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Article: ZnO Nanostructures with Antibacterial Properties Prepared by a Green Electrochemical-Thermal Approach.

Sportelli, Maria Chiara / Picca, Rosaria Anna / Izzi, Margherita / Palazzo, Gerardo / Gristina, Roberto / Innocenti, Massimo / Torsi, Luisa / Cioffi, Nicola

Nanomaterials (Basel, Switzerland)

2020 Volume 10, Issue 3

Abstract: Zinc oxide (ZnO) nanostructures are widely applied materials, and are also capable of antimicrobial action. They can be obtained by several methods, which include physical and chemical approaches. Considering the recent rise of green and low-cost ... ...

Abstract	Zinc oxide (ZnO) nanostructures are widely applied materials, and are also capable of antimicrobial action. They can be obtained by several methods, which include physical and chemical approaches. Considering the recent rise of green and low-cost synthetic routes for nanomaterial development, electrochemical techniques represent a valid alternative to biogenic synthesis. Following a hybrid electrochemical-thermal method modified by our group, here we report on the aqueous electrosynthesis of ZnO nanomaterials based on the use of alternative stabilizers. We tested both benzyl-hexadecyl-dimetylammonium chloride (BAC) and poly-diallyl-(dimethylammonium) chloride (PDDA). Transmission electron microscopy images showed the formation of rod-like and flower-like structures with a variable aspect-ratio. The combination of UV-Vis, FTIR and XPS spectroscopies allowed for the univocal assessment of the material composition as a function of different thermal treatments. In fact, the latter guaranteed the complete conversion of the as-prepared colloidal materials into stoichiometric ZnO species without excessive morphological modification. The antimicrobial efficacy of both materials was tested against
Language	English
Publishing date	2020-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano10030473
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Article: Generalized Fast Discharges Along the Genetic Generalized Epilepsy Spectrum: Clinical and Prognostic Significance.

Cerulli Irelli, Emanuele / Barone, Francesca Antonietta / Mari, Luisa / Morano, Alessandra / Orlando, Biagio / Salamone, Enrico Michele / Marchi, Angela / Fanella, Martina / Fattouch, Jinane / Placidi, Fabio / Giallonardo, Anna Teresa / Izzi, Francesca / Di Bonaventura, Carlo

Frontiers in neurology

2022 Volume 13, Page(s) 844674

Abstract: Objective: To investigate the electroclinical characteristics and the prognostic impact of generalized fast discharges in a large cohort of genetic generalized epilepsy (GGE) patients studied with 24-h prolonged ambulatory electroencephalography (paEEG). ...

Abstract	Objective: To investigate the electroclinical characteristics and the prognostic impact of generalized fast discharges in a large cohort of genetic generalized epilepsy (GGE) patients studied with 24-h prolonged ambulatory electroencephalography (paEEG). Methods: This retrospective multicenter cohort study included 202 GGE patients. The occurrence of generalized paroxysmal fast activity (GPFA) and generalized polyspike train (GPT) was reviewed. GGE patients were classified as having idiopathic generalized epilepsy (IGE) or another GGE syndrome (namely perioral myoclonia with absences, eyelid myoclonia with absences, epilepsy with myoclonic absences, generalized epilepsy with febrile seizures plus, or GGE without a specific epilepsy syndrome) according to recent classification proposals. Results: GPFA/GPT was found in overall 25 (12.4%) patients, though it was significantly less frequent in IGE compared with other GGE syndromes (9.3 vs. 25%, Conclusion: We found that generalized fast discharges were more common than expected in GGE patients when considering the entire GGE spectrum. In addition, our study highlighted that GPFA/GPT could be found along the entire GGE continuum, though their occurrence was more common in less benign GGE syndromes. Finally, we confirmed that GPFA/GPT was associated with difficult-to-treat GGE, as evidenced by the multivariable analysis and the higher ASM load during history.
Language	English
Publishing date	2022-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.844674
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Article ; Online: 18

Fernandes, Mariana / Mari, Luisa / Chiaravalloti, Agostino / Paoli, Barbara / Nuccetelli, Marzia / Izzi, Francesca / Giambrone, Maria Pia / Camedda, Riccardo / Bernardini, Sergio / Schillaci, Orazio / Mercuri, Nicola Biagio / Placidi, Fabio / Liguori, Claudio

Journal of neurology

2022 Volume 269, Issue 10, Page(s) 5356–5367

Abstract: Introduction: Dysregulation of cerebral glucose consumption, alterations in cerebrospinal fluid (CSF) biomarkers, and cognitive impairment have been reported in patients with obstructive sleep apnoea (OSA). On these bases, OSA has been considered a risk ...

