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  1. Article ; Online: Development of a novel dual reproductive organ on a chip: recapitulating bidirectional endocrine crosstalk between the uterine endometrium and the ovary.

    Park, Se-Ra / Kim, Soo-Rim / Lee, Jin Woo / Park, Chan Hum / Yu, Wook-Joon / Lee, Seung-Jin / Chon, Seung Joo / Lee, Dae Ho / Hong, In-Sun

    Biofabrication

    2020  Volume 13, Issue 1

    Abstract: Conventional 2D or even ... ...

    Abstract Conventional 2D or even 3D
    MeSH term(s) Cell Physiological Phenomena ; Endometrium ; Female ; Humans ; Lab-On-A-Chip Devices ; Ovary
    Language English
    Publishing date 2020-10-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2500944-8
    ISSN 1758-5090 ; 1758-5082
    ISSN (online) 1758-5090
    ISSN 1758-5082
    DOI 10.1088/1758-5090/abbd29
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Protective effect of

    Choi, Seung Hak / Lee, Ah Young / Park, Chan Hum / Shin, Yu Su / Cho, Eun Ju

    Food science and biotechnology

    2018  Volume 27, Issue 5, Page(s) 1475–1484

    Abstract: Chronic alcohol consumption induces damage to the brain that can cause various forms of dementia. An abundance of acetaldehyde is produced by excessive alcohol consumption and accumulates in the body to induce oxidative stress, apoptosis, and ... ...

    Abstract Chronic alcohol consumption induces damage to the brain that can cause various forms of dementia. An abundance of acetaldehyde is produced by excessive alcohol consumption and accumulates in the body to induce oxidative stress, apoptosis, and inflammation in neuronal cells, which results in learning and cognitive decline. In the present study, C57BL/N mice were orally administered alcohol (16%) and
    Language English
    Publishing date 2018-09-19
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2000008-X
    ISSN 2092-6456 ; 1226-7708
    ISSN (online) 2092-6456
    ISSN 1226-7708
    DOI 10.1007/s10068-018-0472-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Protective effect of Carthamus tinctorius L. seed on oxidative stress and cognitive impairment induced by chronic alcohol consumption in mice

    Choi, Seung Hak / Lee, Ah Young / Park, Chan Hum / Shin, Yu Su / Cho, Eun Ju

    Food science and biotechnology. 2018 Oct., v. 27, no. 5

    2018  

    Abstract: Chronic alcohol consumption induces damage to the brain that can cause various forms of dementia. An abundance of acetaldehyde is produced by excessive alcohol consumption and accumulates in the body to induce oxidative stress, apoptosis, and ... ...

    Abstract Chronic alcohol consumption induces damage to the brain that can cause various forms of dementia. An abundance of acetaldehyde is produced by excessive alcohol consumption and accumulates in the body to induce oxidative stress, apoptosis, and inflammation in neuronal cells, which results in learning and cognitive decline. In the present study, C57BL/N mice were orally administered alcohol (16%) and Carthamus tinctorius L. seed (CTS) (100 and 200 mg/kg/day). Behavioral experiments showed that memory and cognitive abilities were significantly higher in the CTS groups than the alcohol-treated control group in the T-maze test, novel object recognition test, and Morris water maze test. In addition, CTS inhibited alcohol-induced lipid peroxidation and nitric oxide production in the brain, kidney, and liver. Moreover, alcohol increased acetylcholinesterase activity in the brain, but this was significantly decreased by the administration of CTS. Therefore, CTS may play role in the prevention of alcohol-related dementia.
    Keywords Carthamus tinctorius ; acetaldehyde ; acetylcholinesterase ; alcohol abuse ; alcohol drinking ; alcohols ; apoptosis ; brain ; cognition ; cognitive disorders ; dementia ; enzyme activity ; inflammation ; kidneys ; lipid peroxidation ; liver ; memory ; mice ; neurons ; nitric oxide ; oxidative stress ; protective effect
    Language English
    Dates of publication 2018-10
    Size p. 1475-1484.
    Publishing place Springer Singapore
    Document type Article
    ZDB-ID 2000008-X
    ISSN 1226-7708
    ISSN 1226-7708
    DOI 10.1007/s10068-018-0472-4
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Seomae mugwort and jaceosidin attenuate osteoarthritic cartilage damage by blocking IκB degradation in mice.

