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Article ; Online: Pathophysiologie des akuten Lungenversagens (ARDS).

Notz, Quirin / Hermann, Johannes / Muellenbach, Ralf M / Lotz, Christopher

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

2024 Volume 59, Issue 1, Page(s) 12–22

Abstract: Acute respiratory distress syndrome (ARDS) is a common condition in intensive care medicine. Various intra- and extrapulmonal causes may trigger an epithelial and endothelial permeability increase, which leads to impaired gas exchange due to fluid ... ...

Title translation	Pathophysiology of Acute Respiratory Distress Syndrome.
Abstract	Acute respiratory distress syndrome (ARDS) is a common condition in intensive care medicine. Various intra- and extrapulmonal causes may trigger an epithelial and endothelial permeability increase, which leads to impaired gas exchange due to fluid overload of the alveoli and transmigration of leukocytes. This results in hypoxemia and hypercapnia, as well as deleterious consequences for the macro- and microcirculation with the risk of multi-organ failure and high mortality. This review summarizes ARDS pathophysiology and clinical consequences.
MeSH term(s)	Humans ; Respiratory Distress Syndrome/therapy ; Critical Care ; Multiple Organ Failure ; Water-Electrolyte Imbalance
Language	German
Publishing date	2024-01-08
Publishing country	Germany
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-2043-8602
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Article: Pathophysiologie des akuten Lungenversagens (ARDS)

Notz, Quirin / Hermann, Johannes / Muellenbach, Ralf M. / Lotz, Christopher

AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie

2024 Volume 59, Issue 01, Page(s) 12–22

Keywords	akutes Atemnotsyndrom ; ARDS ; akutes Lungenversagen ; Gasaustausch ; Intensivbehandlung ; mechanische Beatmung ; mechanical ventilation ; acute respiratory distress syndrome ; gas exchange ; critical illness
Language	German
Publishing date	2024-01-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-2043-8602
Database	Thieme publisher's database

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Article ; Online: Extracorporeal cardiopulmonary resuscitation: tool or toy?

Lotz, Christopher / Muellenbach, Ralf M / Spieth, Peter

Minerva anestesiologica

2020 Volume 87, Issue 1, Page(s) 101–105

Abstract: Neurological outcome and quality of live are of uttermost interest in survivors of cardiac arrest. Assuming acceptable rates of return of spontaneous circulation, the long-term effects on neurological function and quality of live after cardiopulmonary ... ...

Abstract	Neurological outcome and quality of live are of uttermost interest in survivors of cardiac arrest. Assuming acceptable rates of return of spontaneous circulation, the long-term effects on neurological function and quality of live after cardiopulmonary resuscitation remain unsatisfactory. Extracorporeal cardiopulmonary resuscitation (eCPR) can reduce low-flow times and therefore provide adequate cerebral tissue perfusion and oxygenation. This may improve favorable outcomes after cardiac arrest. Due to the risk of procedure related complications and ethical issues, this technique should be only performed in selected patients by specially trained and experienced teams. In this review we aimed at providing an insight into the sparse evidence in this field and discussing ethical issues associated with the use of eCPR.
MeSH term(s)	Cardiopulmonary Resuscitation ; Extracorporeal Membrane Oxygenation ; Heart Arrest/therapy ; Humans ; Retrospective Studies ; Time Factors
Language	English
Publishing date	2020-08-04
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	123584-9
ISSN	1827-1596 ; 0026-4717 ; 0375-9393
ISSN (online)	1827-1596
ISSN	0026-4717 ; 0375-9393
DOI	10.23736/S0375-9393.20.14564-4
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Article ; Online: Antikörperbestimmung nach SARS-CoV-2-Impfung: Sinnvolles Monitoring oder bedeutungslos?

Lotz, Christopher / Herrmann, Johannes / Hübsch, Martha-Emilia / Notz, Quirin / Meybohm, Patrick

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

2022 Volume 57, Issue 4, Page(s) 302–306

Abstract: Vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) provides effective protection against infection or severe coronavirus disease 2019 (COVID-19). Moreover, it is regarded as the single most important measure to end the ... ...

