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  1. Article ; Online: Is it worth investigating splenic function in patients with celiac disease?

    Antonio Di Sabatino / Laura Brunetti / Gabriella Carnevale Maffè Paolo Giuffrida / Gino Roberto Corazza

    World Journal of Gastroenterology, Vol 19, Iss 15, Pp 2313-

    2013  Volume 2318

    Abstract: Celiac disease, an immune-mediated enteropathy induced in genetically susceptible individuals by the ingestion of gluten, is the most frequent disorder associated with splenic hypofunction or atrophy. Defective splenic function affects more than one- ... ...

    Abstract Celiac disease, an immune-mediated enteropathy induced in genetically susceptible individuals by the ingestion of gluten, is the most frequent disorder associated with splenic hypofunction or atrophy. Defective splenic function affects more than one-third of adult patients with celiac disease, and it may predispose to a higher risk of infections by encapsulated bacteria and thromboembolic and autoimmune complications, particularly when celiac patients have concomitant pre-malignant and malignant complications (refractory celiac disease, ulcerative jejunoileitis and enteropathy-associated T-cell lymphoma). However, the clinical management of patients with celiac disease does not take into account the evaluation of splenic function, and in patients with high degree of hyposplenism or splenic atrophy the prophylactic immunization with specific vaccines against the polysaccharide antigens of encapsulated bacteria is not currently recommended. We critically re-evaluate clinical and diagnostic aspects of spleen dysfunction in celiac disease, and highlight new perspectives in the prophylactic management of infections in this condition.
    Keywords Hyposplenism ; Memory B cell ; Pitted red cell ; Pneumococcal vaccine ; Splenic atrophy ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Baishideng Publishing Group Co., Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Out of the blue: the Grey-Turner's sign.

    Carnevale-Maffé, Gabriella / Modesti, Pietro Amedeo

    Internal and emergency medicine

    2015  Volume 10, Issue 3, Page(s) 387–388

    MeSH term(s) Back Pain/etiology ; Hemorrhage/diagnosis ; Humans ; Pigmentation Disorders/etiology ; Retroperitoneal Space
    Language English
    Publishing date 2015-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-014-1178-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: The Circulating Level of Soluble Receptor for Advanced Glycation End Products Displays Different Patterns in Ulcerative Colitis and Crohn's Disease: A Cross-Sectional Study.

    Ciccocioppo, Rachele / Imbesi, Venerina / Betti, Elena / Boccaccio, Vincenzo / Kruzliak, Peter / Gallia, Alessandra / Cangemi, Giuseppina Cristina / Maffe, Gabriella Carnevale / Vanoli, Alessandro / Merante, Serena / De Amici, Mara / Falcone, Colomba / Klersy, Catherine / Corazza, Gino Roberto

    Digestive diseases and sciences

    2015  Volume 60, Issue 8, Page(s) 2327–2337

    Abstract: Background: RAGE is a transmembrane receptor expressed on immune and endothelial cells, whose binding with its ligands, the S100 calgranulins, leads to chronic inflammation. Conversely, its soluble form (sRAGE) plays a protective role by acting as a ... ...

    Abstract Background: RAGE is a transmembrane receptor expressed on immune and endothelial cells, whose binding with its ligands, the S100 calgranulins, leads to chronic inflammation. Conversely, its soluble form (sRAGE) plays a protective role by acting as a decoy. We carried out a cross-sectional analysis of the sRAGE and S100A12 serum levels in patients with Crohn's disease (CD) and ulcerative colitis (UC) and searched for a correlation with clinical and biological markers of activity.
    Methods: We enrolled 60 CD, 67 UC patients, and 66 controls (all adults). Disease activity was scored through the clinical, endoscopic, and histologic indexes of severity, whilst disease location and behaviour were assessed according to the Montreal classification. In all cases, the levels of serum sRAGE, S100A12, C-reactive protein, and faecal calprotectin were measured.
    Results: sRAGE levels were significantly lower in UC, both active and inactive, than in controls and CD (817.35, range 437.3-1449; 1211, range 843.7-1618; 1207.5, range 743.15-1875.75; P < 0.05 for both), and inversely correlated with clinical and endoscopic indexes of activity in both IBD groups (P < 0.05 for all) and with the histologic score in the CD group. Moreover, those CD patients with a penetrating behaviour showed a significant reduction in both sRAGE (P = 0.006) and S100A12 (P = 0.034) as compared to those with an inflammatory/stricturing pattern. Although S100A12 levels were not found up-regulated, a negative correlation appeared evident with the clinical (r = -0.38) and endoscopic (r = -0.32) indexes of activity in UC and CD, respectively.
    Conclusion: These data suggest a different role for RAGE in CD and UC, and a potential use of sRAGE as a new biomarker.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Colitis, Ulcerative/blood ; Crohn Disease/blood ; Cross-Sectional Studies ; Female ; Glycation End Products, Advanced/blood ; Humans ; Male ; Middle Aged ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic/blood ; Young Adult
    Chemical Substances Glycation End Products, Advanced ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-015-3619-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.35: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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