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Article ; Online: A novel factor modulating X chromosome dosage compensation in Anopheles.

Krzywinska, Elzbieta / Ribeca, Paolo / Ferretti, Luca / Hammond, Andrew / Krzywinski, Jaroslaw

2023 Volume 33, Issue 21, Page(s) 4697–4703.e4

Abstract: Dosage compensation (DC), a process countering chromosomal imbalance in individuals with heteromorphic sex chromosomes, has been molecularly characterized only in mammals, Caenorhabditis elegans, and fruit flies. ...

Abstract	Dosage compensation (DC), a process countering chromosomal imbalance in individuals with heteromorphic sex chromosomes, has been molecularly characterized only in mammals, Caenorhabditis elegans, and fruit flies.
MeSH term(s)	Animals ; Male ; Female ; Drosophila melanogaster/genetics ; Anopheles/genetics ; Factor X/genetics ; Malaria/genetics ; Mosquito Vectors ; X Chromosome/genetics ; Drosophila/genetics ; Drosophila Proteins/genetics ; Mammals/genetics
Chemical Substances	Factor X (9001-29-0) ; Drosophila Proteins
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.09.001
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Article ; Online: Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells.

Ferretti, Andrew P / Bhargava, Rhea / Dahan, Shani / Tsokos, Maria G / Tsokos, George C

Frontiers in immunology

2018 Volume 9, Page(s) 2113

Abstract: Calcium calmodulin kinase IV (CaMK4) regulates multiple processes that significantly contribute to the lupus-related pathology by controlling the production of IL-2 and IL-17 by T cells, the proliferation of mesangial cells, and the function and ... ...

Abstract	Calcium calmodulin kinase IV (CaMK4) regulates multiple processes that significantly contribute to the lupus-related pathology by controlling the production of IL-2 and IL-17 by T cells, the proliferation of mesangial cells, and the function and structure of podocytes. CaMK4 is also upregulated in podocytes from patients with focal segmental glomerulosclerosis (FSGS). In both immune and non-immune podocytopathies, CaMK4 disrupts the structure and function of podocytes. In lupus-prone mice, targeted delivery of a CaMK4 inhibitor to CD4
MeSH term(s)	Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 4/antagonists & inhibitors ; Calcium-Calmodulin-Dependent Protein Kinase Type 4/metabolism ; Glomerulosclerosis, Focal Segmental/drug therapy ; Glomerulosclerosis, Focal Segmental/enzymology ; Glomerulosclerosis, Focal Segmental/immunology ; Humans ; Interleukin-2/metabolism ; Lupus Nephritis/drug therapy ; Lupus Nephritis/enzymology ; Lupus Nephritis/immunology ; Mesangial Cells/metabolism ; Mice ; Molecular Targeted Therapy ; Podocytes/metabolism ; T-Lymphocytes, Regulatory/metabolism ; Th17 Cells/metabolism
Chemical Substances	Interleukin-2 ; CAMK4 protein, human (EC 2.7.11.17) ; Calcium-Calmodulin-Dependent Protein Kinase Type 4 (EC 2.7.11.17) ; Camk4 protein, mouse (EC 2.7.11.17)
Language	English
Publishing date	2018-10-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.02113
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Article: Shark fin trade bans and sustainable shark fisheries

Ferretti, Francesco / Jacoby, David M. P / Pfleger, Mariah O / White, Timothy D / Dent, Felix / Micheli, Fiorenza / Rosenberg, Andrew A / Crowder, Larry B / Block, Barbara A

Conservation letters. 2020 May, v. 13, no. 3

2020

Abstract: The U.S. Congress is currently discussing the Shark Fin Sales Elimination Act to eliminate shark fin trade at the federal level. This bill was introduced in 2017 and has been proceeding very slowly in Congress because of mixed reviews from the scientific ...

