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  1. Article ; Online: Bio-Guided Optimization of

    Rosa, Gonçalo P / Peixoto, Andreia F / Barreto, Maria Carmo / Seca, Ana M L / Pinto, Diana C G A

    Marine drugs

    2022  Volume 21, Issue 1

    Abstract: Cystoseira abies- ... ...

    Abstract Cystoseira abies-marina
    MeSH term(s) Abies ; Cosmeceuticals/pharmacology ; Phaeophyceae ; Seaweed ; Antioxidants/pharmacology ; Solvents
    Chemical Substances Cosmeceuticals ; Antioxidants ; Solvents
    Language English
    Publishing date 2022-12-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21010035
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  2. Article ; Online: Botulinum toxin as a novel therapeutic approach for auriculotemporal neuralgia.

    Pinto, Maria J / Guerrero, Angel L / Costa, Andreia

    Headache

    2021  Volume 61, Issue 2, Page(s) 392–395

    Abstract: Objectives/background: Auriculotemporal neuralgia is a rare headache disorder. Anesthetic nerve blockade seems to be effective in most cases; however, literature is scarce about the management of refractory cases.: Methods: Case report.: Results: ... ...

    Abstract Objectives/background: Auriculotemporal neuralgia is a rare headache disorder. Anesthetic nerve blockade seems to be effective in most cases; however, literature is scarce about the management of refractory cases.
    Methods: Case report.
    Results: We report a 44-year-old woman with migraine without aura presented with moderate-to-severe right temporoparietal headache. The pain was refractory to multiple pharmacological strategies, including intravenous analgesia. A more throughout examination lead to the diagnosis of auriculotemporal neuralgia and anesthetic nerve blocks were performed. Due to early pain recrudescence, botulinum toxin (BoNT) was tried with better and longstanding pain control.
    Conclusion: BoNT may be a useful treatment option in refractory auriculotemporal neuralgia. The best approach is yet to be established; however, the "follow-the-pain" protocol may be a reasonable option.
    MeSH term(s) Adult ; Botulinum Toxins, Type A/administration & dosage ; Botulinum Toxins, Type A/pharmacology ; Female ; Humans ; Migraine without Aura/therapy ; Nerve Block ; Neuralgia/drug therapy ; Neuromuscular Agents/administration & dosage ; Neuromuscular Agents/pharmacology
    Chemical Substances Neuromuscular Agents ; Botulinum Toxins, Type A (EC 3.4.24.69)
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.14043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Adipose tissue derived stem cell secretome induces motor and histological gains after complete spinal cord injury in

    Assunção-Silva, Rita C / Pinho, Andreia / Cibrão, Jorge R / Pereira, Inês M / Monteiro, Susana / Silva, Nuno A / Campos, Jonas / Rebelo, Ana L / Schlosser, Gerhard / Pinto, Luisa / Pandit, Abhay / Salgado, António J

    Journal of tissue engineering

    2024  Volume 15, Page(s) 20417314231203824

    Abstract: Mesenchymal stem cell-based therapies have been studied for spinal cord injury (SCI) treatment due to their paracrine action upon damaged tissues. MSCs neuroregenerative role may relate to the contents of their secretome in anti-inflammatory cytokines ... ...

    Abstract Mesenchymal stem cell-based therapies have been studied for spinal cord injury (SCI) treatment due to their paracrine action upon damaged tissues. MSCs neuroregenerative role may relate to the contents of their secretome in anti-inflammatory cytokines and growth-permissive factors. We propose using the secretome of MSCs isolated from the adipose tissue-adipose tissue-derived stem cells (ASCs) as a cell-free based therapy for SCI. In vivo studies were conducted in two SCI models,
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2573915-3
    ISSN 2041-7314
    ISSN 2041-7314
    DOI 10.1177/20417314231203824
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  4. Article: Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo.

