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Article ; Online: Multi-Level Precues for Guiding Tasks Within and Between Workspaces in Spatial Augmented Reality.

Volmer, Benjamin / Liu, Jen-Shuo / Matthews, Brandon / Bornkessel-Schlesewsky, Ina / Feiner, Steven / Thomas, Bruce H

IEEE transactions on visualization and computer graphics

2023 Volume 29, Issue 11, Page(s) 4449–4459

Abstract: We explore Spatial Augmented Reality (SAR) precues (predictive cues) for procedural tasks within and between workspaces and for visualizing multiple upcoming steps in advance. We designed precues based on several factors: cue type, color transparency, ... ...

Abstract	We explore Spatial Augmented Reality (SAR) precues (predictive cues) for procedural tasks within and between workspaces and for visualizing multiple upcoming steps in advance. We designed precues based on several factors: cue type, color transparency, and multi-level (number of precues). Precues were evaluated in a procedural task requiring the user to press buttons in three surrounding workspaces. Participants performed fastest in conditions where tasks were linked with line cues with different levels of color transparency. Precue performance was also affected by whether the next task was in the same workspace or a different one.
Language	English
Publishing date	2023-11-06
Publishing country	United States
Document type	Journal Article
ISSN	1941-0506
ISSN (online)	1941-0506
DOI	10.1109/TVCG.2023.3320246
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Article ; Online: Attention to audiovisual speech does not facilitate language acquisition in infants with familial history of autism.

Chawarska, Katarzyna / Lewkowicz, David / Feiner, Hannah / Macari, Suzanne / Vernetti, Angelina

Journal of child psychology and psychiatry, and allied disciplines

2022 Volume 63, Issue 12, Page(s) 1466–1476

Abstract: Background: Due to familial liability, siblings of children with ASD exhibit elevated risk for language delays. The processes contributing to language delays in this population remain unclear.: Methods: Considering well-established links between ... ...

Abstract	Background: Due to familial liability, siblings of children with ASD exhibit elevated risk for language delays. The processes contributing to language delays in this population remain unclear. Methods: Considering well-established links between attention to dynamic audiovisual cues inherent in a speaker's face and speech processing, we investigated if attention to a speaker's face and mouth differs in 12-month-old infants at high familial risk for ASD but without ASD diagnosis (hr-sib; n = 91) and in infants at low familial risk (lr-sib; n = 62) for ASD and whether attention at 12 months predicts language outcomes at 18 months. Results: At 12 months, hr-sib and lr-sib infants did not differ in attention to face (p = .14), mouth preference (p = .30), or in receptive and expressive language scores (p = .36, p = .33). At 18 months, the hr-sib infants had lower receptive (p = .01) but not expressive (p = .84) language scores than the lr-sib infants. In the lr-sib infants, greater attention to the face (p = .022) and a mouth preference (p = .025) contributed to better language outcomes at 18 months. In the hr-sib infants, neither attention to the face nor a mouth preference was associated with language outcomes at 18 months. Conclusions: Unlike low-risk infants, high-risk infants do not appear to benefit from audiovisual prosodic and speech cues in the service of language acquisition despite intact attention to these cues. We propose that impaired processing of audiovisual cues may constitute the link between genetic risk factors and poor language outcomes observed across the autism risk spectrum and may represent a promising endophenotype in autism.
MeSH term(s)	Infant ; Child ; Humans ; Speech ; Autistic Disorder ; Genetic Predisposition to Disease ; Language Development ; Language Development Disorders ; Autism Spectrum Disorder
Language	English
Publishing date	2022-03-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	218136-8
ISSN	1469-7610 ; 0021-9630 ; 0373-8086
ISSN (online)	1469-7610
ISSN	0021-9630 ; 0373-8086
DOI	10.1111/jcpp.13595
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Article ; Online: Motherhood, medicine and cancer.

Feiner, Hannah / Das, Sunit / Turner, Suzanne / Turchin, Kaitie

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2021 Volume 193, Issue 37, Page(s) E1459–E1461

MeSH term(s)	Astrocytoma/psychology ; Brain Neoplasms/psychology ; Female ; Humans ; Mothers/psychology ; Pregnancy ; Pregnancy Complications, Neoplastic/psychology ; Pregnancy Outcome/psychology
Language	English
Publishing date	2021-09-21
Publishing country	Canada
Document type	Journal Article ; Personal Narrative
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.210901
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Article ; Online: Measuring Change During Intervention Using Norm-Referenced, Standardized Measures: A Comparison of Raw Scores, Standard Scores, Age Equivalents, and Growth Scale Values From the Preschool Language Scales-Fifth Edition.

