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Article ; Online: Unconventional Answers to Unprecedented Challenges: The Swedish Experience During the COVID-19 Outbreak.

Valeriani, Giuseppe / Vukovic, Iris Sarajlic / Mollica, Richard

Journal of preventive medicine and public health = Yebang Uihakhoe chi

2020 Volume 53, Issue 4, Page(s) 233–235

Abstract: Since its early stages, the coronavirus disease 2019 (COVID-19) pandemic has posed immense challenges in meeting the public health and healthcare and social care needs of migrants. In line with other reports from United Kingdom and United States, data ... ...

Abstract	Since its early stages, the coronavirus disease 2019 (COVID-19) pandemic has posed immense challenges in meeting the public health and healthcare and social care needs of migrants. In line with other reports from United Kingdom and United States, data from Sweden's health authority show that migrants have been disproportionately affected by COVID-19. Following the World Health Organization's statements, as well as the European Public Health Association's call for action, several centres in Sweden's most populated areas have activated tools to implement national plans for community outreach through initiatives targeting migrants and ethnic minority groups. Unconventional means should be promoted to mitigate the impact of COVID-19 on migrants and the health of the public at large.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Disease Outbreaks ; Ethnic Groups ; Humans ; Minority Groups ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Public Health/methods ; SARS-CoV-2 ; Sweden ; Telemedicine/methods ; Transients and Migrants
Keywords	covid19
Language	English
Publishing date	2020-07-22
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2620879-9
ISSN	2233-4521 ; 1975-8375
ISSN (online)	2233-4521
ISSN	1975-8375
DOI	10.3961/jpmph.20.235
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Article: Clinical Outcomes of Stereotactic Body Radiotherapy (SBRT) for Oligometastatic Patients with Lymph Node Metastases from Gynecological Cancers.

Facondo, Giuseppe / Vullo, Gianluca / De Sanctis, Vitaliana / Rotondi, Margherita / Sigillo, Riccardo Carlo / Valeriani, Maurizio / Osti, Mattia Falchetto

Journal of personalized medicine

2023 Volume 13, Issue 2

Abstract: Background: To evaluate clinical outcomes of stereotactic body radiation therapy (SBRT) as a local treatment for lymph node metastases from gynecological cancers.: Methods: Between November 2007 and October 2021, we retrospectively analyzed 29 lymph ... ...

Abstract	Background: To evaluate clinical outcomes of stereotactic body radiation therapy (SBRT) as a local treatment for lymph node metastases from gynecological cancers. Methods: Between November 2007 and October 2021, we retrospectively analyzed 29 lymph node metastases in 22 oligometastatic/oligoprogressive patients treated with SBRT. The Kaplan-Meier method was used to estimate the rates survival. Univariate analysis for prognostic factors were performed with the log-rank test, and Cox proportional hazards regression was used to estimate hazard ratios (HR). Results: Median age was 62 years (IQR, 50-80 years). Median follow-up was 17 months (IQR 10.5-31 months). The median survival was 22 months (CI 95%: 4.2-39.7, IQR: 12.5-34.5 months). Six months, one year and two year overall survival (OS) were 96.6%, 85.2%, and 48.7%, respectively. Median local control (LC) was not reached. Six months, 1one year and 2 year were 93.1%, 87.9%, and 79.9%, respectively. Distant metastasis free survival (DMFS) at one year, and two year was 53% and 37.1%, respectively Four patients (18%) experienced acute G1-G2 toxicities. No G3-4 acute toxicity was reported, and no late toxicity was observed. Conclusions: SBRT for lymph node recurrence offers excellent in-field tumor control with safe profile and low toxicities. Size, number of oligometastases, and time primary tumor to RT seem to be significant prognostic factors.
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13020229
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Article ; Online: Comparative analysis of toxicity in patients with anal cancer undergoing definitive simultaneous integrated boost (SIB) or sequential integrated boost (SeqB) radiotherapy.

