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Article ; Online: Myocardial perfusion imaging in congenitally corrected transposition of the great arteries.

Matthews, Benjamin / Duddleston, Daniel / Hage, Fadi G

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2023 Volume 30, Issue 6, Page(s) 2907–2910

MeSH term(s)	Humans ; Congenitally Corrected Transposition of the Great Arteries ; Transposition of Great Vessels/diagnostic imaging ; Myocardial Perfusion Imaging ; Arteries
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1007/s12350-023-03344-x
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Article ; Online: PR1P, a VEGF-stabilizing peptide, reduces injury and inflammation in acute lung injury and ulcerative colitis animal models.

Adini, Avner / Ko, Victoria H / Puder, Mark / Louie, Sharon M / Kim, Carla F / Baron, Joseph / Matthews, Benjamin D

Frontiers in immunology

2023 Volume 14, Page(s) 1168676

Abstract: Acute Respiratory Distress Syndrome (ARDS) and Ulcerative Colitis (UC) are each characterized by tissue damage and uncontrolled inflammation. Neutrophils and other inflammatory cells play a primary role in disease progression by acutely responding to ... ...

Abstract	Acute Respiratory Distress Syndrome (ARDS) and Ulcerative Colitis (UC) are each characterized by tissue damage and uncontrolled inflammation. Neutrophils and other inflammatory cells play a primary role in disease progression by acutely responding to direct and indirect insults to tissue injury and by promoting inflammation through secretion of inflammatory cytokines and proteases. Vascular Endothelial Growth Factor (VEGF) is a ubiquitous signaling molecule that plays a key role in maintaining and promoting cell and tissue health, and is dysregulated in both ARDS and UC. Recent evidence suggests a role for VEGF in mediating inflammation, however, the molecular mechanism by which this occurs is not well understood. We recently showed that PR1P, a 12-amino acid peptide that binds to and upregulates VEGF, stabilizes VEGF from degradation by inflammatory proteases such as elastase and plasmin thereby limiting the production of VEGF degradation products (fragmented VEGF (fVEGF)). Here we show that fVEGF is a neutrophil chemoattractant
MeSH term(s)	Animals ; Mice ; Rats ; Acute Lung Injury/metabolism ; Colitis, Ulcerative/drug therapy ; Cytokines/metabolism ; Disease Models, Animal ; Inflammation/chemically induced ; Interleukin-6 ; Peptide Hydrolases ; Peptides/adverse effects ; Respiratory Distress Syndrome/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Cytokines ; Interleukin-6 ; Peptide Hydrolases (EC 3.4.-) ; Peptides ; Vascular Endothelial Growth Factor A ; PR1P peptide
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1168676
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Article: A hierarchical modeling approach to predict the distribution and density of Sierra Nevada Red Fox (

Green, David S / Martin, Marie E / Matthews, Sean M / Akins, Jocelyn R / Carlson, Jennifer / Figura, Pete / Hatfield, Brian E / Perrine, John D / Quinn, Cate B / Sacks, Benjamin N / Stephenson, Thomas R / Stock, Sarah L / Tucker, Jody M

Journal of mammalogy

2023 Volume 104, Issue 4, Page(s) 820–832

Abstract: Carnivores play critical roles in ecosystems, yet many species are declining worldwide. The Sierra Nevada Red Fox ( ...

Abstract	Carnivores play critical roles in ecosystems, yet many species are declining worldwide. The Sierra Nevada Red Fox (
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	218314-6
ISSN	0022-2372
ISSN	0022-2372
DOI	10.1093/jmammal/gyad026
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Article ; Online: Factors Associated With Changes in Alcohol Use During Pregnancy and the Postpartum Transition Among People With HIV in South Africa and Uganda.

Stanton, Amelia M / Hornstein, Benjamin D / Musinguzi, Nicholas / Dolotina, Brett / Orrell, Catherine / Amanyire, Gideon / Asiimwe, Stephen / Cross, Anna / Psaros, Christina / Bangsberg, David / Hahn, Judith A / Haberer, Jessica E / Matthews, Lynn T

Journal of the International Association of Providers of AIDS Care

2023 Volume 22, Page(s) 23259582231161029

Abstract: Identifying factors associated with alcohol use changes during pregnancy is important for developing interventions for people with HIV (PWH). Pregnant PWH (n = 202) initiating antiretroviral therapy in Uganda and South Africa completed two assessments, 6 ...