Kwok, Elaine / Feiner, Hannah / Grauzer, Jeffrey / Kaat, Aaron / Roberts, Megan Y

Journal of speech, language, and hearing research : JSLHR

2022 Volume 65, Issue 11, Page(s) 4268–4279

Abstract: Purpose: Norm-referenced, standardized measures are tools designed to characterize a child's abilities relative to their same-age peers, but they also have been used to measure changes in skills during intervention. This study compared the psychometric ... ...

Abstract	Purpose: Norm-referenced, standardized measures are tools designed to characterize a child's abilities relative to their same-age peers, but they also have been used to measure changes in skills during intervention. This study compared the psychometric properties of four types of available scores from one commonly used standardized measure, the Preschool Language Scales-Fifth Edition (PLS-5), to detect changes in children's language skills during and after a language intervention. Method: This study included data from 110 autistic children aged 18-48 months whose mother participated in an 8-week parent-mediated language intervention. Children's language skills were measured at 3 time points using the PLS-5. Changes in children's expressive and receptive language skills were calculated using raw scores, standard scores, age equivalents, and growth scale values (GSVs). Results: Analysis of raw scores, age equivalents, and GSVs indicated significant improvement in the scores of autistic children in both receptive and expressive language throughout the study (i.e., during the intervention period and in the 3-month period after the intervention). Standard scores suggested improvement only in the receptive language scale during the intervention period. Standard scores showed a floor effect for children who scored at -3 Conclusions: Findings suggested that GSVs were not only psychometrically sound but also the most sensitive measure of direct changes in skills compared to raw, standard, and age-equivalent scores. Floor effects may limit the sensitivity of standard scores to detect changes in children's skills. Strengths, limitations, and interpretations of each of the scoring approaches in measuring changes in skills during intervention were discussed. Supplemental material: https://doi.org/10.23641/asha.21498522.
MeSH term(s)	Child ; Female ; Child, Preschool ; Humans ; Mothers ; Parent-Child Relations ; Parents ; Cognition ; Language Development
Language	English
Publishing date	2022-11-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1364086-0
ISSN	1558-9102 ; 1092-4388
ISSN (online)	1558-9102
ISSN	1092-4388
DOI	10.1044/2022_JSLHR-22-00122
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Article ; Online: Reducing Volatile Anesthetic Waste Using a Commercial Electronic Health Record Clinical Decision Support Tool to Lower Fresh Gas Flows.

Olmos, Andrea V / Robinowitz, David / Feiner, John R / Chen, Catherine L / Gandhi, Seema

Anesthesia and analgesia

2022 Volume 136, Issue 2, Page(s) 327–337

Abstract: ... consumption (mL/MAC-h). Because a simple comparison of 2 time periods may result in false conclusions due ... of the intervention. For sevoflurane, mL/MAC-h decreased by 3.8 mL/MAC-h (95% CI, 3.6-4.1 mL/MAC-h; P < .0001) after ... implementation of the intervention and decreased by 4.1 mL/MAC-h (95% CI, 2.6-5.6 mL/MAC-h; P < .0001 ...

Abstract	Background: Volatile anesthetic consumption can be reduced by minimizing excessive fresh gas flows (FGFs). Currently, it is unknown whether decision support tools embedded within commercial electronic health record systems can be successfully adopted to achieve long-term reductions in FGF rates. The authors describe the implementation of an electronic health record-based clinical decision support tool aimed at reducing FGF and evaluate the effectiveness of this intervention in achieving sustained reductions in FGF rates and volatile anesthetic consumption. Methods: On August 29, 2018, we implemented a decision support tool within the Epic Anesthesia Information Management System (AIMS) to alert providers of high FGF (>0.7 L/min for desflurane and >1 L/min for sevoflurane) during maintenance of anesthesia. July 22, 2015, to July 10, 2018, served as our baseline period before the intervention. The intervention period spanned from August 29, 2018, to December 31, 2019. Our primary outcomes were mean FGF (L/min) and volatile agent consumption (mL/MAC-h). Because a simple comparison of 2 time periods may result in false conclusions due to underlying trends independent of the intervention, we performed segmented regression of the interrupted time series to assess the change in level at the start of the intervention and the differences in slopes before and after the intervention. The analysis was also adjusted for potential confounding variables. Data included 44,899 cases using sevoflurane preintervention with 26,911 cases postintervention, and 17,472 cases using desflurane with 1185 cases postintervention. Results: Segmented regression of the interrupted times series demonstrated a decrease in mean FGF by 0.6 L/min (95% CI, 0.6-0.6 L/min; P < .0001) for sevoflurane and 0.2 L/min (95% CI, 0.2-0.3 L/min; P < .0001) for desflurane immediately after implementation of the intervention. For sevoflurane, mL/MAC-h decreased by 3.8 mL/MAC-h (95% CI, 3.6-4.1 mL/MAC-h; P < .0001) after implementation of the intervention and decreased by 4.1 mL/MAC-h (95% CI, 2.6-5.6 mL/MAC-h; P < .0001) for desflurane. Slopes for both FGF and mL/MAC-h in the postintervention period were statistically less negative than the preintervention slopes (P < .0001 for sevoflurane and P < .01 for desflurane). Conclusions: A commercial AIMS-based decision support tool can be adopted to change provider FGF management patterns and reduce volatile anesthetic consumption in a sustainable fashion.
MeSH term(s)	Sevoflurane ; Desflurane ; Anesthetics, Inhalation ; Isoflurane ; Methyl Ethers ; Electronic Health Records ; Decision Support Systems, Clinical ; Anesthesia, Inhalation
Chemical Substances	Sevoflurane (38LVP0K73A) ; Desflurane (CRS35BZ94Q) ; Anesthetics, Inhalation ; Isoflurane (CYS9AKD70P) ; Methyl Ethers
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000006242
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Uk I Zs.78: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 149: Show issues

