LIVIVO - Search results -

Search results

Result 1 - 10 of total 277776

Search options

Article ; Online: Deciphering the molecular mechanism of Bu Yang Huan Wu Decoction in interference with diabetic pulmonary fibrosis via regulating oxidative stress and lipid metabolism disorder.

Guo, Junfeng / Zhang, Yuwei / Zhou, Rui / Hao, Yanwei / Wu, Xuanyu / Li, Ganggang / Du, Quanyu

Journal of pharmaceutical and biomedical analysis

2024 Volume 243, Page(s) 116061

Abstract: ... but its treatment has yet to be thoroughly investigated. Bu Yang Huan Wu Decoction (BYHWD) is a well-known ...

Abstract	Background: Diabetes mellitus type 2 and pulmonary fibrosis have been found to be closely related in clinical practice. Diabetic pulmonary fibrosis (DPF) is a complication of diabetes mellitus, but its treatment has yet to be thoroughly investigated. Bu Yang Huan Wu Decoction (BYHWD) is a well-known traditional Chinese prescription that has shown great efficacy in treating pulmonary fibrosis with hypoglycemic and hypolipidemic effects. Methods: The active ingredients of BYHWD and the corresponding targets were retrieved from the Traditional Chinese Medicine Systematic Pharmacology Database (TCMSP) and SymMap2. Disease-related targets were obtained from the GeneCard, OMIM and CTD databases. GO enrichment and KEGG pathway enrichment were carried out using the DAVID database. AutoDock Vina software was employed to perform molecular docking. Molecular dynamics simulations of proteinligand complexes were conducted by Gromacs. Animal experiments were further performed to validate the effects of BYHWD on the selected core targets, markers of oxidative stress, serum lipids, blood glucose and pulmonary fibrosis. Results: A total of 84 active ingredients and 830 target genes were screened in BYHWD, among which 56 target genes intersected with DPF-related targets. Network pharmacological analysis revealed that the active ingredients can regulate target genes such as IL-6, TNF-α, VEGFA and CASP3, mainly through AGE-RAGE signaling pathway, HIF-1 signaling pathway and TNF signaling pathway. Molecular docking and molecular dynamics simulations suggested that IL6-astragaloside IV, IL6-baicalein, TNFα-astragaloside IV, and TNFα-baicalein docking complexes could bind stably. Animal experiments showed that BYHWD could reduce the expression of core targets such as VEGFA, CASP3, IL-6 and TNF-α. In addition, BYHWD could reduce blood glucose, lipid, and MDA levels in DPF while increasing the activities of SOD, CAT and GSH-Px. BYHWD attenuated the expression of HYP and collagen I, mitigating pathological damage and collagen deposition within lung tissue. Conclusions: BYHWD modulates lipid metabolism disorders and oxidative stress by targeting the core targets of IL6, TNF-α, VEGFA and CASP3 through the AGE-RAGE signaling pathway, making it a potential therapy for DPF.
MeSH term(s)	Animals ; Tumor Necrosis Factor-alpha ; Pulmonary Fibrosis/drug therapy ; Caspase 3 ; Interleukin-6 ; Blood Glucose ; Lipid Metabolism ; Molecular Docking Simulation ; Diabetes Mellitus, Type 2 ; Oxidative Stress ; Lipid Metabolism Disorders ; Collagen ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Saponins ; Triterpenes
Chemical Substances	Tumor Necrosis Factor-alpha ; astragaloside A (3A592W8XKE) ; Caspase 3 (EC 3.4.22.-) ; Interleukin-6 ; Blood Glucose ; Collagen (9007-34-5) ; Drugs, Chinese Herbal ; Saponins ; Triterpenes
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.116061
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1850: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Combination of UHPLC-Q Exactive-Orbitrap MS, Bioinformatics and Molecular Docking to Reveal the Mechanism of Huan-Lian-Jie-Du Decoction in the Treatment of Diabetic Encephalopathy.

Cao, Dong-Min / Liang, Qing-Feng / Zhang, Zhi-Tong / He, Wen-Jiao / Tang, Dan

Chemistry & biodiversity

2023 Volume 20, Issue 9, Page(s) e202300434

Abstract: Diabetic encephalopathy (DE) is a serious complication of diabetes, which affects patients' quality of life. We aimed to explore HLJDD in the treatment of DE by LC/MS and bioinformatics. UPLC-Q Exactive-Orbitrap MS was employed to clarify the compounds. ... ...

