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  1. Article ; Online: Presentation of Three Novel Tailed Phages Targeting Multiple Strains of

    Jørgensen, Jacob B / Djurhuus, Amaru M / Carstens, Alexander B / Kot, Witold / Neve, Horst / Morris, Cindy E / Hansen, Lars H

    PHAGE (New Rochelle, N.Y.)

    2020  Volume 1, Issue 4, Page(s) 245–250

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2986345-4
    ISSN 2641-6549 ; 2641-6530
    ISSN (online) 2641-6549
    ISSN 2641-6530
    DOI 10.1089/phage.2020.0040
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  2. Article: Genetic Diversity and Population Structure of

    Zeng, Yibing / Xiong, Tao / Liu, Bei / Carstens, Elma / Chen, Xiangling / Xu, Jianping / Li, Hongye

    Phytopathology

    2021  Volume 111, Issue 5, Page(s) 850–861

    Abstract: Phyllosticta ... ...

    Abstract Phyllosticta citriasiana
    MeSH term(s) Ascomycota/genetics ; Genes, Mating Type, Fungal ; Genetic Variation ; Plant Diseases
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208889-7
    ISSN 1943-7684 ; 0031-949X
    ISSN (online) 1943-7684
    ISSN 0031-949X
    DOI 10.1094/PHYTO-12-18-0451-R
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 698: Show issues Location:
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  3. Article: Supplementary prenatal copper increases plasma triiodothyronine and brown adipose tissue uncoupling protein-1 gene expression but depresses thermogenesis in newborn lambs.

    Smith, Stephen B / Sweatt, Craig R / Carstens, Gordon E

    Asian-Australasian journal of animal sciences

    2019  Volume 33, Issue 3, Page(s) 506–514

    Abstract: ... were assigned at birth to a cold (6°C) or warm (28°C) environmental chamber for 48 h. Blood was ... collected from ewes and from lambs and perirenal BAT was collected after 48 h in the environmental chambers ... depressed 48-h rectal temperature (p = 0.03). Cold exposure decreased BAT norepinephrine (NE) and increased ...

    Abstract Objective: We tested the hypothesis that increasing dietary copper (Cu) to gravid ewes would enhance brown adipose tissue (BAT) thermogenesis in their offspring.
    Methods: Twin-bearing ewes were assigned on d 70 of gestation to diets containing 3, 10, or 20 ppm dietary Cu (n = 8 per group). Twin lambs were assigned at birth to a cold (6°C) or warm (28°C) environmental chamber for 48 h. Blood was collected from ewes and from lambs and perirenal BAT was collected after 48 h in the environmental chambers.
    Results: Prenatal Cu exposure increased ewe plasma triiodothyronine (T3) and thyroxine concentration (T4) (p < 0.01) but prenatal Cu exposure had no effect on lamb plasma concentrations of T3, T4, glucose, or nonesterified fatty acid concentration (p ≥ 0.08). The high level of prenatal Cu exposure depressed 48-h rectal temperature (p = 0.03). Cold exposure decreased BAT norepinephrine (NE) and increased BAT dopamine (p ≤ 0.01), but prenatal Cu exposure had no effect on BAT cytochrome C oxidase activity or BAT NE or dopamine (p ≥ 0.07). However, BAT of lambs from high-Cu ewes maintained higher uncoupling protein-1 (UCP1) gene expression than BAT of lambs from low- and medium-Cu ewes following warm or cold exposure in environmental chambers (p = 0.02). Cold exposure caused near depletion of BAT lipid by 48 h (p < 0.001), increased BAT cytochrome c oxidase activity (p < 0.01), and depressed plasma fatty acid concentrations (p < 0.001).
    Conclusion: Although prenatal Cu exposure increased BAT UCP1 expression during warm and cold exposure, prenatal cold Cu exposure depressed 48-h rectal temperature. Cold exposure decreased BAT lipid content by over 80% and decreased lamb plasma fatty acid concentration by over 40%, indicating that fuel reserves for thermogenesis were nearly depleted by 48 h of cold exposure.
    Language English
    Publishing date 2019-05-28
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 743671-3
    ISSN 1976-5517 ; 1011-2367
    ISSN (online) 1976-5517
    ISSN 1011-2367
    DOI 10.5713/ajas.18.0179
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    In stock of ZB MED Bonn / Germany

    Z 4878: Show issues

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  4. Article ; Online: Complete Genome Sequence of Vibrio anguillarum Nontailed Bacteriophage NO16.

