inequity and onset-to-arrival in adult stroke. We aimed to assess the association between health inequity and onset-to-arrival in a pediatric comprehensive stroke center. Methods: A retrospective observational study was conducted on a consecutive cohort of children (>28 days-18 years) diagnosed with acute arterial ischemic stroke (AIS) between 2004 and 2019. Neighborhood-level material deprivation was derived from residential postal codes and used as a proxy measure for health inequity. Patients were stratified by level of neighborhood-level material deprivation, and onset-to-arrival was categorized into 3 groups: <6, 6 to 24, and >24 hours. Association between neighborhood-level material deprivation and onset-to-arrival was assessed in multivariable ordinal logistic regression analyses adjusting for sociodemographic and clinical factors. Results: Two hundred and twenty-nine children were included (61% male; median age [interquartile range] at stroke diagnosis 5.8-years [1.1-11.3]). Over the 16-year study period, there was an increase in proportion of children diagnosed with AIS living in the most deprived neighborhoods and arriving at the emergency room within 6 hours ( Conclusions: Our study suggests an increase in pediatric stroke in deprived neighborhoods and certain communities, and earlier arrival times to the emergency room over time. However, whether these changes are due to an increase in incidence of childhood AIS or increased awareness and diagnosis is yet to be determined. The association between AIS risk factors and material deprivation highlights the intersectionality of clinical factors and social determinants of health. Finally, whether material deprivation impacts onset-to-arrival is likely complex and requires further examination.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.123.045411
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Zs.A 448: Show issues

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Article: Is overreliance on short-acting β

To, Teresa / Zhu, Jingqin / Terebessy, Emilie / Zhang, Kimball / Gershon, Andrea S / Licskai, Christopher

ERJ open research

2022 Volume 8, Issue 1

Abstract: Recent Global Initiative for Asthma (GINA) recommendations reduce the role of short-acting ... ...

Abstract	Recent Global Initiative for Asthma (GINA) recommendations reduce the role of short-acting β
Language	English
Publishing date	2022-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00032-2022
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Article ; Online: Tissue Engineering Graft for Urethral Reconstruction: Is It Ready for Clinical Application?

Ortac, Mazhar / Ekerhult, Teresa Olsen / Zhao, Weixin / Atala, Anthony

Urology research & practice

2023 Volume 49, Issue 1, Page(s) 11–18

Abstract: Despite developing surgical techniques in urethral surgery, the outcome and complications are still unsatisfactory. Alternative treatment modality has been coming up, particularly in patients with longer stricture, under revision surgery, and penile ... ...

Abstract	Despite developing surgical techniques in urethral surgery, the outcome and complications are still unsatisfactory. Alternative treatment modality has been coming up, particularly in patients with longer stricture, under revision surgery, and penile stricture. Tissue engineering grafts are a promising approach for substituting urethral reconstruction. Over the decades, numerous preclinical studies have been published to show the efficacy and safety of different origins of materials, the presence of autologous cells (acellular matrices or autologous cell-seeded matrices), and the construction of engineered tissue (patch or tubularized constructs) on animal models. However, the results of these studies have not yet reached the intended level for daily clinical practice. A PubMed database search was performed for articles, using specific keywords, published between 1998 and 2022, with a selection on using tissue-engineered grafts for urethroplasty. Many materials have been used as a graft, such as acellular bladder matrix, small intestinal submucosa, acellular dermal matrix, and polyglycolic acid with or without cells, and were evaluated according to the functional and anatomical outcomes comprising complications. According to current literature, tubularized scaffolds constructed from co-cultured cells have promising results for the future. However, high-quality evidence through randomized controlled studies with larger sample sizes, with a long-term follow-up is required to determine accurate outcomes.
Language	English
Publishing date	2023-10-25
Publishing country	Turkey
Document type	Journal Article
ISSN	2980-1478
ISSN (online)	2980-1478
DOI	10.5152/tud.2023.22226
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Article ; Online: Sociodemographic Factors and Trends in Bronchiolitis-Related Emergency Department Visit and Hospitalization Rates.

