LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 546

Search options

  1. Book ; Online: Energy Systems and Environment

    Tsvetkov, Pavel

    2018  

    Keywords Energy technology & engineering ; biomass, bioenergy, sustainability, renewable energy, energy efficiency, biochar
    Language English
    Size 1 electronic resource (230 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030645130
    ISBN 9781838815264 ; 1838815260
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Uncharged P-selectin blockers.

    Pochechueva, T V / Galanina, O E / Ushakova, N A / Preobrazhenskaya, M E / Sablina, M A / Nifantiev, N E / Tsvetkov, Yu V / Vozney, Ya V / Imberty, A / Bovin, N V

    Glycoconjugate journal

    2004  Volume 20, Issue 2, Page(s) 91–97

    Abstract: The blocking potency of P- and L-selectin was studied for certain small molecule mannosides and ... used: (1) solid phase static assay based on recombinant selectins, and (2) P-selectin dependent rat ... peritoneal inflammation. betaMan-SC6H4NO2- p was four times more potent P-selectin inhibitor as compared ...

    Abstract The blocking potency of P- and L-selectin was studied for certain small molecule mannosides and their polyacrylamide (PAA, 30 kDa) conjugates in comparison to SiaLe(x) and fucoidan. Two experimental systems were used: (1) solid phase static assay based on recombinant selectins, and (2) P-selectin dependent rat peritoneal inflammation. betaMan-SC6H4NO2- p was four times more potent P-selectin inhibitor as compared to SiaLe(x). Docking of this molecule onto the P-selectin carbohydrate-binding site demonstrated that a nitro group enabled an electrostatic interaction with residue Lys 84, while the phenyl ring and the CH2 at C-6 contacted the CH2 groups of the same Lys residue. In vivo, betaMan-SC6H4NO2- p blocked experimental inflammation better than SiaLe(x), but significantly lower than fucoidan. In vitro Man-polyacrylic acid conjugates appeared to be very potent inhibitors comparable to fucoidan, uncharged Man-PAA proved rather active, comparable to SiaLe(x)-PAA both in vitro, and in vivo, whereas mannan did not display any P-selectin blocking effect.
    MeSH term(s) Acrylic Resins/metabolism ; Animals ; Glycoconjugates/metabolism ; L-Selectin/metabolism ; Mannosides/metabolism ; P-Selectin/metabolism ; Polysaccharides/metabolism ; Rats
    Chemical Substances Acrylic Resins ; Glycoconjugates ; Mannosides ; P-Selectin ; Polysaccharides ; L-Selectin (126880-86-2) ; polyacrylamide (9003-05-8) ; fucoidan (9072-19-9)
    Language English
    Publishing date 2004
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 283770-5
    ISSN 1573-4986 ; 0282-0080
    ISSN (online) 1573-4986
    ISSN 0282-0080
    DOI 10.1023/B:GLYC.0000018583.63140.91
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Homoepitaxial n-core: p-shell gallium nitride nanowires: HVPE overgrowth on MBE nanowires.

    Sanders, Aric / Blanchard, Paul / Bertness, Kris / Brubaker, Matthew / Dodson, Christopher / Harvey, Todd / Herrero, Andrew / Rourke, Devin / Schlager, John / Sanford, Norman / Chiaramonti, Ann N / Davydov, Albert / Motayed, Abhishek / Tsvetkov, Denis

    Nanotechnology

    2011  Volume 22, Issue 46, Page(s) 465703

    Abstract: We present the homoepitaxial growth of p-type, magnesium doped gallium nitride shells by use ...

    Abstract We present the homoepitaxial growth of p-type, magnesium doped gallium nitride shells by use of halide vapor phase epitaxy (HVPE) on n-type gallium nitride nanowires grown by plasma-assisted molecular beam epitaxy (MBE). Scanning electron microscopy shows clear dopant contrast between the core and shell of the nanowire. The growth of magnesium doped nanowire shells shows little or no effect on the lattice parameters of the underlying nanowires, as measured by x-ray diffraction (XRD). Photoluminescence measurements of the nanowires show the appearance of sub-bandgap features in the blue and the ultraviolet, indicating the presence of acceptors. Finally, electrical measurements confirm the presence of electrically active holes in the nanowires.
    Language English
    Publishing date 2011-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/0957-4484/22/46/465703
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients.

    Tsvetkov, Peter / Adamovich, Yaarit / Elliott, Evan / Shaul, Yosef

    The Journal of biological chemistry

    2011  Volume 286, Issue 11, Page(s) 8839–8845

    Abstract: NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoenzyme that is important in maintaining ...