Rotondi, Margherita / Facondo, Giuseppe / Mossa, Stefano / Vullo, Gianluca / Angelicone, Ilaria / Valeriani, Maurizio / Osti, Mattia Falchetto

International journal of colorectal disease

2023 Volume 38, Issue 1, Page(s) 125

Abstract: Purpose: To compare toxicity of radiotherapy (RT) with concomitant chemotherapy (CHT) in patients (pts) with anal cancer treated with simultaneous integrated boost (SIB) versus sequential boost (SeqB).: Methods: Sixty-six patients were treated from ... ...

Abstract	Purpose: To compare toxicity of radiotherapy (RT) with concomitant chemotherapy (CHT) in patients (pts) with anal cancer treated with simultaneous integrated boost (SIB) versus sequential boost (SeqB). Methods: Sixty-six patients were treated from 2007 to 2021. Thirty patients underwent to SeqB concurrent to CHT and 37 to SIB-group. Toxicity assessment has been considered in acute and in late toxicities for gastrointestinal (GI), genitourinary (GU), cutaneous (CU) districts, according to Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0. The Wexner scale among summary scoring systems has been used as a tool to measure fecal incontinence. The chi-square test for ordinal variables were used to evaluate the association between patient and treatment characteristics and acute or late severe toxicity. Univariable logistic regression models were fit to evaluate predictive factors associated with fecal incontinence. Results: Median follow-up was 61.5 months (IQR, 27.1-121.7 months) for all patients. Severe acute toxicity (≥ G2) was observed in 49 patients (74.2%). Late toxicity (≥ G2) occurred in 13 cases (19.6%). In assessment of cutaneous toxicity, there was also a significant reduction in ≥ G1 in SIB group with 29 patients (80.5%) vs SeqB group with 29 patients (96.6%) (p-value = 0.046). Of both groups 11 patients (16.6%) developed fecal incontinence, 8 (22%) in the SIB group and 3 (10%) in the SeqB. Conclusion: SIB for anal cancer treatment results in reduced acute and late cutaneous toxicity compared to SeqB. According to our results the rate of other acute and late toxicities are low and comparable between the two groups.
MeSH term(s)	Humans ; Radiotherapy, Intensity-Modulated/adverse effects ; Fecal Incontinence/etiology ; Radiotherapy Dosage ; Chemoradiotherapy/adverse effects ; Chemoradiotherapy/methods ; Anus Neoplasms/drug therapy ; Anus Neoplasms/radiotherapy
Language	English
Publishing date	2023-05-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-023-04411-y
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Article ; Online: Unconventional Answers to Unprecedented Challenges

Giuseppe Valeriani / Iris Sarajlic Vukovic / Richard Mollica

Journal of Preventive Medicine and Public Health, Vol 53, Iss 4, Pp 233-

The Swedish Experience During the COVID-19 Outbreak

2020 Volume 235

Abstract	Since its early stages, the coronavirus disease 2019 (COVID-19) pandemic has posed immense challenges in meeting the public health and healthcare and social care needs of migrants. In line with other reports from United Kingdom and United States, data from Sweden’s health authority show that migrants have been disproportionately affected by COVID-19. Following the World Health Organization’s statements, as well as the European Public Health Association’s call for action, several centres in Sweden’s most populated areas have activated tools to implement national plans for community outreach through initiatives targeting migrants and ethnic minority groups. Unconventional means should be promoted to mitigate the impact of COVID-19 on migrants and the health of the public at large.
Keywords	covid-19 ; healthcare delivery ; migrants ; telemedicine ; community health ; Medicine ; R ; Public aspects of medicine ; RA1-1270 ; covid19
Subject code	306
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Korean Society for Preventive Medicine
Document type	Article ; Online
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Article ; Online: Stereotactic body radiation therapy (SBRT) for patients with oligometastatic/oligoprogressive adrenal metastases: Outcomes and toxicities profile in a monoinstitutional study.

