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  1. Article: Antifungal effects of echinocandins diminish when exposed to intestinal lumen contents: a finding with potentially significant clinical implications.

    Mehravar, Sepideh / Leite, Gabriela S / Pimentel, Mark / Rezaie, Ali

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1376656

    Abstract: Echinocandins, a prominent class of antifungals, are known for their broad-spectrum activity and favorable safety profiles. However, their bioavailability and efficacy via oral route are suboptimal. In this study, caspofungin and micafungin, the two most ...

    Abstract Echinocandins, a prominent class of antifungals, are known for their broad-spectrum activity and favorable safety profiles. However, their bioavailability and efficacy via oral route are suboptimal. In this study, caspofungin and micafungin, the two most commonly used echinocandins, were evaluated in various
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1376656
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  2. Article ; Online: Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro.

    Leite, Nayara C / Pelayo, Gabriela C / Melton, Douglas A

    Stem cell reports

    2022  Volume 17, Issue 4, Page(s) 766–774

    Abstract: The in vitro production of stem-cell-derived islets (SC-islets) has brought forth the potential of transplanting these cells to restore glycemic control in people with diabetes. Nonetheless, alloimmune and autoimmune responses remain considerable ... ...

    Abstract The in vitro production of stem-cell-derived islets (SC-islets) has brought forth the potential of transplanting these cells to restore glycemic control in people with diabetes. Nonetheless, alloimmune and autoimmune responses remain considerable challenges for a broad clinical implementation of β-cell replacement therapies. β-cell stress has been implicated in the onset of β-cell immunogenicity and death and is likely to contribute to β-cell failure following transplantation. We show that inducing stress and/or administering cytokines causes SC-islet apoptosis, cellular dysfunction, and an increased expression of β-cell stress- and immune-interaction-related genes. We then demonstrate that manipulating some of these genes results in enhanced protection of SC-islets from apoptosis in vitro.
    MeSH term(s) Apoptosis/genetics ; Cytokines/metabolism ; Humans ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans ; Islets of Langerhans Transplantation/methods
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2022.01.018
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  3. Article ; Online: Retrieval and purification of human β cells from stem cell-derived islet engrafted mice.

    Kenty, Jennifer Hyoje-Ryu / Pelayo, Gabriela Cristina / Leite, Nayara Carvalho

    STAR protocols

    2021  Volume 2, Issue 3, Page(s) 100675

    Abstract: Stem cell-derived beta cells (SC-β-cells) engrafted into mice serve as a pre-clinical model of diabetes. It is helpful to recover viable β cells following transplantation to perform tests on the graft. We developed a protocol to retrieve and purify a ... ...

    Abstract Stem cell-derived beta cells (SC-β-cells) engrafted into mice serve as a pre-clinical model of diabetes. It is helpful to recover viable β cells following transplantation to perform tests on the graft. We developed a protocol to retrieve and purify a sufficient number of live β cells from mice following long-term human SC-β-cell engraftment. The protocol enables examination of SC-β-cells undergoing developmental and metabolic changes
    MeSH term(s) Animals ; Cell Separation/methods ; Heterografts ; Humans ; Insulin-Secreting Cells/cytology ; Insulin-Secreting Cells/transplantation ; Islets of Langerhans Transplantation/methods ; Mice ; Stem Cells/cytology
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2021.100675
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  4. Article: The Impact of Clinical Pilates Exercises on Tension-Type Headaches: A Case Series.

    Leite, Agathe / Matignon, Antoine / Marlot, Léa / Coelho, Ana / Lopes, Sofia / Brochado, Gabriela

    Behavioral sciences (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Tension-type-headaches appear as the third most common disease in the general population and have a big impact on quality of life. The aim is to verify the impact of clinical Pilates exercises on pain intensity, impact headaches, neck disability, state ... ...

    Abstract Tension-type-headaches appear as the third most common disease in the general population and have a big impact on quality of life. The aim is to verify the impact of clinical Pilates exercises on pain intensity, impact headaches, neck disability, state of anxiety, depression, stress and quality of sleep in higher-education students. After a sample selection questionnaire was completed, a series of cases was carried out with 9 undergraduate students with tension-type headaches. Five instruments were applied before and after an intervention program: (i) Numerical Rating Scale-NRS, (ii) Headache Impact Test-HIT-6™, (iii) Neck Disability Index, (iv) Depression, Anxiety, Stress Scales and (v) Pittsburgh Sleep Quality Index. Four sessions of 30 min classes of Pilates exercises were held for 2 weeks. The pain intensity decreased in only 2 participants. The impact of tension-type headaches on normal daily life and ability to function was improved in all patients, and only one patient's functional disability caused by pain in the cervical region did not improve. In regard to negative emotional states, 6 individuals reported improvements, and only one individual reported a lower quality of sleep after the program. The exercise program can induce positive effects on disorders associated with tension-type-headaches.
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs13020105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Antifungal Susceptibility and

    Alves, Anelise Maria Costa Vasconcelos / de Brito, Érika Helena Salles / de Araújo, Márcio Flávio Moura / de Hollanda Celestino, Juliana Jales / Leite, Ana Caroline Rocha de Melo / Cruz, Gabriela Silva / Azevedo, Nuno Filipe / Rodrigues, Célia Fortuna

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: The aim of the present study was to characterize biofilms formed ... ...