Abstract	The U.S. Congress is currently discussing the Shark Fin Sales Elimination Act to eliminate shark fin trade at the federal level. This bill was introduced in 2017 and has been proceeding very slowly in Congress because of mixed reviews from the scientific community. Debate exists on whether shark conservation and management are effectively addressed with tightened trade controls for imported shark products or blanket bans that outright end U.S. participation in the shark fin trade. Here we contribute to this debate with a review and analysis of economic, nutritional, ethical, and legal arguments, as well as of the shark fisheries status and shark fin trade. We show that the United States has a limited commercial interest in shark fisheries and contributes to the shark fin trade mainly as a facilitator. A fin trade ban has few tangible economic drawbacks but would have a considerable conservation impact. While making all shark fisheries sustainable is the ultimate goal, in practice this objective is far from achievable everywhere in the world. Conversely, banning shark fin trade is an interim measure that nations like the United States can take with negligible cost and can truly impact the biggest driver of shark exploitation globally.
Keywords	ethics ; fins ; fisheries ; sales ; sharks ; trade ; United States
Language	English
Dates of publication	2020-05
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ISSN	1755-263X
DOI	10.1111/conl.12708
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy.

Cell

2022 Volume 185, Issue 16, Page(s) 2918–2935.e29

Abstract: Neoadjuvant immune checkpoint blockade has shown promising clinical activity. Here, we characterized early kinetics in tumor-infiltrating and circulating immune cells in oral cancer patients treated with neoadjuvant anti-PD-1 or anti-PD-1/CTLA-4 in a ... ...

Abstract	Neoadjuvant immune checkpoint blockade has shown promising clinical activity. Here, we characterized early kinetics in tumor-infiltrating and circulating immune cells in oral cancer patients treated with neoadjuvant anti-PD-1 or anti-PD-1/CTLA-4 in a clinical trial (NCT02919683). Tumor-infiltrating CD8 T cells that clonally expanded during immunotherapy expressed elevated tissue-resident memory and cytotoxicity programs, which were already active prior to therapy, supporting the capacity for rapid response. Systematic target discovery revealed that treatment-expanded tumor T cell clones in responding patients recognized several self-antigens, including the cancer-specific antigen MAGEA1. Treatment also induced a systemic immune response characterized by expansion of activated T cells enriched for tumor-infiltrating T cell clonotypes, including both pre-existing and emergent clonotypes undetectable prior to therapy. The frequency of activated blood CD8 T cells, notably pre-treatment PD-1-positive KLRG1-negative T cells, was strongly associated with intra-tumoral pathological response. These results demonstrate how neoadjuvant checkpoint blockade induces local and systemic tumor immunity.
MeSH term(s)	CD8-Positive T-Lymphocytes ; Humans ; Immunotherapy ; Lymphocytes, Tumor-Infiltrating ; Neoadjuvant Therapy ; Neoplasms/therapy ; Programmed Cell Death 1 Receptor ; Tumor Microenvironment
Chemical Substances	Programmed Cell Death 1 Receptor
Language	English
Publishing date	2022-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2022.06.018
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Nanoparticle Delivery of Anti-inflammatory LNA Oligonucleotides Prevents Airway Inflammation in a HDM Model of Asthma.

Ramelli, Sabrina C / Comer, Brian S / McLendon, Jared M / Sandy, Lydia L / Ferretti, Andrew P / Barrington, Robert / Sparks, Jeff / Matar, Majed / Fewell, Jason / Gerthoffer, William T

Molecular therapy. Nucleic acids

2020 Volume 19, Page(s) 1000–1014

Abstract: To address the problem of poor asthma control due to drug resistance, an antisense oligonucleotide complementary to mmu-miR-145a-5p (antimiR-145) was tested in a house dust mite mouse model of mild/moderate asthma. miR-145 was targeted to reduce ... ...