    Ribeiro, Joana / Araújo-Silva, Henrique / Fernandes, Mário / da Silva, Joilna Alves / Pinto, Francisco das Chagas L / Pessoa, Otília Deusdenia L / Santos, Hélcio Silva / de Menezes, Jane Eire Silva Alencar / Gomes, Andreia C

    Natural products and bioprospecting

    2024  Volume 14, Issue 1, Page(s) 16

    Abstract: According to The World Alzheimer Report 2023 by Alzheimer's Disease International (ADI) estimates that 33 to 38.5 million people worldwide suffer from Alzheimer's Disease (AD). A crucial hallmark associated with this disease is associated with the ... ...

    Abstract According to The World Alzheimer Report 2023 by Alzheimer's Disease International (ADI) estimates that 33 to 38.5 million people worldwide suffer from Alzheimer's Disease (AD). A crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (AChE) activity. Marine organisms synthesize several classes of compounds, some of which exhibit significant AChE inhibition, such as petrosamine, a coloured pyridoacridine alkaloid. The aim of this work was to characterize the activity of petrosamine isolated for the first time from a Brazilian marine sponge, using two neurotoxicity models with aluminium chloride, as exposure to aluminium is associated with the development of neurodegenerative diseases. The in vitro model was based in a neuroblastoma cell line and the in vivo model exploited the potential of zebrafish (Danio rerio) embryos in mimicking hallmarks of AD. To our knowledge, this is the first report on petrosamine's activity over these parameters, either in vitro or in vivo, in order to characterize its full potential for tackling neurotoxicity.
    Language English
    Publishing date 2024-02-22
    Publishing country Germany
    Document type Journal Article
    ISSN 2192-2195
    ISSN 2192-2195
    DOI 10.1007/s13659-024-00439-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Highly Diluted Glyphosate Mitigates Its Effects on

    Nagai, Mirian Yaeko Dias de Oliveira / Mohammad, Suham Nowrooz / Pinto, Andreia Adelaide G / Coimbra, Ednar Nascimento / Peres, Giovani Bravin / Suffredini, Ivana Barbosa / Bernardi, Maria Martha / Tournier, Alexander L / Jerman, Igor / Cartwright, Steven John / Bonamin, Leoni Villano

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Glyphosate is an herbicide widely used in agriculture but can present chronic toxicity in low concentrations. ...

    Abstract Glyphosate is an herbicide widely used in agriculture but can present chronic toxicity in low concentrations.
    MeSH term(s) Animals ; Artemia ; Herbicides/toxicity ; Water/pharmacology ; Cysts ; Glyphosate
    Chemical Substances Herbicides ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Ciliary Feature Counter: A program for the Quantitative Assessment of Cilia to Diagnose Primary Ciliary Dyskinesia.

    Pinto, Andreia L / Rai, Ranjit K / Hogg, Claire / Burgoyne, Thomas

    Diagnostics (Basel, Switzerland)

    2020  Volume 10, Issue 8

    Abstract: Primary ciliary dyskinesia (PCD) is a disorder that affects motile cilia in the airway that are required for the removal of mucus, debris, and pathogens. It is important to diagnose PCD in early childhood to preserve lung function. The confirmation of a ... ...

    Abstract Primary ciliary dyskinesia (PCD) is a disorder that affects motile cilia in the airway that are required for the removal of mucus, debris, and pathogens. It is important to diagnose PCD in early childhood to preserve lung function. The confirmation of a diagnosis relies on the assessment of ciliary ultrastructure by transmission electron microscopy (TEM). TEM involves the quantitative assessment of the ciliary ultrastructure to identify PCD defects as well as abnormalities resulting from infection. Many specialist diagnostic centres still rely on physical counters to tally results and paper notes to summarise findings before transferring the results to computer databases/records. To speed up the diagnostic data collection and increase the protection of patient information, we have developed digital ciliary feature counters that conform to the PCD reporting international consensus guideline. These counters can be used on a computer or tablet, and automatically generate notes regarding sample observations. We show that the digital counters are easy to use and can generate TEM diagnostic reports that will be useful for many PCD diagnostic centres.
    Language English
    Publishing date 2020-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics10080524
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  7. Article ; Online: Ciliary Feature Counter

    Andreia L. Pinto / Ranjit K. Rai / Claire Hogg / Thomas Burgoyne

    Diagnostics, Vol 10, Iss 524, p

    A program for the Quantitative Assessment of Cilia to Diagnose Primary Ciliary Dyskinesia

    2020  Volume 524

    Abstract: Primary ciliary dyskinesia (PCD) is a disorder that affects motile cilia in the airway that are required for the removal of mucus, debris, and pathogens. It is important to diagnose PCD in early childhood to preserve lung function. The confirmation of a ... ...

