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Audio / Video ; Online: Dr. Ethan Taylor

Johal, Am / Taylor, Ethan

COVID-19 and Selenium — Below the Radar

2020

Abstract: In this episode we talk with Dr. Ethan Taylor, professor in the Department of Chemistry and ...

Abstract	In this episode we talk with Dr. Ethan Taylor, professor in the Department of Chemistry and Biochemistry at the University of North Carolina. With our host Am Johal, he discusses the current research on selenium as an anti-pathogenic factor in emerging zoonotic viral infections, such as COVID-19.
Keywords	covid19
Language	English
Publishing date	2020-06-05
Publishing country	ca
Document type	Audio / Video ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Audio / Video ; Online: Dr. Ethan Taylor

Taylor, Ethan / Johal, Am / Smith, Paige / Feng, Kathy / Pinillos, Fiorella / SFU's Vancity Office of Community Engagement

COVID-19 and Selenium — Below the Radar Conversations

2020

Abstract: In this episode we talk with Dr. Ethan Taylor, professor in the Department of Chemistry and ... on selenium as an anti-pathogenic factor in emerging zoonotic viral infections, such as COVID-19. Dr. Ethan ... Taylor is a Professor in the Department of Chemistry and Biochemistry at the University of North Carolina ...

Abstract	In this episode we talk with Dr. Ethan Taylor, professor in the Department of Chemistry and Biochemistry at the University of North Carolina. With our host Am Johal, he discusses the current research on selenium as an anti-pathogenic factor in emerging zoonotic viral infections, such as COVID-19. Dr. Ethan Taylor is a Professor in the Department of Chemistry and Biochemistry at the University of North Carolina in Greensboro. His current research focus is on selenium as an anti-pathogenic factor in emerging zoonotic viral infections: SARS & COVID-19, HIV/AIDS, Ebola, Zika, influenza, and other viruses with RNA genomes. Global pandemics like COVID-19 and more lethal variants of avian/swine flu will continue to occur unless humans can desist from eating animals, e.g., bats have been key factors in the origin of SARS, COVID-19, and the 2014 Ebola outbreak; HIV/AIDS came from apes as bushmeat.
Keywords	covid19
Language	English
Publishing date	2020-05-29
Publishing country	ca
Document type	Audio / Video ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis of β-Hydroxy-α,α-difluorosulfonamides from Carbanions of Difluoromethanesulfonamides.

Soley, Jacob / Taylor, Scott D

The Journal of organic chemistry

2021 Volume 86, Issue 9, Page(s) 6577–6591

Abstract: ... difluoromethanesulfonamides with KHMDS in the presence of an aldehyde or ketone. The reaction exhibited a dramatic counterion ...

Abstract	The synthesis of β-hydroxy-α,α-difluorosulfonamides was achieved by reacting difluoromethanesulfonamides with KHMDS in the presence of an aldehyde or ketone. The reaction exhibited a dramatic counterion effect with KHMDS or NaHMDS usually giving excellent yields in minutes, while lithium bases gave little or no product. Excellent yields and high diastereomeric ratios were achieved with
MeSH term(s)	Aldehydes ; Amino Acids ; Ketones ; Peptides ; Stereoisomerism
Chemical Substances	Aldehydes ; Amino Acids ; Ketones ; Peptides
Language	English
Publishing date	2021-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.1c00378
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Article: Synthesis of β-Hydroxy-α,α-difluorosulfonamides from Carbanions of Difluoromethanesulfonamides

Soley, Jacob / Taylor, Scott D.

Journal of organic chemistry. 2021 Apr. 13, v. 86, no. 9

2021

Abstract: ... difluoromethanesulfonamides with KHMDS in the presence of an aldehyde or ketone. The reaction exhibited a dramatic counterion ...

Abstract	The synthesis of β-hydroxy-α,α-difluorosulfonamides was achieved by reacting difluoromethanesulfonamides with KHMDS in the presence of an aldehyde or ketone. The reaction exhibited a dramatic counterion effect with KHMDS or NaHMDS usually giving excellent yields in minutes, while lithium bases gave little or no product. Excellent yields and high diastereomeric ratios were achieved with Nᵅ-benzyl-Nᵅ-phenylfluorenyl (PhF)-protected chiral amino aldehydes derived from amino acids. Following deprotection, a β-hydroxy-α,α-sulfonamide reacted under peptide coupling and Mitsunobu conditions to furnish a peptidomimetic in an excellent overall yield.
Keywords	aldehydes ; lithium ; organic chemistry ; peptides
Language	English
Dates of publication	2021-0413
Size	p. 6577-6591.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.1c00378
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Article: Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor.

ACS medicinal chemistry letters

2019 Volume 10, Issue 6, Page(s) 911–916

Abstract: Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series ...

