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Article: Spontaneous intracranial hypotension complicated by unilateral subdural hematoma, coma, and the rare Kernohan's notch phenomenon.

Ozyigit, Ahmet

2023 Volume 11, Issue 1, Page(s) e6899

Abstract: Spontaneous intracranial hypotension (SIH) is a highly underdiagnosed condition with a wide range of manifestations. Although SIH has traditionally been viewed as having a benign disease course, recent evidence suggests otherwise. In this case report, we ...

Abstract	Spontaneous intracranial hypotension (SIH) is a highly underdiagnosed condition with a wide range of manifestations. Although SIH has traditionally been viewed as having a benign disease course, recent evidence suggests otherwise. In this case report, we present a 71-year-old woman who was previously treated with a tapered dose of corticosteroids for an episode of SIH with behavioral manifestations. In this current report, we present her second episode which was complicated by a unilateral sub-acute subdural hematoma leading to loss of consciousness and coma. While the patient regained full consciousness and recovered considerably, she still suffers from ipsilateral hemiparesis as a result of Kernohan's notch phenomenon 2 years post-hospitalization. To the author's knowledge, this is the first case to involve persistent motor deficit after the resolution of SIH. We believe that surgical hematoma evacuation prior to addressing the cerebrospinal fluid leak may have contributed to aggregated downward displacement of the brain precipitating Kernohan's notch phenomenon.
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.6899
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Spontaneous intracranial hypotension complicated by unilateral subdural hematoma, coma, and the rare Kernohan's notch phenomenon

Ahmet Ozyigit

Clinical Case Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)

2023

Abstract: Abstract Spontaneous intracranial hypotension (SIH) is a highly underdiagnosed condition with a wide range of manifestations. Although SIH has traditionally been viewed as having a benign disease course, recent evidence suggests otherwise. In this case ... ...

Abstract	Abstract Spontaneous intracranial hypotension (SIH) is a highly underdiagnosed condition with a wide range of manifestations. Although SIH has traditionally been viewed as having a benign disease course, recent evidence suggests otherwise. In this case report, we present a 71‐year‐old woman who was previously treated with a tapered dose of corticosteroids for an episode of SIH with behavioral manifestations. In this current report, we present her second episode which was complicated by a unilateral sub‐acute subdural hematoma leading to loss of consciousness and coma. While the patient regained full consciousness and recovered considerably, she still suffers from ipsilateral hemiparesis as a result of Kernohan's notch phenomenon 2 years post‐hospitalization. To the author's knowledge, this is the first case to involve persistent motor deficit after the resolution of SIH. We believe that surgical hematoma evacuation prior to addressing the cerebrospinal fluid leak may have contributed to aggregated downward displacement of the brain precipitating Kernohan's notch phenomenon.
Keywords	coma ; epidural blood patch ; Kernohan's notch phenomenon ; spontaneous intracranial hypotension ; stroke ; subdural hematoma ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: Understanding Covid-19 transmission: The effect of temperature and health behavior on transmission rates.

Ozyigit, Ahmet

Infection, disease & health

2020 Volume 25, Issue 4, Page(s) 233–238

Abstract: Background: Covid-19 pandemic is an uncharted territory for the world's population. Countries are seeing measures they would have never considered under democratic governance in an attempt to contain case numbers. The role of outside air temperatures ... ...

Abstract	Background: Covid-19 pandemic is an uncharted territory for the world's population. Countries are seeing measures they would have never considered under democratic governance in an attempt to contain case numbers. The role of outside air temperatures have been implicated as a potential factor involved in disease transmission. However, to this date, there has been no clear evidence to suggest either way. Along with temperatures, infection control and protection measures as well as how well people adopt these measures are likely to play a role in disease transmission and case growth rates seen across countries. Methods: The current study uses panel data estimation for the original EU-15 countries in an attempt to explain the role of outside air temperatures, health behavior and government-imposed containment measures on Covid-19 transmission rates. Results: The preliminary evidence suggests that containment measures are highly effective in slowing down the spread of Covid-19. Years of education also appears to have a small but negative association with disease transmission rates suggesting that populations with higher educational attainments may be doing a better job of self-protection. Temperature appears to have a very small, but statistically significant impact on the viral transmission rate where a 1 °C increase in temperatures is estimated to reduce Covid-19 transmission by 0.9 percent. Conclusion: Results are robust and clear. Temperature plays a small but significant role on Covid-19 transmission rates. However, it is quite possible that we may not have yet reached temperatures which may exert more pronounced effects on viral activity. Further research is warranted when more data becomes available, especially covering the months of July and August.
MeSH term(s)	Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Europe/epidemiology ; Health Behavior ; Humans ; Infection Control/methods ; Pandemics ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Temperature
Keywords	covid19
Language	English
Publishing date	2020-07-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2902143-1
ISSN	2468-0869 ; 2468-0451
ISSN (online)	2468-0869
ISSN	2468-0451
DOI	10.1016/j.idh.2020.07.001
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Article ; Online: Understanding Covid-19 transmission

Ozyigit, Ahmet

Infection, Disease & Health

The effect of temperature and health behavior on transmission rates

2020 Volume 25, Issue 4, Page(s) 233–238

Keywords	Public Health, Environmental and Occupational Health ; Infectious Diseases ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2902143-1
ISSN	2468-0869 ; 2468-0451
ISSN (online)	2468-0869
ISSN	2468-0451
DOI	10.1016/j.idh.2020.07.001
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Article: Understanding Covid-19 transmission: The effect of temperature and health behavior on transmission rates

Ozyigit, Ahmet

Infect Dis Health

Abstract: BACKGROUND: Covid-19 pandemic is an uncharted territory for the world's population. Countries are seeing measures they would have never considered under democratic governance in an attempt to contain case numbers. The role of outside air temperatures ... ...

Abstract	BACKGROUND: Covid-19 pandemic is an uncharted territory for the world's population. Countries are seeing measures they would have never considered under democratic governance in an attempt to contain case numbers. The role of outside air temperatures have been implicated as a potential factor involved in disease transmission. However, to this date, there has been no clear evidence to suggest either way. Along with temperatures, infection control and protection measures as well as how well people adopt these measures are likely to play a role in disease transmission and case growth rates seen across countries. METHODS: The current study uses panel data estimation for the original EU-15 countries in an attempt to explain the role of outside air temperatures, health behavior and government-imposed containment measures on Covid-19 transmission rates. RESULTS: The preliminary evidence suggests that containment measures are highly effective in slowing down the spread of Covid-19. Years of education also appears to have a small but negative association with disease transmission rates suggesting that populations with higher educational attainments may be doing a better job of self-protection. Temperature appears to have a very small, but statistically significant impact on the viral transmission rate where a 1 °C increase in temperatures is estimated to reduce Covid-19 transmission by 0.9 percent. CONCLUSION: Results are robust and clear. Temperature plays a small but significant role on Covid-19 transmission rates. However, it is quite possible that we may not have yet reached temperatures which may exert more pronounced effects on viral activity. Further research is warranted when more data becomes available, especially covering the months of July and August.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #635809
Database	COVID19

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Article ; Online: Expression profile of prostaglandin enzymes in cystic endometrial hyperplasia in dogs

Yeşim KORLU / Özkan YAVAŞ / Ahmet AKTAR / Berkay BOZKURT / Musa Özgür ÖZYİĞİT / Gözde Rabia ÖZALP

Kafkas Universitesi Veteriner Fakültesi Dergisi, Vol 29, Iss 1, Pp 21-

the results of a hypothesis in clinical trial

2023 Volume 31

Abstract: The expressions of prostaglandin synthesis enzymes and estrogen, progesterone receptors in canine cystic endometrial hyperplasia (CEH) were reported in this manuscript. Uterine tissue samples were collected from bitches with CEH (n=5), CEH-P (Cystic ... ...

Abstract	The expressions of prostaglandin synthesis enzymes and estrogen, progesterone receptors in canine cystic endometrial hyperplasia (CEH) were reported in this manuscript. Uterine tissue samples were collected from bitches with CEH (n=5), CEH-P (Cystic endometrial hyperplasia-Pyometra) (n=5) and healthy-negative control group, CG (n=5). Immunohistochemistry was carried out for the estrogen (ER) and progesterone receptor (PR) detection. Shock-frozen samples were utilized in mRNA extraction and Real-Time PCR was performed. Gene expression of PTGS2/COX2, PTGES, PTGER4, PGFS, PTGFR and PGR were detected higher in the CEH group compared with CG. The PGFS and PTGFR (FP) mRNA expressions were significantly increased in CEH compared with other groups. Expression of progesterone receptor mRNA (PGR) was highest in CEH and statistically different from the CEH-P group (P<0.05). No PR immunostaining was observed. ER staining had been detected in endometrial glands, endometrial stoma and myometrium, however hyperplasic glands in propria mucosa had lower or no ER scores. Based on the results of this study, the high levels of prostaglandin enzymes and low ER scores in CEH could be a preliminary step for the next stages of severe differentiation of endometrium.
Keywords	canine ; cystic endometrial hyperplasia ; estrogen receptor ; prostaglandin ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Kafkas University, Faculty of Veterinary Medicine
Document type	Article ; Online
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Article ; Online: In silico discovery of diagnostic/vaccine candidate antigenic epitopes and a multi-epitope peptide vaccine (NaeVac) design for the brain-eating amoeba Naegleria fowleri causing human meningitis.

Köseoğlu, Ahmet Efe / Özgül, Filiz / Işıksal, Elif Naz / Şeflekçi, Yusuf / Tülümen, Deniz / Özgültekin, Buminhan / Deniz Köseoğlu, Gülsüm / Özyiğit, Sena / Ihlamur, Murat / Ekenoğlu Merdan, Yağmur

Gene

2024 Volume 902, Page(s) 148192

Abstract: Naegleria fowleri, the brain-eating amoeba, is a free-living amoeboflagellate with three different life cycles (trophozoite, flagellated, and cyst) that lives in a variety of habitats around the world including warm freshwater and soil. It causes a ... ...

Abstract	Naegleria fowleri, the brain-eating amoeba, is a free-living amoeboflagellate with three different life cycles (trophozoite, flagellated, and cyst) that lives in a variety of habitats around the world including warm freshwater and soil. It causes a disease called naegleriasis leading meningitis and primary amoebic meningoencephalitis (PAM) in humans. N. fowleri is transmitted through contaminated water sources such as insufficiently chlorinated swimming pool water or contaminated tap water, and swimmers are at risk. N. fowleri is found all over the world, and most infections were reported in both developed and developing countries with high mortality rates and serious clinical findings. Until now, there is no FDA approved vaccine and early diagnosis is urgent against this pathogen. In this study, by analyzing the N. fowleri vaccine candidate proteins (Mp2CL5, Nfa1, Nf314, proNP-A and proNP-B), it was aimed to discover diagnostic/vaccine candidate epitopes and to design a multi-epitope peptide vaccine against this pathogen. After the in silico evaluation, three prominent diagnostic/vaccine candidate epitopes (EAKDSK, LLPHIRILVY, and FYAKLLPHIRILVYS) with the highest antigenicities were discovered and a potentially highly immunogenic/antigenic multi-epitope peptide vaccine (NaeVac) was designed against the brain-eating amoeba N. fowleri causing human meningitis.
MeSH term(s)	Humans ; Naegleria fowleri ; Amoeba ; Protein Subunit Vaccines ; Epitopes ; Vaccines ; Meningitis ; Water ; Brain
Chemical Substances	Protein Subunit Vaccines ; Epitopes ; Vaccines ; Water (059QF0KO0R)
Language	English
Publishing date	2024-01-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2024.148192
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Article ; Online: Manufacturing of quantum-tunneling MIM nanodiodes via rapid atmospheric CVD in terahertz band.

Ozyigit, Dogu / Ullah, Farman / Gulsaran, Ahmet / Bastug Azer, Bersu / Shahin, Ahmed / Musselman, Kevin / Bajcsy, Michal / Yavuz, Mustafa

Scientific reports

2023 Volume 13, Issue 1, Page(s) 20733

Abstract: Quantum-tunneling metal-insulator-metal (MIM) diodes have emerged as a significant area of study in the field of materials science and electronics. Our previous work demonstrated the successful fabrication of these diodes using atmospheric pressure ... ...

Abstract	Quantum-tunneling metal-insulator-metal (MIM) diodes have emerged as a significant area of study in the field of materials science and electronics. Our previous work demonstrated the successful fabrication of these diodes using atmospheric pressure chemical vapor deposition (AP-CVD), a scalable method that surpasses traditional vacuum-based methods and allows for the fabrication of high-quality Al
Language	English
Publishing date	2023-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47775-5
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Article: Built-In Packaging for Two-Terminal Devices.

Gulsaran, Ahmet / Bastug Azer, Bersu / Ozyigit, Dogu / Saritas, Resul / Kocer, Samed / Abdel-Rahman, Eihab / Yavuz, Mustafa

Micromachines

2023 Volume 14, Issue 7

Abstract: Conventional packaging and interconnection methods for two-terminal devices, e.g., diodes often involve expensive and bulky equipment, introduce parasitic effects and have reliability issues. In this study, we propose a built-in packaging method and ... ...

Abstract	Conventional packaging and interconnection methods for two-terminal devices, e.g., diodes often involve expensive and bulky equipment, introduce parasitic effects and have reliability issues. In this study, we propose a built-in packaging method and evaluate its performance compared to probing and wire bonding methods. The built-in packaging approach offers a larger overlap area, improved contact resistance, and direct connection to testing equipment. The experimental results demonstrate a 12% increase in current, an 11% reduction in resistance, and improved performance of the diode. The proposed method is promising for enhancing sensing applications, wireless power transmission, energy harvesting, and solar rectennas. Overall, the built-in packaging method offers a simpler, cheaper, more compact and more reliable packaging solution, paving the way for more efficient and advanced technologies in these domains.
Language	English
Publishing date	2023-07-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14071473
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Article ; Online: Heavy Metal Levels and Mineral Nutrient Status in Different Parts of Various Medicinal Plants Collected from Eastern Mediterranean Region of Turkey.

Karahan, Faruk / Ozyigit, Ibrahim Ilker / Saracoglu, Ibrahim Adnan / Yalcin, Ibrahim Ertugrul / Ozyigit, Asli Hocaoglu / Ilcim, Ahmet

Biological trace element research

2019 Volume 197, Issue 1, Page(s) 316–329

Abstract: Medicinal plants have been used for treatment of many diseases since the ancient times with traditional knowledge being transferred from generation to generation. However, in recent years, many natural habitats have been contaminated due to increased ... ...

Abstract	Medicinal plants have been used for treatment of many diseases since the ancient times with traditional knowledge being transferred from generation to generation. However, in recent years, many natural habitats have been contaminated due to increased anthropogenic activities. Plants which are exposed to heavy metal toxicity may experience several serious problems. Furthermore, the inclusion of these plants into the food chain poses a threat to human health as well. Additionally, presence of heavy metals directly effect mineral nutrition and consequently the food quality. The aim of this study herewith is to determine the heavy metal content and mineral nutrient status of some medicinal plants to have insight on their health repercussions on plants and humans. The concentrations of Al, B, Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb and Zn in commonly used parts (root, rhizome, seed, resin, gall, fruit) especially for remedial purposes of 17 medicinal plants collected from Turkey were analyzed by ICP-OES. The measured values for concentrations from lowest to highest were (in mg kg
MeSH term(s)	Environmental Monitoring ; Humans ; Mediterranean Region ; Metals, Heavy/analysis ; Minerals ; Nutrients ; Plants, Medicinal ; Soil Pollutants/analysis ; Turkey
Chemical Substances	Metals, Heavy ; Minerals ; Soil Pollutants
Language	English
Publishing date	2019-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-019-01974-2
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