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Article ; Online: Transvaginal ultrasound imaging of female urethral diverticulum before and after voiding.

Shafat Heller, L / Feiner, B / Sharabi, H / Brodner, Y / Shrim, A

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

2021 Volume 58, Issue 4, Page(s) 640–641

MeSH term(s)	Diverticulum/diagnostic imaging ; Female ; Humans ; Middle Aged ; Ultrasonography/methods ; Urethral Diseases/diagnostic imaging ; Urination ; Vagina/diagnostic imaging
Language	English
Publishing date	2021-09-15
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1073183-0
ISSN	1469-0705 ; 0960-7692
ISSN (online)	1469-0705
ISSN	0960-7692
DOI	10.1002/uog.23766
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Article ; Online: Vaspin: A Novel Biomarker Linking Gluteofemoral Body Fat and Type 2 Diabetes Risk.

Wang, Harry Hezhou / Chong, Michael / Perrot, Nicolas / Feiner, James / Hess, Sibylle / Yusuf, Salim / Gerstein, Hertzel / Paré, Guillaume / Pigeyre, Marie

Diabetes care

2023 Volume 47, Issue 2, Page(s) 259–266

Abstract: Objective: To determine whether adiposity depots modulate vaspin levels and whether vaspin predicts type 2 diabetes (T2D) risk, through epidemiological and genetic analyses.: Research design and methods: We assessed the relationship of plasma vaspin ... ...

Abstract	Objective: To determine whether adiposity depots modulate vaspin levels and whether vaspin predicts type 2 diabetes (T2D) risk, through epidemiological and genetic analyses. Research design and methods: We assessed the relationship of plasma vaspin concentration with incident and prevalent T2D and adiposity-related variables in 1) the Prospective Urban and Rural Epidemiology (PURE) biomarker substudy (N = 10,052) and 2) the Outcome Reduction with Initial Glargine Intervention (ORIGIN) trial (N = 7,840), using regression models. We then assessed whether vaspin is causally associated with T2D and whether genetic variants associated with MRI-measured adiposity depots modulate vaspin levels, using two-sample Mendelian randomization (MR). Results: A 1-SD increase in circulating vaspin levels was associated with a 16% increase in incident T2D in the PURE cohort (hazard ratio 1.16; 95% CI 1.09-1.23; P = 4.26 × 10-7) and prevalent T2D in the ORIGIN cohort (odds ratio [OR] 1.16; 95% CI 1.07-1.25; P = 2.17 × 10-4). A 1-unit increase in BMI and triglyceride levels was associated with a 0.08-SD (95% CI 0.06-0.10; P = 2.04 × 10-15) and 0.06-SD (95% CI 0.04-0.08; P = 4.08 × 10-13) increase, respectively, in vaspin in the PURE group. Consistent associations were observed in the ORIGIN cohort. MR results reinforced the association between vaspin and BMI-adjusted T2D risk (OR 1.01 per 1-SD increase in vaspin level; 95% CI 1.00-1.02; P = 2.86 × 10-2) and showed that vaspin was increased by 0.10 SD per 1-SD decrease in genetically determined gluteofemoral adiposity (95% CI 0.02-0.18; P = 2.01 × 10-2). No relationships were found between subcutaneous or visceral adiposity and vaspin. Conclusions: These findings support that higher vaspin levels are related to increased T2D risk and reduced gluteofemoral adiposity, positioning vaspin as a promising clinical predictor for T2D.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/epidemiology ; Prospective Studies ; Obesity ; Biomarkers ; Adiposity/genetics ; Adipose Tissue ; Insulin Glargine ; Mendelian Randomization Analysis ; Body Mass Index
Chemical Substances	Biomarkers ; Insulin Glargine (2ZM8CX04RZ)
Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc23-1488
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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy.

