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  1. Book: Cerebrovascular ultrasound in stroke prevention and treatment

    Alexandrov, Andrei V.

    2011  

    Author's details ed. by Andrei V. Alexandrov
    Keywords Stroke / ultrasonography ; Stroke / diagnosis ; Stroke / therapy
    Language English
    Size XV, 280 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Wiley-Blackwell
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016725688
    ISBN 978-1-4051-9576-8 ; 1-4051-9576-2
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Cerebrovascular ultrasound in stroke prevention and treatment

    Alexandrov, Andrei V.

    2004  

    Author's details ed. by Andrei V. Alexandrov
    Keywords Cerebrovascular Accident / ultrasonography ; Cerebrovascular Accident / therapy
    Language English
    Size XII, 267 S. : Ill., graph. Darst.
    Publisher Futura
    Publishing place Elmsford, NY u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013961979
    ISBN 1-4051-0381-7 ; 978-1-4051-0381-7
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Accuracy of the Society of Radiologists in Ultrasound (SRU) Carotid Doppler Velocity Criteria for Grading North American Symptomatic Carotid Endarterectomy Trial (NASCET) Stenosis: A Meta-Analysis.

    Polak, Joseph F / Alexandrov, Andrei V

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2022  Volume 42, Issue 7, Page(s) 1423–1435

    Abstract: Purpose: The Society of Radiologists in Ultrasound (SRU) consensus panel proposed six Doppler velocity cut points for classifying internal carotid artery (ICA) stenosis of 50% and 70% according to the North American Symptomatic Carotid Endarterectomy ... ...

    Abstract Purpose: The Society of Radiologists in Ultrasound (SRU) consensus panel proposed six Doppler velocity cut points for classifying internal carotid artery (ICA) stenosis of 50% and 70% according to the North American Symptomatic Carotid Endarterectomy Trial (NASCET) method. Their relative accuracies have not been compared.
    Materials and methods: Meta-analysis performed following comprehensive literature review and identification of manuscripts with graphs of individual patient NASCET ICA stenosis measured by arteriography versus ICA peak-systolic velocity (PSV), end-diastolic velocity (EDV) and ICA PSV to common carotid artery (CCA) PSV. True positives, true negatives, false positives, and false negatives were calculated and used in two-level mixed effects models. Hierarchical summary receiver operating characteristic (ROC) curves were generated. Areas under the ROC curves were estimated.
    Results: Nine studies performed between 1993 and 2016 were identified after review of 337 manuscripts. There were 1738 bifurcation data points extracted for PSV, 1026 for EDV, and 775 for ICA/CCA ratio. The highest sensitivity was 96% (95% CI: 93%, 98%) for PSV of 125 cm/s (50% stenosis) and highest specificity 86% (95% CI: 71%, 93%) for PSV of 230 cm/s (70% stenosis). Areas under the ROC curves ranged from a high of 0.93 (95% CI: 0.92, 0.95) for PSV (50% stenosis) to a low of 0.86 (95% CI: 0.84, 0.88) for EDV (70% stenosis).
    Conclusions: The SRU consensus Doppler cut points vary in their accuracies for predicting ICA stenosis. The PSV cut points have tradeoffs: high sensitivity/low specificity for 50% stenosis and high specificity/moderate sensitivity for 70% stenosis.
    MeSH term(s) Humans ; Endarterectomy, Carotid ; Carotid Artery, Internal/diagnostic imaging ; Constriction, Pathologic ; Ultrasonography, Doppler, Duplex/methods ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/surgery ; Angiography ; Sensitivity and Specificity ; ROC Curve ; North America ; Blood Flow Velocity ; Predictive Value of Tests
    Language English
    Publishing date 2022-12-17
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.16150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Innovations in Prehospital Stroke Management Utilizing Mobile Stroke Units.

    Alexandrov, Anne W / Alexandrov, Andrei V

    Continuum (Minneapolis, Minn.)

    2020  Volume 26, Issue 2, Page(s) 506–512

    Abstract: Using a representative case, this article discusses prehospital innovations for patients with acute large vessel occlusion ischemic stroke, including mobile stroke unit care supported by advanced field imaging. ...

