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  1. Article ; Online: Reply: Additional viewpoints from transplant surgeons on Banff consensus recommendations for the assessment of steatotic donor livers.

    Neil, Desley A H / Smith, Maxwell L / Minervini, Marta / Demetris, A Jake

    Hepatology (Baltimore, Md.)

    2024  

    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000788
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    Zs.A 1660: Show issues Location:
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  2. Article ; Online: Letter to the Editor: Machine perfusion and acute rejection: Not as simple as it seems-The influence of retransplantation.

    Neil, Desley A H / Hann, Angus / Perera, M Thamara P R

    Hepatology (Baltimore, Md.)

    2023  Volume 78, Issue 4, Page(s) E68

    MeSH term(s) Reoperation ; Heart Transplantation ; Graft Rejection ; Perfusion
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000481
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  3. Article ; Online: Outcomes of renal transplantation in adult patients with primary focal segmental glomerulosclerosis: a single-centre experience over 5 decades.

    Jyothish, Manasi / Berry, Miriam / Neil, Desley

    Clinical medicine (London, England)

    2020  Volume 20, Issue Suppl 2, Page(s) s111

    MeSH term(s) Adult ; Glomerulosclerosis, Focal Segmental ; Humans ; Kidney ; Kidney Transplantation ; Recurrence
    Language English
    Publishing date 2020-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.20-2-s111
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    Zs.A 5439: Show issues Location:
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  4. Article ; Online: The Effect of Continuous Liver Normothermic Machine Perfusion on the Severity of Histological Bile Duct Injury.

    Gilbo, Nicholas / Neil, Desley / Brais, Rebecca / Fieuws, Steffen / Lo Faro, Letizia / Friend, Peter / Ploeg, Rutger / Monbaliu, Diethard

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 11645

    Abstract: Static Cold Storage (SCS) injures the bile duct, while the effect of Normothermic Machine Perfusion (NMP) is unknown. In a sub-study of the COPE trial on liver NMP, we investigated the impact of preservation type on histological bile duct injury score ( ... ...

    Abstract Static Cold Storage (SCS) injures the bile duct, while the effect of Normothermic Machine Perfusion (NMP) is unknown. In a sub-study of the COPE trial on liver NMP, we investigated the impact of preservation type on histological bile duct injury score (BDIS). Transplants with at least one bile duct biopsy, either at end of preservation or 1 h post-reperfusion, were considered. BDIS was determined by assessing peribiliary glands injury, stromal and mural loss, haemorrhage, and thrombosis. A bivariate linear model compared BDIS (estimate, CI) between groups. Sixty-five transplants and 85 biopsies were analysed. Twenty-three grafts were preserved with SCS and 42 with NMP, with comparable baseline characteristics except for a shorter cold ischemic time in NMP. The BDIS increased over time regardless of preservation type (
    MeSH term(s) Humans ; Perfusion ; Bile Ducts ; Reperfusion ; Biopsy ; Liver
    Language English
    Publishing date 2023-09-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.11645
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    Zs.A 2358: Show issues Location:
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  5. Article ; Online: Evidence for Alloimmune Sinusoidal Injury in

    Sebagh, Mylène / Yilmaz, Funda / Kounis, Ilias / Saliba, Faouzi / Feray, Cyrille / Taupin, Jean-Luc / Cherqui, Daniel / Azoulay, Daniel / Samuel, Didier / Coilly, Audrey / Demetris, Antony-Jake / Neil, Desley

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 11306

    Abstract: Posttransplant nodular regenerative hyperplasia (NRH) mostly remains unexplained. Microvascular injury due to antibody-mediated rejection (AMR) is suspected, but lack of donor specific antibody (DSA) testing makes it difficult to prove. Centered around a ...

    Abstract Posttransplant nodular regenerative hyperplasia (NRH) mostly remains unexplained. Microvascular injury due to antibody-mediated rejection (AMR) is suspected, but lack of donor specific antibody (DSA) testing makes it difficult to prove. Centered around a 1-year period of routine DSA testing, concomitant protocol, and indicated posttransplant liver biopsies (LB), recipients with NRH (
    MeSH term(s) Humans ; Liver Transplantation/adverse effects ; Liver/pathology ; Hyperplasia/etiology ; Hyperplasia/pathology ; Antibodies ; Fibrosis ; Graft Rejection
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.11306
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  6. Article ; Online: Is Hepatocyte Necrosis a Good Marker of Donor Liver Viability During Machine Perfusion?

    Neil, Desley A H / Mergental, Hynek / Hann, Angus / Laing, Richard W / Hartog, Hermien / Mirza, Darius F / Perera, M Thamara P R

    Hepatology communications

    2021  Volume 6, Issue 2, Page(s) 435–436

    MeSH term(s) Hepatocytes ; Humans ; Liver ; Liver Transplantation ; Living Donors ; Necrosis ; Perfusion
    Language English
    Publishing date 2021-09-02
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1002/hep4.1816
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  7. Article ; Online: Hydroxychloroquine-induced cardiomyopathy accelerated after gastric banding.