Abstract	Identifying factors associated with alcohol use changes during pregnancy is important for developing interventions for people with HIV (PWH). Pregnant PWH (n = 202) initiating antiretroviral therapy in Uganda and South Africa completed two assessments, 6 months apart (T1, T2). Categories were derived based on AUDIT-C scores: "no use" (AUDIT-C = 0 at T1 and T2), "new use" (AUDIT-C = 0 at T1, >0 at T2), "quit" (AUDIT-C > 0 at T1, =0 at T2), and "continued use" (AUDIT-C > 0, T1 and T2). Factors associated with these categories were assessed. Most participants had "no use" (68%), followed by "continued use" (12%), "quit" (11%), and "new use" (9%). Cohabitating with a partner was associated with lower relative risk of "continued use." Borderline significant associations between food insecurity and higher risk of "new use" and between stigma and reduced likelihood of "quitting" also emerged. Alcohol use interventions that address partnership, food security, and stigma could benefit pregnant and postpartum PWH.
MeSH term(s)	Female ; Pregnancy ; Humans ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; South Africa/epidemiology ; Uganda/epidemiology ; Postpartum Period ; Alcohol Drinking/epidemiology
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2709037-1
ISSN	2325-9582 ; 2325-9574
ISSN (online)	2325-9582
ISSN	2325-9574
DOI	10.1177/23259582231161029
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Article ; Online: The Prominin-1-Derived Peptide Improves Cardiac Function Following Ischemia.

Adini, Avner / Adini, Irit / Grad, Etty / Tal, Yuval / Danenberg, Haim D / Kang, Peter M / Matthews, Benjamin D / D'Amato, Robert J

International journal of molecular sciences

2021 Volume 22, Issue 10

Abstract: Myocardial infarction (MI) remains the leading cause of death in the western world. Despite advancements in interventional revascularization technologies, many patients are not candidates for them due to comorbidities or lack of local resources. Non- ... ...

Abstract	Myocardial infarction (MI) remains the leading cause of death in the western world. Despite advancements in interventional revascularization technologies, many patients are not candidates for them due to comorbidities or lack of local resources. Non-invasive approaches to accelerate revascularization within ischemic tissues through angiogenesis by providing Vascular Endothelial Growth Factor (VEGF) in protein or gene form has been effective in animal models but not in humans likely due to its short half-life and systemic toxicity. Here, we tested the hypothesis that PR1P, a small VEGF binding peptide that we developed, which stabilizes and upregulates endogenous VEGF, could be used to improve outcome from MI in rodents. To test this hypothesis, we induced MI in mice and rats via left coronary artery ligation and then treated animals with every other day intraperitoneal PR1P or scrambled peptide for 14 days. Hemodynamic monitoring and echocardiography in mice and echocardiography in rats at 14 days showed PR1P significantly improved multiple functional markers of heart function, including stroke volume and cardiac output. Furthermore, molecular biology and histological analyses of tissue samples showed that systemic PR1P targeted, stabilized and upregulated endogenous VEGF within ischemic myocardium. We conclude that PR1P is a potential non-invasive candidate therapeutic for MI.
MeSH term(s)	AC133 Antigen/metabolism ; Animals ; Disease Models, Animal ; Female ; Ischemia/complications ; Ischemia/metabolism ; Ischemia/pathology ; Mice ; Mice, Inbred C57BL ; Myocardial Infarction/etiology ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Infarction/prevention & control ; Neovascularization, Physiologic/drug effects ; Peptide Fragments/pharmacology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Ventricular Function, Left/drug effects
Chemical Substances	AC133 Antigen ; Peptide Fragments ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2021-05-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22105169
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Article ; Online: Balancing Innovation and Value of Biological Meshes in Hernia: Who Is in Charge?