    Kalatzis, Panos G / Carstens, Alexander B / Katharios, Pantelis / Castillo, Daniel / Hansen, Lars H / Middelboe, Mathias

    Microbiology resource announcements

    2019  Volume 8, Issue 15

    Abstract: A rare nontailed virus designated NO16 was isolated ... ...

    Abstract A rare nontailed virus designated NO16 was isolated against
    Language English
    Publishing date 2019-04-11
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00020-19
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  5. Article ; Online: Safety of Stromal Vascular Fraction Cell Therapy for Chronic Kidney Disease of Unknown Cause (Mesoamerican Nephropathy).

    Carstens, Michael H / García, Nelson / Mandayam, Sreedhar / Workeneh, Biruh / Pastora, Indiana / Calderón, Carlos / Bertram, Kenneth A / Correa, Diego

    Stem cells translational medicine

    2022  Volume 12, Issue 1, Page(s) 7–16

    Abstract: Chronic kidney disease of unknown cause (CKDu), also known as Mesoamerican nephropathy, typically presents as an ischemic nephropathy with chronic tubulointerstitial fibrosis in normotensive patients, rapidly progressing to kidney failure. In this first- ... ...

    Abstract Chronic kidney disease of unknown cause (CKDu), also known as Mesoamerican nephropathy, typically presents as an ischemic nephropathy with chronic tubulointerstitial fibrosis in normotensive patients, rapidly progressing to kidney failure. In this first-in-human, open-label, safety study, we followed 18 patients with CKDu (stages 3-5) for 36 months after receiving a single infusion of angiogenic/anti-fibrotic autologous adipose-derived stromal vascular fraction (SVF) cells into their kidneys bilaterally via renal artery catheterization. SVF therapy was safe and well tolerated. There were no SVF-related serious adverse events and no procedural complications. Color Doppler evaluation at 2 months demonstrated increased perfusion to the interlobar and/or arcuate artery levels in each kidney evaluated (36/36) with a reduction in resistance index at the hilar artery (35/36) kidneys. Beyond 12 months, patients with initial eGFR <30 mL/minute/1.73 m2 deteriorated, whereas those ≥30 mL/minute/1.73 m2 further sustained their renal function, suggesting a possible renal protective effect in that group.
    MeSH term(s) Humans ; Adipose Tissue ; Cell- and Tissue-Based Therapy ; Chronic Kidney Diseases of Uncertain Etiology ; Fibrosis ; Kidney/pathology ; Renal Insufficiency, Chronic/therapy ; Stromal Cells ; Stromal Vascular Fraction
    Language English
    Publishing date 2022-12-22
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2642270-0
    ISSN 2157-6580 ; 2157-6580
    ISSN (online) 2157-6580
    ISSN 2157-6580
    DOI 10.1093/stcltm/szac080
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  6. Article ; Online: Discerning the global phylogeographic distribution of Phyllosticta citricarpa by means of whole genome sequencing.

    Coetzee, Beatrix / Carstens, Elma / Fourie, Paul H / Dewdney, Megan M / Rollins, Jeffrey A / Manzano León, Ana M / Donovan, Nerida J / Glienke, Chirlei / Miles, Andrew K / Li, Hongye / Bester-van der Merwe, Aletta E

    Fungal genetics and biology : FG & B

    2022  Volume 162, Page(s) 103727

    Abstract: Phyllosticta citricarpa is a fungal pathogen causing citrus black spot (CBS). As a regulated pest in some countries, the presence of the pathogen limits the export of fruit and is therefore of agricultural and economic importance. In this study, we used ... ...