    Abstract NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoenzyme that is important in maintaining the cellular redox state and regulating protein degradation. The NQO1 polymorphism C609T has been associated with increased susceptibility to various age-related pathologies. We show here that NQO1 protein level is regulated by the E3 ligase STUB1/CHIP (C terminus of Hsc70-interacting protein). NQO1 binds STUB1 via the Hsc70-interacting domain (tetratricopeptide repeat domain) and undergoes ubiquitination and degradation. We demonstrate here that the product of the C609T polymorphism (P187S) is a stronger STUB1 interactor with increased susceptibility to ubiquitination by the E3 ligase STUB1. Furthermore, age-dependent decrease of STUB1 correlates with increased NQO1 accumulation. Remarkably, examination of hippocampi from Alzheimer disease patients revealed that in half of the cases examined the NQO1 protein level was undetectable due to C609T polymorphism, suggesting that the age-dependent accumulation of NQO1 is impaired in certain Alzheimer disease patients.
    MeSH term(s) Aging/genetics ; Aging/metabolism ; Alzheimer Disease/enzymology ; Alzheimer Disease/genetics ; HEK293 Cells ; HSC70 Heat-Shock Proteins/genetics ; HSC70 Heat-Shock Proteins/metabolism ; Hippocampus/enzymology ; Humans ; NAD(P)H Dehydrogenase (Quinone)/genetics ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Polymorphism, Genetic ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination/genetics
    Chemical Substances HSC70 Heat-Shock Proteins ; HSPA8 protein, human ; Nerve Tissue Proteins ; NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2) ; NQO1 protein, human (EC 1.6.5.2) ; STUB1 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2011-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M110.193276
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book ; Online: Nuclear Power : Operation, Safety and Environment

    Tsvetkov, Pavel

    2011  

    Keywords Electrical engineering
    Size 1 electronic resource (382 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046193
    ISBN 9789535160366 ; 9535160362
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Book ; Online: Nuclear Power : Deployment, Operation and Sustainability

    Tsvetkov, Pavel

    2011  

    Keywords Electrical engineering
    Size 1 electronic resource (524 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021049977
    ISBN 9789535160458 ; 9535160451
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Book ; Online: Nuclear Power : Control, Reliability and Human Factors

    Tsvetkov, Pavel

    2011  

    Keywords Electrical engineering
    Size 1 electronic resource (442 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021049437
    ISBN 9789535160625 ; 9535160621
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Book ; Online: Nuclear Power : System Simulations and Operation

    Tsvetkov, Pavel

    2011  

    Keywords Electrical engineering
    Size 1 electronic resource (206 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021049410
    ISBN 9789535160410 ; 9535160419
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.

    Asher, Gad / Dym, Orly / Tsvetkov, Peter / Adler, Julia / Shaul, Yosef

    Biochemistry

    2006  Volume 45, Issue 20, Page(s) 6372–6378

    Abstract: NAD(P)H quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes two-electron ... reduction of quinones to hydroquinones utilizing NAD(P)H as an electron donor. NQO1 binds and stabilizes ... which competes with NAD(P)H for binding to NQO1. Dicoumarol also disrupts the binding of NQO1 to p53, p73, and ...

    Abstract NAD(P)H quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes two-electron reduction of quinones to hydroquinones utilizing NAD(P)H as an electron donor. NQO1 binds and stabilizes several short-lived proteins including the tumor suppressors p53 and p73 and the enzyme ornithine decarboxylase (ODC). Dicoumarol is a widely used potent competitive inhibitor of NQO1 enzymatic activity, which competes with NAD(P)H for binding to NQO1. Dicoumarol also disrupts the binding of NQO1 to p53, p73, and ODC and induces their ubiquitin-independent proteasomal degradation. We report here the crystal structure of human NQO1 in complex with dicoumarol at 2.75 A resolution. We have identified the interactions of dicoumarol with the different residues of NQO1 and the conformational changes imposed upon dicoumarol binding. The most prominent conformational changes that occur in the presence of dicoumarol involve Tyr 128 and Phe 232 that are present on the surface of the NQO1 catalytic pocket. On the basis of the comparison of the NQO1 structure in complex with different NQO1 inhibitors and our previous analysis of NQO1 mutants, we propose that the specific conformation of Tyr 128 and Phe 232 is important for NQO1 interaction with p53 and other client proteins.
    MeSH term(s) Animals ; Apoproteins/metabolism ; Benzoquinones/chemistry ; Benzoquinones/metabolism ; Catalytic Domain ; Crystallization ; Crystallography, X-Ray ; Dicumarol/chemistry ; Dicumarol/metabolism ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Humans ; Indolequinones/chemistry ; Indolequinones/metabolism ; Models, Molecular ; NAD(P)H Dehydrogenase (Quinone)/chemistry ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Phenylalanine/metabolism ; Protein Binding ; Protein Conformation ; Rats ; Triazines/chemistry ; Triazines/metabolism ; Tyrosine/metabolism
    Chemical Substances 5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione ; Apoproteins ; Benzoquinones ; Enzyme Inhibitors ; Indolequinones ; Triazines ; Tyrosine (42HK56048U) ; Phenylalanine (47E5O17Y3R) ; Cibacron Blue F 3GA (5DV0L8V99J) ; Dicumarol (7QID3E7BG7) ; NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2) ; NQO1 protein, human (EC 1.6.5.2) ; NQO1 protein, rat (EC 1.6.5.2) ; duroquinone (X0Q8791R69)
    Language English
    Publishing date 2006-05-23
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/bi0600087
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book ; Online: Nuclear Power

    Tsvetkov, Pavel

    2010  

    Keywords Electrical engineering
    Size 1 electronic resource (398 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021049396
    ISBN 9789535159407 ; 9535159402
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top