Abstract	To address the problem of poor asthma control due to drug resistance, an antisense oligonucleotide complementary to mmu-miR-145a-5p (antimiR-145) was tested in a house dust mite mouse model of mild/moderate asthma. miR-145 was targeted to reduce inflammation, regulate epithelial-mesenchymal transitions, and promote differentiation of structural cells. In addition, several chemical variations of a nontargeting oligonucleotide were tested to define sequence-dependent effects of the miRNA antagonist. After intravenous administration, oligonucleotides complexed with a pegylated cationic lipid nanoparticle distributed to most cells in the lung parenchyma but were not present in smooth muscle or the mucosal epithelium of the upper airways. Treatment with antimiR-145 and a nontargeting oligonucleotide both reduced eosinophilia, reduced obstructive airway remodeling, reduced mucosal metaplasia, and reduced CD68 immunoreactivity. Poly(A) RNA-seq verified that antimiR-145 increased levels of many miR-145 target transcripts. Genes upregulated in human asthma and the mouse model of asthma were downregulated by oligonucleotide treatments. However, both oligonucleotides significantly upregulated many genes of interferon signaling pathways. These results establish effective lung delivery and efficacy of locked nucleic acid/DNA oligonucleotides administered intravenously, and suggest that some of the beneficial effects of oligonucleotide therapy of lung inflammation may be due to normalization of interferon response pathways.
Language	English
Publishing date	2020-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2662631-7
ISSN	2162-2531
ISSN	2162-2531
DOI	10.1016/j.omtn.2019.12.033
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Article ; Online: Antisense MicroRNA Therapy of Airway Remodeling in House Dust Mite-sensitized Mice.

Ramelli, Sabrina / McLendon, Jared Milligan / Ferretti, Andrew P / Fewell, Jason / Barrington, Robert / Gerthoffer, William T

Annals of the American Thoracic Society

2016 Volume 13 Suppl 1, Page(s) S101–2

Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.201507-414MG
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Zs.A 5828: Show issues

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Article ; Online: The future of quantum biology.

Marais, Adriana / Adams, Betony / Ringsmuth, Andrew K / Ferretti, Marco / Gruber, J Michael / Hendrikx, Ruud / Schuld, Maria / Smith, Samuel L / Sinayskiy, Ilya / Krüger, Tjaart P J / Petruccione, Francesco / van Grondelle, Rienk

Journal of the Royal Society, Interface

2018 Volume 15, Issue 148

Abstract: Biological systems are dynamical, constantly exchanging energy and matter with the environment in order to maintain the non-equilibrium state synonymous with living. Developments in observational techniques have allowed us to study biological dynamics on ...

Abstract	Biological systems are dynamical, constantly exchanging energy and matter with the environment in order to maintain the non-equilibrium state synonymous with living. Developments in observational techniques have allowed us to study biological dynamics on increasingly small scales. Such studies have revealed evidence of quantum mechanical effects, which cannot be accounted for by classical physics, in a range of biological processes. Quantum biology is the study of such processes, and here we provide an outline of the current state of the field, as well as insights into future directions.
MeSH term(s)	Biophysics/trends ; Quantum Theory ; Systems Biology/trends
Language	English
Publishing date	2018-11-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2156283-0
ISSN	1742-5662 ; 1742-5689
ISSN (online)	1742-5662
ISSN	1742-5689
DOI	10.1098/rsif.2018.0640
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Article ; Online: Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy

Cell. 2022 Aug., v. 185, no. 16 p.2918-2935.e29

2022

Abstract	Neoadjuvant immune checkpoint blockade has shown promising clinical activity. Here, we characterized early kinetics in tumor-infiltrating and circulating immune cells in oral cancer patients treated with neoadjuvant anti-PD-1 or anti-PD-1/CTLA-4 in a clinical trial (NCT02919683). Tumor-infiltrating CD8 T cells that clonally expanded during immunotherapy expressed elevated tissue-resident memory and cytotoxicity programs, which were already active prior to therapy, supporting the capacity for rapid response. Systematic target discovery revealed that treatment-expanded tumor T cell clones in responding patients recognized several self-antigens, including the cancer-specific antigen MAGEA1. Treatment also induced a systemic immune response characterized by expansion of activated T cells enriched for tumor-infiltrating T cell clonotypes, including both pre-existing and emergent clonotypes undetectable prior to therapy. The frequency of activated blood CD8 T cells, notably pre-treatment PD-1-positive KLRG1-negative T cells, was strongly associated with intra-tumoral pathological response. These results demonstrate how neoadjuvant checkpoint blockade induces local and systemic tumor immunity.
Keywords	T-lymphocytes ; antigens ; clinical trials ; cytotoxicity ; immune response ; immunotherapy ; memory ; mouth neoplasms ; T cells ; cancer ; neoadjuvant therapy ; tissue-resident memory T cells ; single-cell RNA sequencing
Language	English
Dates of publication	2022-08
Size	p. 2918-2935.e29.
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2022.06.018
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Article ; Online: Case report: A persistently expanded T cell response in an exceptional responder to radiation and atezolizumab for metastatic non-small cell lung cancer.