Abstract	Introduction: Dysregulation of cerebral glucose consumption, alterations in cerebrospinal fluid (CSF) biomarkers, and cognitive impairment have been reported in patients with obstructive sleep apnoea (OSA). On these bases, OSA has been considered a risk factor for Alzheimer's disease (AD). This study aimed to measure cognitive performance, CSF biomarkers, and cerebral glucose consumption in OSA patients and to evaluate the effects of continuous positive airway pressure (CPAP) treatment on these biomarkers over a 12-month period. Methods: Thirty-four OSA patients and 34 controls underwent Results: Significantly reduced glucose consumption was observed in the bilateral praecuneus, posterior cingulate cortex, and frontal areas in OSA patients than controls. At baseline, OSA patients also showed lower β-amyloid Conclusions: Cognitive impairment, reduced cerebral glucose consumption, and alterations in CSF biomarkers were observed in OSA patients, which may reinforce the hypothesis of AD neurodegenerative processes triggered by OSA. Notably, cognition and brain glucose consumption improved after beneficial CPAP treatment. Further studies are needed to evaluate the long-term effects of CPAP treatment on these AD biomarkers.
MeSH term(s)	Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/therapy ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Cognition ; Cognitive Dysfunction/cerebrospinal fluid ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/etiology ; Continuous Positive Airway Pressure ; Fluorodeoxyglucose F18 ; Glucose ; Humans ; Positron-Emission Tomography/methods ; Sleep Apnea, Obstructive/diagnostic imaging ; Sleep Apnea, Obstructive/therapy ; tau Proteins/cerebrospinal fluid
Chemical Substances	Amyloid beta-Peptides ; Biomarkers ; tau Proteins ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-05-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-022-11182-z
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Article ; Online: Periodic sharp wave complexes identify a distinctive phenotype in Creutzfeldt-Jacob disease.

Castelli, Alessandro / Placidi, Fabio / Bonomi, Chiara Giuseppina / Di Giuliano, Francesca / Martorana, Alessandro / Pizzicannella, Giulia / Liguori, Claudio / Manfredi, Natalia / Mari, Luisa / Pagano, Andrea / Bramato, Valentina / Mercuri, Nicola Biagio / Izzi, Francesca

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2022 Volume 143, Page(s) 124–132

Abstract: Objective: The aim of our study was to evaluate the diagnostic and prognostic value of Electroencephalogram (EEG), brain Magnetic Resonance Imaging (MRI) and cerebrospinal fluid features, currently representing Creutzfeldt-Jacob Disease (CJD) diagnostic ...

Abstract	Objective: The aim of our study was to evaluate the diagnostic and prognostic value of Electroencephalogram (EEG), brain Magnetic Resonance Imaging (MRI) and cerebrospinal fluid features, currently representing Creutzfeldt-Jacob Disease (CJD) diagnostic criteria. Methods: A retrospective study on rapidly progressive dementia patients admitted at the Neurology Clinic of the University of Rome "Tor Vergata" between 2015 and 2020 was conducted. We evaluated clinical, EEG, cerebrospinal fluid and neuroradiological findings. Results: Our analysis included 13 patients with probable CJD and 18 patients with non-CJD rapidly progressive dementia. Periodic sharp wave complexes were observed in 7/13 CJD and in 4/18 non-CJD patients (p =.151). The sub-analysis according to the EEG features revealed that CJD patients with earlier periodic sharp wave complexes had a significantly lower average survival time (p =.003), a shorter time to admission (p =.003) and lower levels of cerebrospinal fluid p-tau (p =.008) compared to CJD patients without periodic sharp wave complexes. Finally, they did not show signs of signal alteration on Fluid Attenuated Inversion Recovery images. Conclusions: Despite the lowest diagnostic specificity and sensibility among the CJD criteria, periodic sharp wave complexes could identify a distinctive phenotype hallmarked by a faster evolution, a reduced survival time and specific MRI and cerebrospinal fluid features. Significance: The early presence of the typical EEG pattern may play a prognostic role in CJD.
MeSH term(s)	Brain/diagnostic imaging ; Brain/pathology ; Creutzfeldt-Jakob Syndrome/diagnostic imaging ; Electroencephalography ; Humans ; Magnetic Resonance Imaging ; Phenotype ; Retrospective Studies
Language	English
Publishing date	2022-09-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2022.08.025
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Article ; Online: ZnO Nanostructures with Antibacterial Properties Prepared by a Green Electrochemical-Thermal Approach