Mahant, Sanjay / Borkhoff, Cornelia M / Parkin, Patricia C / Imsirovic, Haris / Tuna, Meltem / Macarthur, Colin / To, Teresa / Gill, Peter J

JAMA network open

2024 Volume 7, Issue 4, Page(s) e248976

Abstract: Importance: Bronchiolitis is the most common and most cumulatively expensive condition in pediatric hospital care. Few population-based studies have examined health inequalities in bronchiolitis outcomes over time.: Objective: To examine trends in ... ...

Abstract	Importance: Bronchiolitis is the most common and most cumulatively expensive condition in pediatric hospital care. Few population-based studies have examined health inequalities in bronchiolitis outcomes over time. Objective: To examine trends in bronchiolitis-related emergency department (ED) visit and hospitalization rates by sociodemographic factors in a universally funded health care system. Design, setting, and participants: This repeated cross-sectional cohort study was performed from April 1, 2004, to March 31, 2022, using population-based health administrative data from children younger than 2 years in Ontario, Canada. Main outcome and measures: Bronchiolitis ED visit and hospitalization rates per 1000 person-years reported for the equity stratifiers of sex, residence location (rural vs urban), and material resources quintile. Trends in annual rates by equity stratifiers were analyzed using joinpoint regression and estimating the average annual percentage change (AAPC) with 95% CI and the absolute difference in AAPC with 95% CI from April 1, 2004, to March 31, 2020. Results: Of 2 921 573 children included in the study, 1 422 088 (48.7%) were female and 2 619 139 (89.6%) lived in an urban location. Emergency department visit and hospitalization rates were highest for boys, those with rural residence, and those with least material resources. There were no significant between-group absolute differences in the AAPC in ED visits per 1000 person-years by sex (female vs male; 0.22; 95% CI, -0.92 to 1.35; P = .71), residence (rural vs urban; -0.31; 95% CI -1.70 to 1.09; P = .67), or material resources (quintile 5 vs 1; -1.17; 95% CI, -2.57 to 0.22; P = .10). Similarly, there were no significant between-group absolute differences in the AAPC in hospitalizations per 1000 person-years by sex (female vs male; 0.53; 95% CI, -1.11 to 2.17; P = .53), residence (rural vs urban; -0.62; 95% CI, -2.63 to 1.40; P = .55), or material resources (quintile 5 vs 1; -0.93; 95% CI -3.80 to 1.93; P = .52). Conclusions and relevance: In this population-based cohort study of children in a universally funded health care system, inequalities in bronchiolitis ED visit and hospitalization rates did not improve over time.
MeSH term(s)	Humans ; Emergency Service, Hospital/statistics & numerical data ; Emergency Service, Hospital/trends ; Male ; Female ; Hospitalization/statistics & numerical data ; Hospitalization/trends ; Infant ; Bronchiolitis/epidemiology ; Bronchiolitis/therapy ; Ontario/epidemiology ; Cross-Sectional Studies ; Sociodemographic Factors ; Rural Population/statistics & numerical data ; Rural Population/trends ; Infant, Newborn ; Cohort Studies ; Urban Population/statistics & numerical data ; Urban Population/trends ; Child, Preschool ; Emergency Room Visits
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2024.8976
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Article ; Online: Early life exposure to pollens and increased risks of childhood asthma: a prospective cohort study in Ontario children.

Stanescu, Cristina / Talarico, Robert / Weichenthal, Scott / Villeneuve, Paul J / Smargiassi, Audrey / Stieb, David M / To, Teresa / Hebbern, Christopher / Crighton, Eric / Lavigne, Éric

The European respiratory journal

2024 Volume 63, Issue 4

MeSH term(s)	Child ; Humans ; Prospective Studies ; Ontario/epidemiology ; Asthma/epidemiology ; Pollen ; Environmental Exposure/adverse effects
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Letter
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.01568-2023
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 292: Show issues

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