Abstract	Diabetic encephalopathy (DE) is a serious complication of diabetes, which affects patients' quality of life. We aimed to explore HLJDD in the treatment of DE by LC/MS and bioinformatics. UPLC-Q Exactive-Orbitrap MS was employed to clarify the compounds. The modules and hub targets of DE were gained from WGCNA. Subsequently, an Herb-Compound-Target network was constructed and enrichment analysis was used. In addition, a protein-protein interaction (PPI) network was constructed and molecular docking was used to verify the above analysis. As result, 138 compounds and 10 prototypes in brain were identified. In network pharmacology, 8 modules and 5692 hub targets were obtained from WGCNA. An Herb-Compound-Target network was constructed by 4 herbs, 10 compounds and 56 targets. The enrichment analysis showed that the treatment of DE with HLJDD involve oxidative stress and neuroprotection. Beside, SRC, JUN, STAT3, MAPK1 and PIK3R1 were identified and as hub targets of HLJDD in treating DE. Moreover, Molecular docking showed that five hub targets had strong affinity with the corresponding alkaloids. Therefore, we explored the underlying mechanisms of HLJDD in the treatment of DE and to provide the theoretical and scientific basis for subsequent experimental studies and clinical applications.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Drugs, Chinese Herbal/pharmacology ; Chromatography, High Pressure Liquid ; Quality of Life ; Computational Biology ; Diabetes Mellitus/drug therapy
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202300434
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Efficacy and safety of Jin-shui Huan-xian granule for idiopathic pulmonary fibrosis: study protocol for a multicenter, randomized, double-blind, placebo-controlled trial.

Yang, Shu-Guang / Yu, Xue-Qing / Li, Jian-Sheng / Xie, Yang / Zhang, Wei / Ban, Chengjun / Feng, Jihong / Wu, Lei / Lu, Xuechao / Zhao, Limin / Meng, Yong / Zhou, Miao / He, Yong / Luo, Weixian

Trials

2022 Volume 23, Issue 1, Page(s) 725

Abstract: ... limited treatments are available. Jin-shui Huan-xian granule (JHG), which is a Chinese medicine herbal ...

Abstract	Background and rationale: Idiopathic pulmonary fibrosis is a critical disease with a poor prognosis. Although different studies have been conducted for the treatment of idiopathic pulmonary fibrosis, limited treatments are available. Jin-shui Huan-xian granule (JHG), which is a Chinese medicine herbal compound, has shown promising efficacy in reducing frequencies of acute exacerbations, improving exercise capacity the quality of life of patients with idiopathic pulmonary fibrosis. This study is to evaluate the efficacy and safety of JHG for IPF. Subjects and methods: This is a multicenter, randomized, double-blind, placebo-controlled clinical trial. A total of 312 idiopathic pulmonary fibrosis patients will be enrolled and randomly allocated to one of the two groups with 1:1. After a 2-week washout period, 52-week treatment will also be performed for all the patients. Patients in the experimental group and the control group will be given JHG and JHG placebo, respectively. Outcome measures including acute exacerbations, pulmonary function, dyspnea, exercise capacity, and quality of life will be evaluated in this study. Discussion: Based on our previous study, it is hypothesized that JHG will reduce acute exacerbations; improve exercise capacity, pulmonary function, and quality of life; and delay the disease progression-free. High-level evidence-based support for TCM in IPF will also be obtained in this study. Trial registration: ClinicalTrials.gov NCT04187690. Register on December 11, 2019.
MeSH term(s)	Double-Blind Method ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/drug therapy ; Lung ; Multicenter Studies as Topic ; Quality of Life ; Randomized Controlled Trials as Topic ; Treatment Outcome
Language	English
Publishing date	2022-09-02
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-022-06684-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Efficacy and safety of Jin-shui Huan-xian granule for idiopathic pulmonary fibrosis

Shu-guang Yang / Xue-qing Yu / Jian-sheng Li / Yang Xie / Wei Zhang / Chengjun Ban / Jihong Feng / Lei Wu / Xuechao Lu / Limin Zhao / Yong Meng / Miao Zhou / Yong He / Weixian Luo

Trials, Vol 23, Iss 1, Pp 1-

study protocol for a multicenter, randomized, double-blind, placebo-controlled trial

2022 Volume 10

Abstract: ... limited treatments are available. Jin-shui Huan-xian granule (JHG), which is a Chinese medicine herbal ...