Maria Chiara Sportelli / Rosaria Anna Picca / Margherita Izzi / Gerardo Palazzo / Roberto Gristina / Massimo Innocenti / Luisa Torsi / Nicola Cioffi

Nanomaterials, Vol 10, Iss 3, p

2020 Volume 473

Abstract	Zinc oxide (ZnO) nanostructures are widely applied materials, and are also capable of antimicrobial action. They can be obtained by several methods, which include physical and chemical approaches. Considering the recent rise of green and low-cost synthetic routes for nanomaterial development, electrochemical techniques represent a valid alternative to biogenic synthesis. Following a hybrid electrochemical-thermal method modified by our group, here we report on the aqueous electrosynthesis of ZnO nanomaterials based on the use of alternative stabilizers. We tested both benzyl-hexadecyl-dimetylammonium chloride (BAC) and poly-diallyl-(dimethylammonium) chloride (PDDA). Transmission electron microscopy images showed the formation of rod-like and flower-like structures with a variable aspect-ratio. The combination of UV−Vis, FTIR and XPS spectroscopies allowed for the univocal assessment of the material composition as a function of different thermal treatments. In fact, the latter guaranteed the complete conversion of the as-prepared colloidal materials into stoichiometric ZnO species without excessive morphological modification. The antimicrobial efficacy of both materials was tested against Bacillus subtilis as a Gram-positive model microorganism.
Keywords	zinc oxide ; electrochemical synthesis ; bac ; pdda ; nanorod ; xps ; tem ; b. subtilis ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Levetiracetam, lamotrigine and carbamazepine: which monotherapy during pregnancy?

Mari, Luisa / Placidi, Fabio / Romigi, Andrea / Tombini, Mario / Del Bianco, Chiara / Ulivi, Martina / Liguori, Claudio / Manfredi, Natalia / Castelli, Alessandro / Mercuri, Nicola Biagio / Izzi, Francesca

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2021 Volume 43, Issue 3, Page(s) 1993–2001

Abstract: Objective: Epilepsy treatment during pregnancy is still challenging. The study is aimed at comparing the efficacy and safety of carbamazepine (CBZ), lamotrigine (LTG) and levetiracetam (LEV) monotherapies during pregnancy in women with focal (FE) or ... ...

Abstract	Objective: Epilepsy treatment during pregnancy is still challenging. The study is aimed at comparing the efficacy and safety of carbamazepine (CBZ), lamotrigine (LTG) and levetiracetam (LEV) monotherapies during pregnancy in women with focal (FE) or generalized (GE) epilepsy. Methods: A multicentre retrospective study was conducted to evaluate seizures frequency and seizure freedom (SF) rate during 3 months before pregnancy, each trimester of gestation and post-partum period in women on monotherapy with CBZ, LTG and LEV. Results: Fifty-seven pregnancies (45 FE, 12 GE) on monotherapy (29 CBZ, 11 LTG, 17 LEV) were included. A significant reduction of seizure frequency was found in the first trimester of pregnancy as compared with that one before pregnancy (p = 0.004), more evident in GE (p = 0.003) and in LEV group (p = 0.004). The SF rate significantly increased in the first trimester in comparison to that one before pregnancy and persisted in the post-partum period in the whole sample (p < 0.001) and in women on LEV (p = 0.004). Besides, 88.57% of SF women before pregnancy remained unchanged during gestation and the post-partum period. One major heart malformation in CBZ and no major malformations in LTG and LEV groups were found. Conclusions: A better clinical outcome during pregnancy emerged since the first trimester in comparison to the before-pregnancy period, mostly evident in women with GE and LEV therapy, reinforcing the hypothesis of a protective role of pregnancy versus seizures. SF before pregnancy represents a significant predictive factor of good clinical outcome during gestation and the post-partum period. Compared to CBZ, LTG and LEV showed a better safety profile.
MeSH term(s)	Anticonvulsants/adverse effects ; Carbamazepine/adverse effects ; Female ; Humans ; Lamotrigine/adverse effects ; Levetiracetam/therapeutic use ; Pregnancy ; Retrospective Studies ; Triazines/adverse effects
Chemical Substances	Anticonvulsants ; Triazines ; Carbamazepine (33CM23913M) ; Levetiracetam (44YRR34555) ; Lamotrigine (U3H27498KS)
Language	English
Publishing date	2021-09-01
Publishing country	Italy
Document type	Journal Article ; Multicenter Study
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-021-05542-2
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Article: Modeling the term structure of monetary rates

