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  1. Book ; Online: Ion Channel Trafficking and Cardiac Arrhythmias

    Heyden, Marcel A.G. van der / Abriel, Hugues / Li, Baoxin / Delisle, Brian P.

    2018  

    Keywords Physiology ; Science (General)
    Size 1 electronic resource (123 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101944
    ISBN 9782889456437 ; 2889456439
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: The burden of cystic fibrosis in North Africa.

    El Makhzen, Nada / Daimi, Houria / Bouguenouch, Laila / Abriel, Hugues

    Frontiers in genetics

    2024  Volume 14, Page(s) 1295008

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1295008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: NCCR TransCure - Excellence in Membrane Transport Research from 2010 until 2022.

    Abriel, Hugues / Reymond, Jean-Louis

    Chimia

    2022  Volume 76, Issue 12, Page(s) 989

    Language English
    Publishing date 2022-12-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1516-7
    ISSN 0009-4293
    ISSN 0009-4293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  4. Article: The NCCR TransCure: An Incubator for Interdisciplinary Research.

    Rossetti, Valentina / Abriel, Hugues

    Chimia

    2022  Volume 76, Issue 12, Page(s) 992–995

    Abstract: The National Center of Competence in Research (NCCR) TransCure, funded by the Swiss National Science Foundation and the University of Bern, was active from 2010 to 2022. It provided unique research and educational framework in the membrane transporter ... ...

    Abstract The National Center of Competence in Research (NCCR) TransCure, funded by the Swiss National Science Foundation and the University of Bern, was active from 2010 to 2022. It provided unique research and educational framework in the membrane transporter and ion channel field. Thanks to an interdisciplinary approach comprising physiology, structural biology, and chemistry, in parallel to a rich offer in complementary areas such as education and technology transfer, the network achieved outstanding scientific results and contributed to the education of young scientists. In this review, we present the main features and milestones of the NCCR TransCure.
    MeSH term(s) Interdisciplinary Research ; Interdisciplinary Studies ; Incubators
    Language English
    Publishing date 2022-12-21
    Publishing country Switzerland
    Document type Review ; Journal Article
    ZDB-ID 1516-7
    ISSN 0009-4293
    ISSN 0009-4293
    DOI 10.2533/chimia.2022.992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A detailed analysis of single-channel Na

    Selimi, Zoja / Rougier, Jean-Sébastien / Abriel, Hugues / Kucera, Jan P

    The Journal of physiology

    2023  Volume 601, Issue 17, Page(s) 3847–3868

    Abstract: Cardiac voltage-gated sodium ( ... ...

    Abstract Cardiac voltage-gated sodium (Na
    MeSH term(s) Mice ; Humans ; Animals ; Rabbits ; HEK293 Cells ; Myocytes, Cardiac/physiology ; Myocardium
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The NCCR TransCure

    Valentina Rossetti / Hugues Abriel

    CHIMIA, Vol 76, Iss

    An Incubator for Interdisciplinary Research

    2022  Volume 12

    Abstract: The National Center of Competence in Research (NCCR) TransCure, funded by the Swiss National Science Foundation and the University of Bern, was active from 2010 to 2022. It provided unique research and educational framework in the membrane transporter ... ...

    Abstract The National Center of Competence in Research (NCCR) TransCure, funded by the Swiss National Science Foundation and the University of Bern, was active from 2010 to 2022. It provided unique research and educational framework in the membrane transporter and ion channel field. Thanks to an interdisciplinary approach comprising physiology, structural biology, and chemistry, in parallel to a rich offer in complementary areas such as education and technology transfer, the network achieved outstanding scientific results and contributed to the education of young scientists. In this review, we present the main features and milestones of the NCCR TransCure.
    Keywords Drug discovery ; Education and training ; Interdisciplinarity ; Chemistry ; QD1-999
    Language German
    Publishing date 2022-12-01T00:00:00Z
    Publisher Swiss Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Genetic background of Brugada syndrome is more complex than what we would like it to be!

    Abriel, Hugues

    Cardiovascular research

    2015  Volume 106, Issue 3, Page(s) 351–352

    MeSH term(s) Brugada Syndrome/genetics ; Female ; Humans ; Male ; NAV1.8 Voltage-Gated Sodium Channel/genetics ; Polymorphism, Single Nucleotide
    Chemical Substances NAV1.8 Voltage-Gated Sodium Channel
    Language English
    Publishing date 2015-06-01
    Publishing country England
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvv135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
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  8. Article ; Online: Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice.

    Arullampalam, Prakash / Essers, Maria C / Boukenna, Mey / Guichard, Sabrina / Rougier, Jean-Sébastien / Abriel, Hugues

    Physiological reports

    2023  Volume 11, Issue 16, Page(s) e15783

    Abstract: TRPM4 is a calcium-activated, voltage-modulated, nonselective ion channel widely expressed in various cells and tissues. TRPM4 regulates the influx of sodium ions, thus playing a role in regulating the membrane potential. In the heart, TRPM4 is expressed ...

    Abstract TRPM4 is a calcium-activated, voltage-modulated, nonselective ion channel widely expressed in various cells and tissues. TRPM4 regulates the influx of sodium ions, thus playing a role in regulating the membrane potential. In the heart, TRPM4 is expressed in both cardiomyocytes and cells of the conductive pathways. Clinical studies have linked TRPM4 mutations to several cardiac disorders. While data from experimental studies have demonstrated TRPM4's functional significance in cardiac physiology, its exact roles in the heart have remained unclear. In this study, we investigated the role of TRPM4 in cardiac physiology in a newly generated Trpm4 knockdown mouse model. Male and female Trpm4 knockdown (Trpm4
    MeSH term(s) Animals ; Female ; Male ; Mice ; Cardiac Electrophysiology ; Electrocardiography ; Electrophysiologic Techniques, Cardiac ; Hemodynamics ; Myocytes, Cardiac ; TRPM Cation Channels/genetics ; Gene Knockdown Techniques
    Chemical Substances TRPM Cation Channels ; TRPM4 protein, mouse
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cardiac Sodium Current Under Sympathetic Control

    Marionneau, Céline / Abriel, Hugues

    Circulation research

    2019  Volume 124, Issue 5, Page(s) 674–676

    MeSH term(s) Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Heart ; Protein Phosphatase 2 ; Sodium
    Chemical Substances Sodium (9NEZ333N27) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Protein Phosphatase 2 (EC 3.1.3.16)
    Language English
    Publishing date 2019-02-28
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.119.314680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.70: Show issues Location:
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  10. Article ; Online: Cardiac sodium channel Na(v)1.5 mechanosensitivity is inhibited by ranolazine.

    Abriel, Hugues

    Circulation

    2012  Volume 125, Issue 22, Page(s) 2681–2683

    MeSH term(s) Acetanilides/pharmacology ; Animals ; Humans ; Kidney/drug effects ; Myocytes, Cardiac/drug effects ; NAV1.5 Voltage-Gated Sodium Channel ; Piperazines/pharmacology ; Ranolazine ; Sodium Channels/drug effects
    Chemical Substances Acetanilides ; NAV1.5 Voltage-Gated Sodium Channel ; Piperazines ; SCN5A protein, human ; Sodium Channels ; Ranolazine (A6IEZ5M406)
    Language English
    Publishing date 2012-06-05
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.112.110908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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