Abstract	Abstract Background and rationale Idiopathic pulmonary fibrosis is a critical disease with a poor prognosis. Although different studies have been conducted for the treatment of idiopathic pulmonary fibrosis, limited treatments are available. Jin-shui Huan-xian granule (JHG), which is a Chinese medicine herbal compound, has shown promising efficacy in reducing frequencies of acute exacerbations, improving exercise capacity the quality of life of patients with idiopathic pulmonary fibrosis. This study is to evaluate the efficacy and safety of JHG for IPF. Subjects and methods This is a multicenter, randomized, double-blind, placebo-controlled clinical trial. A total of 312 idiopathic pulmonary fibrosis patients will be enrolled and randomly allocated to one of the two groups with 1:1. After a 2-week washout period, 52-week treatment will also be performed for all the patients. Patients in the experimental group and the control group will be given JHG and JHG placebo, respectively. Outcome measures including acute exacerbations, pulmonary function, dyspnea, exercise capacity, and quality of life will be evaluated in this study. Discussion Based on our previous study, it is hypothesized that JHG will reduce acute exacerbations; improve exercise capacity, pulmonary function, and quality of life; and delay the disease progression-free. High-level evidence-based support for TCM in IPF will also be obtained in this study. Trial registration ClinicalTrials.gov NCT04187690. Register on December 11, 2019
Keywords	Idiopathic pulmonary fibrosis ; Traditional Chinese medicine ; Jin-shui Huan-xian granule ; Randomized controlled trial ; Study protocol ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Conference proceedings: Zhang Huan

Dziewior, Yilmaz / Zhang, Huan

[dieser Katalog erscheint anlässlich der Ausstellung "Zhang Huan" im Kunstverein Hamburg vom 30. November 2002 bis 9. Februar 2003 und im Museum Bochum vom 5. April bis 15. Juni 2003]

2003

Title variant	Ausstellungskatalog
Institution	Ausstellung Zhang Huan Kunstverein in Hamburg
Event/congress	Ausstellung Zhang Huan (2002.11.30-2003.02.09, Hamburg) ; Ausstellung Zhang Huan (2003.04.05-06.15, Bochum)
Author's details	Kunstverein in Hamburg. [Hrsg. Yilmaz Dziewior]
Keywords	Inszenierte Fotografie
Language	German ; English
Size	119 S, zahlr. Ill
Publisher	Hatje Cantz
Publishing place	Ostfildern-Ruit
Document type	Book ; Conference proceedings
Note	Text dt. und engl.
ISBN	3775712208 ; 9783775712200
Database	Former special subject collection: coastal and deep sea fishing

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Research on the Impact of Rural Population Structure Changes on the Net Carbon Sink of Agricultural Production-Take Huan County in the Loess Hilly Region of China as an Example

Libang Ma / Wenbo Zhang / Shanshan Wu / Zhihao Shi

Frontiers in Environmental Science, Vol

2022 Volume 10

Abstract: ... process of agricultural production. This paper takes Huan County in the Loess Hilly Region of China as the evaluation object ... 1) From 2009 to 2018, the number of rural labor force in Huan County was seriously lost, the quality ... The Loess Hilly Region in the northwest of Huan County was “grain-trending,” and the River Valley and Plain ...

Abstract	People are the fundamental purpose and driving force of agricultural development. The changes in population structure can directly affect social and economic development of rural areas and the entire process of agricultural production. This paper takes Huan County in the Loess Hilly Region of China as the evaluation object, the townships as the evaluation unit, the change of rural population structure as the key point, and the agricultural production as the mediating factor, to study the mechanism of agricultural net carbon sinks. The results show: 1) From 2009 to 2018, the number of rural labor force in Huan County was seriously lost, the quality of the labor force was steadily improved, and the age of the labor force was increased. The number of agricultural employees dropped from 72.6 to 49.4%. The number of people with high school education or above increased from 9.7 to 15.1%. Those over working age who participated in the labor force rose from 5.2 to 8.3%. 2) The Loess Hilly Region in the northwest of Huan County was “grain-trending,” and the River Valley and Plain Area in the southeast was “grain-removing.” The input structure index both increased first and then decreased. and the Loess Hilly Region was more dependent on the fertilizer. 3) The rural population structure affects the agricultural net carbon sink by affecting the planting structure index and the input structure index. The rural population quantity and quality structure have a significant positive effect on the agricultural net carbon sink, while the population age structure has a significant negative effect on the agricultural net carbon sink. 4) From the mediating effect, the loss of population can cause fluctuations in the agricultural net carbon sink. The improvement of population quality will promote the growth of the agricultural net carbon sink, and the aging of the population will cause the decline of the agricultural net carbon sink. 5) The return of the labor force, the improvement of labor force quality, the improvement of ...
Keywords	rural population structure ; agricultural production ; net carbon sink ; multiple mediating effects model ; Huan County of the Loess Hilly region in China ; Environmental sciences ; GE1-350
Subject code	630
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book: Yi huan guan xi de jing ji xue yan jiu