Title translation	Measurement of Anti-SARS CoV-2 Antibodies following Vaccination: Valuable Monitoring or Irrelevant Tool?
Abstract	Vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) provides effective protection against infection or severe coronavirus disease 2019 (COVID-19). Moreover, it is regarded as the single most important measure to end the pandemic. Individual vaccination effectiveness is often judged via measurement of anti-SARS-CoV-2 antibodies. However, considering the complexity of the humoral and cellular immune response the question arises whether the relation of anti-SARS-CoV-2 antibody titers and COVID-19 vaccine effectiveness is a myth or a fact? The current article aims to answer this question and provide a short review of the immunological mechanisms of SARS-CoV-2 vaccination. Recommendations for clinical practice are given based on the current evidence and known problems of anti-SARS-CoV-2 antibody measurements after vaccination.
MeSH term(s)	Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Vaccination
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines
Language	German
Publishing date	2022-04-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-1783-3932
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Article ; Online: Sevoflurane as opposed to propofol anesthesia preserves mitochondrial function and alleviates myocardial ischemia/reperfusion injury.

Lotz, Christopher / Stumpner, Jan / Smul, Thorsten M

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2020 Volume 129, Page(s) 110417

Abstract: Background: Pharmacological interventions reducing myocardial ischemia and reperfusion (I/R) injury include the administration of anesthetics. Both sevoflurane as well as propofol have been shown to elicit cardiac protection via distinct molecular ... ...

Abstract	Background: Pharmacological interventions reducing myocardial ischemia and reperfusion (I/R) injury include the administration of anesthetics. Both sevoflurane as well as propofol have been shown to elicit cardiac protection via distinct molecular mechanisms. We investigated the hypothesis that sevoflurane in contrary to propofol anesthesia elicits cardiac protection against I/R-injury via mitochondrial mechanisms of disease. Methods: Male New Zealand white rabbits (n = 42) were subjected 30 min of coronary artery occlusion followed by 3 h of reperfusion. After induction with pentobarbital, the animals either received sevoflurane or propofol to maintain general anesthesia. Infarct size was determined gravimetrically after triphenyltetrazolium chlorid-staining. Cardiac mitochondria were isolated and mitochondrial oxygen consumption was measured using a Clark electrode. Mitochondrial respiratory chain complex activities (I-IV) were analyzed utilizing specific assays. Data are mean ± SD. Results: Sevoflurane anesthesia significantly decreased the resulting myocardial infarct size compared to propofol anesthesia (p = 0.0275 vs. propofol). Mitochondria from animals receiving propofol anesthesia showed a significantly reduced mitochondrial respiratory control ratio (p = 0.01909 vs. sham) and impaired activities of respiratory complex I (p = 0.0147 vs. sham; p < 0.01 vs. sevoflurane) as well as respiratory complex IV (p = 0.0181 vs. sham). Mitochondrial dysfunction was absent in sevoflurane anesthesized animals. Furthermore, a significantly higher portion of complex I was found to be in its deactive form during I/R-injury in animals receiving sevoflurane anesthesia (p = 0.0123 vs. propofol). Conclusions: Sevoflurane as opposed to propofol anesthesia preserved mitochondrial respiration and elicited cardiac protection against I/R-injury.
MeSH term(s)	Anesthetics, Inhalation/pharmacology ; Anesthetics, Intravenous/pharmacology ; Animals ; Disease Models, Animal ; Electron Transport Complex I/metabolism ; Electron Transport Complex IV/metabolism ; Male ; Mitochondria, Heart/drug effects ; Mitochondria, Heart/metabolism ; Mitochondria, Heart/pathology ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Infarction/prevention & control ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/prevention & control ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Oxygen Consumption ; Propofol/pharmacology ; Rabbits ; Sevoflurane/pharmacology
Chemical Substances	Anesthetics, Inhalation ; Anesthetics, Intravenous ; Sevoflurane (38LVP0K73A) ; Electron Transport Complex IV (EC 1.9.3.1) ; Electron Transport Complex I (EC 7.1.1.2) ; Propofol (YI7VU623SF)
Language	English
Publishing date	2020-06-20
Publishing country	France
Document type	Comparative Study ; Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2020.110417
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Article ; Online: Mitochondria and Pharmacologic Cardiac Conditioning-At the Heart of Ischemic Injury.

Lotz, Christopher / Herrmann, Johannes / Notz, Quirin / Meybohm, Patrick / Kehl, Franz

International journal of molecular sciences

2021 Volume 22, Issue 6

Abstract: Pharmacologic cardiac conditioning increases the intrinsic resistance against ischemia and reperfusion (I/R) injury. The cardiac conditioning response is mediated via complex signaling networks. These networks have been an intriguing research field for ... ...