    Abstract Primary ciliary dyskinesia (PCD) is a disorder that affects motile cilia in the airway that are required for the removal of mucus, debris, and pathogens. It is important to diagnose PCD in early childhood to preserve lung function. The confirmation of a diagnosis relies on the assessment of ciliary ultrastructure by transmission electron microscopy (TEM). TEM involves the quantitative assessment of the ciliary ultrastructure to identify PCD defects as well as abnormalities resulting from infection. Many specialist diagnostic centres still rely on physical counters to tally results and paper notes to summarise findings before transferring the results to computer databases/records. To speed up the diagnostic data collection and increase the protection of patient information, we have developed digital ciliary feature counters that conform to the PCD reporting international consensus guideline. These counters can be used on a computer or tablet, and automatically generate notes regarding sample observations. We show that the digital counters are easy to use and can generate TEM diagnostic reports that will be useful for many PCD diagnostic centres.
    Keywords cilia ; primary ciliary dyskinesia ; digital counter ; Medicine (General) ; R5-920
    Subject code 303
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Bio-Guided Optimization of Cystoseira abies-marina Cosmeceuticals Extraction by Advanced Technologies

    Rosa, Gonçalo P. / Peixoto, Andreia F. / Barreto, Maria Carmo / Seca, Ana M. L. / Pinto, Diana C. G. A.

    Mar Drugs. 2022 Dec. 31, v. 21, no. 1

    2022  

    Abstract: Cystoseira abies-marina (reclassified as Gongolaria abies-marina) is a brown seaweed species rich in meroterpenoids, presenting interesting antioxidant, antitumor, and anti-inflammatory activities. However, there is still a lot to uncover regarding the ... ...

    Abstract Cystoseira abies-marina (reclassified as Gongolaria abies-marina) is a brown seaweed species rich in meroterpenoids, presenting interesting antioxidant, antitumor, and anti-inflammatory activities. However, there is still a lot to uncover regarding the bioactive potential of this species, as evidenced by the lack of records of antiaging activities from Cystoseira abies-marina, making this macroalga an excellent candidate for studies of its cosmeceutical potential. Ultrasound-(UAE) and microwave-assisted extraction (MAE) are advanced sustainable technologies that are very efficient in enhancing bioactive compound extraction. Applying these extraction techniques to a new biological matrix often calls for optimizing the parameters toward the best extraction yield. Since Cystoseira abies-marina is a new matrix for both UAE and MAE techniques, the present work proposes the optimization of the extraction process, using a novel approach: instead of only focusing on increasing the yield, the goal of this work is to determine the parameters for UAE and MAE that lead to extracts with better antiaging activities. For this bio-guided approach, several Cystoseira abies-marina extracts were prepared by UAE and MAE under varying conditions of solvent, time, and algae/solvent ratios. Their antiaging activities were then determined, and all the results combined to unveil the conditions yielding extracts with higher cosmeceutical potential. Using statistical tools, it was found that, for UAE, the best conditions were ethyl acetate, 15 min, and a ratio of 1:4, which led to an extract with high yield, and causing the strong inhibition of tyrosinase and elastase. In turn, ethanol, 10 min, and a ratio of 1:4 were the best conditions for MAE, leading to the extract with the best antioxidant activity. The results show that the proposed bio-guided approach was effective in obtaining extracts with high cosmeceutical potential, unveiling the possibility of modulating an extract’s activity by changing the extraction method.
    Keywords Cystoseira ; antioxidant activity ; antioxidants ; bioactive compounds ; cosmetics ; elastase ; ethanol ; ethyl acetate ; macroalgae ; meroterpenoids ; microwave treatment ; solvents
    Language English
    Dates of publication 2022-1231
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21010035
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Avelumab as First-Line Maintenance Treatment in Locally Advanced or Metastatic Urothelial Carcinoma.

    Mansinho, André / Cruz, Andreia / Marconi, Lorenzo / Pinto, Cidália / Augusto, Isabel

    Advances in therapy

    2023  Volume 40, Issue 10, Page(s) 4134–4150

    Abstract: This work provides a summary of guideline recommendations and an expert position on the use of maintenance avelumab therapy based on a review of current international clinical practice guidelines for locally advanced or metastatic urothelial carcinoma ( ... ...

    Abstract This work provides a summary of guideline recommendations and an expert position on the use of maintenance avelumab therapy based on a review of current international clinical practice guidelines for locally advanced or metastatic urothelial carcinoma (UC). A PubMed literature search was conducted in March 2022 (updated in July 2023) to identify guidelines for locally advanced or metastatic UC. An expert panel (four oncologists and one urologist) reviewed the guidelines and clinical evidence, and discussed practical questions regarding the use of avelumab maintenance therapy in this clinical setting. The National Comprehensive Cancer Network, European Association of Urology and European Society for Medical Oncology guidelines recommend first-line cisplatin-containing chemotherapy for cisplatin-eligible patients, carboplatin-gemcitabine for cisplatin-ineligible patients who are fit for carboplatin, or immunotherapy with programmed death ligand-1 (PD-L1) inhibitors (e.g. atezolizumab) in platinum-ineligible patients. Maintenance avelumab is recommended in patients with response/stable disease following chemotherapy (regardless of PD-L1 status). In patients who relapse after/during chemotherapy, options include immunotherapy, erdafitinib [in those with fibroblast growth factor receptor (FGFR) mutations], enfortumab vedotin or further chemotherapy. The expert panel provided the following practical guidance: (1) consider maintenance avelumab in all eligible patients; (2) continue avelumab until disease progression/unacceptable toxicity; (3) ideally, administer six cycles of platinum-based chemotherapy prior to maintenance avelumab; (4) perform radiological evaluation after four chemotherapy cycles and prior to maintenance avelumab; (5) carboplatin-gemcitabine followed by maintenance avelumab is preferred in cisplatin-ineligible patients (regardless of PD-L1 expression), but consider first-line immunotherapy in PD-L1-positive patients and platinum-ineligible patients (regardless of PD-L1 status); and (6) for patients who relapse on avelumab, second-line options include enfortumab vedotin, FGFR inhibitors (in those with FGFR mutations) or clinical trial inclusion. In conclusion, avelumab maintenance therapy is recommended following platinum-based chemotherapy in all eligible patients with locally advanced or metastatic UC, continued until disease progression or unacceptable toxicity.
    MeSH term(s) Humans ; B7-H1 Antigen ; Carcinoma, Transitional Cell/drug therapy ; Cisplatin ; Carboplatin ; Urinary Bladder Neoplasms/drug therapy ; Neoplasm Recurrence, Local ; Platinum ; Disease Progression ; Immune Checkpoint Inhibitors
    Chemical Substances avelumab (KXG2PJ551I) ; B7-H1 Antigen ; Cisplatin (Q20Q21Q62J) ; Carboplatin (BG3F62OND5) ; Platinum (49DFR088MY) ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-023-02624-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2101: Show issues Location:
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  10. Article ; Online: Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium

    Andreia L. Pinto / Ranjit K. Rai / Jonathan C. Brown / Paul Griffin / James R. Edgar / Anand Shah / Aran Singanayagam / Claire Hogg / Wendy S. Barclay / Clare E. Futter / Thomas Burgoyne

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: Human airway epithelium infected with SARS-CoV-2 shows viral entry occurring at the apical plasma membrane, excluding cilia. Here, the visualization of viral fusion at the cell surface and budding profiles within infected cells through high-resolution ... ...

    Abstract Human airway epithelium infected with SARS-CoV-2 shows viral entry occurring at the apical plasma membrane, excluding cilia. Here, the visualization of viral fusion at the cell surface and budding profiles within infected cells through high-resolution electron microscopy and tomography provide new insight into the infection process.
    Keywords Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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