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Article ; Online: Using two self-developed InDel panels to explore forensic traits and ancestral components in the Hui group.

Yuan, Xi / Wang, Xi / Lan, Qiong / Li, Shuanglin / Lin, Yifeng / Zhao, Ming / Xu, Hui / Lei, Fanzhang / Shen, Chunmei / Zhu, Bofeng

Genomics

2023 Volume 116, Issue 1, Page(s) 110756

Abstract: ... of these two panels were tested in the Chinese Hui group. By calculating forensic parameters and simulating ... paternity testing, and could assist in kinship identification in the Hui group. For full siblings, the true ...

Abstract	To address the challenges faced by forensic examiners in degraded DNA analysis, we have developed two different panels for various forensic applications, encompassing an AIM-InDel panel for ancestry inference and a Multi-InDel panel for individual identification, respectively. Herein, the efficiencies of these two panels were tested in the Chinese Hui group. By calculating forensic parameters and simulating family relationships, we verified that the Multi-InDel panel could be an effective tool for individual identification, paternity testing, and could assist in kinship identification in the Hui group. For full siblings, the true positive rate of kinship discrimination was 96.553%, when the threshold of log
MeSH term(s)	Humans ; China ; Ethnicity/genetics ; Gene Frequency ; Genetics, Population ; INDEL Mutation ; Minority Groups ; Phenotype ; East Asian People/genetics
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2023.110756
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Article ; Online: Comparative analysis of the clinical features of nonvalvular atrial fibrillation among Tibetan, Han, and Hui patients in Qinghai Province, China.

Cao, Jiandong / Ma, Xiaofeng / Deng, Yong / Wang, Hong / Zhang, Shengqi / Zhao, Longxiang / Cao, Feifei

Heart & lung : the journal of critical care

2024 Volume 66, Page(s) 9–15

Abstract: ... to compares cardiac features in AF among Tibetan, Han, and Hui patients to develop tailored prevention and ... This study included a total of 3445 Tibetan, Han, and Hui patients diagnosed with nonvalvular ... between Tibetan, Han, and Hui patients (P < 0.05). Tibetan, Han, and Hui patients also differed ...

Abstract	Background: Global nonvalvular AF rises, impacting health severely. In Qinghai, China's diverse setting, studying AF among varied ethnic groups is crucial OBJECTIVES: The purpose of this study was to compares cardiac features in AF among Tibetan, Han, and Hui patients to develop tailored prevention and treatment strategies for this region, the goal was to enhance the understanding of AF and provide an empirical basis for developing prevention and treatment strategies specific to this region METHODS: This study included a total of 3445 Tibetan, Han, and Hui patients diagnosed with nonvalvular atrial fibrillation and treated at the Qinghai Cardiovascular and Cerebrovascular Specialist Hospital, China, between January 2019 and January 2021. We analyzed the differences in cardiac structure, comorbidities, and other influencing factors among the different ethnic groups RESULTS: We found significant differences in gender, age, smoking history, lone atrial fibrillation, left heart failure, dilated cardiomyopathy, and diabetes between Tibetan, Han, and Hui patients (P < 0.05). Tibetan, Han, and Hui patients also differed with regard to left ventricular end-diastolic volume, left ventricular ejection fraction, fractional shortening, NT-proBNP, glycated hemoglobin, red blood cell distribution width, platelet count, platelet hematocrit, platelet distribution width, homocysteine (Hcy), C-reactive protein, and superoxide dismutase (SOD) (P < 0.05) CONCLUSION: Our study revealed variations in comorbidities, cardiac structure, and blood indexes among Tibetan, Han, and Hui AF patients, highlighting distinct patterns in complications and biomarker levels across ethnic groups.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	193129-5
ISSN	1527-3288 ; 0147-9563
ISSN (online)	1527-3288
ISSN	0147-9563
DOI	10.1016/j.hrtlng.2024.03.001
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Article ; Online: The effect and pharmacology of Yizhi Sheng Hui decoction on Alzheimer's disease.

Li, Qiubing / Hou, Yi / Zhao, Baosheng / Li, Yingfan / Zhang, Xinyu / Mei, Rong / Wang, Shuo / Wang, Peng / Liu, Ying

Annals of palliative medicine

2021 Volume 10, Issue 5, Page(s) 5244–5251

Abstract: ... after treatment with the traditional Chinese medicine compound, Yizhi Sheng Hui (YZSH) decoction. This study ...