Coffey, David G / Xu, Yuexin / Towlerton, Andrea M H / Kowanetz, Marcin / Hegde, Priti / Darwish, Martine / Yadav, Mahesh / Blanchette, Craig / Ruppert, Shannon M / Bertino, Sarah / Xu, Qikai / Ferretti, Andrew / Weinheimer, Adam / Hellmann, Matthew / Qin, Angel / Thomas, Dafydd / Warren, Edus H / Ramnath, Nithya

Frontiers in immunology

2022 Volume 13, Page(s) 961105

Abstract: Most patients with advanced non-small cell lung cancer (NSCLC) do not achieve a durable remission after treatment with immune checkpoint inhibitors. Here we report the clinical history of an exceptional responder to radiation and anti-program death- ... ...

Abstract	Most patients with advanced non-small cell lung cancer (NSCLC) do not achieve a durable remission after treatment with immune checkpoint inhibitors. Here we report the clinical history of an exceptional responder to radiation and anti-program death-ligand 1 (PD-L1) monoclonal antibody, atezolizumab, for metastatic NSCLC who remains in a complete remission more than 8 years after treatment. Sequencing of the patient's T cell repertoire from a metastatic lesion and the blood before and after anti-PD-L1 treatment revealed oligoclonal T cell expansion. Characterization of the dominant T cell clone, which comprised 10% of all clones and increased 10-fold in the blood post-treatment, revealed an activated CD8
MeSH term(s)	Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; HLA-A2 Antigen ; Humans ; Immune Checkpoint Inhibitors ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; T-Lymphocytes
Chemical Substances	Antibodies, Monoclonal, Humanized ; HLA-A2 Antigen ; Immune Checkpoint Inhibitors ; atezolizumab (52CMI0WC3Y)
Language	English
Publishing date	2022-09-09
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.961105
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Article ; Online: Prevalence of persistent SARS-CoV-2 in a large community surveillance study.

Ghafari, Mahan / Hall, Matthew / Golubchik, Tanya / Ayoubkhani, Daniel / House, Thomas / MacIntyre-Cockett, George / Fryer, Helen R / Thomson, Laura / Nurtay, Anel / Kemp, Steven A / Ferretti, Luca / Buck, David / Green, Angie / Trebes, Amy / Piazza, Paolo / Lonie, Lorne J / Studley, Ruth / Rourke, Emma / Smith, Darren L /

Bashton, Matthew / Nelson, Andrew / Crown, Matthew / McCann, Clare / Young, Gregory R / Santos, Rui Andre Nunes Dos / Richards, Zack / Tariq, Mohammad Adnan / Cahuantzi, Roberto / Barrett, Jeff / Fraser, Christophe / Bonsall, David / Walker, Ann Sarah / Lythgoe, Katrina

Nature

2024 Volume 626, Issue 8001, Page(s) 1094–1101

Abstract: Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future ... ...

Abstract	Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future outbreaks
MeSH term(s)	Humans ; Amino Acid Substitution ; Antibodies, Monoclonal/immunology ; COVID-19/epidemiology ; COVID-19/virology ; Evolution, Molecular ; Health Surveys ; Immunocompromised Host/immunology ; Mutation ; Persistent Infection/epidemiology ; Persistent Infection/virology ; Post-Acute COVID-19 Syndrome/epidemiology ; Post-Acute COVID-19 Syndrome/virology ; Prevalence ; RNA, Viral/analysis ; RNA, Viral/genetics ; SARS-CoV-2/chemistry ; SARS-CoV-2/classification ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Selection, Genetic ; Self Report ; Time Factors ; Viral Load ; Virus Replication
Chemical Substances	Antibodies, Monoclonal ; RNA, Viral
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07029-4
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

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