    Lee, Hyemi / Jang, Dain / Jeon, Jimin / Cho, Chanmi / Choi, Sangil / Han, Seong Jae / Oh, Eunjeong / Nam, Jiho / Park, Chan Hum / Shin, Yu Su / Yun, Seung Pil / Yang, Siyoung / Kang, Li-Jung

    Journal of cellular and molecular medicine

    2020  Volume 24, Issue 14, Page(s) 8126–8137

    Abstract: Seomae mugwort, a Korean native variety of Artemisia argyi, exhibits physiological effects against various diseases. However, its effects on osteoarthritis (OA) are unclear. In this study, a Seomae mugwort extract prevented cartilage destruction in an OA ...

    Abstract Seomae mugwort, a Korean native variety of Artemisia argyi, exhibits physiological effects against various diseases. However, its effects on osteoarthritis (OA) are unclear. In this study, a Seomae mugwort extract prevented cartilage destruction in an OA mouse model. In vitro and ex vivo analyses revealed that the extract suppressed MMP3, MMP13, ADAMTS4 and ADAMTS5 expression induced by IL-1β, IL-6 and TNF-α and inhibited the loss of extracellular sulphated proteoglycans. In vivo analysis revealed that oral administration of the extract suppressed DMM-induced cartilage destruction. We identified jaceosidin in Seomae mugwort and showed that this compound decreased MMP3, MMP13, ADAMTS4 and ADAMTS5 expression levels, similar to the action of the Seomae mugwort extract in cultured chondrocytes. Interestingly, jaceosidin and eupatilin combined had similar effects to Seomae mugwort in the DMM-induced OA model. Induction of IκB degradation by IL-1β was blocked by the extract and jaceosidin, whereas JNK phosphorylation was only suppressed by the extract. These results suggest that the Seomae mugwort extract and jaceosidin can attenuate cartilage destruction by suppressing MMPs, ADAMTS4/5 and the nuclear factor-κB signalling pathway by blocking IκB degradation. Thus, the findings support the potential application of Seomae mugwort, and particularly jaceosidin, as natural therapeutics for OA.
    MeSH term(s) Animals ; Artemisia/chemistry ; Arthritis, Experimental ; Biomarkers ; Cartilage, Articular/drug effects ; Cartilage, Articular/metabolism ; Cartilage, Articular/pathology ; Cell Survival/drug effects ; Cells, Cultured ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Disease Models, Animal ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Gene Expression ; I-kappa B Proteins/metabolism ; Immunohistochemistry ; Interleukin-1beta/pharmacology ; Matrix Metalloproteinases/metabolism ; Mice ; Models, Biological ; NF-kappa B/metabolism ; Osteoarthritis/drug therapy ; Osteoarthritis/etiology ; Osteoarthritis/metabolism ; Osteoarthritis/pathology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Proteoglycans/metabolism ; Proteolysis ; Signal Transduction/drug effects
    Chemical Substances Biomarkers ; Flavonoids ; I-kappa B Proteins ; Interleukin-1beta ; NF-kappa B ; Plant Extracts ; Proteoglycans ; jaceosidin (18085-97-7) ; Matrix Metalloproteinases (EC 3.4.24.-)
    Language English
    Publishing date 2020-06-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.15471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The effects of an electronic medical record on the completeness of documentation in the anesthesia record.

    Jang, Junghwa / Yu, Seung Hum / Kim, Chun-Bae / Moon, Youngkyu / Kim, Sukil

    International journal of medical informatics

    2013  Volume 82, Issue 8, Page(s) 702–707

    Abstract: Objectives: The purpose of this study is to evaluate the completeness of anesthesia recording before and after the introduction of an electronic anesthesia record.: Methods: The study was conducted in a Korean teaching hospital where the EMR was ... ...

    Abstract Objectives: The purpose of this study is to evaluate the completeness of anesthesia recording before and after the introduction of an electronic anesthesia record.
    Methods: The study was conducted in a Korean teaching hospital where the EMR was implemented in October 2008. One hundred paper anesthesia records from July to September 2008 and 150 electronic anesthesia records during the same period in 2009 were randomly sampled. Thirty-four essential items were selected out of all the anesthesia items and grouped into automatically transferred items and manual entry items. 1, .5 and 0 points were given for each item of complete entry, incomplete entry and no entry respectively. The completeness of documentation was defined as the sum of the scores. The influencing factors on the completeness of documentation were evaluated in total and by the groups.
    Results: The average completeness score of the electronic anesthesia records was 3.15% higher than that of the paper records. A multiple regression model showed the type of the anesthesia record was a significant factor on the completeness of anesthesia records in all items (β=.98, p<.05) and automatically transferred items (β=.56, p<.01). The type of the anesthesia records had no influence on the completeness in manual entry items.
    Conclusions: The completeness of an anesthesia record was improved after the implementation of the electronic anesthesia record. The reuse of the data from the EMR was the main contributor to the improved completeness.
    MeSH term(s) Anesthesia/standards ; Anesthesia Department, Hospital/standards ; Documentation/standards ; Hospital Information Systems/standards ; Humans ; Medical Records Systems, Computerized/standards
    Language English
    Publishing date 2013-08
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 1466296-6
    ISSN 1872-8243 ; 1386-5056
    ISSN (online) 1872-8243
    ISSN 1386-5056
    DOI 10.1016/j.ijmedinf.2013.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Role of Interleukin-22 and Its Receptor in the Development and Pathogenesis of Experimental Autoimmune Uveitis.