Izzi, Luisa

Handbook of heavy tailed distributions in finance , p. 481-508

2003 , Page(s) 481–508

Author's details	Luisa Izzi
Keywords	Zins ; Zinsstruktur ; Theorie ; Statistische Verteilung
Language	English
Size	graph. Darst
Publisher	Elsevier
Publishing place	Amsterdam [u.a.]
Document type	Article
Database	ECONomics Information System

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Book: Basel III credit rating systems

Izzi, Luisa / Oricchio, Gianluca / Vitale, Laura

an applied guide to quantitative and qualitative models

(Palgrave Macmillan finance and capital markets series)

2012

Author's details	Luisa Izzi, Gianluca Oricchio and Laura Vitale
Series title	Palgrave Macmillan finance and capital markets series
Keywords	Credit ratings/Mathematical models ; Risk/Mathematical models ; Basler Akkord ; Kreditwürdigkeit
Language	English
Size	xx, 344 p, ill, 24 cm
Publisher	Palgrave Macmillan
Publishing place	Houndmills, Basingstoke, Hampshire u.a.
Document type	Book
Note	Includes bibliographical references and index
ISBN	9780230294240 ; 0230294243
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Article ; Online: Long-term efficacy and safety of lacosamide and levetiracetam monotherapy in elderly patients with focal epilepsy: A retrospective study.

Del Bianco, Chiara / Placidi, Fabio / Liguori, Claudio / Mari, Luisa / Ulivi, Martina / Ornello, Raffaele / Pisani, Antonio / Mercuri, Nicola Biagio / Izzi, Francesca

Epilepsy & behavior : E&B

2019 Volume 94, Page(s) 178–182

Abstract: Objectives: Epilepsy management in elderly patients is often complex because of several concomitant comorbidities that may limit the use of some antiepileptic drugs (AEDs). Levetiracetam (LEV) is a second-generation AED widely used in elderly patients ... ...