Abstract	Background: Alzheimer's disease (AD) has gradually increased as society has aged and is now a serious social problem. In the clinical treatment of AD, patients show improvement in cognitive function after treatment with the traditional Chinese medicine compound, Yizhi Sheng Hui (YZSH) decoction. This study systematically investigates the effect and pharmacology of the YZSH decoction on AD. Methods: In this study, 24 SAMP8 AD model mice were randomly divided into three groups: an untreated control group, a group treated with the YZSH decoction, and a positive control group treated with donepezil hydrochloride. Eight SAMR1 mice were placed in the normal control group. A Morris water maze test and a step-down test were conducted at 8 and 13 weeks after continuous intragastric administration of the two drugs. After 13 weeks of administration, the hippocampal expression of Aβ1-42 and tau protein were measured. Results: There was no change in the latent period duration and the number of platform crossings in each group after 8 weeks of administration, but after 13 weeks of administration, the latent period of the treatment group and the positive control group were significantly shorter than the untreated control group. Initially, the SAMP8 mice showed a lower spatial exploration ability than the SAMR1 mice. However, after 13 weeks of administration, the treatment group and the control group exhibited a better exploration ability. Compared with the SAMR1 mice, the on-stage evasion time and step-down errors significantly increased in the untreated group. Compared with the untreated group, mice in the treatment group and the positive control group showed a shorter latent period after 8 weeks of administration, and the on-stage evasion time for both groups was significantly reduced after 13 weeks of administration. The treatment group showed fewer instances of electric shock. Hippocampal expression of Aβ1-42 was high in the untreated group, was much lower in the positive control group, and no Aβ1-42 expression was observed in the treatment group. Conclusions: The YZSH decoction improved the learning and memory of mice with AD, related to the inhibition of Aβ1-42 expression.
MeSH term(s)	Aged ; Alzheimer Disease/drug therapy ; Animals ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Learning ; Memory ; Mice
Chemical Substances	Drugs, Chinese Herbal ; yi-zhi (1QBV21VOZI)
Language	English
Publishing date	2021-05-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-20-1629
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Article ; Online: Establishment of SIAISi017-A, an induced pluripotent stem cell(iPSC)line from a healthy 25-year-old Chinese Hui.

Zhang, Yi / Shou, Jiajun / Gu, Wentao / Di, Weihao / Zhao, Jian / Wang, Ying / Gu, Shixin

Stem cell research

2022 Volume 60, Page(s) 102645

Abstract: With the development of cytology, the establishment of cell models in vitro has become a powerful means to study the mechanism and treatment of diseases. Here we successfully generated the IPSC-derived modeling system of a 25-year-old healthy male. His ... ...

Abstract	With the development of cytology, the establishment of cell models in vitro has become a powerful means to study the mechanism and treatment of diseases. Here we successfully generated the IPSC-derived modeling system of a 25-year-old healthy male. His peripheral blood mononuclear cells (PBMC) were reprogrammed using human OKSM (SOX2, OCT3/4, KLF4, and C-MYC) transcription factors using a non-integrated additional vector system. Immunocytochemistry demonstrated that IPSCS expressed all the markers of pluripotency and demonstrated their ability to differentiate spontaneously from three hypoderms in vitro. Karyotype is normal.
MeSH term(s)	Adult ; Asians ; Cell Differentiation ; China ; Humans ; Induced Pluripotent Stem Cells ; Leukocytes, Mononuclear ; Male ; Transcription Factors/genetics
Chemical Substances	Transcription Factors
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2393143-7
ISSN	1876-7753 ; 1873-5061
ISSN (online)	1876-7753
ISSN	1873-5061
DOI	10.1016/j.scr.2021.102645
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Article ; Online: Sequencing and Genomic Analysis of Sorghum DNA Introgression Variant Line R21 and Recipient Rice Jin Hui 1 Revealed Repetitive Element Variation.

Zhang, Ting / Li, Xiaodong / Zhao, Zijun / Wu, Renhong / Yang, Zhenglin / He, Guanghua

International journal of molecular sciences

2022 Volume 23, Issue 19

Abstract: ... was created by introgressing the genomic DNA of sorghum into the recipient restorer line Jin Hui 1 ... Assembly of rice R21 and Jin Hui 1 genomes was performed using PacBio sequencing technology. Comparative ... at different copy numbers on the telomeric position of chromosomes 9 or 10 in R21, Jin Hui 1, and several rice ...

