LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 10458

Search options

  1. Article ; Online: Fano interference between collective modes in cuprate high-T

    Chu, Hao / Kovalev, Sergey / Wang, Zi Xiao / Schwarz, Lukas / Dong, Tao / Feng, Liwen / Haenel, Rafael / Kim, Min-Jae / Shabestari, Parmida / Hoang, Le Phuong / Honasoge, Kedar / Dawson, Robert David / Putzky, Daniel / Kim, Gideok / Puviani, Matteo / Chen, Min / Awari, Nilesh / Ponomaryov, Alexey N / Ilyakov, Igor /
    Bluschke, Martin / Boschini, Fabio / Zonno, Marta / Zhdanovich, Sergey / Na, Mengxing / Christiani, Georg / Logvenov, Gennady / Jones, David J / Damascelli, Andrea / Minola, Matteo / Keimer, Bernhard / Manske, Dirk / Wang, Nanlin / Deinert, Jan-Christoph / Kaiser, Stefan

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 1343

    Abstract: Cuprate high-T ...

    Abstract Cuprate high-T
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36787-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer.

    Kasikova, Lenka / Rakova, Jana / Hensler, Michal / Lanickova, Tereza / Tomankova, Jana / Pasulka, Josef / Drozenova, Jana / Mojzisova, Katerina / Fialova, Anna / Vosahlikova, Sarka / Laco, Jan / Ryska, Ales / Dundr, Pavel / Kocian, Roman / Brtnicky, Tomas / Skapa, Petr / Capkova, Linda / Kovar, Marek / Prochazka, Jan /
    Praznovec, Ivan / Koblizek, Vladimir / Taskova, Alice / Tanaka, Hisashi / Lischke, Robert / Mendez, Fernando Casas / Vachtenheim, Jiri / Heinzelmann-Schwarz, Viola / Jacob, Francis / McNeish, Iain A / Halaska, Michal J / Rob, Lukas / Cibula, David / Orsulic, Sandra / Galluzzi, Lorenzo / Spisek, Radek / Fucikova, Jitka

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2528

    Abstract: Intratumoral tertiary lymphoid structures (TLSs) have been associated with improved outcome in various cohorts of patients with cancer, reflecting their contribution to the development of tumor-targeting immunity. Here, we demonstrate that high-grade ... ...

    Abstract Intratumoral tertiary lymphoid structures (TLSs) have been associated with improved outcome in various cohorts of patients with cancer, reflecting their contribution to the development of tumor-targeting immunity. Here, we demonstrate that high-grade serous ovarian carcinoma (HGSOC) contains distinct immune aggregates with varying degrees of organization and maturation. Specifically, mature TLSs (mTLS) as forming only in 16% of HGSOCs with relatively elevated tumor mutational burden (TMB) are associated with an increased intratumoral density of CD8
    MeSH term(s) Humans ; Female ; CD8-Positive T-Lymphocytes ; Tertiary Lymphoid Structures ; Ovarian Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating ; Phenotype ; Carcinoma, Non-Small-Cell Lung ; Lung Neoplasms ; Tumor Microenvironment
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46873-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Reduction of deoxynivalenol, T-2 and HT-2 toxins and associated

    Meyer, Jens C / Birr, Tim / Hennies, Inga / Wessels, Detlev / Schwarz, Karin

    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

    2022  Volume 39, Issue 6, Page(s) 1163–1183

    Abstract: Oats ( ...

    Abstract Oats (
    MeSH term(s) Avena/microbiology ; Edible Grain/chemistry ; Food Contamination/analysis ; Fusarium ; Mycotoxins/analysis ; T-2 Toxin/analogs & derivatives ; Trichothecenes
    Chemical Substances Mycotoxins ; Trichothecenes ; T-2 Toxin (I3FL5NM3MO) ; deoxynivalenol (JT37HYP23V) ; HT-2 toxin (NC6C26RM46)
    Language English
    Publishing date 2022-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2462951-0
    ISSN 1944-0057 ; 1944-0049
    ISSN (online) 1944-0057
    ISSN 1944-0049
    DOI 10.1080/19440049.2022.2059576
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Controllers of cutaneous regulatory T cells: ultraviolet radiation and the skin microbiome.

    Schwarz, Thomas / Schwarz, Agatha

    Biological chemistry

    2021  Volume 402, Issue 12, Page(s) 1575–1581

    Abstract: ... as their induction. In this scenario regulatory T cells (Treg) play an important role. Accordingly a variety ...