    Yejin Kim / Tae Wan Kim / Yun Seong Park / Eui Man Jeong / Dong-Sup Lee / In-Gyu Kim / Hum Chung / Young-Il Hwang / Wang Jae Lee / Hyeong Gon Yu / Jae Seung Kang

    PLoS ONE, Vol 11, Iss 5, p e

    2016  Volume 0154904

    Abstract: IL-22 is a pro- and anti-inflammatory cytokine that is mainly produced by T cells and NK cells. Recent studies have reported the increased number of IL-22 producing T cells in patients with autoimmune noninfectious uveitis; however, the correlation ... ...

    Abstract IL-22 is a pro- and anti-inflammatory cytokine that is mainly produced by T cells and NK cells. Recent studies have reported the increased number of IL-22 producing T cells in patients with autoimmune noninfectious uveitis; however, the correlation between IL-22 and uveitis remains unclear. In this study, we aimed to determine the specific role of IL-22 and its receptor in the pathogenesis of uveitis. Serum concentration of IL-22 was significantly increased in uveitis patients. IL-22Rα was expressed in the retinal pigment epithelial cell line, ARPE-19. To examine the effect of IL-22, ARPE-19 was treated with recombinant IL-22. The proliferation of ARPE-19 and the production of monocyte chemoattractant protein (MCP)-1 from ARPE-19 were clearly elevated. IL-22 induced MCP-1 which facilitated the migration of inflammatory cells. Moreover, IL-22 increased the IL-22Rα expression in ARPE-19 through the activation of PI3K/Akt. Experimental animal models of uveitis induced by interphotoreceptor retinoid binding protein 1-20 (IRBP1-20) exhibited elevation of hyperplasia RPE and IL-22 production. When CD4+ T cells from the uveitis patients were stimulated with IRBP1-20, the production of IL-22 definitely increased. In addition, we examine the regulatory role of cysteamine, which has an anti-inflammatory role in the cornea, in uveitis through the down-regulation of IL-22Rα expression. Cysteamine effectively suppressed the IRBP1-20-induced IL-22Rα expression and prevented the development of IRBP1-20-induced uveitis in the experimental animal model. These finding suggest that IL-22 and its receptor have a crucial role in the development and pathogenesis of uveitis by facilitating inflammatory cell infiltration, and that cysteamine may be a useful therapeutic drug in treating uveitis by down-regulating IL-22Rα expression in RPE.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Factors associated with participation of Korean women in cervical cancer screening examination by age group.

    Lee, Minjee / Chang, Hoo Sun / Park, Eun-Cheol / Yu, Seung-Hum / Sohn, Myongsei / Lee, Sang Gyu

    Asian Pacific journal of cancer prevention : APJCP

    2011  Volume 12, Issue 6, Page(s) 1457–1462

    Abstract: Purpose: Cervical cancer is the 6th most common cancer among Korean women, and the prevalence of cervical cancer was 21.9 (per 100,000) in 2008. This study was designed to identify factors associated with Korean women' s participation by age group in ... ...