Zhang, Qi

2011

Title variant	Yihuan guanxi de jingjixue yanjiu
Author's details	Zhang Qi, Zhu Junsheng, Li Wenzhong deng zhu
MeSH term(s)	Hospital-Patient Relations ; Economics, Medical ; Professional-Patient Relations
Keywords	China
Language	Chinese
Size	2, iii, 315 pages :, illustrations ;, 24 cm
Edition	Di 1 ban.
Document type	Book
ISBN	9787504589835 ; 7504589837
Database	Catalogue of the US National Library of Medicine (NLM)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book: Zhang yin huan ri ji

Zhang, Yinhuan / Ren, Qing / Ma, Zhongwen

(Jin xian dai ming ren ri ji cong kan ; 近现代名人日记丛刊)

2004

Title variant	Zhang Yinhuan riji
Author's details	Ren qing, ma zhong wen zheng li
Series title	Jin xian dai ming ren ri ji cong kan 近现代名人日记丛刊
Keywords	Diplomats ; China
Language	Chinese
Size	4, 596 p., [4] p. of plates, ill, 20 cm
Edition	Di 1 ban
Publisher	Shang hai shu dian chu ban she
Publishing place	Shang hai
Document type	Book
Note	"Quan guo gu ji zheng li chu ban gui hua ling dao xiao zu zi zhu chu ban"--T.p. verso ; Includes index
ISBN	7806781854 ; 9787806781852
Database	Former special subject collection: coastal and deep sea fishing

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book: Yan huan shuai lao he kang pi lao Zhong yao xian dai yan jiu yu ying yong

Zhang, Tiejun

(Zhong yao xian dai yan jiu yu ying yong cong shu)

2007

Author's details	zhu bian Zhang Tiejun, Chen Changqing ; zhu shen Liu Changxiao, Tang Lida ; fu zhu bian Yu Hong, Zhao Zhuanyou ; bian wei Ma Li ... [et al.] ; bian xie ren yuan Ma Li ... [et al.]
Series title	Zhong yao xian dai yan jiu yu ying yong cong shu
MeSH term(s)	Aging/drug effects ; Fatigue/drug therapy ; Medicine, Chinese Traditional
Language	Chinese
Size	2, 2, 4, 737 p. ;, 27 cm.
Edition	Di 1 ban.
Publisher	Ren min wei sheng chu ban she
Publishing place	Beijing Shi
Document type	Book
ISBN	9787117063883 ; 7117063882
Database	Catalogue of the US National Library of Medicine (NLM)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: [Effects of bu yang huan wu decoction on astrocytes after cerebral ischemia and reperfusion].

Lai, Zhen / Wang, Sha-yan / Geng, Xiao-yin / Deng, Chang-qing / Zhang, Ruan-zhang

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2002 Volume 27, Issue 10, Page(s) 763–765

Abstract: Objective: To study the effects of Bu Yang Huan Wu Decoction on astrocytes after cerebral ischemia ... a peak after cerebral ischemia for 15 min followed by reperfusion for 24 hours. Bu Yang Huan Wu Decoction ... by reperfusion for 48 hours, Bu Yang Huan Wu Decoction increased the expression.: Conclusion: The regulation ...

Abstract	Objective: To study the effects of Bu Yang Huan Wu Decoction on astrocytes after cerebral ischemia and reperfusion. Method: Cerebral ischemia model in gerbils was produced by ligating bilateral common carotid artery. The dynamic expressin of GFAP were determined by immunochemistry after cerebyal ischemia for 15 min followed by reperfusion for 24 hours and 48 hours. Result: GFAP positive reactions reached a peak after cerebral ischemia for 15 min followed by reperfusion for 24 hours. Bu Yang Huan Wu Decoction decreased the expression. GFAP positive reactions decreased after cerebral ischemia for 15 min followed by reperfusion for 48 hours, Bu Yang Huan Wu Decoction increased the expression. Conclusion: The regulation of Bu Yang Huan Wu Decoction on astrocytes after cerebral ischemia and reperfusion may be related to repairing process after cerebral ischemia.
MeSH term(s)	Animals ; Astrocytes/drug effects ; Brain Ischemia/complications ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Female ; Glial Fibrillary Acidic Protein/metabolism ; Hippocampus/metabolism ; Male ; Plants, Medicinal/chemistry ; Reperfusion Injury/etiology ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology
Chemical Substances	Drugs, Chinese Herbal ; Glial Fibrillary Acidic Protein ; buyang huanwu
Language	Chinese
Publishing date	2002-10
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3056: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito