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  1. Article: Robert Hall More, M.D., M.Sc.: a pioneer of modern pathology in Canada (1912-2003).

    Haust, M Daria

    Pathology, research and practice

    2004  Volume 200, Issue 5, Page(s) 367–370

    MeSH term(s) Canada ; History, 20th Century ; Pathology/history
    Language English
    Publishing date 2004-06-09
    Publishing country Germany
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2004.02.007
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  2. Article: Tetrahydrofuran (THF) for routine dehydration, clearing, and infiltration.

    HAUST, M D

    Technical bulletin of the Registry of Medical Technologists. American Society of Clinical Pathologists. Registry of Medical Technologists

    2003  Volume 29, Issue 3, Page(s) 33–37

    MeSH term(s) Biomedical Technology ; Biophysical Phenomena ; Dehydration ; Furans ; Medical Laboratory Science
    Chemical Substances Furans ; tetrahydrofuran (3N8FZZ6PY4) ; furan (UC0XV6A8N9)
    Language English
    Publishing date 2003-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391754-x
    ISSN 0097-0654
    ISSN 0097-0654
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  3. Article: Early mural reactions to fibrinogen injections into aortic wall of rabbits.

    Haust, M D

    Annals of the New York Academy of Sciences

    1997  Volume 811, Page(s) 361–7; discussion 367–8

    MeSH term(s) Animals ; Aorta/drug effects ; Aorta/pathology ; Aorta/ultrastructure ; Fibrinogen/administration & dosage ; Microscopy, Electron ; Rabbits
    Chemical Substances Fibrinogen (9001-32-5)
    Language English
    Publishing date 1997-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.1997.tb52015.x
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  4. Article ; Online: Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients.

    Degner, Detlef / Haust, Merle / Meller, Johannes / Rüther, Eckart / Reulbach, Udo

    European archives of psychiatry and clinical neuroscience

    2014  Volume 265, Issue 1, Page(s) 67–72

    Abstract: Thyroid diseases are often associated with psychiatric disorders. The prevalence of autoimmune thyroiditis in the general population is estimated to be at about 5-14 %. A clinical study was conducted to evaluate the association between autoimmune ... ...

    Abstract Thyroid diseases are often associated with psychiatric disorders. The prevalence of autoimmune thyroiditis in the general population is estimated to be at about 5-14 %. A clinical study was conducted to evaluate the association between autoimmune thyroiditis and depression in psychiatric outpatients. Fifty-two patients with depression and nineteen patients with schizophrenia (serving as control group), attending a psychiatric outpatient unit, were included. In addition to the measurement of thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, antithyroid peroxidase (anti-TPO) antibodies, and anti-thyroglobulin antibodies, ultrasound examination of the thyroid gland was performed. The proportion of pathologically increased anti-TPO levels in patients with depression was high. Furthermore, the distribution of pathologically increased anti-TPO levels was significantly (χ (2) = 5.5; p = 0.019) different between patients with depression (32.7 %) and patients with schizophrenia (5.3 %). In a gender- and age-adjusted logistic regression, the odds ratio of uni- or bipolar patients with depression for an autoimmune thyroiditis was ten times higher (95 % CI = 1.2-85.3) when compared with schizophrenia patients. TSH basal level did not differ between patients with depression and patients with schizophrenia. Our study demonstrates a strong association between anti-TPO levels, which are considered to be of diagnostic value for autoimmune thyroiditis (in combination with a hypoechoic thyroid in ultrasonography) with uni- or bipolar depression. It should be noted that the routinely measured TSH level is not sufficient in itself to diagnose this relevant autoimmune comorbidity.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Autoantibodies/blood ; Bipolar Disorder/blood ; Bipolar Disorder/complications ; Depressive Disorder/blood ; Depressive Disorder/complications ; Female ; Humans ; Male ; Middle Aged ; Schizophrenia/blood ; Schizophrenia/complications ; Thyroiditis, Autoimmune/blood ; Thyroiditis, Autoimmune/complications ; Thyrotropin/blood ; Thyroxine/blood ; Triiodothyronine/blood ; Young Adult
    Chemical Substances Autoantibodies ; anti-thyroglobulin ; Triiodothyronine (06LU7C9H1V) ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2014-09-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-014-0529-1
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  5. Article: The concept and history of satellite symposia associated with international symposia on atherosclerosis.

    Haust, M D

    The Canadian journal of cardiology

    1995  Volume 11 Suppl G, Page(s) 133G–137G

    MeSH term(s) Congresses as Topic ; Coronary Artery Disease/physiopathology ; Humans
    Language English
    Publishing date 1995-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
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  6. Article: Satellite Symposia of the International Symposia on Atherosclerosis-- brief history and selected aspects.

