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  1. Book: Cases in Paediatric Critical Care Transfer and Retrieval Medicine

    Fosker, Sam / Riphagen, Shelley

    2022  

    Size 332 p.
    Publisher Cambridge University Press
    Document type Book
    Note PDA Manuell_14
    Format 234 x 156 x 20
    ISBN 9781108931113 ; 1108931111
    Database PDA

    Kategorien

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  2. Article ; Online: Understanding Covid and the associated post-infectious hyper-inflammatory state (PIMS-TS) in children.

    Riphagen, Shelley

    Medical hypotheses

    2020  Volume 144, Page(s) 110029

    Abstract: When SARS-CoV2 infection was first reported from China, very few children had severe lung or systemic disease. Approximately six weeks after the first adult cases were reported in the United Kingdom, a small subgroup of children of largely non-white ... ...

    Abstract When SARS-CoV2 infection was first reported from China, very few children had severe lung or systemic disease. Approximately six weeks after the first adult cases were reported in the United Kingdom, a small subgroup of children of largely non-white backgrounds, presented with severe hyper-inflammatory disease, most likely associated with Covid. The possible reasons for this ethnic predilection are explored.
    MeSH term(s) Adult ; COVID-19 ; Child ; China ; Humans ; RNA, Viral ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome ; United Kingdom
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Understanding Covid and the associated post-infectious hyper-inflammatory state (PIMS-TS) in children

    Riphagen, Shelley

    Med Hypotheses

    Abstract: When SARS-CoV2 infection was first reported from China, very few children had severe lung or systemic disease. Approximately six weeks after the first adult cases were reported in the United Kingdom, a small subgroup of children of largely non-white ... ...

    Abstract When SARS-CoV2 infection was first reported from China, very few children had severe lung or systemic disease. Approximately six weeks after the first adult cases were reported in the United Kingdom, a small subgroup of children of largely non-white backgrounds, presented with severe hyper-inflammatory disease, most likely associated with Covid. The possible reasons for this ethnic predilection are explored.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #612687
    Database COVID19

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  4. Article ; Online: Ventilatory management of critically ill children in the emergency setting, during transport and retrieval.

    Riphagen, Shelley / Bird, Ruth

    Paediatric anaesthesia

    2021  Volume 32, Issue 2, Page(s) 330–339

    Abstract: Critical illness in children is uncommon. The acute stabilization and resuscitation of critically ill children remains challenging to even the most experienced operator. Cardiorespiratory illness represents the largest subgroup of diseases causing ... ...

    Abstract Critical illness in children is uncommon. The acute stabilization and resuscitation of critically ill children remains challenging to even the most experienced operator. Cardiorespiratory illness represents the largest subgroup of diseases causing critical illness and, thus adds a layer of complexity and additional challenge to the safe intubation and establishment of effective ventilation of this group of children. Children have unique physiological and anatomical differences to adults, and present the team involved in their resuscitation and stabilization with challenges exaggerated by critical illness. The consideration of pathophysiological implications of disease and the equipment available during transport and retrieval from the roadside or nonspecialist setting to pediatric intensive care allows the clinician involved in resuscitation, stabilization, and establishment of ventilation to employ targeted strategies to optimize ventilatory success. This review focuses on the types of ventilatory challenges that must be addressed when managing critically ill children in the local settings in which they present, and the resources available to optimize the outcome prior to and during transfer to a higher level of care.
    MeSH term(s) Adult ; Child ; Critical Care ; Critical Illness/therapy ; Humans
    Language English
    Publishing date 2021-12-13
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.14358
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  5. Article ; Online: Hyperinflammatory shock in children during COVID-19 pandemic.

    Riphagen, Shelley / Gomez, Xabier / Gonzalez-Martinez, Carmen / Wilkinson, Nick / Theocharis, Paraskevi

    Lancet (London, England)

    2020  Volume 395, Issue 10237, Page(s) 1607–1608

    MeSH term(s) Betacoronavirus ; COVID-19 ; Cardiovascular System ; Child ; Coronavirus Infections ; Humans ; Inflammation ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Shock
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31094-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Management of severe bronchiolitis: impact of NICE guidelines.

    Griffiths, Benedict / Riphagen, Shelley / Lillie, Jon

    Archives of disease in childhood

    2018  Volume 105, Issue 5, Page(s) 483–485

    Abstract: Objective: To understand the impact of the National Institute for Health and Care Excellence (NICE) bronchiolitis guidelines on the management of children referred to paediatric intensive care unit (PICU) with bronchiolitis.: Design and setting: Data ...