    Abstract Using a representative case, this article discusses prehospital innovations for patients with acute large vessel occlusion ischemic stroke, including mobile stroke unit care supported by advanced field imaging.
    MeSH term(s) Aged ; Ambulances/organization & administration ; Combined Modality Therapy ; Female ; Fibrinolytic Agents/administration & dosage ; Humans ; Infarction, Middle Cerebral Artery/diagnosis ; Infarction, Middle Cerebral Artery/therapy ; Ischemic Stroke/diagnosis ; Ischemic Stroke/diagnostic imaging ; Ischemic Stroke/drug therapy ; Ischemic Stroke/therapy ; Nurse Practitioners ; Organizational Innovation ; Thrombectomy ; Time-to-Treatment/organization & administration ; Tissue Plasminogen Activator/administration & dosage
    Chemical Substances Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2020-04-13
    Publishing country United States
    Document type Journal Article
    ISSN 1538-6899
    ISSN (online) 1538-6899
    DOI 10.1212/CON.0000000000000850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reducing Ischemic Stroke in Diabetes: The Role of GLP-1 RAs.

    Anderson, John E / Butler, Javed / Alexandrov, Andrei V

    The Journal of family practice

    2023  Volume 72, Issue 6 Suppl, Page(s) S55–S60

    Abstract: Key takeaways: Stroke is a significant cause of mortality worldwide, and diabetes is an independent risk factor for ischemic stroke occurrence and recurrence. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) lower the risk of ischemic stroke ... ...

    Abstract Key takeaways: Stroke is a significant cause of mortality worldwide, and diabetes is an independent risk factor for ischemic stroke occurrence and recurrence. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) lower the risk of ischemic stroke through beneficial effects on traditional stroke risk factors such as hyperglycemia, hypertension, and dyslipidemia. Primary care practitioners (PCPs) can play a substantial role in reducing ischemic stroke; studies have indicated that patients who have a PCP at the time of first stroke have a lower risk of stroke recurrence. Clinical practice guidelines recommend treating type 2 diabetes in patients with or at risk for cardiovascular (CV) disease with glucose-lowering agents with proven CV benefit, such as GLP-1 RAs and sodium-glucose cotransporter-2 (SGLT2) inhibitors. Based on meta-analyses of CV outcomes trials, GLP-1 RAs have a substantial and statistically significant benefit on ischemic stroke risk reduction, whereas SGLT2 inhibitors have a nonsignificant effect. The use of GLP-1 RAs, in addition to non-pharmacologic and pharmacologic management of traditional stroke risk factors, is a key component of complex therapy for ischemic stroke risk reduction.
    MeSH term(s) Humans ; Cardiovascular Diseases/etiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide-1 Receptor/agonists ; Hypoglycemic Agents ; Ischemic Stroke/complications ; Ischemic Stroke/drug therapy
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents
    Language English
    Publishing date 2023-08-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197883-4
    ISSN 1533-7294 ; 0094-3509
    ISSN (online) 1533-7294
    ISSN 0094-3509
    DOI 10.12788/jfp.0624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Improving Outcomes After Stroke: From Stroke Units to Mobile Stroke Units.

    Alexandrov, Andrei V / Nilanont, Yongchai

    Stroke

    2021  Volume 52, Issue 9, Page(s) 3072–3074

    Abstract: A proactive clinical approach to stroke care improved functional outcomes with implementation of specialized in-hospital stroke units, urgently delivered systemic thrombolysis, mechanical thrombectomy and most recently with mobile stroke units deployed ... ...

    Abstract A proactive clinical approach to stroke care improved functional outcomes with implementation of specialized in-hospital stroke units, urgently delivered systemic thrombolysis, mechanical thrombectomy and most recently with mobile stroke units deployed in the field. An 18% absolute difference in outcomes as a shift across all modified Rankin Scale strata at 3 months in the recent Berlin study may not be explained by just 8.8% more patients treated within the golden hour for thrombolytic treatment from symptom onset. These findings parallel the findings in the largest controlled multi-center BEST-MSU trial (Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit) to date. A shortcoming in blinding of the investigators to the mode of transportation is similar to blinding to the endovascular treatment in PROBE (Prospective Randomized Open, Blinded End-Point) design used in thrombectomy trials. A faster access to stroke experts and brain imaging in the field for all patients suspect of stroke regardless symptom nature, severity, duration or resolution delivered by mobile stroke units is likely the reason for improved outcomes akin the impact observed in the initial multidisciplinary approach to in-hospital stroke units and reperfusion therapies delivery.
    MeSH term(s) Hospital Units ; Humans ; Mobile Health Units ; Stroke/therapy ; Treatment Outcome
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.121.034616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Conference proceedings: Thrombolysis and acute stroke treatment

