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  1. Article ; Online: Treatment efficacy in secondary Raynaud's phenomenon - Authors' reply.

    Roustit, Matthieu / Khouri, Charles / Cracowski, Jean-Luc

    The Lancet. Rheumatology

    2024  Volume 2, Issue 3, Page(s) e132–e133

    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Letter
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(20)30031-X
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  2. Article ; Online: [No title information]

    Bouhanick, Béatrice / Cracowski, Jean-Luc / Faillie, Jean-Luc

    Therapie

    2021  Volume 76, Issue 4, Page(s) 359–360

    Title translation DPP-4 inhibitors and severe course of illness in patients with COVID-19.
    MeSH term(s) COVID-19 ; Dipeptidyl-Peptidase IV Inhibitors ; Humans ; SARS-CoV-2
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors
    Language French
    Publishing date 2021-01-18
    Publishing country France
    Document type Editorial ; Comment
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.1016/j.therap.2021.01.051
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    Ue I Zs.272: Show issues Location:
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  3. Article ; Online: Outcome of patients hospitalized for Covid-19 and exposure to angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers in France: Results of the ACECoV study.

    Alexandre, Joachim / Cracowski, Jean-Luc

    Fundamental & clinical pharmacology

    2021  Volume 35, Issue 1, Page(s) 192–193

    MeSH term(s) Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Angiotensins ; COVID-19 ; France ; Humans ; Hypertension ; SARS-CoV-2
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Angiotensins
    Language English
    Publishing date 2021-01-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639134-5
    ISSN 1472-8206 ; 0767-3981
    ISSN (online) 1472-8206
    ISSN 0767-3981
    DOI 10.1111/fcp.12637
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    Zs.A 2247: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Laser speckle contrast imaging to assess microcirculation.

    Hellmann, Marcin / Kalinowski, Leszek / Cracowski, Jean-Luc

    Cardiology journal

    2022  

    Language English
    Publishing date 2022-11-07
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2488680-4
    ISSN 1898-018X ; 1897-5593
    ISSN (online) 1898-018X
    ISSN 1897-5593
    DOI 10.5603/CJ.a2022.0097
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    Zs.A 6770: Show issues Location:
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  5. Article ; Online: Validity, relevance and interpretation of pharmacovigilance disproportionality analyses.

    Cortes, Benjamin / Jambon-Barbara, Clément / Cracowski, Jean-Luc / Khouri, Charles

    Bone

    2023  Volume 170, Page(s) 116685

    MeSH term(s) Humans ; Pharmacovigilance ; Databases, Factual ; Drug-Related Side Effects and Adverse Reactions/epidemiology
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Letter
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2023.116685
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    Zs.A 1571: Show issues Location:
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    Zs.MO 332: Show issues

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  6. Article ; Online: Benefit-risk balance of COVID drugs. New prospects.

    Cracowski, Jean-Luc / Richard, Vincent / Molimard, Mathieu

    Therapie

    2022  Volume 77, Issue 5, Page(s) 505–507

    MeSH term(s) COVID-19 ; Humans ; Risk Assessment ; SARS-CoV-2
    Language English
    Publishing date 2022-09-06
    Publishing country France
    Document type Editorial
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.1016/j.therap.2022.09.001
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    Ue I Zs.272: Show issues Location:
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  7. Article: Negative pressure wound therapy with instillation and dwell time in debridement of fibrinous leg ulcers.

    Achiti, Alexandru / Zenati, Nora / Seinturier, Christophe / Cracowski, Jean-Luc / Blaise, Sophie

    Journal of wound care

    2024  Volume 33, Issue 3, Page(s) 166–170

    Abstract: Objective: In conjunction with appropriate wound care, negative pressure wound therapy with instillation and dwell time (NPWTi-d) may be used as an adjunct therapy for acute or hard-to-heal (chronic) wounds, especially when infected. However, there are ... ...

    Abstract Objective: In conjunction with appropriate wound care, negative pressure wound therapy with instillation and dwell time (NPWTi-d) may be used as an adjunct therapy for acute or hard-to-heal (chronic) wounds, especially when infected. However, there are very few data on the use of NPWTi-d in the treatment of fibrinous wounds that are difficult to debride mechanically. The main objective of this study was to describe changes in the fibrin area of such wounds, before and after treatment with NPWTi-d.
    Method: This was a monocentric, observational, prospective pilot study evaluating the NPWTi-d medical device. Eligible patients included in the study were those with hard-to-heal lower limb ulcers who had previously undergone unsuccessful specific debridement treatment for their wound, with failure of manual mechanic debridement for at least six weeks' duration, and whose wounds had a fibrinous surface area of >70% of the total wound surface area. The primary endpoint was the difference in the percentage of fibrinous surface area before and after treatment.
    Results: A total of 14 patients who received treatment for lower limb ulcers between October 2017 and August 2019 were included in the study. There was a significant shrinkage rate of the fibrinous wound surface between the start and end of treatment (83.6±14.5% and 32.2±19.7%, respectively; p<0.001).
    Conclusion: This study showed a significant decrease in fibrin area in wounds treated with NPWTi-d, with good tolerance. We believe that NPWTi-d has its place in the multidisciplinary management of patients with hard-to-heal ulcers. Additional randomised studies are required to confirm these findings.
    Declaration of interest: The authors have no conflicts of interest.
    MeSH term(s) Humans ; Debridement ; Wound Infection/therapy ; Negative-Pressure Wound Therapy ; Ulcer ; Pilot Projects ; Prospective Studies ; Leg Ulcer/therapy ; Fibrin ; Therapeutic Irrigation
    Chemical Substances Fibrin (9001-31-4)
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 1353951-6
    ISSN 0969-0700
    ISSN 0969-0700
    DOI 10.12968/jowc.2024.33.3.166
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    Zs.A 4572: Show issues Location:
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  8. Article ; Online: Diabète et COVID-19.