    Abstract Purpose: Cervical cancer is the 6th most common cancer among Korean women, and the prevalence of cervical cancer was 21.9 (per 100,000) in 2008. This study was designed to identify factors associated with Korean women' s participation by age group in cervical cancer screening.
    Methods: Based on the 2007-2009 Korea Health and Nutrition Examination Survey, we studied 6,964 women who were 30 years or older without a history of cervical cancer and completed a health questionnaire, physical examination, and nutrition examination. Information about their participation in cervical cancer screening examination was collected using a self-administered questionnaire. Multiple logistic regression was performed to identify factors associated with their participation in cervical cancer screening over the last 2 years.
    Results: Approximately 51.9% of women had been screened for cervical cancer over the previous 2 years. Women aged 65 years or older were less likely to undergo the screening than women aged 30-64 years. In the multiple logistic regression analysis, private health insurance, smoking, and body mass index were significantly associated with participation of women aged 30-44 years old in cervical cancer screening examination. Education, health insurance type, private health insurance, and smoking were significantly associated with the participation rate for women aged 45-64 years old. Participation of women aged 65 years or older was associated with private health insurance, body mass index, oral contraceptives, hormone replacement therapy, age at first birth, and number of pregnancies.
    Conclusion: Indicators of socio-demographic factors, health behavioral factors and reproductive factors seem to have varying impacts on Korean women' s participation in cervical cancer screening according to age group. These results demonstrate the need for more aggressive and age-based interventions and policy programs to improve the cervical cancer screening rate.
    MeSH term(s) Adult ; Age Factors ; Aged ; Demography ; Early Detection of Cancer/methods ; Female ; Humans ; Middle Aged ; Patient Compliance ; Patient Participation ; Republic of Korea ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/prevention & control ; Vaginal Smears/statistics & numerical data
    Language English
    Publishing date 2011
    Publishing country Thailand
    Document type Journal Article
    ISSN 2476-762X
    ISSN (online) 2476-762X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Maturation profiles of peripheral blood dendritic cells in patients with endogenous uveitis

    Kim, Tae Wan / Kang, Jae Seung / Kong, Joo Myoung / Bae, Seyeon / Yu, Yeonsil / Chung, Hum / Yu, Hyeong Gon

    Immunology Letters. 2012 Feb. 29, v. 142, no. 1-2

    2012  

    Abstract: To determine whether or not maturation of dendritic cells (DCs) is associated with pathogenesis of endogenous uveitis, we analyzed expression of maturation markers, including CD80, CD86, and human leukocyte antigen (HLA)-DR, in peripheral blood (PB) DCs ... ...

    Abstract To determine whether or not maturation of dendritic cells (DCs) is associated with pathogenesis of endogenous uveitis, we analyzed expression of maturation markers, including CD80, CD86, and human leukocyte antigen (HLA)-DR, in peripheral blood (PB) DCs for comparison between healthy controls (HCs) and uveitis patients. A total of 21 patients and 16 HCs were included. Flow cytometric analysis was performed using PB DCs during the active phase of intraocular inflammation. CD86 and HLA-DR expression was higher in PB DCs from uveitis patients versus HCs, whereas that of CD80 was not significantly different. Levels of CD86 and HLA-DR expression tended to parallel those of inflammatory activity, and decreased after anti-inflammatory therapy. However, expression of CD86 and HLA-DR, even in remission, was not completely down-regulated to the low levels found in HCs. Our results indicate the maturation of DCs may play a role in the pathogenesis of endogenous uveitis. The relatively high expression of HLA-DR and co-stimulatory molecules even in the quiescence of inflammation suggests maturation of DCs may be associated with chronicity and recurrence of uveitis.
    Keywords HLA antigens ; anti-inflammatory activity ; blood ; dendritic cells ; flow cytometry ; inflammation ; pathogenesis ; patients ; remission ; therapeutics
    Language English
    Dates of publication 2012-0229
    Size p. 14-19.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2011.10.012
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: The Role of Interleukin-22 and Its Receptor in the Development and Pathogenesis of Experimental Autoimmune Uveitis.

    Kim, Yejin / Kim, Tae Wan / Park, Yun Seong / Jeong, Eui Man / Lee, Dong-Sup / Kim, In-Gyu / Chung, Hum / Hwang, Young-Il / Lee, Wang Jae / Yu, Hyeong Gon / Kang, Jae Seung

    PloS one

    2016  Volume 11, Issue 5, Page(s) e0154904

    Abstract: IL-22 is a pro- and anti-inflammatory cytokine that is mainly produced by T cells and NK cells. Recent studies have reported the increased number of IL-22 producing T cells in patients with autoimmune noninfectious uveitis; however, the correlation ... ...