Facondo, Giuseppe / Vullo, Gianluca / Valeriani, Maurizio / Ascolese, Anna Maria / De Sanctis, Vitaliana / Osti, Mattia Falchetto

Cancer treatment and research communications

2021 Volume 29, Page(s) 100481

Abstract: Aims: To evaluate survival outcomes and toxicology profiles in oligometastatic/oligoprogressive patients treated with SBRT for adrenal metastases.: Methods: We retrospectively analyzed 25 metastatic adrenal lesions in 24 oligometastatic/ ... ...

Abstract	Aims: To evaluate survival outcomes and toxicology profiles in oligometastatic/oligoprogressive patients treated with SBRT for adrenal metastases. Methods: We retrospectively analyzed 25 metastatic adrenal lesions in 24 oligometastatic/oligoprogressive patients undergoing ablative Stereotactic Body Radiation Therapy (SBRT) between February 2010 and November 2019 in our department. The primary endpoint was overall survival (OS). Secondary endpoints were local overall response rate (ORR), acute and late toxicities. Results: The most common primary tumor was non-small cell lung cancer (54%). Twenty-one patients received chemo or immuno-therapy. The median planning target volume (PTV) was 41.7 cm Conclusions: SBRT for oligometastatic/oligoprogressive patients with adrenal metastases showed acceptable survival outcomes and a safe toxicity profile.
MeSH term(s)	Adrenal Gland Neoplasms/complications ; Adrenal Gland Neoplasms/mortality ; Aged ; Aged, 80 and over ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Radiosurgery/methods ; Retrospective Studies ; Survival Analysis
Language	English
Publishing date	2021-10-21
Publishing country	England
Document type	Journal Article
ISSN	2468-2942
ISSN (online)	2468-2942
DOI	10.1016/j.ctarc.2021.100481
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Article ; Online: Tackling Ethnic Health Disparities Through Community Health Worker Programs: A Scoping Review on Their Utilization During the COVID-19 Outbreak.

Valeriani, Giuseppe / Sarajlic Vukovic, Iris / Bersani, Francesco Saverio / Sadeghzadeh Diman, Anahita / Ghorbani, Abdolbaset / Mollica, Richard

Population health management

2022 Volume 25, Issue 4, Page(s) 517–526

Abstract: The coronavirus disease (COVID-19) outbreak has magnified existing health inequities linked to social determinants of health, with racial and ethnic minorities being disproportionately affected by the pandemic. A proposed strategy to address these ... ...

Abstract	The coronavirus disease (COVID-19) outbreak has magnified existing health inequities linked to social determinants of health, with racial and ethnic minorities being disproportionately affected by the pandemic. A proposed strategy to address these inequities is based on the implementation of community health worker (CHW) programs able to bridge the gaps between marginalized communities and the formal health care systems. A scoping review was conducted through searching 4 databases: PubMed, Scopus, Web of Science, and Science Direct. Inclusion criteria focused on studies defining any kind of adopted CHW intervention to address inequities related to racial/ethnic groups during the COVID-19 crisis, published from December 31, 2019, to October 31, 2021. Narrative synthesis was undertaken to summarize the findings. In total, 23 studies met the inclusion out of the 107 search results. Data converged on the relevant potential of CHWs on engaging with community leaders, addressing social determinants of health, and issues related to structural racism, promoting culturally tailored health information, and encouraging institutions to policy change in favor of people left behind. Although vulnerability of racial and ethnic minorities was already present before the COVID-19 outbreak, the pandemic has represented a wakeup call to address it more efficiently. In recent years, CHWs have increasingly been acknowledged as valuable members of the health care workforce. As health disparities may increase after our multicultural societies begin to recover from COVID-19, CHWs may play a crucial role in addressing system-level changes to have broad and lasting effects on health outcomes.
MeSH term(s)	COVID-19 ; Community Health Workers ; Delivery of Health Care ; Disease Outbreaks ; Ethnicity ; Humans
Language	English
Publishing date	2022-04-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2454546-6
ISSN	1942-7905 ; 1942-7891
ISSN (online)	1942-7905
ISSN	1942-7891
DOI	10.1089/pop.2021.0364
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Article: Unconventional Answers to Unprecedented Challenges: The Swedish Experience During the COVID-19 Outbreak