    Abstract For the maintenance of homeostasis termination of immune reactions is as equally important as their induction. In this scenario regulatory T cells (Treg) play an important role. Accordingly a variety of inflammatory diseases are caused by an impairment of Treg. Hence, it is important to identify triggers by which Treg can be induced and activated, respectively. For quite a long time it is known that ultraviolet radiation can induce Treg which inhibit cutaneous immune reactions including contact hypersensitivity. Since these Treg inhibit in an antigen-specific fashion they may harbor therapeutic potential. However similar Treg can be induced also by other triggers which include vitamin D and antimicrobial peptides. Recently it was discovered that the gut microbiome controls the development of Treg in the intestine. The same may apply for the skin. Short chain fatty acids, microbiota-derived bacterial fermentation products, appear to induce and to activate Treg in the skin. Topical application of short chain fatty acids was shown to inhibit contact hypersensitivity and to reduce inflammation in the murine imiquimod-induced psoriasis-like skin inflammation model. Together, these data indicate that induction and activation of Treg may be a potential therapeutic strategy to treat inflammatory diseases in the future.
    MeSH term(s) Animals ; Antimicrobial Peptides ; Mice ; T-Lymphocytes, Regulatory ; Ultraviolet Rays
    Chemical Substances Antimicrobial Peptides
    Language English
    Publishing date 2021-09-13
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2021-0252
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.

    Schwarz, Agatha / Philippsen, Rebecca / Piticchio, Serena G / Hartmann, Jan N / Häsler, Robert / Rose-John, Stefan / Schwarz, Thomas

    Frontiers in immunology

    2023  Volume 14, Page(s) 1038689

    Abstract: ... by inducing regulatory T cells (Treg). This applies also to the skin and in this setting ...

    Abstract The organ-specific microbiome plays a crucial role in tissue homeostasis, among other things by inducing regulatory T cells (Treg). This applies also to the skin and in this setting short chain fatty acids (SCFA) are relevant. It was demonstrated that topical application of SCFA controls the inflammatory response in the psoriasis-like imiquimod (IMQ)-induced murine skin inflammation model. Since SCFA signal
    MeSH term(s) Animals ; Humans ; Mice ; Imiquimod/adverse effects ; Inflammation/metabolism ; Interleukin-17/metabolism ; Mice, Knockout ; Microbiota ; Psoriasis/metabolism ; T-Lymphocytes, Regulatory/metabolism ; Adenylyl Cyclases/metabolism
    Chemical Substances Imiquimod (P1QW714R7M) ; Interleukin-17 ; ADCY10 protein, human (EC 4.6.1.1) ; Adenylyl Cyclases (EC 4.6.1.1)
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1038689
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Can’t intubate, can’t ventilate: Die chirurgische Atemwegssicherung als letzte Notfallmaßnahme

    Schwarz, J. / Ostermaier, V. / Mahler, O. / Jost, C. / Hossfeld, B.

    Rettungsdienst

    2023  Volume 46, Issue 10, Page(s) 60

    Language German
    Document type Article
    ZDB-ID 632510-5
    ISSN 0178-2525
    Database Current Contents Medicine

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2741: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: T cell immunity is key to the pandemic endgame

    Megan Schwarz / Slim Mzoughi / Daniel Lozano-Ojalvo / Anthony T. Tan / Antonio Bertoletti / Ernesto Guccione

    Current Research in Immunology, Vol 3, Iss , Pp 215-

    How to measure and monitor it

    2022  Volume 221

    Abstract: ... have demonstrated that while neutralizing antibodies can protect us from viral infection, T cell ... on quantification of cellular immunity.Despite this evidence, an assessment of T cell responses is still overlooked ... non-antigen specific T-cells. These assays range from the analysis of the T cell-receptor (TCR ...

    Abstract As vaccine deployment improves the healthcare emergency status caused by the SARS-CoV-2 pandemic, we need reliable tools to evaluate the duration of protective immunity at a global scale. Seminal studies have demonstrated that while neutralizing antibodies can protect us from viral infection, T cell-mediated cellular immunity provides long-term protection from severe COVID-19, even in the case of emerging new variants of concern (VOC). Indeed, the emergence of VOCs, able to substantially escape antibodies generated by current vaccines, has made the analysis of correlates of humoral protection against infection obsolete. The focus should now shift towards immunological correlates of protection from disease based on quantification of cellular immunity.Despite this evidence, an assessment of T cell responses is still overlooked. This is largely due to technical challenges and lack of validated diagnostic tests. Here, we review the current state of the art of available tests to distinguish between SARS-CoV-2 antigen-specific Tcells and non-antigen specific T-cells. These assays range from the analysis of the T cell-receptor (TCR) diversity (i.e. Immunoseq and MHC tetramer staining) to the detection of functional T cell activation (i.e. ICS, AIM, Elispot, ELLA, dqTACT, etc.) either from purified Peripheral Blood Mononuclear Cells (PBMCs) or whole blood.We discuss advantages and disadvantages of each assay, proposing their ideal use for different scopes. Finally, we argue how it is paramount to deploy cheap, standardized, and scalable assays to measure T cell functionality to fill this critical diagnostic gap and manage these next years of the pandemic.
    Keywords T-cells ; SARS-CoV-2 ; Cellular immunity ; qPCR ; Specialties of internal medicine ; RC581-951
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: CD5: from antiquated T cell marker to immunotherapy's new hope.