    Lodge, Freya M / Moody, William E / Tosounidou, Sofia / Chue, Colin D / Curtis, Elizabeth / Neil, Desley A H / Bradlow, William

    Lancet (London, England)

    2021  Volume 398, Issue 10314, Page(s) 1913

    MeSH term(s) Antirheumatic Agents/adverse effects ; Cardiomyopathy, Restrictive/chemically induced ; Cardiomyopathy, Restrictive/diagnostic imaging ; Echocardiography ; Female ; Gastroplasty/adverse effects ; Heart/diagnostic imaging ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/adverse effects ; Hypertrophy, Left Ventricular ; Lupus Erythematosus, Systemic/drug therapy ; Magnetic Resonance Imaging ; Middle Aged
    Chemical Substances Antirheumatic Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2021-11-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)02177-2
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  8. Article ; Online: Lactic Acidosis, Hypoglycemia, and Eosinophilia: Novel Markers of Antibody-Mediated Rejection Causing Graft Ischemia.

    Halle-Smith, James M / Hann, Angus / Cain, Owen L / Perera, M Thamara P R / Neil, Desley A H

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2021  Volume 27, Issue 12, Page(s) 1857–1860

    MeSH term(s) Acidosis, Lactic/complications ; Acidosis, Lactic/etiology ; Eosinophilia/complications ; Graft Rejection ; Humans ; Hypoglycemia/etiology ; Ischemia/diagnosis ; Ischemia/etiology ; Liver Transplantation/adverse effects
    Language English
    Publishing date 2021-07-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.26101
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    Zs.A 4702: Show issues Location:
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  9. Article ; Online: Survey of liver pathologists to assess attitudes towards digital pathology and artificial intelligence.

    McGenity, Clare / Randell, Rebecca / Bellamy, Christopher / Burt, Alastair / Cratchley, Alyn / Goldin, Robert / Hubscher, Stefan G / Neil, Desley A H / Quaglia, Alberto / Tiniakos, Dina / Wyatt, Judy / Treanor, Darren

    Journal of clinical pathology

    2023  Volume 77, Issue 1, Page(s) 27–33

    Abstract: Aims: A survey of members of the UK Liver Pathology Group (UKLPG) was conducted, comprising consultant histopathologists from across the UK who report liver specimens and participate in the UK National Liver Pathology External Quality Assurance scheme. ... ...

    Abstract Aims: A survey of members of the UK Liver Pathology Group (UKLPG) was conducted, comprising consultant histopathologists from across the UK who report liver specimens and participate in the UK National Liver Pathology External Quality Assurance scheme. The aim of this study was to understand attitudes and priorities of liver pathologists towards digital pathology and artificial intelligence (AI).
    Methods: The survey was distributed to all full consultant members of the UKLPG via email. This comprised 50 questions, with 48 multiple choice questions and 2 free-text questions at the end, covering a range of topics and concepts pertaining to the use of digital pathology and AI in liver disease.
    Results: Forty-two consultant histopathologists completed the survey, representing 36% of fully registered members of the UKLPG (42/116). Questions examining digital pathology showed respondents agreed with the utility of digital pathology for primary diagnosis 83% (34/41), second opinions 90% (37/41), research 85% (35/41) and training and education 95% (39/41). Fatty liver diseases were an area of demand for AI tools with 80% in agreement (33/41), followed by neoplastic liver diseases with 59% in agreement (24/41). Participants were concerned about AI development without pathologist involvement 73% (30/41), however, 63% (26/41) disagreed when asked whether AI would replace pathologists.
    Conclusions: This study outlines current interest, priorities for research and concerns around digital pathology and AI for liver pathologists. The majority of UK liver pathologists are in favour of the application of digital pathology and AI in clinical practice, research and education.
    MeSH term(s) Humans ; Pathologists ; Artificial Intelligence ; Surveys and Questionnaires ; Liver Diseases
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jcp-2022-208614
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  10. Article ; Online: Pathological changes secondary to pacing leads within the coronary veins.

    Coelho-Lima, Jose / Chapman, Joanne / Lim, Hoong Sern / Neil, Desley A H

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2020  Volume 46, Page(s) 107197

    Abstract: Changes within the Coronary veins secondary to pacing leads have not been described, this study assessed these changes in explanted hearts. Macroscopically fibrous sheaths formed around longstanding leads, leading to slit like channels for venous return ... ...

    Abstract Changes within the Coronary veins secondary to pacing leads have not been described, this study assessed these changes in explanted hearts. Macroscopically fibrous sheaths formed around longstanding leads, leading to slit like channels for venous return in smaller veins. Histologically changes included bland fibrosis, a foreign body response to the lead, a chronic inflammatory response and inflammatory destruction of the media. Individuals responded in different ways with no clear relationship of changes to duration of the lead.
    MeSH term(s) Coronary Vessels/pathology ; Equipment Design ; Fibrosis ; Foreign-Body Reaction/etiology ; Foreign-Body Reaction/pathology ; Humans ; Inflammation/etiology ; Inflammation/pathology ; Pacemaker, Artificial/adverse effects
    Language English
    Publishing date 2020-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2020.107197
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