Valeriani, Giuseppe / Vukovic, Iris Sarajlic / Mollica, Richard

J Prev Med Public Health

Abstract	Since its early stages, the coronavirus disease 2019 (COVID-19) pandemic has posed immense challenges in meeting the public health and healthcare and social care needs of migrants. In line with other reports from United Kingdom and United States, data from Sweden's health authority show that migrants have been disproportionately affected by COVID-19. Following the World Health Organization's statements, as well as the European Public Health Association's call for action, several centres in Sweden's most populated areas have activated tools to implement national plans for community outreach through initiatives targeting migrants and ethnic minority groups. Unconventional means should be promoted to mitigate the impact of COVID-19 on migrants and the health of the public at large.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #696856
Database	COVID19

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Article ; Online: Clinical Outcomes and Toxicity of CT-guided High Dose-rate Brachytherapy in Women With Locally-advanced Cervical Cancer.

DE Sanctis, Vitaliana / Facondo, Giuseppe / Vullo, Gianluca / Anzellini, Dimitri / Sanguineti, Giuseppe / Nardangeli, Alessia / Marmiroli, Luca / Tortoreto, Francesca / Gentile, Piercarlo / Annessi, Ivan / Donato, Vittorio / Chiostrini, Cinzia / Tombolini, Vincenzo / DE Felice, Francesca / Valeriani, Maurizio / Osti, Mattia Falchetto

Cancer diagnosis & prognosis

2023 Volume 3, Issue 2, Page(s) 194–200

Abstract: Background/aim: To evaluate the outcome and toxicities in patients with locally advanced cervical cancer (LACC) treated with radiochemotherapy and intracavitary brachytherapy.: Patients and methods: This study included 67 patients with LACC treated ... ...

Abstract	Background/aim: To evaluate the outcome and toxicities in patients with locally advanced cervical cancer (LACC) treated with radiochemotherapy and intracavitary brachytherapy. Patients and methods: This study included 67 patients with LACC treated between 2010 and 2018. The most represented stage was FIGO IIB. The patients were treated with external beam radiotherapy (EBRT) to the pelvis and boost to the cervix and parametrials. Concomitant chemotherapy (CHT) with cisplatin (CDDP) 40 mg/mq was planned. Subsequently, the patients underwent CT-based endouterine brachytherapy (BT). The response was evaluated at 3 months with PET-CT and/or pelvic magnetic resonance imaging (MRI). Since then, the patients have been followed with clinical instrumental controls every 4 months for the first 2 years and every 6 months for the following 3 years. Local response was assessed with pelvic MRI and/or PET-CT scan at the end of intracavitary BT) according to RECIST 1.1 criteria. Results: The median duration of treatment was 55 days (range=40-73 days). The prescription dose to the planning target volume (PTV) was delivered in 25 to 30 (median 28) daily fractions. The EBRT median dose to the pelvis and gross tumor volume were 50.4 Gy (range=45-56.25) and 61.6 Gy (range=45-70.4), respectively. The 1-year, 2-year, 3-year, and 5-year overall survival rates were 92.44%, 80.81%, 78.84%, and 76.45% respectively. The actuarial 1-year, 2-year, 3-year, and 5-year disease-free survival rates were 89.5%, 83.6%, 81%, and 78.2% respectively. Conclusion: This study analyzed acute and chronic toxicity, survival, and local control in cervical cancer patients treated with IMRT followed by CT-planned high dose rate-brachytherapy. Patients demonstrated satisfactory outcomes and incidence of acute and late toxicities.
Language	English
Publishing date	2023-03-03
Publishing country	Greece
Document type	Journal Article
ISSN	2732-7787
ISSN (online)	2732-7787
DOI	10.21873/cdp.10201
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Article ; Online: S100B Affects Gut Microbiota Biodiversity.

Romano Spica, Vincenzo / Valeriani, Federica / Orsini, Massimiliano / Clementi, Maria Elisabetta / Seguella, Luisa / Gianfranceschi, Gianluca / Di Liddo, Rosa / Di Sante, Gabriele / Ubaldi, Francesca / Ria, Francesco / Esposito, Giuseppe / Michetti, Fabrizio

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: This in vivo study in mice addresses the relationship between the biodiversity of the microbiota and the levels of S100B, a protein present in enteroglial cells, but also in foods such as milk. A positive significant correlation was observed between ... ...