    Schwarz, Sandra / Linnebacher, Michael

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 216

    MeSH term(s) CD5 Antigens ; T-Lymphocytes ; Immunotherapy
    Chemical Substances CD5 Antigens
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01494-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Depletion of Ly6G-Expressing Neutrophilic Cells Leads to Altered Peripheral T-Cell Homeostasis and Thymic Development in Neonatal Mice.

    Rühle, Jessica / Ginzel, Marco / Dietz, Stefanie / Schwarz, Julian / Lajqi, Trim / Beer-Hammer, Sandra / Poets, Christian F / Gille, Christian / Köstlin-Gille, Natascha

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: ... inhibit but also specifically modulate the function of T-cells. In this study, we investigated ... whether neonatal neutrophils are already involved in T-cell development in the thymus. For this purpose, we used ... resulted in altered peripheral T-cell homeostasis with a decreased CD4+/CD8+ T-cell ratio and decreased ...

    Abstract Newborns and especially preterm infants are much more susceptible to infections than adults. Due to immature adaptive immunity, especially innate immune cells play an important role in a newborn's infection defense. Neonatal neutrophils exhibit profound differences in their functionality compared to neutrophils of adults. In particular, neonates possess a relevant population of suppressive neutrophils, which not only inhibit but also specifically modulate the function of T-cells. In this study, we investigated whether neonatal neutrophils are already involved in T-cell development in the thymus. For this purpose, we used a newly developed model of antibody-mediated immune cell depletion in which we administered a depleting antibody to pregnant and then lactating dams. Using this method, we were able to sufficiently deplete Ly6G-positive neutrophils in offspring. We demonstrated that the depletion of neutrophils in newborn mice resulted in altered peripheral T-cell homeostasis with a decreased CD4+/CD8+ T-cell ratio and decreased expression of CD62L. Neutrophil depletion even affected T-cell development in the thymus, with increased double positive thymocytes and a decreased CD4+/CD8+ single positive thymocyte ratio. Altogether, we demonstrated a previously unknown mechanism mediating neutrophils' immunomodulatory effects in newborns.
    MeSH term(s) Animals ; Female ; Humans ; Infant, Newborn ; Mice ; Pregnancy ; Adaptive Immunity ; Animals, Newborn ; Infant, Premature ; Lactation ; Thymus Gland/immunology ; Neutrophils/immunology ; T-Lymphocytes/immunology
    Chemical Substances Ly6G antigen, mouse
    Language English
    Publishing date 2023-04-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24097763
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis.

    Schwarz, Carsten / Eschenhagen, Patience / Schmidt, Henrijette / Hohnstein, Thordis / Iwert, Christina / Grehn, Claudia / Roehmel, Jobst / Steinke, Eva / Stahl, Mirjam / Lozza, Laura / Tikhonova, Ekaterina / Rosati, Elisa / Stervbo, Ulrik / Babel, Nina / Mainz, Jochen G / Wisplinghoff, Hilmar / Ebel, Frank / Jia, Lei-Jie / Blango, Matthew G /
    Hortschansky, Peter / Brunke, Sascha / Hube, Bernhard / Brakhage, Axel A / Kniemeyer, Olaf / Scheffold, Alexander / Bacher, Petra

    The Journal of clinical investigation

    2023  Volume 133, Issue 5

    Abstract: ... characterized.METHODSWe used antigen-reactive T cell enrichment (ARTE) to investigate fungus-reactive Th cells ...

    Abstract BACKGROUNDThe fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types of A. fumigatus-specific Th cells in pwCF and their contribution to protective immunity or inflammation remain poorly characterized.METHODSWe used antigen-reactive T cell enrichment (ARTE) to investigate fungus-reactive Th cells in peripheral blood of pwCF and healthy controls.RESULTSWe show that clonally expanded, high-avidity A. fumigatus-specific effector Th cells, which were absent in healthy donors, developed in pwCF. Individual patients were characterized by distinct Th1-, Th2-, or Th17-dominated responses that remained stable over several years. These different Th subsets target different A. fumigatus proteins, indicating that differential antigen uptake and presentation directs Th cell subset development. Patients with allergic bronchopulmonary aspergillosis (ABPA) are characterized by high frequencies of Th2 cells that cross-recognize various filamentous fungi.CONCLUSIONOur data highlight the development of heterogenous Th responses targeting different protein fractions of a single fungal pathogen and identify the development of multispecies cross-reactive Th2 cells as a potential risk factor for ABPA.FUNDINGGerman Research Foundation (DFG), under Germany's Excellence Strategy (EXC 2167-390884018 "Precision Medicine in Chronic Inflammation" and EXC 2051-390713860 "Balance of the Microverse"); Oskar Helene Heim Stiftung; Christiane Herzog Stiftung; Mukoviszidose Institut gGmb; German Cystic Fibrosis Association Mukoviszidose e.V; German Federal Ministry of Education and Science (BMBF) InfectControl 2020 Projects AnDiPath (BMBF 03ZZ0838A+B).
    MeSH term(s) Aspergillus fumigatus ; Cystic Fibrosis ; Immunity ; Aspergillosis, Allergic Bronchopulmonary ; Immunoglobulin E ; Inflammation
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI161593
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top