    Abstract Phyllosticta citricarpa is a fungal pathogen causing citrus black spot (CBS). As a regulated pest in some countries, the presence of the pathogen limits the export of fruit and is therefore of agricultural and economic importance. In this study, we used high throughput sequencing data to infer the global phylogeographic distribution of this pathogen, including 71 isolates from eight countries, Argentina, Australia, Brazil, China, Cuba, Eswatini, South Africa and the United States of America. We assembled draft genomes and used a pairwise read mapping approach for the detection and enumeration of variants between isolates. We performed SSR marker discovery based on the assembled genome with the best assembly statistics, and generated genotype profiles for all isolates with 1987 SSR markers in silico. Furthermore, we identified 32,560 SNPs relative to a reference sequence followed by population genetic analyses based on the three datasets; pairwise variant counts, SSR genotypes and SNP genotypes. All three analysis approaches gave similar overall results. Possible pathways of dissemination among the populations from China, Australia, southern Africa and the Americas are postulated. The Chinese population is the most diverse, and is genetically the furthest removed from all other populations, and is therefore considered the closest to the origin of the pathogen. Isolates from Australia, Eswatini and the South African province Mpumalanga are closely associated and clustered together with those from Argentina and Brazil. The Eastern Cape, North West, and KwaZulu-Natal populations in South Africa grouped in another cluster, while isolates from Limpopo are distributed between the two aforementioned clusters. Southern African populations showed a close relationship to populations in North America, and could be a possible source of P. citricarpa populations that are now found in North America. This study represents the largest whole genome sequencing survey of P. citricarpa to date and provides a more comprehensive assessment of the population genetic diversity and connectivity of P. citricarpa from different geographic origins. This information could further assist in a better understanding of the epidemiology of the CBS pathogen, its long-distance dispersal and dissemination pathways, and can be used to refine phytosanitary regulations and management programmes for the disease.
    MeSH term(s) Ascomycota/genetics ; Citrus/microbiology ; Plant Diseases/microbiology ; South Africa ; Whole Genome Sequencing
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1319820-8
    ISSN 1096-0937 ; 1087-1845 ; 0147-5975
    ISSN (online) 1096-0937
    ISSN 1087-1845 ; 0147-5975
    DOI 10.1016/j.fgb.2022.103727
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2431: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Disintegration of the NuRD Complex in Primary Human Muscle Stem Cells in Critical Illness Myopathy.

    Schneider, Joanna / Sundaravinayagam, Devakumar / Blume, Alexander / Marg, Andreas / Grunwald, Stefanie / Metzler, Eric / Escobar, Helena / Müthel, Stefanie / Wang, Haicui / Wollersheim, Tobias / Weber-Carstens, Steffen / Akalin, Altuna / Di Virgilio, Michela / Tursun, Baris / Spuler, Simone

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Critical illness myopathy (CIM) is an acquired, devastating, multifactorial muscle-wasting disease with incomplete recovery. The impact on hospital costs and permanent loss of quality of life is enormous. Incomplete recovery might imply that the function ...

    Abstract Critical illness myopathy (CIM) is an acquired, devastating, multifactorial muscle-wasting disease with incomplete recovery. The impact on hospital costs and permanent loss of quality of life is enormous. Incomplete recovery might imply that the function of muscle stem cells (MuSC) is impaired. We tested whether epigenetic alterations could be in part responsible. We characterized human muscle stem cells (MuSC) isolated from early CIM and analyzed epigenetic alterations (CIM
    MeSH term(s) Humans ; Animals ; Mice ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Critical Illness ; Quality of Life ; Muscular Diseases/metabolism ; Muscle, Skeletal/metabolism ; Stem Cells
    Chemical Substances Mi-2 Nucleosome Remodeling and Deacetylase Complex (EC 3.5.1.98)
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032772
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  8. Article: Complete Genome Sequences of Four Novel Escherichia coli Bacteriophages Belonging to New Phage Groups.

