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Article ; Online: Effect of Babao Dan on angiogenesis of gastric cancer

Guan, Jian-Hua / Cao, Zhi-Yun / Guan, Bin / Wei, Li-Hui / Peng, Jun / Chen, You-Qin / Sferra, Thomas Joseph / Sankararaman, Senthilkumar / Zhan, Zhi-Xue / Lin, Jiu-Mao

Translational cancer research

2022 Volume 10, Issue 2, Page(s) 953–965

Abstract: Background: To further elucidate the anti-angiogenesis effect of Babao Dan (BBD) : Methods ...

Abstract	Background: To further elucidate the anti-angiogenesis effect of Babao Dan (BBD) Methods: After induced by VEGFA, GC cells (AGS, MGC80-3 and BGC823) were treated by different concentrations of BBD and then were detected cell viability, migration and VEGFA level. And the anti-angiogenesis effect of BBD was evaluated with HUVECs. To furtherly mimic the tumor microenvironment of angiogenesis, VEGFA as an inducer (10 ng/mL) was used to trigger a cascade of angiogenesis of HUVECs Results: The viability and migration of GC cells with VEGFA-induced or non-induced and VEGFA levels in GC cells were significantly inhibited by BBD with concentration-dependent manner (P<0.01). BBD significantly inhibited the HUVECs viability with concentration-dependent manner (P<0.01), which was consistent with the inhibitory action on augmentation of cell viability induced by VEGFA (P<0.01). BBD exhibited the similar inhibitory trend on cyto behavioral variability such as wound repairing (P<0.05), migration (P<0.01) and tube formation (P<0.01) and activation effect on cell apoptosis rate (P<0.01) with VEGFA-induced or non-induced. Moreover, BBD notably regulated the levels of VEGFA, VEGFR2, matrix metalloprotein 2 (MMP2) and matrix metalloprotein 9 (MMP9) of HUVECs on present or absent of VEGFA with dose-dependent manner. Conclusions: BBD inhibited GC growth against VEGFA-induced angiogenesis of HUVECs by VEGFA/VEGFR2 signaling pathway
Language	English
Publishing date	2022-01-15
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-20-2559
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Article ; Online: A network pharmacology-based study of the potential targets and mechanisms of action of Qibao Meiran Dan in delaying skin aging.

Ke, Dan / Zhang, Han / Tian, Li-Ming / Han, Miao / Zhang, Chong / Tian, Dai-Zhi / Chen, Long / Zhan, Li-Rui / Zong, Shi-Qin / Zhang, Ping

Journal of cosmetic dermatology

2022 Volume 21, Issue 10, Page(s) 4956–4964

Abstract: ... and mechanisms of action of Qibao Meiran Dan in relation to delaying skin aging.: Methods ... integrated database, were used to screen the active ingredients and targets of Qibao Meiran Dan ... showed that cell morphology was clearer and more refractive in the Qibao Meiran Dan group ...

Abstract	Objective: The aim of this study was to use network pharmacology to explore the potential targets and mechanisms of action of Qibao Meiran Dan in relation to delaying skin aging. Methods: The traditional Chinese medicine systems pharmacology database and analysis platform, and the traditional Chinese medicine integrated database, were used to screen the active ingredients and targets of Qibao Meiran Dan. The human gene database GeneCards and the gene database of the National Center for Biotechnology Information were jointly adopted to obtain skin aging-related target genes. The search tool for the retrieval of interacting genes/proteins (STRING) database was used for core analysis of protein-protein interaction. Results: In total, 72 effective active ingredients, 273 action targets, 234 skin aging target genes, and 64 intersecting core targets were identified. GO enrichment analysis provided 393 biological process entries, and the KEGG analysis was represented by the tumor necrosis factor (TNF) signaling pathway, where the core targets of TNF-α and matrix metalloproteinase-1 (MMP-1) were enriched. The experimental results showed that cell morphology was clearer and more refractive in the Qibao Meiran Dan group than in the model group. Conclusion: Qibao Meiran Dan may regulate oxidative stress injury and collagen metabolism by downregulating the expression of TNF-α and MMP-1, thus slowing skin aging.
MeSH term(s)	Humans ; Drugs, Chinese Herbal/pharmacology ; Matrix Metalloproteinase 1/genetics ; Skin Aging ; Tumor Necrosis Factor-alpha ; Network Pharmacology
Chemical Substances	Drugs, Chinese Herbal ; Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14908
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Article ; Online: Transition metal-free B(dan)-installing reaction (dan: naphthalene-1,8-diaminato): H-B(dan) as a B(dan) electrophile.