    Haust, M D

    Atherosclerosis

    1995  Volume 117, Issue 2, Page(s) 151–158

    MeSH term(s) Arteriosclerosis/history ; Congresses as Topic/history ; History, 20th Century ; Humans
    Language English
    Publishing date 1995-10
    Publishing country Ireland
    Document type Historical Article ; Journal Article
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/0021-9150(95)05637-c
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  7. Article: Ciliated cultured dermal fibroblasts in a patient with hyperornithinemia, hyperammonemia and homocitrullinuria (HHH) syndrome.

    Haust, M D

    Pathology, research and practice

    1995  Volume 191, Issue 10, Page(s) 1062–1065

    Abstract: Hyperornithinemia, hyperammonemia and homocitrullinuria (HHH)-syndrome is a rare autosomal recessive disorder of the urea cycle, probably caused by a defect in ornithine transport across the hepatic inner mitochondrial membrane. Single rudimentary cilia ... ...

    Abstract Hyperornithinemia, hyperammonemia and homocitrullinuria (HHH)-syndrome is a rare autosomal recessive disorder of the urea cycle, probably caused by a defect in ornithine transport across the hepatic inner mitochondrial membrane. Single rudimentary cilia were present in approximately ten percent of post-divisional or dividing fibroblasts cultured from the skin of a patient with the HHH-syndrome, whereas no such organelles were observed in dermal fibroblasts cultured from normal controls. Since single rudimentary ("primary," "oligo," "solitary") cilia have been observed in a variety of cells in animals and men but the stimuli for their formation and their significance remain controversial, a brief report on their presence in the as yet unreported condition (HHH-syndrome) was considered of interest; hopefully, it might contribute to the ultimate unravelling of some of the unresolved problems. It is of note that unlike the author's previous findings of these unusual organelles in cells affected by a pathological process (atherosclerosis), the rudimentary cilia were observed in the present instance in dividing or postdivisional cells. The implications of these (and other) observations must await further work.
    MeSH term(s) Amino Acid Metabolism, Inborn Errors/metabolism ; Amino Acid Metabolism, Inborn Errors/pathology ; Ammonia/blood ; Animals ; Cells, Cultured ; Cilia/ultrastructure ; Citrulline/urine ; Endoplasmic Reticulum, Rough/ultrastructure ; Fibroblasts/metabolism ; Fibroblasts/ultrastructure ; Humans ; Microscopy, Electron ; Mitochondria/ultrastructure ; Ornithine/blood ; Skin/ultrastructure ; Syndrome ; Urea/metabolism
    Chemical Substances Citrulline (29VT07BGDA) ; Ammonia (7664-41-7) ; Urea (8W8T17847W) ; Ornithine (E524N2IXA3)
    Language English
    Publishing date 1995-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/s0344-0338(11)80613-8
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  8. Article: Aortic features in Tangier disease and pathogenetic considerations--Part I. Fatty dots and streaks.

    Haust, M D

    European journal of epidemiology

    1992  Volume 8 Suppl 1, Page(s) 36–47

    Abstract: Morphological studies of aortic fatty dots and streaks, and the adjacent normally appearing intima, in a 5 3/4-year-old boy who died of pneumonia, showed several hitherto unreported features. In lesions, lipid vacuoles and/or other cytoplasmic " ... ...

    Abstract Morphological studies of aortic fatty dots and streaks, and the adjacent normally appearing intima, in a 5 3/4-year-old boy who died of pneumonia, showed several hitherto unreported features. In lesions, lipid vacuoles and/or other cytoplasmic "inclusions" (ultrastructurally considered to present complex forms of lipids) were present on occasion in the endothelium but consistently involved the (intimal) smooth muscle cells (SMC). Similar changes were present in the adjacent intima, but were here less prominent and "tapered off" distally. A moderate number of macrophages also contained cytoplasmic lipids but such cells entirely free of lipid inclusions were observed, too. Most surprisingly, dilated and many cisternae of rough-surfaced endoplasmic reticulum (ER) in the SMC of lesions were associated spatially with cytoplasmic droplets and other forms of lipids. The results of these studies question the generally accepted central role of macrophages as being primarily involved in the pathogenesis of tissue changes in Tangier disease. It is possible that in view of the absence or paucity of high-density lipoproteins (HDL) and alterations of (their) apo A-I and apo A-II (as well as of other lipids), the arterial SMC may be in some way involved in the metabolism of the above substances in this disorder. Support of this tentative (and highly speculative) assumption must await further work utilizing tissues and cells other than those containing macrophages and other derivatives of reticulo-endothelial system.
    MeSH term(s) Aorta/metabolism ; Aorta/pathology ; Aorta/ultrastructure ; Apolipoprotein A-I/metabolism ; Apolipoprotein A-II/metabolism ; Arteriosclerosis/etiology ; Arteriosclerosis/pathology ; Child, Preschool ; Humans ; Lipoproteins, HDL/metabolism ; Male ; Microscopy, Electron ; Staining and Labeling/methods ; Tangier Disease/complications ; Tangier Disease/metabolism ; Tangier Disease/pathology
    Chemical Substances Apolipoprotein A-I ; Apolipoprotein A-II ; Lipoproteins, HDL
    Language English
    Publishing date 1992-05
    Publishing country Netherlands
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/bf00145348
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  9. Article: The Canadian Atherosclerosis Society--history and present status.