    Carstens, Alexander B / Kot, Witold / Hansen, Lars H

    Genome announcements

    2015  Volume 3, Issue 4

    Abstract: Here, we describe the sequencing and genome annotations of a set of four Escherichia coli bacteriophages (phages) belonging to newly discovered groups previously consisting of only a single phage and thus expand our knowledge of these phage groups. ...

    Abstract Here, we describe the sequencing and genome annotations of a set of four Escherichia coli bacteriophages (phages) belonging to newly discovered groups previously consisting of only a single phage and thus expand our knowledge of these phage groups.
    Language English
    Publishing date 2015-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.00741-15
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  9. Book ; Online: Arena-Rosnav 2.0

    Kästner, Linh / Carstens, Reyk / Zeng, Huajian / Kmiecik, Jacek / Le, Tuan Anh / Bhuiyan, Teham / Meinardus, Boris / Lambrecht, Jens

    A Development and Benchmarking Platform for Robot Navigation in Highly Dynamic Environments

    2023  

    Abstract: Following up on our previous works, in this paper, we present Arena-Rosnav 2.0 an extension to our previous works Arena-Bench and Arena-Rosnav, which adds a variety of additional modules for developing and benchmarking robotic navigation approaches. The ... ...

    Abstract Following up on our previous works, in this paper, we present Arena-Rosnav 2.0 an extension to our previous works Arena-Bench and Arena-Rosnav, which adds a variety of additional modules for developing and benchmarking robotic navigation approaches. The platform is fundamentally restructured and provides unified APIs to add additional functionalities such as planning algorithms, simulators, or evaluation functionalities. We have included more realistic simulation and pedestrian behavior and provide a profound documentation to lower the entry barrier. We evaluated our system by first, conducting a user study in which we asked experienced researchers as well as new practitioners and students to test our system. The feedback was mostly positive and a high number of participants are utilizing our system for other research endeavors. Finally, we demonstrate the feasibility of our system by integrating two new simulators and a variety of state of the art navigation approaches and benchmark them against one another. The platform is openly available at https://github.com/Arena-Rosnav.

    Comment: 8 pages, 5 figures
    Keywords Computer Science - Robotics ; Computer Science - Artificial Intelligence
    Subject code 629
    Publishing date 2023-02-20
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Custodiol-MP for ex vivo lung perfusion - A comparison in a porcine model of donation after circulatory determination of death.

    Kalka, Katharina / Keldenich, Zoe / Carstens, Henning / Walter, Björn / Rauen, Ursula / Ruhparwar, Arjang / Weymann, Alexander / Kamler, Markus / Reiner, Gerald / Koch, Achim

    The International journal of artificial organs

    2021  Volume 45, Issue 2, Page(s) 162–173

    Abstract: ... differed significantly between groups (averaged over 4 h: SS 274 ± 178 mmHg; C-MP 284 ± 151 mmHg ...

    Abstract Introduction: Ex vivo lung perfusion (EVLP) is an established technique to evaluate and eventually recondition lungs prior to transplantation. Custodiol-MP (C-MP) solution is a new solution, designed for clinical machine perfusion, that has been used for kidneys. The aim of this study was to compare the effects of EVLP with Custodiol-MP on lung functional outcomes to the gold standard of EVLP with Steen Solution™.
    Material and methods: In a porcine EVLP model of DCDD (Donation after Circulatory Determination of Death), lungs were perfused with Steen Solution™ (SS,
    Results: Oxygenation capacity differed significantly between groups (averaged over 4 h: SS 274 ± 178 mmHg; C-MP 284 ± 151 mmHg
    MeSH term(s) Animals ; Death ; Extracorporeal Circulation ; Lung ; Lung Transplantation ; Organ Preservation ; Perfusion ; Swine
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80456-3
    ISSN 1724-6040 ; 0391-3988
    ISSN (online) 1724-6040
    ISSN 0391-3988
    DOI 10.1177/0391398821990663
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1439: Show issues Location:
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