    Abstract The aim of the present study was to characterize biofilms formed by
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020310
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  6. Article: Chitosan-Calcium Aluminate as a Cell-homing Scaffold: Its Bioactivity Testing in a Microphysiological Dental Pulp Platform.

    Bordini, Ester Alves Ferreira / Stuani, Vitor de Toledo / Correa, Lígia Espoliar / Cassiano, Fernanda Balestrero / Lovison, Marcella Fernandes / Leite, Maria Luisa / Hebling, Josimeri / de Souza Costa, Carlos Alberto / Soares, Diana Gabriela

    Alternatives to laboratory animals : ATLA

    2024  Volume 52, Issue 2, Page(s) 107–116

    Abstract: ... In ... ...

    Abstract In vitro
    MeSH term(s) Animals ; Chitosan ; Tissue Scaffolds/chemistry ; Dental Pulp ; Biocompatible Materials/chemistry ; Cell Differentiation ; Cells, Cultured ; Tissue Engineering ; Aluminum Compounds ; Calcium Compounds
    Chemical Substances Chitosan (9012-76-4) ; calcium aluminate (12042-78-3) ; Biocompatible Materials ; Aluminum Compounds ; Calcium Compounds
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 605800-0
    ISSN 0261-1929
    ISSN 0261-1929
    DOI 10.1177/02611929241232558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3391: Show issues Location:
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  7. Article ; Online: Interleukin-10 Knockout Mice Do Not Reliably Exhibit Macroscopic Inflammation: A Natural History Endoscopic Surveillance Study.

    Kim, Seung Young / Park, Jae Ho / Leite, Gabriela / Pimentel, Mark / Rezaie, Ali

    Digestive diseases and sciences

    2023  Volume 68, Issue 5, Page(s) 1858–1862

    Abstract: Background: Interleukin (IL)-10 knockout (KO) mice, a model for inflammatory bowel disease (IBD), develop chronic enterocolitis due to an aberrant immune response to enteric antigens. Endoscopy, the gold standard for evaluation of human mucosal health, ... ...

    Abstract Background: Interleukin (IL)-10 knockout (KO) mice, a model for inflammatory bowel disease (IBD), develop chronic enterocolitis due to an aberrant immune response to enteric antigens. Endoscopy, the gold standard for evaluation of human mucosal health, is not widely available for murine models.
    Aims: To assess the natural history of left-sided colitis in IL-10 KO mice via serial endoscopies.
    Methods: BALB/cJ IL-10 KO mice underwent regular endoscopic assessments from 2 up to 8 months of age. Procedures were recorded and blindly evaluated using a 4-component endoscopic score: mucosal wall transparency, intestinal bleeding, focal lesions and perianal lesions (0-3 points each). An endoscopic score ≥ 1 point was considered as the presence of colitis/flare.
    Results: IL-10 KO mice (N = 40, 9 female) were assessed. Mean age at first endoscopy was 62.5 ± 2.5 days; average number of procedures per mouse was 6.0 ± 1.3. A total of 238 endoscopies were conducted every 24.8 ± 8.3 days, corresponding to 124.1 ± 45.2 days of surveillance per mouse. Thirty-three endoscopies in 24 mice (60%) detected colitis, mean endoscopy score 2.5 ± 1.3 (range: 1-6.3). Nineteen mice (47.5%) had one episode of colitis and 5 (12.5%) had 2-3 episodes. All exhibited complete spontaneous healing on subsequent endoscopies.
    Conclusions: In this large-scale endoscopic surveillance study of IL-10 KO mice, 40% of mice did not develop endoscopic left-sided colitis. Furthermore, IL-10 KO mice did not exhibit persistent colitis and universally exhibited complete spontaneous healing without treatment. The natural history of colitis in IL-10 KO mice may not be comparable with that of IBD in humans and requires careful consideration.
    MeSH term(s) Animals ; Female ; Mice ; Colitis/genetics ; Colitis/pathology ; Disease Models, Animal ; Endoscopy ; Inflammation ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/pathology ; Interleukin-10/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Male
    Chemical Substances Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-023-07871-y
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    Ui V Zs.35: Show issues Location:
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  8. Article ; Online: SEGURANÇA ALIMENTAR E OS PROGRAMAS SOCIAIS

    Gabriela C. Covalchuk / Rodrigo Pereira Leite / Augusta Pelinski Raiher / Mirna de Lima Medeiros

    Informe Gepec, Vol 27, Iss

    ESTUDO DE CASO DO MUNICÍPIO DE PONTA GROSSA - PR / Food Security and Social Programs: A Case Study in the Municipality of Ponta Grossa -PR in Brazil

    2023  Volume 1

    Abstract: Este artigo buscou analisar a importância dos programas sociais na mitigação da insegurança alimentar durante a pandemia da COVID-19, considerando os domicílios mais vulneráveis de Ponta Grossa-PR. Para isso, foi utilizado informações de uma pesquisa ... ...