Li, Jialun / Seki, Michinari / Kamio, Shintaro / Yoshida, Hiroto

Chemical communications (Cambridge, England)

2020 Volume 56, Issue 47, Page(s) 6388–6391

Abstract: H-B(dan) was demonstrated to serve as a B(dan) electrophile, despite its highly diminished boron ... Lewis acidity, leading to direct and transition metal-free approach to R-B(dan) of high synthetic ... utility upon treatment with Grignard reagents. Iterative cross-coupling of 5-bromo-2-pyridyl-B(dan ...

Abstract	H-B(dan) was demonstrated to serve as a B(dan) electrophile, despite its highly diminished boron-Lewis acidity, leading to direct and transition metal-free approach to R-B(dan) of high synthetic utility upon treatment with Grignard reagents. Iterative cross-coupling of 5-bromo-2-pyridyl-B(dan), synthesized by the present method, was also achieved.
Language	English
Publishing date	2020-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d0cc02560g
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Article ; Online: Multiomics profiling of the therapeutic effect of Dan-deng-tong-nao capsule on cerebral ischemia-reperfusion injury.

Shi, Yingying / Du, Qiuzheng / Li, Zhuolun / Xue, Lianping / Jia, Qingquan / Zheng, Tianyuan / Liu, Jiyun / Ren, Ruobing / Sun, Zhi

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 128, Page(s) 155335

Abstract: ... and metabolic disorders. Dan-deng-tong-nao capsule (DDTN) is a traditional Chinese medicine used ...

Abstract	Background: Stroke is a complex physiological process associated with intestinal flora dysbiosis and metabolic disorders. Dan-deng-tong-nao capsule (DDTN) is a traditional Chinese medicine used clinically to treat cerebral ischemia-reperfusion injury (CIRI) for many years. However, little is known about the effects of DDTN in the treatment of CIRI from the perspective of gut microbiota and metabolites. Purpose: This study aimed to investigate the regulatory roles of DDTN in endogenous metabolism and gut microbiota in CIRI rats, thus providing a basis for clinical rational drug use and discovering natural products with potential physiological activities in DDTN for the treatment of CIRI. Methods: The chemical composition of DDTN in vitro and in vivo was investigated using ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLCHRMS), followed by target prediction using reverse molecular docking. Secondly, a biological evaluation of DDTN ameliorating neural damage in CIRI was performed at the whole animal level. Then, an integrated omics approach based on UHPLCHRMS and 16S rRNA sequencing was proposed to reveal the anti-CIRI effect and possible mechanism of DDTN. Finally, exploring the intrinsic link between changes in metabolite profiles, changes in the intestinal flora, and targets of components to reveal DDTN for the treatment of CIRI. Results: A total of 112 chemical components of DDTN were identified in vitro and 10 absorbed constituents in vivo. The efficacy of DDTN in the treatment of CIRI was confirmed by alleviating cerebral infarction and neurological deficits. After the DDTN intervention, 21 and 26 metabolites were significantly altered in plasma and fecal, respectively. Based on the fecal microbiome, a total of 36 genera were enriched among the different groups. Finally, the results of the network integration analysis showed that the 10 potential active ingredients of DDTN could mediate the differential expression of 24 metabolites and 6 gut microbes by targeting 25 target proteins. Conclusion: This study was the first to outline the landscapes of metabolites as well as gut microbiota regulated by DDTN in CIRI rats using multi-omics data, and comprehensively revealed the systematic relationships among ingredients, targets, metabolites, and gut microbiota, thus providing new perspectives on the mechanism of DDTN in the treatment of CIRI.
MeSH term(s)	Animals ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/chemistry ; Reperfusion Injury/drug therapy ; Gastrointestinal Microbiome/drug effects ; Male ; Rats, Sprague-Dawley ; Rats ; Brain Ischemia/drug therapy ; Molecular Docking Simulation ; Chromatography, High Pressure Liquid ; RNA, Ribosomal, 16S ; Capsules ; Multiomics
Chemical Substances	Drugs, Chinese Herbal ; RNA, Ribosomal, 16S ; Capsules
Language	English
Publishing date	2024-01-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.155335
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Article ; Online: A newly-discovered tea population variety processed Bai Mu Dan white tea: Flavor characteristics and chemical basis.