Abstract	Objectives: Epilepsy management in elderly patients is often complex because of several concomitant comorbidities that may limit the use of some antiepileptic drugs (AEDs). Levetiracetam (LEV) is a second-generation AED widely used in elderly patients with epilepsy while lacosamide (LCM), which has been recently approved in European Union (EU) as monotherapy for the treatment of focal onset seizures, is affected by a scarcity of data in such frail population. This study is aimed at assessing the efficacy and the tolerability of LCM as monotherapy in elderly patients affected by focal onset epilepsy compared with those receiving LEV. Methods: A retrospective chart review of patients aged ≥65 years suffering from focal onset seizures, with or without secondary generalization on LCM monotherapy or LEV monotherapy, was performed. Data regarding demographic characteristics, seizure type and etiology, LCM and LEV daily dose, number of lifetime AEDs, seizure frequency at baseline and at 12 months of follow-up, and seizure freedom rates were reported. Results: In this observational retrospective study, 22 patients on LCM (10 males, 12 females, mean age: 76.23 ± 7.5) and 24 patients on LEV (10 males, 14 females, mean age: 73.58 ± 6.39) were enrolled. Mean LCM daily dose was 204.51 ± 88.51 mg and mean LEV daily dose was 1281.25 ± 378.15 mg. All patients had comorbidities on chronic treatment. At 12 months of follow-up, mean monthly seizure frequency reduced from 4.23 ± 8.53 to 0.33 ± 0.9 (p < .001) in LCM group and from 2.29 ± 6.11 to 0.2 ± 0.81 (p < .001) in LEV group. Furthermore, 16/22 (72.7%) LCM patients were seizure-free at 12 months of follow-up while seizure freedom was achieved by 17/24 (70.8%) patients in LEV group. Discussion and conclusion: Epilepsy management in elderly patients is often challenging. In this retrospective real-life study, the efficacy and the tolerability of LCM as monotherapy was favorable even at low doses in older patients and comparable with LEV with a high rate of long-term seizure freedom. Considering the frequent comorbidities and the risk of drug-drug interactions, LCM monotherapy may be a valuable option in elderly patients with focal onset epilepsy because of its favorable pharmacokinetic profile.
MeSH term(s)	Aged ; Aged, 80 and over ; Anticonvulsants/therapeutic use ; Comorbidity ; Drug Interactions ; Epilepsies, Partial/drug therapy ; European Union ; Female ; Frail Elderly ; Humans ; Lacosamide/therapeutic use ; Levetiracetam/therapeutic use ; Male ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Anticonvulsants ; Levetiracetam (44YRR34555) ; Lacosamide (563KS2PQY5)
Language	English
Publishing date	2019-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2019.02.022
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Article ; Online: Efficacy and tolerability of perampanel and levetiracetam as first add-on therapy in patients with epilepsy: A retrospective single center study.

Liguori, Claudio / Izzi, Francesca / Manfredi, Natalia / D'Elia, Alessio / Mari, Luisa / Mercuri, Nicola Biagio / Fabio, Placidi

Epilepsy & behavior : E&B

2018 Volume 80, Page(s) 173–176

Abstract: Perampanel (PER) is a third generation antiepileptic drug (AED), recently approved as add-on therapy in both focal and generalized seizures. Levetiracetam (LEV) is a second generation AED, widely used in patients with epilepsy because of its favorable ... ...

Abstract	Perampanel (PER) is a third generation antiepileptic drug (AED), recently approved as add-on therapy in both focal and generalized seizures. Levetiracetam (LEV) is a second generation AED, widely used in patients with epilepsy because of its favorable safety and efficacy profiles. Perampanel and LEV treatments have been associated with the occurrence of similar adverse events (AEs) (sleepiness, irritability, depression, anxiety, aggressiveness). The aim of the present retrospective single center study was to verify the efficacy and tolerability of PER and LEV used as first add-on therapy in patients with epilepsy affected by secondarily generalized seizures. We collected data from 15 patients treated with PER and 26 patients treated with LEV and followed at our site with follow-up visits at 3, 6, and 12months. This retrospective study documented the comparable efficacy of PER and LEV as first add-on treatments in patients affected by uncontrolled secondarily generalized seizures. However, more patients withdrawn LEV because of AEs compared with PER at the 3- and 12-month follow-up visits. The better tolerability of PER observed in this study could be related to the low therapeutic dose of PER prescribed when it is used as first adjunctive treatment for better controlling secondarily generalized seizures.
MeSH term(s)	Adult ; Aggression ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Anticonvulsants/therapeutic use ; Anxiety ; Depression ; Dizziness/chemically induced ; Drug-Related Side Effects and Adverse Reactions ; Epilepsy/drug therapy ; Epilepsy/epidemiology ; Female ; Humans ; Irritable Mood/drug effects ; Levetiracetam/administration & dosage ; Levetiracetam/adverse effects ; Levetiracetam/therapeutic use ; Male ; Middle Aged ; Pyridones/administration & dosage ; Pyridones/adverse effects ; Pyridones/therapeutic use ; Retrospective Studies ; Seizures/drug therapy ; Treatment Outcome ; Wakefulness
Chemical Substances	Anticonvulsants ; Pyridones ; Levetiracetam (44YRR34555) ; perampanel (H821664NPK)
Language	English
Publishing date	2018-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2018.01.001
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