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  1. Article ; Online: Assessing Safety Without Animal Testing: The Road Ahead.

    Daston, George P / Mahony, Catherine / Thomas, Russell S / Vinken, Mathieu

    Toxicological sciences : an official journal of the Society of Toxicology

    2022  Volume 187, Issue 2, Page(s) 214–218

    MeSH term(s) Animal Testing Alternatives ; Animals
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/kfac039
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1709: Show issues Location:
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  2. Article ; Online: Bisphenol exposure, hazard and regulation.

    Willhite, Calvin C / Daston, George P

    Toxicology

    2019  Volume 425, Page(s) 152243

    MeSH term(s) Animals ; Benzhydryl Compounds/toxicity ; Environmental Exposure/adverse effects ; Environmental Exposure/legislation & jurisprudence ; Government Regulation ; Humans ; Phenols/toxicity ; United States ; United States Environmental Protection Agency
    Chemical Substances Benzhydryl Compounds ; Phenols ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2019-07-10
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 184557-3
    ISSN 1879-3185 ; 0300-483X
    ISSN (online) 1879-3185
    ISSN 0300-483X
    DOI 10.1016/j.tox.2019.152243
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  3. Book: Molecular and cellular methods in developmental toxicology

    Daston, George P.

    [this book was based on a continuing education course given at the annual meeting of the Teratology Society in 1994]

    (CRC Press methods in toxicology)

    1997  

    Title variant Developmental toxicology
    Institution Teratology Society
    Author's details ed. by George P. Daston
    Series title CRC Press methods in toxicology
    Keywords Embryology / laboratory manuals / congresses ; Molecular Biology / laboratory manuals / congresses ; Toxicity Tests / laboratory manuals / congresses ; Cytological Techniques / congresses ; Teratogenitätstest
    Language English
    Size 284 S. : zahlr. Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT008357383
    ISBN 0-8493-3342-3 ; 978-0-8493-3342-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    1998 A 3241 order for loan Magazin

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  4. Article ; Online: Is omphalocele a non-specific malformation in New Zealand White rabbits?

    Daston, George P / Beekhuijzen, Manon

    Reproductive toxicology (Elmsford, N.Y.)

    2018  Volume 78, Page(s) 29–39

    Abstract: We evaluated the incidence of omphalocele, a malformation that occurs sporadically in many studies. We assembled data on external malformations using all treatment groups from every study published in three major journals over the past 35 years using New ...

    Abstract We evaluated the incidence of omphalocele, a malformation that occurs sporadically in many studies. We assembled data on external malformations using all treatment groups from every study published in three major journals over the past 35 years using New Zealand White rabbits. Fifty-eight papers were included: 4905 litters and 36,977 fetuses. Omphalocele was reported in 43% and was among the most common defects, occurring at a rate of 1.10% (litter) and 0.16% (fetus). The defect did not appear to be treatment-related, although it may have been in two studies, based on rate and dose-responsiveness. Removing these two studies from the analysis, the defect was still prevalent (0.77% litter, 0.11% fetal incidence). Three studies evaluated the effects of food restriction and omphalocele was observed with food restriction in two of them, suggesting that decreased maternal weight gain or food consumption may be causal. Otherwise, it appears to be spontaneous and common.
    MeSH term(s) Animals ; Congenital Abnormalities/etiology ; Congenital Abnormalities/veterinary ; Eating ; Female ; Hernia, Umbilical/etiology ; Hernia, Umbilical/veterinary ; Pregnancy ; Rabbits ; Toxicity Tests ; Weight Gain
    Language English
    Publishing date 2018-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639342-1
    ISSN 1873-1708 ; 0890-6238
    ISSN (online) 1873-1708
    ISSN 0890-6238
    DOI 10.1016/j.reprotox.2018.03.006
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  5. Article ; Online: Letter to the editor regarding recent publication titled "Developing an internal threshold of toxicological concern (iTTC)" by Arnot et al. (2022).

    Ellison, Corie A / Arnot, Jon A / Felter, Susan P / Daston, George P / Becker, Richard A / Toose, Liisa / Armitage, James M / Sangion, Alessandro / Looky, Alexandra / Brown, Trevor N / Li, Li

    Journal of exposure science & environmental epidemiology

    2023  Volume 33, Issue 5, Page(s) 840–841

    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2218551-3
    ISSN 1559-064X ; 1559-0631
    ISSN (online) 1559-064X
    ISSN 1559-0631
    DOI 10.1038/s41370-023-00571-9
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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: Laboratory models and their role in assessing teratogenesis.

    Daston, George P

    American journal of medical genetics. Part C, Seminars in medical genetics

    2011  Volume 157C, Issue 3, Page(s) 183–187

    Abstract: Laboratory models have an important role in identifying exposures with teratogenic potential, determining mechanisms of abnormal development, and supporting or refuting the biological plausibility of associations identified in human studies. Laboratory ... ...