Lin, Yanping / Huang, Yibiao / Zhou, Su / Li, Xiaolan / Tao, Yike / Pan, Yani / Feng, Xinyu / Guo, Haowei / Chen, Ping / Chu, Qiang

Food chemistry

2024 Volume 446, Page(s) 138851

Abstract: The quality of white tea (WT) is impacted by selected tea cultivars. To explore the organoleptic quality of a recently-discovered WT ("Caicha", CC), HS-SPME/GC-MS and UPLC were employed to identify volatile and non-volatile compounds in tea samples. ... ...

Abstract	The quality of white tea (WT) is impacted by selected tea cultivars. To explore the organoleptic quality of a recently-discovered WT ("Caicha", CC), HS-SPME/GC-MS and UPLC were employed to identify volatile and non-volatile compounds in tea samples. Multiple statistical methods demonstrated the distinctions between CC and four mainstream WT varieties from main producing areas. CC exhibited abundant volatile alcohol, terpenoids, ketone, aldehyde and ester, as well as non-volatile lignans and coumarins, phenolic acids and low-molecular carbohydrates. These substances combinedly contributed to the flavor attributes of CC, characterized by an intense herbal/citrus-like cleanness and flower/fruit-like sweetness, scarce in existing commercial WT varieties. Sensory evaluation corroborated these findings. In conclusion, we have processed a new tea variety (CC) with WT manufacturing technology, and discovered the unique cleanness and sweetness of it. This study enriches the raw material database for WT production and blending, and boosts the development of more premium WT varieties.
MeSH term(s)	Tea/chemistry ; Camellia sinensis/chemistry ; Volatile Organic Compounds/analysis ; Gas Chromatography-Mass Spectrometry/methods ; Lignans
Chemical Substances	Tea ; Volatile Organic Compounds ; Lignans
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138851
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Book ; Online: RecSys-DAN

Wang, Cheng / Niepert, Mathias / Li, Hui

Discriminative Adversarial Networks for Cross-Domain Recommender Systems

2019

Abstract: ... RecSys-DAN focuses on alleviating the cross-domain and within-domain data sparsity and data imbalance and ... for a discriminator. Four neural architectural instances of ResSys-DAN are proposed and explored. Empirical results ... RecSys-DAN achieves competitive performance as compared to the state-of-the-art supervised methods. More ...

Abstract	Data sparsity and data imbalance are practical and challenging issues in cross-domain recommender systems. This paper addresses those problems by leveraging the concepts which derive from representation learning, adversarial learning and transfer learning (particularly, domain adaptation). Although various transfer learning methods have shown promising performance in this context, our proposed novel method RecSys-DAN focuses on alleviating the cross-domain and within-domain data sparsity and data imbalance and learns transferable latent representations for users, items and their interactions. Different from existing approaches, the proposed method transfers the latent representations from a source domain to a target domain in an adversarial way. The mapping functions in the target domain are learned by playing a min-max game with an adversarial loss, aiming to generate domain indistinguishable representations for a discriminator. Four neural architectural instances of ResSys-DAN are proposed and explored. Empirical results on real-world Amazon data show that, even without using labeled data (i.e., ratings) in the target domain, RecSys-DAN achieves competitive performance as compared to the state-of-the-art supervised methods. More importantly, RecSys-DAN is highly flexible to both unimodal and multimodal scenarios, and thus it is more robust to the cold-start recommendation which is difficult for previous methods. Comment: 10 pages, IEEE-TNNLS
Keywords	Computer Science - Information Retrieval ; Computer Science - Machine Learning
Subject code	006
Publishing date	2019-03-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dan-Deng-Tong-Nao softgel capsule promotes angiogenesis of cerebral microvasculature to protect cerebral ischemia reperfusion injury via activating HIF-1α-VEGFA-Notch1 signaling pathway.