    Del Zoppo, Gregory J. / Alexandrov, Andrei V.

    preparing for the next decade ; ... Conference Entitled "Thrombolysis and Acute Stroke Treatment (TAST) in 2011: Preparing for the Next Decade", held on December 1 - 3, 2011 at the New York Academy of Sciences

    (Annals of the New York Academy of Sciences ; 1268)

    2012  

    Event/congress Conference Entitled Thrombolysis and Acute Stroke Treatment (TAST) in 2011: Preparing for the Next Decade (2011, NewYorkNY)
    Author's details iss ed. Gregory J. del Zoppo and Andrei V. Alexandrov
    Series title Annals of the New York Academy of Sciences ; 1268
    Collection
    Language English
    Size 157 S. : Ill., graph. Darst.
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT017422488
    ISBN 978-1-57331-869-3 ; 1-57331-869-8
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: ASNM and ASN joint guidelines for transcranial Doppler ultrasonic monitoring: An update.

    Razumovsky, Alexander Y / Jahangiri, Faisal R / Balzer, Jeffrey / Alexandrov, Andrei V

    Journal of neuroimaging : official journal of the American Society of Neuroimaging

    2022  Volume 32, Issue 5, Page(s) 781–797

    Abstract: Today, it seems prudent to reconsider how ultrasound technology can be used for providing intraoperative neurophysiologic monitoring that will result in better patient outcomes and decreased length and cost of hospitalization. An extensive and rapidly ... ...

    Abstract Today, it seems prudent to reconsider how ultrasound technology can be used for providing intraoperative neurophysiologic monitoring that will result in better patient outcomes and decreased length and cost of hospitalization. An extensive and rapidly growing literature suggests that the essential hemodynamic information provided by transcranial Doppler (TCD) ultrasonography neuromonitoring (TCDNM) would provide effective monitoring modality for improving outcomes after different types of vascular, neurosurgical, orthopedic, cardiovascular, and cardiothoracic surgeries and some endovascular interventional or diagnostic procedures, like cardiac catheterization or cerebral angiography. Understanding, avoiding, and preventing peri- or postoperative complications, including neurological deficits following abovementioned surgeries, endovascular intervention, or diagnostic procedures, represents an area of great public and economic benefit for society, especially considering the aging population. The American Society of Neurophysiologic Monitoring and American Society of Neuroimaging Guidelines Committees formed a joint task force and developed updated guidelines to assist in the use of TCDNM in the surgical and intensive care settings. Specifically, these guidelines define (1) the objectives of TCD monitoring; (2) the responsibilities and behaviors of the neurosonographer during monitoring; (3) instrumentation and acquisition parameters; (4) safety considerations; (5) contemporary rationale for TCDNM; (6) TCDNM perspectives; and (7) major recommendations.
    MeSH term(s) Aged ; Cerebrovascular Circulation ; Critical Care ; Humans ; Neuroimaging ; Postoperative Complications ; Ultrasonics ; Ultrasonography, Doppler, Transcranial/methods
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1071724-9
    ISSN 1552-6569 ; 1051-2284
    ISSN (online) 1552-6569
    ISSN 1051-2284
    DOI 10.1111/jon.13013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Letter by Katsanos et al Regarding Article, "Functional Outcome Following Stroke Thrombectomy in Clinical Practice".

    Katsanos, Aristeidis H / Alexandrov, Andrei V / Tsivgoulis, Georgios

    Stroke

    2019  Volume 50, Issue 12, Page(s) e426

    MeSH term(s) Humans ; Stroke ; Thrombectomy
    Language English
    Publishing date 2019-10-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.119.027166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A plain computed tomography scan is sufficient to consider thrombolysis in patients with unknown time of onset.

    Alexandrov, Andrei V

    Stroke

    2013  Volume 44, Issue 5, Page(s) 1492–1493

    MeSH term(s) Brain Ischemia/diagnostic imaging ; Cerebral Angiography ; Decision Making ; Humans ; Stroke/diagnostic imaging ; Thrombolytic Therapy ; Time Factors
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.113.000912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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