    Abstract Laboratory models have an important role in identifying exposures with teratogenic potential, determining mechanisms of abnormal development, and supporting or refuting the biological plausibility of associations identified in human studies. Laboratory animals are the most widely used models, but are rapidly being supplemented by in vitro tools. Testing paradigms that have been in place since the mid-1960s for pharmaceuticals, and soon thereafter for industrial chemicals and pesticides, have been used to evaluate the potential developmental toxicity of thousands of agents. These models have served as the principal basis for regulatory decisions about acceptable exposure levels and restrictions on use of certain drugs during pregnancy.
    MeSH term(s) Animals ; Developmental Disabilities/chemically induced ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Models, Animal ; Risk Assessment ; Teratogens/toxicity ; Toxicity Tests/methods
    Chemical Substances Teratogens
    Language English
    Publishing date 2011-08-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2108622-9
    ISSN 1552-4876 ; 0148-7299 ; 1552-4868
    ISSN (online) 1552-4876
    ISSN 0148-7299 ; 1552-4868
    DOI 10.1002/ajmg.c.30312
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  7. Article ; Online: Obituary. Edward W. Carney, 1959-2015.

    Daston, George P / Rogers, John M

    Birth defects research. Part B, Developmental and reproductive toxicology

    2015  Volume 104, Issue 2, Page(s) 53–54

    MeSH term(s) Embryonic Development ; History, 20th Century ; History, 21st Century ; Humans ; Reproduction ; Toxicology/history
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 2104792-3
    ISSN 1542-9741 ; 1542-0752 ; 1542-9733 ; 1542-975X
    ISSN (online) 1542-9741
    ISSN 1542-0752 ; 1542-9733 ; 1542-975X
    DOI 10.1002/bdrb.21141
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  8. Article ; Online: Introduction to special issue on developmental and reproductive toxicology in China.

    Daston, George P

    Birth defects research. Part B, Developmental and reproductive toxicology

    2010  Volume 89, Issue 1, Page(s) 1

    MeSH term(s) Abnormalities, Drug-Induced ; China ; Clinical Trials as Topic ; Congenital Abnormalities/diagnosis ; Congenital Abnormalities/etiology ; Female ; Fetus/drug effects ; Humans ; Male ; Reproduction/drug effects ; Risk Assessment/methods ; Toxicology/methods
    Language English
    Publishing date 2010-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2104792-3
    ISSN 1542-9741 ; 1542-0752 ; 1542-9733 ; 1542-975X
    ISSN (online) 1542-9741
    ISSN 1542-0752 ; 1542-9733 ; 1542-975X
    DOI 10.1002/bdrb.20239
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  9. Article ; Online: A New Approach Methodology (NAM) Based Assessment of Butylated hydroxytoluene (BHT) for Endocrine Disruption Potential.

    De Abrew, K Nadira / Natoli, Ted / Lester, Cathy C / Wang, Xiaohong / Shobair, Mahmoud / Subramanian, Arvind / Daston, George P

    Toxicological sciences : an official journal of the Society of Toxicology

    2022  Volume 190, Issue 2, Page(s) 227–241

    Abstract: ... analogs to BHT using the P&G read across framework (Wu et al., 2010). Neither BHT nor any of its analogs ...

    Abstract Butylated hydroxytoluene (BHT) is a synthetic antioxidant widely used in many industrial sectors. BHT is a well-studied compound for which there are many favorable regulatory decisions. However, a recent opinion by the French Agency for Food, Environmental and Occupational Health and Safety (ANSES) hypothesizes a role for BHT in endocrine disruption (ANSES (2021). This opinion is based on observations in mostly rat studies where changes to thyroid physiology are observed. Enzymatic induction of Cytochrome P450-mediated thyroid hormone catabolism has been proposed as a mechanism for these observations, however, a causal relationship has not been proven. Other evidence proposed in the document includes a read across argument to butylated hydroxyanisole (BHA), another Community Rolling Action Plan (CoRAP)-listed substance with endocrine disruption concerns. We tested the hypothesis that BHT is an endocrine disruptor by using a Next Generation Risk Assessment (NGRA) method. Four different cell lines: A549, HCC1428, HepG2, and MCF7 were treated with BHT and a series of BHT analogs at 5 different concentrations, RNA was isolated from cell extracts and run on the L1000 gene array platform. A toxicogenomics-based assessment was performed by comparing BHT's unique genomic signature to a large external database containing signatures of other compounds (including many known endocrine disruptors) to identify if any endocrine disruption-related modes of action (MoAs) are prevalent among BHT and other compounds with similar genomic signatures. In addition, we performed a toxicogenomics-based structure activity relationship (SAR) assessment of BHT and a series of structurally similar analogs to understand if endocrine disruption is a relevant MoA for chemicals that are considered suitable analogs to BHT using the P&G read across framework (Wu et al., 2010). Neither BHT nor any of its analogs connected to compounds that had endocrine activity for estrogens, androgens, thyroid, or steroidogenesis.
    MeSH term(s) Rats ; Animals ; Butylated Hydroxytoluene/toxicity ; Butylated Hydroxyanisole ; Antioxidants ; Estrogens ; Endocrine Disruptors/toxicity
    Chemical Substances Butylated Hydroxytoluene (1P9D0Z171K) ; Butylated Hydroxyanisole (25013-16-5) ; Antioxidants ; Estrogens ; Endocrine Disruptors
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/kfac099
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  10. Book: Comprehensive toxicology / 12

    Knudsen, Thomas / Daston, George P. / McQueen, Charlene A.

    2010  

    Author's details ed.-in-chief, Charlene A. McQueen
    Collection Comprehensive toxicology
    Language English
    Size XVII, 367 S. : Ill., graph. Darst., Kt.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016438021
    ISBN 978-0-08-046880-8 ; 0-08-046880-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 10960 order for loan Magazin

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