Wang, Lei / Li, Jiacheng / Wang, Yang / Ge, Chaowen / Huang, Qi / Li, Lili / Wang, Ning / Chen, Yuang / Zhou, Xian / Chang, Dennis / Li, Dan / Hou, Jincai

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 118, Page(s) 154966

Abstract: Background: A proprietary Chinese herbal product called Dan-Deng-Tong-Nao softgel capsule (DDTNC ...

Abstract	Background: A proprietary Chinese herbal product called Dan-Deng-Tong-Nao softgel capsule (DDTNC) is used to treat ischemic stroke. However, the preventive mechanisms of DDTNC against cerebral ischemia reperfusion injury (CIRI) haven not been characterized. Objective: To explore the mechanisms of protective effects of DDTNC against CIRI from both internal and external levels. Methods: Chemical characterization was performed using UPLC. The potential protective mechanisms of DDTNC against CIRI were predicted using network pharmacology. Model of middle cerebral artery occlusion/reperfusion (MCAO/R) was established in rats. An model of brain microvascular endothelial cells (BMECs) induced by oxygen-glucose deprivation/reoxygenation (OGD/R) was also established. We evaluated neurological deficits, cerebral infarct volume, cortical neuron damage, and mitochondrial swelling in vivo. We evaluated the expression of VEGFR2, VEGFA, HIF-1α, CD31, and CD34 in ischemic cortex, and VEGF, bFGF, BDNF, angiostatin, and endostatin in serum of rats and in BMEC supernatants. We also evaluated cell viability, cytotoxicity, intracellular ROS, apoptosis, and migration ability in vitro. Results: Seven components were detected in DDTNC. KEGG enrichment analysis showed that DDTNC may modulate angiogenesis via the HIF-1 signaling pathway. DDTNC treatment reduced neurological score and infarct volume, and improved cell morphology of damaged neurons. Transmission electron microscopy showed that DDTNC reduced mitochondria swelling in cortical neurons. Furthermore, DDTNC reduced intracellular ROS and inhibited apoptosis. DDTNC boosted the expression of CD31, CD34, VEGFR2, VEGFA and HIF-1α, highlighting its involvement in angiogenesis, according to immunofluorescence studies. Furthermore, DDTNC enhanced tube formation and migration of BMECs in vitro. ELISA and western blotting indicated that DDTNCCSF induced the expression of VEGF, BDNF and bFGF, reduced the level of angiostatin and endostatin, increased the protein expression of VEGFA, Notch1 and HIF-1α in vitro and in vivo. Conclusions: DDTNC promoted angiogenesis to protect brain tissue against MCAO/R, and exerted protective effects against OGD/R in BMECs via activating HIF-1α-VEGFA-NOTCH1 signal transduction pathway.
MeSH term(s)	Rats ; Animals ; Endothelial Cells ; Vascular Endothelial Growth Factor A/metabolism ; Angiostatins/metabolism ; Angiostatins/pharmacology ; Angiostatins/therapeutic use ; Brain-Derived Neurotrophic Factor/metabolism ; Endostatins/metabolism ; Endostatins/pharmacology ; Endostatins/therapeutic use ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Microvessels/metabolism ; Receptor, Notch1/metabolism
Chemical Substances	Vascular Endothelial Growth Factor A ; Angiostatins (86090-08-6) ; Brain-Derived Neurotrophic Factor ; Endostatins ; Reactive Oxygen Species ; Notch1 protein, rat ; Receptor, Notch1
Language	English
Publishing date	2023-07-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154966
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Article ; Online: Ethynyl-B(dan) in [3+2] Cycloaddition and Larock Indole Synthesis: Synthesis of Stable Boron-Containing Heteroaromatic Compounds.