Abstract	Pharmacologic cardiac conditioning increases the intrinsic resistance against ischemia and reperfusion (I/R) injury. The cardiac conditioning response is mediated via complex signaling networks. These networks have been an intriguing research field for decades, largely advancing our knowledge on cardiac signaling beyond the conditioning response. The centerpieces of this system are the mitochondria, a dynamic organelle, almost acting as a cell within the cell. Mitochondria comprise a plethora of functions at the crossroads of cell death or survival. These include the maintenance of aerobic ATP production and redox signaling, closely entwined with mitochondrial calcium handling and mitochondrial permeability transition. Moreover, mitochondria host pathways of programmed cell death impact the inflammatory response and contain their own mechanisms of fusion and fission (division). These act as quality control mechanisms in cellular ageing, release of pro-apoptotic factors and mitophagy. Furthermore, recently identified mechanisms of mitochondrial regeneration can increase the capacity for oxidative phosphorylation, decrease oxidative stress and might help to beneficially impact myocardial remodeling, as well as invigorate the heart against subsequent ischemic insults. The current review highlights different pathways and unresolved questions surrounding mitochondria in myocardial I/R injury and pharmacological cardiac conditioning.
MeSH term(s)	Adenosine Triphosphate/biosynthesis ; Animals ; Cell Death/drug effects ; Humans ; Ischemic Preconditioning, Myocardial/methods ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondrial Dynamics/drug effects ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/etiology ; Myocardial Ischemia/metabolism ; Myocardial Reperfusion Injury/etiology ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/prevention & control ; Myocardium/metabolism ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Oxidative Phosphorylation/drug effects ; Oxidative Stress/drug effects ; Regeneration ; Signal Transduction/drug effects ; Translational Medical Research
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2021-03-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22063224
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Article ; Online: Mechanical Ventilation during Extracorporal Support: The Relevance of Vt.

Kredel, Markus / Lotz, Christopher / Rolfes, Caroline / Muellenbach, Ralf

American journal of respiratory and critical care medicine

2019 Volume 199, Issue 7, Page(s) 930–931

MeSH term(s)	Extracorporeal Membrane Oxygenation ; Humans ; Lung ; Lung Injury ; Respiration, Artificial ; Respiratory Distress Syndrome
Language	English
Publishing date	2019-01-03
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201810-1985LE
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Article ; Online: Simulative validation of a novel experiment carrier for the Einstein-Elevator.

Sperling, Richard / Raupert, Marvin / Lotz, Christoph / Overmeyer, Ludger

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19366

Abstract: In order to develop hardware that can be used in space, tests under those space conditions are often important to ensure the functionality in advance. Facilities that are used to recreate gravity conditions of space include space stations, satellites, ... ...

Abstract	In order to develop hardware that can be used in space, tests under those space conditions are often important to ensure the functionality in advance. Facilities that are used to recreate gravity conditions of space include space stations, satellites, parabolic flights and earthbound facilities. Drop towers are earthbound facilities, that can replicate the gravitational conditions of free falling in space by dropping objects. Those objects would not experience any measurable force due to gravity according to Einstein's famous thought experiment. The Einstein-Elevator is one of the first active driven drop towers with an experiment carrier falling inside a gondola. A major indicator for the quality of the facility is the residual acceleration of the payload. With the Einstein-Elevators current setup vibrations of the experiment carrier cause measurable residual accelerations of higher than [Formula: see text]g. To achieve the targeted 0-g-quality with a residual acceleration of less than 1 [Formula: see text]g (microgravity) in the Einstein-Elevator, a new experiment carrier is required that minimizes the residual acceleration for a payload. This paper describes a design of the experiment carrier for the Einstein-Elevator that is able to reach microgravity and analyzes its functionality using FEM-simulations.
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-46483-4
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Article ; Online: Unconventional approaches to mechanical ventilation-step-by-step through the COVID-19 crisis.

Lotz, Christopher / Notz, Quirin / Kranke, Peter / Kredel, Markus / Meybohm, Patrick

Critical care (London, England)

2020 Volume 24, Issue 1, Page(s) 233

MeSH term(s)	COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Humans ; Intensive Care Units ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Respiration, Artificial/methods ; Ventilators, Mechanical/supply & distribution
Keywords	covid19
Language	English
Publishing date	2020-05-18
Publishing country	England
Document type	Editorial
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-020-02954-y
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Article ; Online: Retraction Notice to

Nathan C. Boles / Sarah E. Hirsch / Sheila Le / Barbara Corneo / Fadi Najm / Andrew P. Minotti / Qingjie Wang / Steven Lotz / Paul J. Tesar / Christopher A. Fasano

Cell Reports, Vol 43, Iss 1, Pp 113625- (2024)

NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells

1481

Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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