Abstract	This in vivo study in mice addresses the relationship between the biodiversity of the microbiota and the levels of S100B, a protein present in enteroglial cells, but also in foods such as milk. A positive significant correlation was observed between S100B levels and Shannon values, which was reduced after treatment with Pentamidine, an inhibitor of S100B function, indicating that the correlation was influenced by the modulation of S100B activity. Using the bootstrap average method based on the distribution of the S100B concentration, three groups were identified, exhibiting a significant difference between the microbial profiles. Operational taxonomic units, when analyzed by SIMPER analysis, showed that genera regarded to be eubiotic were mainly concentrated in the intermediate group, while genera potentially harboring pathobionts often appeared to be more concentrated in groups where the S100B amounts were very low or high. Finally, in a pilot experiment, S100B was administered orally, and the microbial profiles appeared to be modified accordingly. These data may open novel perspectives involving the possibility of S100B-mediated regulation in the intestinal microbiota.
MeSH term(s)	Mice ; Animals ; Gastrointestinal Microbiome ; Pentamidine/pharmacology ; Microbiota ; Biodiversity ; RNA, Ribosomal, 16S/genetics ; S100 Calcium Binding Protein beta Subunit
Chemical Substances	Pentamidine (673LC5J4LQ) ; RNA, Ribosomal, 16S ; S100b protein, mouse ; S100 Calcium Binding Protein beta Subunit
Language	English
Publishing date	2023-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032248
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Article: Efficacy of Residual Site Radiation Therapy (ISRT) in Patients with Primary Mediastinal Lymphoma with Deauville Score 4 Following R-CHT: Results of a Retrospective Mono Institutional Study.

Facondo, Giuseppe / Serio, Mattia / Vullo, Gianluca / Bianchi, Maria Paola / Pelliccia, Sabrina / Di Rocco, Alice / Lanzolla, Tiziana / Valeriani, Maurizio / Di Napoli, Arianna / Tafuri, Agostino / Martelli, Maurizio / Osti, Mattia Falchetto / De Sanctis, Vitaliana

Journal of clinical medicine

2023 Volume 12, Issue 11

Abstract: Background: In order to evaluate the efficacy of residual site radiation therapy (RSRT) in terms of progression-free survival (PFS) and overall survival (OS) in patients with primary mediastinal lymphoma (PMBCL) with Deauville Score 4 (DS 4) following ... ...

Abstract	Background: In order to evaluate the efficacy of residual site radiation therapy (RSRT) in terms of progression-free survival (PFS) and overall survival (OS) in patients with primary mediastinal lymphoma (PMBCL) with Deauville Score 4 (DS 4) following rituximab and chemotherapy treatment (R-ICHT). Methods: Thirty-one patients with PMBCL were recruited. After completion of R-ICHT, patients were staged with 18F-fluorodeoxyglucose positron-emission tomography, showing DS 4, and were treated with adjuvant RSRT. The chosen techniques for RT delivery were intensity-modulated radiation therapy (IMRT) or three-dimensional conformal RT (3D-CRT). Most patients underwent the first one using cone-beam computed tomography (CBCT). All patients were evaluated every 3 months for the first 2 years and every 6 months afterwards for a period of at least 5 years, with clinical and radiological procedures as required. Results: All patients received RSRT with a dose of 30 Gy in 15 fractions. The median follow-up time of 52.7 months (IQR: 26-64.1 months). The 5-year OS rate was 100%. The 2-year and 5-year PFS rates were 96.7% and 92.5%, respectively. Patients with relapsed disease had been treated with high-dose chemotherapy (HDC) and autologous stem cell transplantation (auto-SCT). Conclusion: RSRT in patients with PMBCL treated with ICHT and DS 4 did not impact unfavorably on patient survival.
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12113777
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