Poulose, Benjamin K / Matthews, Brent D / Rosen, Michael J

JAMA surgery

2016 Volume 151, Issue 4, Page(s) 381–382

MeSH term(s)	Hernia ; Herniorrhaphy ; Humans ; Prostheses and Implants ; Surgical Mesh
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	2701841-6
ISSN	2168-6262 ; 2168-6254
ISSN (online)	2168-6262
ISSN	2168-6254
DOI	10.1001/jamasurg.2015.5236
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Article ; Online: Plasma proteomic evidence for increased Alzheimer's disease-related brain pathology after SARS-CoV-2 infection

Duff, Eugene P / Zetterberg, Henrik / Heslegrave, Amanda / Dehghan, Abbas / Elliott, Paul / Allen, Naomi / Runz, Heiko / Laban, Rhiannon / Veleva, Elena / Whelan, Christopher D / Sun, Benjamin B / Matthews, Paul M

medRxiv

Abstract: Viral infections have been linked to an increased risk for dementia. We investigated whether SARS-CoV-2 infection increases preclinical brain pathology associated with Alzheimer9s disease (AD) by comparing changes in plasma biomarkers in UK Biobank ... ...

Abstract	Viral infections have been linked to an increased risk for dementia. We investigated whether SARS-CoV-2 infection increases preclinical brain pathology associated with Alzheimer9s disease (AD) by comparing changes in plasma biomarkers in UK Biobank participants with and without prior SARS-CoV-2 infection. We discovered an association between SARS-CoV-2 infection and reduced plasma Aβ42:Aβ40 concentration ratio. In older participants, SARS-CoV-2 infection was associated with both lower plasma Aβ42 and higher plasma pTau-181. These biomarker changes, which have been associated with beta-amyloid accumulation and prodromal AD, were associated with increased brain imaging signatures of AD, poorer cognitive scores, and worse assessments of overall health and appeared to be greater in participants who had been hospitalised with COVID-19. Protein biomarker risk scores for other diseases were also raised among individuals who had past SARS-CoV-2 infections. Our data provide support for the hypothesis that viral infections can accelerate prodromal AD pathology and highlight biomarker profiles indicative of an increased risk of dementia and systemic diseases after SARS-CoV-2 infection, particularly in older people.
Keywords	covid19
Language	English
Publishing date	2024-02-03
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2024.02.02.24302132
Database	COVID19

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Article ; Online: Local Public Health Surveillance of Heroin-Related Morbidity and Mortality, Orange County, Florida, 2010-2014.

Hudson, Toni-Marie L / Klekamp, Benjamin G / Matthews, Sarah D

Public health reports (Washington, D.C. : 1974)

2017 Volume 132, Issue 1_suppl, Page(s) 80S–87S

Abstract: Objectives: Heroin-related deaths have increased substantially in the past 10 years in the United States, particularly in Florida. Our objectives were to measure heroin-related morbidity and mortality rates in Orange County, Florida, and to assess ... ...

Abstract	Objectives: Heroin-related deaths have increased substantially in the past 10 years in the United States, particularly in Florida. Our objectives were to measure heroin-related morbidity and mortality rates in Orange County, Florida, and to assess trends in those rates during 2010-2014. Methods: We used 3 heroin surveillance methods, based on data from the Florida Medical Examiner, the Florida Agency for Health Care Administration (AHCA), and the Electronic Surveillance System for the Early Notification of Community-Based Epidemics-Florida (ESSENCE-FL). We conducted descriptive and geographic spatial analyses of all 3 data sets, determined heroin-related mortality and morbidity (emergency department [ED] visit) rates, and compared the timeliness of data availability from the 3 data sources. Results: Heroin-related deaths in Orange County increased by 590%, from 10 in 2010 to 69 in 2014. Heroin-related ED visits during the same period increased 12-fold (from 13 to 154) and 6-fold (from 49 to 307) when based on AHCA and ESSENCE-FL data, respectively. ESSENCE-FL identified 140% more heroin-related visits than did AHCA. Spatial analysis found geographic clustering of heroin-related morbidity and mortality. Hospitals facing the greatest burden of heroin-related ED visits were close to communities with the highest crude heroin-related ED visit rates. Of the 3 data sources, ESSENCE-FL provided the timeliest data availability. Conclusions: These 3 data sources can be considered acceptable surveillance systems for monitoring heroin-related events in Orange County. The timely availability of data from ESSENCE-FL makes it the most useful source for obtaining near-real-time data about the heroin epidemic, potentially leading to improved identification of populations most in need of interventions to reduce morbidity and mortality.
MeSH term(s)	Adolescent ; Adult ; Emergency Service, Hospital/statistics & numerical data ; Female ; Florida/epidemiology ; Heroin Dependence/epidemiology ; Heroin Dependence/mortality ; Humans ; Male ; Middle Aged ; Morbidity ; Public Health Surveillance/methods ; Spatial Analysis
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	120953-x
ISSN	1468-2877 ; 0033-3549
ISSN (online)	1468-2877
ISSN	0033-3549
DOI	10.1177/0033354917709783
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Article ; Online: Use of Surveillance Systems in Detection of a Ciguatera Fish Poisoning Outbreak - Orange County, Florida, 2014.