    Abstract Este artigo buscou analisar a importância dos programas sociais na mitigação da insegurança alimentar durante a pandemia da COVID-19, considerando os domicílios mais vulneráveis de Ponta Grossa-PR. Para isso, foi utilizado informações de uma pesquisa realizada por Raiher et al (2022), construída a partir de uma amostra probabilística de 302 famílias, as quais representaram a população total atendida com o benefício eventual de auxílio alimentação de Ponta Grossa-PR (total de 5.305 famílias). Com essas informações, utilizou o método Propensity Score Matching visando mensurar o efeito dos programas sociais na insegurança alimentar. Como corolário, teve-se um agravamento da fome no município de Ponta Grossa-PR durante a pandemia, de modo que quase metade da população estava em grave vulnerável alimentar. E os programas sociais se apresentaram essenciais para o rompimento da insegurança alimentar destes domicílios, apresentando um efeito significativo. Abstract : This article sought to analyze the importance of social programs in mitigating food insecurity during the COVID-19 pandemic, considering the most vulnerable households in Ponta Grossa-PR. For this, information from a survey carried out by Raiher et al (2022) was used, constructed from a probabilistic sample of 302 families, which represented the total population served with the occasional benefit of food aid in Ponta Grossa-PR (total of 5,305 families). With this information, he used the Propensity Score Matching method to measure the effect of social programs on food insecurity. As a corollary, there was a worsening of hunger in the municipality of Ponta Grossa-PR during the pandemic, so that almost half of the population was seriously vulnerable to food. And the social programs were essential for breaking the food insecurity of these households, with a significant effect.
    Keywords Segurança alimentar ; vulnerabilidade social ; Covid-19 ; desenvolvimento social ; Agriculture (General) ; S1-972 ; Agricultural industries ; HD9000-9495
    Language Portuguese
    Publishing date 2023-03-01T00:00:00Z
    Publisher Universidade Estadual do Oeste do Paraná
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: An electrochemical genomagnetic assay for detection of SARS-CoV-2 and Influenza A viruses in saliva.

    Santos, Daniel Júnior Almeida Dos / Oliveira, Tássia Regina de / Araújo, Gabriela Martins de / Pott-Junior, Henrique / Melendez, Matias Eliseo / Sabino, Ester Cerdeira / Leite, Oldair Donizeti / Faria, Ronaldo Censi

    Biosensors & bioelectronics

    2024  Volume 255, Page(s) 116210

    Abstract: Viral respiratory infections represent a major threat to the population's health globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 disease and in some cases the symptoms can be confused with Influenza disease caused ... ...

    Abstract Viral respiratory infections represent a major threat to the population's health globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 disease and in some cases the symptoms can be confused with Influenza disease caused by the Influenza A viruses. A simple, fast, and selective assay capable of identifying the etiological agent and differentiating the diseases is essential to provide the correct clinical management to the patient. Herein, we described the development of a genomagnetic assay for the selective capture of viral RNA from SARS-CoV-2 and Influenza A viruses in saliva samples and employing a simple disposable electrochemical device for gene detection and quantification. The proposed method showed excellent performance detecting RNA of SARS-CoV-2 and Influenza A viruses, with a limit of detection (LoD) and limit of quantification (LoQ) of 5.0 fmol L
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19/diagnosis ; Influenza A virus/genetics ; Influenza, Human/diagnosis ; Saliva ; Reproducibility of Results ; Biosensing Techniques
    Language English
    Publishing date 2024-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2024.116210
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
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  10. Article: The small bowel microbiome changes significantly with age and aspects of the ageing process.

    Leite, Gabriela / Pimentel, Mark / Barlow, Gillian M / Mathur, Ruchi

    Microbial cell (Graz, Austria)

    2021  Volume 9, Issue 1, Page(s) 21–23

    Abstract: ... plays critical roles in host metabolism and immune function. In this paper (Leite ...

    Abstract Gut microbiome changes have been associated with human ageing and implicated in age-related diseases including Alzheimer's disease and Parkinson's disease. However, studies to date have used stool samples, which do not represent the entire gut. Although more challenging to access, the small intestine plays critical roles in host metabolism and immune function. In this paper (Leite
    Language English
    Publishing date 2021-12-27
    Publishing country Austria
    Document type Journal Article ; Comment
    ZDB-ID 2814756-X
    ISSN 2311-2638
    ISSN 2311-2638
    DOI 10.15698/mic2022.01.768
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