    Abstract IL-22 is a pro- and anti-inflammatory cytokine that is mainly produced by T cells and NK cells. Recent studies have reported the increased number of IL-22 producing T cells in patients with autoimmune noninfectious uveitis; however, the correlation between IL-22 and uveitis remains unclear. In this study, we aimed to determine the specific role of IL-22 and its receptor in the pathogenesis of uveitis. Serum concentration of IL-22 was significantly increased in uveitis patients. IL-22Rα was expressed in the retinal pigment epithelial cell line, ARPE-19. To examine the effect of IL-22, ARPE-19 was treated with recombinant IL-22. The proliferation of ARPE-19 and the production of monocyte chemoattractant protein (MCP)-1 from ARPE-19 were clearly elevated. IL-22 induced MCP-1 which facilitated the migration of inflammatory cells. Moreover, IL-22 increased the IL-22Rα expression in ARPE-19 through the activation of PI3K/Akt. Experimental animal models of uveitis induced by interphotoreceptor retinoid binding protein 1-20 (IRBP1-20) exhibited elevation of hyperplasia RPE and IL-22 production. When CD4+ T cells from the uveitis patients were stimulated with IRBP1-20, the production of IL-22 definitely increased. In addition, we examine the regulatory role of cysteamine, which has an anti-inflammatory role in the cornea, in uveitis through the down-regulation of IL-22Rα expression. Cysteamine effectively suppressed the IRBP1-20-induced IL-22Rα expression and prevented the development of IRBP1-20-induced uveitis in the experimental animal model. These finding suggest that IL-22 and its receptor have a crucial role in the development and pathogenesis of uveitis by facilitating inflammatory cell infiltration, and that cysteamine may be a useful therapeutic drug in treating uveitis by down-regulating IL-22Rα expression in RPE.
    MeSH term(s) Adult ; Animals ; Case-Control Studies ; Cell Line ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Chemokine CCL2/metabolism ; Cysteamine/pharmacology ; Down-Regulation/drug effects ; Feedback, Physiological ; Female ; Humans ; Hyperplasia ; Interleukins/blood ; Interleukins/metabolism ; Interleukins/pharmacology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Male ; Mice, Inbred C57BL ; Receptors, Interleukin/metabolism ; Recombinant Proteins/pharmacology ; Uveitis/blood ; Uveitis/metabolism ; Uveitis/pathology ; Interleukin-22
    Chemical Substances Chemokine CCL2 ; Interleukins ; Receptors, Interleukin ; Recombinant Proteins ; interleukin-22 receptor ; Cysteamine (5UX2SD1KE2)
    Language English
    Publishing date 2016-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0154904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Maturation profiles of peripheral blood dendritic cells in patients with endogenous uveitis.

    Kim, Tae Wan / Kang, Jae Seung / Kong, Joo Myoung / Bae, Seyeon / Yu, Yeonsil / Chung, Hum / Yu, Hyeong Gon

    Immunology letters

    2012  Volume 142, Issue 1-2, Page(s) 14–19

    Abstract: To determine whether or not maturation of dendritic cells (DCs) is associated with pathogenesis of endogenous uveitis, we analyzed expression of maturation markers, including CD80, CD86, and human leukocyte antigen (HLA)-DR, in peripheral blood (PB) DCs ... ...

    Abstract To determine whether or not maturation of dendritic cells (DCs) is associated with pathogenesis of endogenous uveitis, we analyzed expression of maturation markers, including CD80, CD86, and human leukocyte antigen (HLA)-DR, in peripheral blood (PB) DCs for comparison between healthy controls (HCs) and uveitis patients. A total of 21 patients and 16 HCs were included. Flow cytometric analysis was performed using PB DCs during the active phase of intraocular inflammation. CD86 and HLA-DR expression was higher in PB DCs from uveitis patients versus HCs, whereas that of CD80 was not significantly different. Levels of CD86 and HLA-DR expression tended to parallel those of inflammatory activity, and decreased after anti-inflammatory therapy. However, expression of CD86 and HLA-DR, even in remission, was not completely down-regulated to the low levels found in HCs. Our results indicate the maturation of DCs may play a role in the pathogenesis of endogenous uveitis. The relatively high expression of HLA-DR and co-stimulatory molecules even in the quiescence of inflammation suggests maturation of DCs may be associated with chronicity and recurrence of uveitis.
    MeSH term(s) Adult ; B7-1 Antigen/metabolism ; B7-2 Antigen/metabolism ; Case-Control Studies ; Cell Differentiation ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Dendritic Cells/pathology ; Female ; Flow Cytometry ; HLA-DR Antigens/metabolism ; Humans ; Inflammation/immunology ; Male ; Middle Aged ; Uveitis/immunology ; Uveitis/physiopathology
    Chemical Substances B7-1 Antigen ; B7-2 Antigen ; HLA-DR Antigens
    Language English
    Publishing date 2012-02-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2011.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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