Riera, Roger / Tauler, Jana / Feiner-Gracia, Natàlia / Borrós, Salvador / Fornaguera, Cristina / Albertazzi, Lorenzo

ChemMedChem

2022 Volume 17, Issue 13, Page(s) e202100633

Abstract: ... oligopeptides (arginine - R; histidine - H; and lysine - K) among polymer libraries, since the oligopeptide ...

Abstract	Nanomedicine emerged some decades ago with the hope to be the solution for most unmet medical needs. However, tracking materials at nanoscale is challenging to their reduced size, below the resolution limit of most conventional techniques. In this context, we propose the use of direct stochastic optical reconstruction microscopy (dSTORM) to study time stability and cell trafficking after transfection of oligopeptide end-modified poly(β-aminoester) (OM-pBAE) nanoparticles. We selected different combinations of cationic end oligopeptides (arginine - R; histidine - H; and lysine - K) among polymer libraries, since the oligopeptide combination demonstrated to be useful for different applications, such as vaccination and gene silencing. We demonstrate that their time evolution as well as their cell uptake and trafficking are dependent on the oligopeptide. This study opens the pave to broad mechanistic studies at nanoscale that could enable a rational selection of specific pBAE nanoparticles composition after determining their stability and cell trafficking.
MeSH term(s)	Green Fluorescent Proteins/chemistry ; Green Fluorescent Proteins/genetics ; Microscopy ; Nanoparticles/chemistry ; Oligopeptides/chemistry ; Transfection
Chemical Substances	Oligopeptides ; Green Fluorescent Proteins (147336-22-9)
Language	English
Publishing date	2022-03-18
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.202100633
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Article ; Online: Segmenting and tracking cell instances with cosine embeddings and recurrent hourglass networks.

Payer, Christian / Štern, Darko / Feiner, Marlies / Bischof, Horst / Urschler, Martin

Medical image analysis

2019 Volume 57, Page(s) 106–119

Abstract: ... in-house dataset of muscle fibers from H&E-stained microscopy images, we also evaluate our proposed ...

Abstract	Differently to semantic segmentation, instance segmentation assigns unique labels to each individual instance of the same object class. In this work, we propose a novel recurrent fully convolutional network architecture for tracking such instance segmentations over time, which is highly relevant, e.g., in biomedical applications involving cell growth and migration. Our network architecture incorporates convolutional gated recurrent units (ConvGRU) into a stacked hourglass network to utilize temporal information, e.g., from microscopy videos. Moreover, we train our network with a novel embedding loss based on cosine similarities, such that the network predicts unique embeddings for every instance throughout videos, even in the presence of dynamic structural changes due to mitosis of cells. To create the final tracked instance segmentations, the pixel-wise embeddings are clustered among subsequent video frames by using the mean shift algorithm. After showing the performance of the instance segmentation on a static in-house dataset of muscle fibers from H&E-stained microscopy images, we also evaluate our proposed recurrent stacked hourglass network regarding instance segmentation and tracking performance on six datasets from the ISBI celltracking challenge, where it delivers state-of-the-art results.
MeSH term(s)	Algorithms ; Cell Tracking/methods ; Datasets as Topic ; Humans ; Image Processing, Computer-Assisted/methods ; Microscopy ; Muscle Fibers, Skeletal/cytology ; Neural Networks, Computer ; Video Recording
Language	English
Publishing date	2019-06-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1356436-5
ISSN	1361-8423 ; 1361-8431 ; 1361-8415
ISSN (online)	1361-8423 ; 1361-8431
ISSN	1361-8415
DOI	10.1016/j.media.2019.06.015
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Article: Peptide stapling by late-stage Suzuki-Miyaura cross-coupling.

Gruß, Hendrik / Feiner, Rebecca C / Mseya, Ridhiwan / Schröder, David C / Jewgiński, Michał / Müller, Kristian M / Latajka, Rafał / Marion, Antoine / Sewald, Norbert

Beilstein journal of organic chemistry

2022 Volume 18, Page(s) 1–12

Abstract: The development of peptide stapling techniques to stabilise α-helical secondary structure motifs of peptides led to the design of modulators of protein-protein interactions, which had been considered undruggable for a long time. We disclose a novel ... ...

Abstract	The development of peptide stapling techniques to stabilise α-helical secondary structure motifs of peptides led to the design of modulators of protein-protein interactions, which had been considered undruggable for a long time. We disclose a novel approach towards peptide stapling utilising macrocyclisation by late-stage Suzuki-Miyaura cross-coupling of bromotryptophan-containing peptides of the catenin-binding domain of axin. Optimisation of the linker length in order to find a compromise between both sufficient linker rigidity and flexibility resulted in a peptide with an increased α-helicity and enhanced binding affinity to its native binding partner β-catenin. An increased proteolytic stability against proteinase K has been demonstrated.
Language	English
Publishing date	2022-01-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2192461-2
ISSN	1860-5397
ISSN	1860-5397
DOI	10.3762/bjoc.18.1
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