Li, Jialun / Tanaka, Hideya / Imagawa, Taiki / Tsushima, Takumi / Nakamoto, Masaaki / Tan, Jiajing / Yoshida, Hiroto

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 30, Issue 8, Page(s) e202303403

Abstract: The cycloaddition of nitrile oxides with ethynyl-B(dan) (dan=naphthalene-1,8-diaminato) allowed ... the facile preparation of diverse isoxazolyl-B(dan) compounds, all of which displayed excellent ... protodeborylation-resistant properties. The dan-installation on the boron center proves vital to the high stability ...

Abstract	The cycloaddition of nitrile oxides with ethynyl-B(dan) (dan=naphthalene-1,8-diaminato) allowed the facile preparation of diverse isoxazolyl-B(dan) compounds, all of which displayed excellent protodeborylation-resistant properties. The dan-installation on the boron center proves vital to the high stability of the products as well as the perfect regioselectivity arising from hydrogen bond-directed orientation in the cycloaddition. The diminished boron-Lewis acidity of ethynyl-B(dan) also renders it amenable to azide-alkyne cycloaddition, Larock indole synthesis and related heteroannulations. The obtained boron-containing triazole, indoles, benzofuran and indenone exhibit sufficient resistance toward protodeborylation. Despite the commonly accepted transmetalation-inactive property derived from the diminished Lewis acidity, the synthesized heteroaryl-B(dan) compound was still found to be convertible to the oligoarene via sequential Suzuki-Miyaura coupling.
Language	English
Publishing date	2023-12-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202303403
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Article: [Effects of Li-Dan-He-Ji on regulating oxidative stress and antagonising infantile cholestatic hepatic fibrosis].

Yi, Wei / Yan, Suqi / Tang, Jianqiao / Ma, Xiang / Su, Mengjie / Li, Hong

Zhonghua wei zhong bing ji jiu yi xue

2023 Volume 35, Issue 7, Page(s) 741–745

Abstract: Objective: To explore the clinical effect of Li-Dan-He-Ji in the treatment of infantile ... randomized controlled trial. They were divided into the conventional treatment group and Li-Dan-He-Ji group according ... according to the guidelines. In the Li-Dan-He-Ji group, the self-made Chinese medicinal compound Li-Dan ...