Klekamp, Benjamin G / Bodager, Dean / Matthews, Sarah D

MMWR. Morbidity and mortality weekly report

2015 Volume 64, Issue 40, Page(s) 1142–1144

Abstract: What is already known on this topic? Ciguatera fish poisoning (CFP), caused by the ingestion of predatory reef-dwelling fish harboring ciguatoxins is one of the most commonly reported fish-associated marine intoxications. Ciguatoxin retains toxicity ... ...

Abstract	What is already known on this topic? Ciguatera fish poisoning (CFP), caused by the ingestion of predatory reef-dwelling fish harboring ciguatoxins is one of the most commonly reported fish-associated marine intoxications. Ciguatoxin retains toxicity regardless of freezing or cooking. Prompt treatment can reduce debilitating neurologic symptoms that are associated with CFP.What is added by this report? Syndromic surveillance systems in Florida identified six adults with CFP following consumption of black grouper. Five patients sought medical attention; health care providers did not make a diagnosis of CFP or report the cases to public health authorities, and none of the patients received treatment. Close collaboration among several investigating agencies allowed traceback efforts to link black grouper consumed by all patients to a common international distributor.What are the implications for public health practice? Syndromic surveillance systems capable of detecting CFP are essential public health tools to identify outbreaks and enhance investigations. Medical and public health practitioners should be educated to inquire about recent fish consumption when evaluating patients with clinically compatible signs and symptoms to allow for prompt treatment, and report suspected CFP cases to public health authorities to facilitate source-food traceback efforts. Public education on avoidance of consumption of relatively large predatory reef fish species known to be from ciguatoxic-endemic areas might reduce the risk for CFP.
MeSH term(s)	Adult ; Animals ; Ciguatera Poisoning/diagnosis ; Ciguatera Poisoning/epidemiology ; Disease Outbreaks ; Female ; Fishes ; Florida/epidemiology ; Humans ; Male ; Middle Aged ; Population Surveillance ; Seafood/poisoning
Language	English
Publishing date	2015-10-16
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm6440a3
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Article ; Online: Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis.

Potla, Ratnakar / Hirano-Kobayashi, Mariko / Wu, Hao / Chen, Hong / Mammoto, Akiko / Matthews, Benjamin D / Ingber, Donald E

Journal of cell science

2020 Volume 133, Issue 20

Abstract: One of the most rapid (less than 4 ms) transmembrane cellular mechanotransduction events involves activation of transient receptor potential vanilloid 4 (TRPV4) ion channels by mechanical forces transmitted across cell surface β1 integrin receptors on ... ...

Abstract	One of the most rapid (less than 4 ms) transmembrane cellular mechanotransduction events involves activation of transient receptor potential vanilloid 4 (TRPV4) ion channels by mechanical forces transmitted across cell surface β1 integrin receptors on endothelial cells, and the transmembrane solute carrier family 3 member 2 (herein denoted CD98hc, also known as SLC3A2) protein has been implicated in this response. Here, we show that β1 integrin, CD98hc and TRPV4 all tightly associate and colocalize in focal adhesions where mechanochemical conversion takes place. CD98hc knockdown inhibits TRPV4-mediated calcium influx induced by mechanical forces, but not by chemical activators, thus confirming the mechanospecificity of this signaling response. Molecular analysis reveals that forces applied to β1 integrin must be transmitted from its cytoplasmic C terminus via the CD98hc cytoplasmic tail to the ankyrin repeat domain of TRPV4 in order to produce ultrarapid, force-induced channel activation within the focal adhesion.
MeSH term(s)	Cell Adhesion ; Endothelial Cells/metabolism ; Integrin beta1/genetics ; Integrin beta1/metabolism ; Mechanotransduction, Cellular ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism
Chemical Substances	Integrin beta1 ; TRPV Cation Channels
Language	English
Publishing date	2020-11-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.248823
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