    Bouhanick, Béatrice / Cracowski, Jean-Luc / Faillie, Jean-Luc

    Therapie

    2020  

    Abstract: According to previous reports, diabetes seems to be associated with serious clinical events due to COVID-19. But is diabetes per se a risk factor of being infected by the virus? We discuss these points. Data about the antidiabetic drugs are scarce. ... ...

    Title translation Diabetes and COVID-19.
    Abstract According to previous reports, diabetes seems to be associated with serious clinical events due to COVID-19. But is diabetes per se a risk factor of being infected by the virus? We discuss these points. Data about the antidiabetic drugs are scarce. Dipeptidylpeptidase-4 (DPP-4) is found as both a cell surface protein ubiquitously expressed in many tissues and as a soluble molecule found in serum/plasma, fluids. DPP-4 is involved in infection of cells by some viruses. We relate data about the use of DPP-4 inhibitors in diabetic patients. We conclude relating French and international recommendations in people with diabetes.
    Language French
    Publishing date 2020-04-23
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.1016/j.therap.2020.04.004
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  9. Article ; Online: Diabetes and COVID-19.

    Bouhanick, Béatrice / Cracowski, Jean-Luc / Faillie, Jean-Luc

    Therapie

    2020  Volume 75, Issue 4, Page(s) 327–333

    Abstract: According to previous reports, diabetes seems to be a risk factor which worsens the serious clinical events caused by COVID-19. But is diabetes per se a risk factor that increases the probability of getting the virus? This paper will discuss this point. ... ...

    Abstract According to previous reports, diabetes seems to be a risk factor which worsens the serious clinical events caused by COVID-19. But is diabetes per se a risk factor that increases the probability of getting the virus? This paper will discuss this point. There are not many research data on antidiabetic drugs in this context. The potential influence of glucose-lowering agents on the severity of COVID-19 has not been described yet. Dipeptidylpeptidase-4 (DPP-4) is a cell surface protein ubiquitously expressed in many tissues and it is also a soluble molecule found in serum/plasma fluids. DPP-4 is involved in infection of cells by some viruses. This paper reviews data about the use of DPP-4 inhibitors and others diabetes drugs on COVID-19 patients. As such, no available evidence has yet suggested that glucose-lowering drugs - including those targeting DPP4-related pathways - produce any significant harm or benefit in the context of human infections. However, insulin must remain the first-choice agent in the management of critically ill-hospitalized patients, while it is recommended to suspend other agents in unstable patients. This paper provides related French and international recommendations for people with diabetes who got infected by COVID-19 and upholds that infections may alter glucose control and may require additional vigilance.
    MeSH term(s) Animals ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/epidemiology ; Dipeptidyl-Peptidase IV Inhibitors/administration & dosage ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/pharmacology ; Insulin/administration & dosage ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Risk Factors ; Severity of Illness Index
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents ; Insulin
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.1016/j.therap.2020.05.006
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  10. Article ; Online: Human Skin Microcirculation.

    Cracowski, Jean-Luc / Roustit, Matthieu

    Comprehensive Physiology

    2020  Volume 10, Issue 3, Page(s) 1105–1154

    Abstract: The anatomy and physiology of the microcirculation in human skin are complex. Normal cutaneous microcirculation is organized in two parallel plexuses with capillary loops extending perpendicularly from the superficial plexus. The physiological regulation ...

    Abstract The anatomy and physiology of the microcirculation in human skin are complex. Normal cutaneous microcirculation is organized in two parallel plexuses with capillary loops extending perpendicularly from the superficial plexus. The physiological regulation of cutaneous microcirculation includes specific sympathetic activation, which causes vasoconstriction through the release of norepinephrine, neuropeptide Y, and ATP. A sympathetic cholinergic system is mainly involved in vasodilation through the co-transmission of acetylcholine, vasoactive intestinal peptide, and pituitary adenylate cyclase-activating peptide. Sensory nerves play a major role through the release of calcitonin gene-related peptide and substance P. Endothelium-dependent vasomotion implicates nitric oxide, prostacyclin, endothelium-dependent hyperpolarizing factors, and endothelin. Myogenic response also plays a role and explains why autoregulation is weak but exists in glabrous human skin. Variations in skin blood flow result from highly complex interactions between these mechanisms. In this article, we will detail the anatomy, physiology, and current methods of exploring the human microcirculation. We will further discuss the part played by cutaneous microvascular impairment in the pathophysiology of cardiovascular and metabolic diseases, or diseases more specifically affecting the skin. © 2020 American Physiological Society. Compr Physiol 10:1105-1154, 2020.
    MeSH term(s) Animals ; Humans ; Microcirculation ; Skin/blood supply ; Skin Diseases/etiology ; Skin Diseases/physiopathology
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2040-4603
    ISSN (online) 2040-4603
    DOI 10.1002/cphy.c190008
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