Abstract	Transferring the genome of distant species to crops is an efficient way to create new germplasms. However, the molecular mechanisms involved are unclear. In this study, a new rice restorer line R21 with heat tolerance was created by introgressing the genomic DNA of sorghum into the recipient restorer line Jin Hui 1. Assembly of rice R21 and Jin Hui 1 genomes was performed using PacBio sequencing technology. Comparative genome analysis and coverage statistics showed that the repetitive sequence atr0026 was a candidate introgression fragment of sorghum DNA. Sequence similarity analysis revealed that atr0026 was distributed at different copy numbers on the telomeric position of chromosomes 9 or 10 in R21, Jin Hui 1, and several rice varieties, indicating that the repetitive sequence from sorghum was highly conserved in rice. The repeat annotation in Gramineae indicated that ribosomal DNA loci that existed in atr0026 may be cause a rearrangement of chromosomes 9 and 10 of the R21 genome, resulting in a copy number variation at the 5' end of it. Our study lays the foundation for further elucidation of the molecular mechanisms underlying the heat tolerance of sorghum DNA introgression variant line R21, which is of great significance for guiding crop genetic breeding.
MeSH term(s)	DNA Copy Number Variations ; DNA, Ribosomal ; Edible Grain/genetics ; Genome, Plant ; Genomics ; Oryza/genetics ; Plant Breeding ; Repetitive Sequences, Nucleic Acid ; Sorghum/genetics
Chemical Substances	DNA, Ribosomal
Language	English
Publishing date	2022-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231911864
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Article: Male-Dominated Migration and Massive Assimilation of Indigenous East Asians in the Formation of Muslim Hui People in Southwest China.

Wang, Qiyan / Zhao, Jing / Ren, Zheng / Sun, Jin / He, Guanglin / Guo, Jianxin / Zhang, Hongling / Ji, Jingyan / Liu, Yubo / Yang, Meiqing / Yang, Xiaomin / Chen, Jinwen / Zhu, Kongyang / Wang, Rui / Li, Yingxiang / Chen, Gang / Huang, Jiang / Wang, Chuan-Chao

Frontiers in genetics

2021 Volume 11, Page(s) 618614

Abstract: The origin and diversification of Muslim Hui people in China via demic or simple cultural diffusion ... single nucleotide polymorphisms (SNPs) from 45 Hui and 14 Han Chinese individuals collected from Guizhou province in southwest ...

Abstract	The origin and diversification of Muslim Hui people in China via demic or simple cultural diffusion is a long-going debate. We here generated genome-wide data at nearly 700,000 single nucleotide polymorphisms (SNPs) from 45 Hui and 14 Han Chinese individuals collected from Guizhou province in southwest China. We applied principal component analysis (PCA), ADMIXTURE,
Language	English
Publishing date	2021-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2020.618614
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Article ; Online: Provincial-Scale Research on the Eco-Security Structure in the Form of an Ecological Network of the Upper Yellow River: A Case Study of the Ningxia Hui Autonomous Region

Yang, Zhonghua / Ma, Caihong / Liu, Yuanyuan / Zhao, Honghong / Hua, Yuqi / Ou, Shengya / Fan, Xin

Land. 2023 July 04, v. 12, no. 7

2023

Abstract: Important for promoting the integrated protection and systematic management of mountains, rivers, forests, farmlands, lakes, grasslands, and sandy areas, ecological networks form the backbone of the regional ecological security pattern. An improved ... ...

Abstract	Important for promoting the integrated protection and systematic management of mountains, rivers, forests, farmlands, lakes, grasslands, and sandy areas, ecological networks form the backbone of the regional ecological security pattern. An improved morphological spatial pattern analysis coupled with a minimum cumulative resistance model (MSPA–MCR) based on multi-source data was used to study, on a provincial scale, the ecological security pattern of Ningxia, an ecologically fragile region in the upper reaches of the Yellow River in China. The results show the following: (1) A reasonable classification of ecological sources and ecological corridors is key to constructing hierarchical ecological networks. Classifying ecological sources by replacing patch areas with energy factors and identifying the importance of ecological corridors by modifying the gravity model with the energy factors proposed in this paper could improve the rationality of the hierarchical structure division of ecological networks. (2) Grassland as the substrate vegetation type is an important ecological source type in arid and semi-arid ecologically fragile areas, and forests and lake wetlands are the main ecological source types in mountainous areas and oasis areas, respectively. The study area was located in the arid–semi-arid transitional area, with a variety of ecological types, such as mountain, oasis, and desert. Therefore, the complex ecological source types of forest–grassland–wetland appear in some areas. (3) There are 45 ecological patch groups that can be classified as ecological sources in Ningxia, including 10 primary source groups. The number of primary source groups is small, and their spatial distribution is unbalanced. There are two categories of ecological corridors, the river corridor and the mountain corridor, and the network connectivity is poor. (4) The ecological network structure of Ningxia is presented as an ecological security structure consisting of one belt, three screens, three corridors, and five clusters, forming a hierarchical nested ecological network security structure system.
Keywords	case studies ; energy ; grasslands ; lakes ; land ; models ; mountains ; oases ; rivers ; China ; Yellow River
Language	English
Dates of publication	2023-0704
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2682955-1
ISSN	2073-445X
ISSN	2073-445X
DOI	10.3390/land12071341
Database	NAL-Catalogue (AGRICOLA)