    Abstract Objective: To understand the impact of the National Institute for Health and Care Excellence (NICE) bronchiolitis guidelines on the management of children referred to paediatric intensive care unit (PICU) with bronchiolitis.
    Design and setting: Data were collected on all children referred to a regional PICU transport service with the clinical diagnosis of bronchiolitis during the winter prior to the NICE consultation period (2011-2012) and during the winter after publication (2015-2016). Management initiated by the referring hospital was assessed.
    Results: There were 165 infants referred with bronchiolitis in epoch 1 and 187 in epoch 2. Nebuliser use increased from 28% in epoch 1 to 53% in epoch 2. Increased use of high-flow nasal cannula oxygen and reduction in continuous positive airway pressure use were observed. The use of antibiotics did not change between epochs.
    Conclusion: The use of nebulised therapies has increased in the management of severe bronchiolitis despite national guidance to the contrary.
    MeSH term(s) Bronchiolitis/therapy ; Humans ; Infant ; Infant, Newborn ; Practice Guidelines as Topic ; Retrospective Studies ; Severity of Illness Index
    Language English
    Publishing date 2018-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2018-315199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cutaneous manifestations of paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2: a single-centre experience.

    Dear, Kate / Psomadakis, Cristina / Dost, Samiullah / Lalagianni, Nikolina / Oldham, Jaimie / Hew, Ai / Kenny, Julia / Riphagen, Shelley / Greenblatt, Danielle / Flohr, Carsten / Abdelrahman, Wedad

    The British journal of dermatology

    2022  Volume 186, Issue 5, Page(s) 902–903

    MeSH term(s) COVID-19/complications ; Child ; Humans ; SARS-CoV-2 ; Skin Diseases ; Systemic Inflammatory Response Syndrome/complications ; Systemic Inflammatory Response Syndrome/diagnosis
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Letter
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.20907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Can critical care transport be safely reduced in children intubated during emergency management of status epilepticus in the United Kingdom: a national audit with case-control analysis.

    Knight, Philip / Norman, Victoria / Gully, Rochelle / Wood, Dora / Raffaj, Dusan / Riddick, Laura / Hancock, Stephen / Revanna, Sanjay / Uvaise, Mohammed / Herring, Sasha / Worrall, Mark / Daye, Ashley / Terris, Mark / O'Brien, Cormac / Kumar, Ananth / Scott, Sophie / Pritchard, Lisa / Palaniappan, Srinivasan / Hughes, Charlotte /
    Griksaitis, Michael J / Riphagen, Shelley / Ramnarayan, Padmanabhan

    Archives of disease in childhood

    2024  

    Abstract: Objective: This study describes the baseline clinical characteristics, predictors of successful extubation at referring hospitals and short-term outcomes of children intubated for status epilepticus and referred to United Kingdom (UK) paediatric ... ...

    Abstract Objective: This study describes the baseline clinical characteristics, predictors of successful extubation at referring hospitals and short-term outcomes of children intubated for status epilepticus and referred to United Kingdom (UK) paediatric critical care transport teams (PCCTs).
    Design: Multicentre audit with case-control analysis, conducted between 1 September 2018 and 1 September 2020.
    Setting: This study involved 10 UK PCCTs.
    Patients: Children over 1 month of age intubated during emergency management for status epilepticus (SE), referred to UK PCCTs. Patients with trauma, requiring time-critical neurosurgical intervention or those with a tracheostomy were excluded.
    Interventions: No interventions were implemented.
    Measurements and main results: Out of the 1622 referrals for SE, 1136 (70%) were intubated at referral. The median age was 3 years (IQR 1.25-6.54 years). Among the intubated children, 396 (34.8%) were extubated locally by the referring team, with 19 (4.8%) requiring reintubation. Therefore, the overall rate of successful extubation was 33% (377/1136). There was significant variation between PCCTs, with local extubation rates ranging from 2% to 74%. Multivariable analyses showed region/PCCT, contributing diagnosis, acute changes on CT, preceding encephalopathy and type of continuous sedation (midazolam) used postintubation were significantly associated with transfer to a critical care unit.
    Conclusion: This study highlights wide regional variation in early extubation practices. Regions with high successful extubation rates have established extubation guidelines from PCCTs. Successful extubation represents critical care transports that have been avoided.
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2023-326320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Hyperinflammatory shock in children during COVID-19 pandemic

    Riphagen, Shelley / Gomez, Xabier / Gonzalez-Martinez, Carmen / Wilkinson, Nick / Theocharis, Paraskevi

    Lancet

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #197837
    Database COVID19

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  10. Article ; Online: Hyperinflammatory shock in children during COVID-19 pandemic

    Riphagen, Shelley / Gomez, Xabier / Gonzalez-Martinez, Carmen / Wilkinson, Nick / Theocharis, Paraskevi

    The Lancet

    2020  Volume 395, Issue 10237, Page(s) 1607–1608

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)31094-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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