Abstract	Objective: To explore the clinical effect of Li-Dan-He-Ji in the treatment of infantile cholestatic hepatic fibrosis. Methods: Patients who met the diagnostic criteria of infantile cholestatic hepatic fibrosis in the department of integrated traditional Chinese and Western medicine and the department of gastroenterology of Wuhan Children's Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology from January to December 2021 were included in the study by prospective randomized controlled trial. They were divided into the conventional treatment group and Li-Dan-He-Ji group according to the random number table. The patients in the conventional treatment group were given conventional treatment according to the guidelines. In the Li-Dan-He-Ji group, the self-made Chinese medicinal compound Li-Dan-He-Ji (prescription: Herba Artemisiae Scopariae, Fructus Forsythiae, Radix et Rhizoma Rhei preparata, Radix Polygoni Multiflori Preparata, Radix Paeoniae Rubra, Ramulus Cinnamomi, Fructus Aurantii, Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Carapax Trionycis, and Radix Glycyrrhizae) was given on the basis of the routine treatment, by oral, enema or nasal feeding, 60 mL each day, divided into 2 or 3 times, for 28 days. Outpatient follow-up was maintained for 4 weeks. Before and after treatment, serum liver fibrosis 4 items [type IV collagen (IV-C), hyaluronidase (HA), type III procollagen (PC III), laminin (LN)], liver function and cholestasis-related markers [total bilirubin (TBil), direct bilirubin (DBil), total bile acid (TBA), alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γ-GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST)], oxidative stress markers [superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH)], liver stiffness measurement (LSM) detected by transient elastography (TE), aspartate aminotransferase-to-platelet ratio index (APRI), and liver and spleen retraction time were recorded in the two groups. Results: During the observation period, a total of 40 cases of cholestatic hepatic fibrosis were treated, including 21 cases in the conventional treatment group and 19 cases in the Li-Dan-He-Ji group. Before treatment, the differences in serum liver fibrosis 4 items, serum liver function and cholestasis-related markers, oxidative stress indexes, LSM and APRI of the two groups were not statistically significant. After treatment, the liver fibrosis 4 items, liver function and cholestasis-related markers, LSM, and APRI were all significantly decreased in both groups, and the indexes in the Li-Dan-He-Ji group were significantly lower than those in the conventional treatment group [HA (ng/L): 165.81±21.57 vs. 203.87±25.88, PC III (μg/L): 69.86±9.32 vs. 81.82±7.39, IV-C (μg/L): 204.14±38.97 vs. 239.08±24.93, LN (μg/L): 162.40±17.39 vs. 190.86±15.97, TBil (μmol/L): 37.58±27.63 vs. 53.06±45.09, DBil (μmol/L): 20.55±19.34 vs. 30.08±27.39, ALP (U/L): 436.50±217.58 vs. 469.60±291.69, γ-GGT (U/L): 66.78±35.84 vs. 87.00±32.82, ALT (U/L): 64.75±50.53 vs. 75.20±50.19, AST (U/L): 77.25±54.23 vs. 96.80±59.77, TBA (μmol/L): 74.35±44.44 vs. 85.45±39.50, LSM (kPa): 5.24±0.39 vs. 7.53±3.16, APRI: 0.52±0.39 vs. 0.98±0.29, all P < 0.05]. After treatment, MDA in the two groups were significantly lower than those before treatment, and SOD and GSH were significantly higher than those before treatment. The level of SOD in the Li-Dan-He-Ji group was significantly higher than that in the conventional treatment group (kU/L: 64.56±6.69 vs. 51.58±5.98, P < 0.05). In addition, the liver retraction time (day: 20.13±10.97 vs. 24.33±13.46) and spleen retraction time (day: 25.93±13.01 vs. 29.14±14.52) in the Li-Dan-He-Ji group were significantly shorter than those in the conventional treatment group (both P < 0.05). Conclusions: The use of Li-Dan-He-Ji in the treatment of cholestatic hepatic fibrosis can effectively improve the indicators of cholestasis, hepatic fibrosis, oxidative stress and clinical symptoms in children.
MeSH term(s)	Child ; Humans ; Prospective Studies ; Cholestasis/drug therapy ; Cholestasis/metabolism ; Cholestasis/pathology ; Liver ; Liver Cirrhosis/drug therapy ; Bilirubin/metabolism ; Bilirubin/pharmacology ; Oxidative Stress ; Aspartate Aminotransferases/metabolism ; Superoxide Dismutase/metabolism
Chemical Substances	Bilirubin (RFM9X3LJ49) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Superoxide Dismutase (EC 1.15.1.1)
Language	Chinese
Publishing date	2023-08-07
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.cn121430-20230316-00186
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Article: Effect of Dan-Lou tablets on coronary heart disease revealed by microarray analysis integrated with molecular mechanism studies.

Li, Zhu / Cheng, Qi / He, Yuanyuan / Wang, Shuo / Xie, Jing / Zheng, Yanchao / Liu, Yijia / Li, Lin / Gao, Shan / Yu, Chunquan

Heliyon

2023 Volume 9, Issue 5, Page(s) e15777

Abstract: Dan-Lou tablets (DLT) effectively treat coronary heart disease (CHD). However, its pharmacological ...

Abstract	Dan-Lou tablets (DLT) effectively treat coronary heart disease (CHD). However, its pharmacological mechanism in CHD treatment requires further investigation. This study aimed to elucidate the underlying pharmacological mechanisms of DLT in the treatment of CHD through clinical trials, microarray research, bioinformatics analysis, and molecular mechanism research. In this study, DLT improved coagulation function, endothelial injury, and levels of lipids, metalloproteases, adhesion molecules, inflammatory mediators, and homocysteine. The results of molecular biology research demonstrated that DLT can increase the gene and protein expressions of meningioma expressed antigen 5 (MGEA5) and mouse doubleminute 2 (MDM2) and inhibited the gene and protein expressions of signal transcription and transcription activator 5 B (STAT5B), tropomyosin-1 (TPM1), and aromatic hydrocarbon receptor nuclear transpose (ARNT). The results indicate that DLT reduced the extent of vascular endothelial damage in CHD rats by reducing the expressions of STAT5B, TPM1, and MDM2; inhibiting the inflammatory reaction; and increasing the expressions of ARNT and MGEA5.
Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15777
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