    Haust, M D

    The Canadian journal of cardiology

    1991  Volume 7, Issue 8, Page(s) 366–384

    Abstract: Since its inception in 1983 the Canadian Atherosclerosis Society (CAS) has established itself firmly on the national and international scene as a forceful scientific voice. Its presence and activities have had their dominant expression at annual meetings ...

    Abstract Since its inception in 1983 the Canadian Atherosclerosis Society (CAS) has established itself firmly on the national and international scene as a forceful scientific voice. Its presence and activities have had their dominant expression at annual meetings held jointly with the Royal College of Physicians and Surgeons of Canada (RCPSC) and the Canadian Society for Clinical Investigation (CSCI) and in sponsoring other scientific and educational events, the most important of which was the Canadian Consensus Conference on Cholesterol (Ottawa, March 1988). It provided a forum for interaction between the scientific community, government, funding agencies, industry and the general public, and culminated in concrete recommendations for the populace of Canada. It also 'induced' a continuum in governmental and public concern for health with respect to atherosclerosis, and beyond it, the field of cardiovascular diseases. This dialogue continues. As a member (Constituent Society) of the International Atherosclerosis Society (IAS), the CAS has a voice in the international community, its policies and activities. The membership increase from 69 in 1983 to 175 in 1991 reflects steady growth of the CAS. The Society has been active in other areas (publications, awards for young investigators, and common educational endeavours with other groups) and will be host to the 1994 International Symposium on Atherosclerosis. Over a short period of only eight years, all of the above attests to sufficient progress (or achievement) for any scientific society. And yet, there remain quite a few areas not addressed as yet and some sad experiences (eg, that with the Long Term Planning Committee) that must be quickly remedied, if the Society is to keep pace with the everchanging emphasis in research that in the final analysis aims at improving the overall well-being and health of all Canadians. Inherent in the definition of history is the premise that accounts be provided of facts only. Historians who research their subjects derive these facts from studying the necessary accounts relating to these 'facts', using different and preferably controversial resources, so as to present the facts as objectively as possible. It is impossible, however, to fulfill all the above criteria for a historian who lived through every phase of 'life' of the subject of his or her account, because no matter how objective one wishes to remain (and bends backwards to achieve this) there will be always an element of a personal prism through which the historian lived the 'life' with his subject. For being human and thus unable to eliminate entirely that personal component, this writer asks humbly for the reader's understanding.
    MeSH term(s) Arteriosclerosis ; Canada ; History, 20th Century ; Societies, Medical/history ; Societies, Medical/organization & administration
    Language English
    Publishing date 1991-10
    Publishing country England
    Document type Historical Article ; Journal Article ; Portrait ; Research Support, Non-U.S. Gov't
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
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  10. Article: The genesis of atherosclerosis in pediatric age-group.

    Haust, M D

    Pediatric pathology

    1990  Volume 10, Issue 1-2, Page(s) 253–271

    Abstract: The three forms of origin of the atherosclerotic plaque of adults, that is, the fatty streaks, gelatinous elevations, and microthrombi, all occur in arteries of normal infants and children. Some of these may become arrested or regress, but many progress ... ...

    Abstract The three forms of origin of the atherosclerotic plaque of adults, that is, the fatty streaks, gelatinous elevations, and microthrombi, all occur in arteries of normal infants and children. Some of these may become arrested or regress, but many progress to the prominent lesions that precipitate various clinical catastrophies. The aim of modern medicine is to modify or eliminate many of the factors known to advance the atherosclerotic process and thus decrease the incidence of this disease, which ranks highest on the list of causes of morbidity and mortality in the Western world. Of these factors, some may be controlled by dietary means (low salt; low total fat and cholesterol; appropriate ratios of saturated to mono- and polyunsaturated fatty acids; high content of complex carbohydrates and fiber); controlling hypertension, diabetes, and obesity; abstaining from cigarette smoking; and vigorous physical activities. Because patterns of life-style are determined in childhood and adolescence, and because it is only during that period of life that measures to prevent progression of atherosclerosis may be predictably effective, it becomes increasingly apparent that atherosclerosis is, indeed, a pediatric problem.
    MeSH term(s) Arteriosclerosis/etiology ; Arteriosclerosis/pathology ; Arteriosclerosis/prevention & control ; Child Nutritional Physiological Phenomena ; Child, Preschool ; Humans ; Infant ; Infant Nutritional Physiological Phenomena ; Infant, Newborn ; Life Style ; Risk Factors ; Thrombosis/pathology
    Language English
    Publishing date 1990
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605998-3
    ISSN 0277-0938
    ISSN 0277-0938
    DOI 10.3109/15513819009067112
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