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Article: [Spatial-temporal distribution of human brucellosis and its correlation with the number of livestock in Ningxia Hui Autonomous Region, 2012-2018].

Zhao, Y / Guo, Z Q / Zhao, J H / Liang, P F

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2020 Volume 41, Issue 6, Page(s) 872–876

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Animals ; Brucellosis/epidemiology ; Cattle ; China/epidemiology ; Humans ; Incidence ; Livestock ; Sheep ; Spatio-Temporal Analysis ; Swine
Language	Chinese
Publishing date	2020-06-21
Publishing country	China
Document type	Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.cn112338-20190925-00701
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Article ; Online: Establishment of SIAISi017-A, an induced pluripotent stem cell(iPSC)line from a healthy 25-year-old Chinese Hui

Yi Zhang / Jiajun Shou / Wentao Gu / Weihao Di / Jian Zhao / Ying Wang / Shixin Gu

Stem Cell Research, Vol 60, Iss , Pp 102645- (2022)

2022

Abstract	With the development of cytology, the establishment of cell models in vitro has become a powerful means to study the mechanism and treatment of diseases. Here we successfully generated the IPSC-derived modeling system of a 25-year-old healthy male. His peripheral blood mononuclear cells (PBMC) were reprogrammed using human OKSM (SOX2, OCT3/4, KLF4, and C-MYC) transcription factors using a non-integrated additional vector system. Immunocytochemistry demonstrated that IPSCS expressed all the markers of pluripotency and demonstrated their ability to differentiate spontaneously from three hypoderms in vitro. Karyotype is normal.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: The Trend of Grassland Restoration and Its Driving Forces in Ningxia Hui Autonomous Region of China from 1988 to 2018

Xiujuan Zhang / Yuting Zhao / Kexin Ma / Danni Wang / Huilong Lin

Sustainability, Vol 14, Iss 16, p

2022 Volume 10404

Abstract: Since the implementation of the grassland ecological protection policy of prohibition grazing on natural grasslands throughout the territory in 2003, the growth of grasslands in Ningxia has improved. This study investigated the spatial differentiation ... ...

Abstract	Since the implementation of the grassland ecological protection policy of prohibition grazing on natural grasslands throughout the territory in 2003, the growth of grasslands in Ningxia has improved. This study investigated the spatial differentiation mechanism of normalized vegetation index (NDVI) in Ningxia grasslands from 1988 to 2018, analyzed the relative contributions of climate change (CC) and human activities (HA) to NDVI changes, and predicted the future trend of grassland changes. The results show that except in winter, the annual, seasonal and monthly average values of NDVI after grazing prohibition were higher than those before grazing prohibition. After grazing prohibition, the growth rate decreased by 17.91%, but the degradation rate increased by 3.92%. After grazing prohibition, the proportion of medium coverage increased by 16.15%, mainly in the path of “lower coverage grassland→medium coverage grassland”. The transformation trend was mainly positive, and the ecological construction project has achieved remarkable results. The main factors affecting NDVI differentiation in Ningxia grassland were snow depth, potential evapotranspiration, radiation, and precipitation. After grazing prohibition, the explanatory power of each factor and the interaction between the factors decreased significantly, but the explanatory power of wind speed was greatly improved. After the grazing prohibition, 53.22% of the total area was affected by human activities and climate change. The relative contribution of human activities decreased in NDVI-increased areas but increased in NDVI-decreased areas.
Keywords	NDVI ; driving forces ; transition matrix ; geographical detector model ; Ningxia ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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