Abstract	Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series of CETP inhibitors to improve their pharmaceutical profile is described. Polar groups at the
Language	English
Publishing date	2019-05-06
Publishing country	United States
Document type	Journal Article
ISSN	1948-5875
ISSN	1948-5875
DOI	10.1021/acsmedchemlett.9b00086
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An Overview of Recent Advances of the Catalytic Selective Oxidation of Ethane to Oxygenates

Robert D. Armstrong / Graham J. Hutchings / Stuart H. Taylor

Catalysts, Vol 6, Iss 5, p

2016 Volume 71

Abstract: ... Direct ethane oxidation to oxygenates is a difficult aim, but potentially rewarding, and it could lead ... of such processes. Research into direct ethane oxidation is therefore disparate, with approaches ranging ... perspectives. Herein we describe some recent developments within the field of catalytic ethane oxidation ...

Abstract	The selective partial oxidation of short chain alkanes is a key challenge within catalysis research. Direct ethane oxidation to oxygenates is a difficult aim, but potentially rewarding, and it could lead to a paradigm shift in the supply chain of several bulk chemicals. Unfortunately, low C–H bond reactivity and kinetically labile products are just some reasons affecting the development and commercialisation of such processes. Research into direct ethane oxidation is therefore disparate, with approaches ranging from oxidation in the gas phase at high temperatures to enzyme catalysed hydroxylation under ambient conditions. Furthermore, in overcoming the barrier posed by the chemically inert C–H bond a range of oxidants have been utilised. Despite years of research, this remains an intriguing topic from both academic and commercial perspectives. Herein we describe some recent developments within the field of catalytic ethane oxidation focusing on the formation of oxygenated products, whilst addressing the key challenges which are still to be overcome.
Keywords	catalysis ; ethane ; partial oxidation ; natural gas ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	540 ; 660
Language	English
Publishing date	2016-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Expanding the SAR of Nontoxic Antiplasmodial Indolyl-3-ethanone Ethers and Thioethers.

Lunga, Mayibongwe J / Chisango, Ruramai L / Weyers, Carli / Isaacs, Michelle / Taylor, Dale / Edkins, Adrienne L / Khanye, Setshaba D / Hoppe, Heinrich C / Veale, Clinton G L

ChemMedChem

2018 Volume 13, Issue 13, Page(s) 1353–1362

Abstract: ... antimalarials, resulting in the discovery of 1-(5-chloro-1H-indol-3-yl)-2-[(4-cyanophenyl)thio]ethanone (13) and ... 1-(5-chloro-1H-indol-3-yl)-2-[(4-nitrophenyl)thio]ethanone (14), whose activity was equipotent ...

Abstract	Despite major strides in reducing Plasmodium falciparum infections, this parasite still accounts for roughly half a million annual deaths. This problem is compounded by the decreased efficacy of artemisinin combination therapies. Therefore, the development and optimisation of novel antimalarial chemotypes is critical. In this study, we describe our strategic approach to optimise a class of previously reported antimalarials, resulting in the discovery of 1-(5-chloro-1H-indol-3-yl)-2-[(4-cyanophenyl)thio]ethanone (13) and 1-(5-chloro-1H-indol-3-yl)-2-[(4-nitrophenyl)thio]ethanone (14), whose activity was equipotent to that of chloroquine against the P. falciparum 3D7 strain. Furthermore, these compounds were found to be nontoxic to HeLa cells as well as being non-haemolytic to uninfected red blood cells. Intriguingly, several of our most promising compounds were found to be less active against the isogenic NF54 strain, highlighting possible issues with long-term dependability of malarial strains. Finally compound 14 displayed similar activity against both the NF54 and K1 strains, suggesting that it inhibits a pathway that is uncompromised by K1 resistance.
MeSH term(s)	Antimalarials/chemical synthesis ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Antimalarials/toxicity ; Erythrocytes/drug effects ; Ethers/chemical synthesis ; Ethers/chemistry ; Ethers/pharmacology ; Ethers/toxicity ; HeLa Cells ; Hemolysis/drug effects ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Indoles/pharmacology ; Indoles/toxicity ; Molecular Structure ; Parasitic Sensitivity Tests ; Plasmodium falciparum/drug effects ; Structure-Activity Relationship ; Sulfides/chemical synthesis ; Sulfides/chemistry ; Sulfides/pharmacology ; Sulfides/toxicity
Chemical Substances	Antimalarials ; Ethers ; Indoles ; Sulfides
Language	English
Publishing date	2018-06-07
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.201800235
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Article ; Online: Niobium phosphates as new highly selective catalysts for the oxidative dehydrogenation of ethane.

Weng, Weihao / Davies, Mathew / Whiting, Gareth / Solsona, Benjamin / Kiely, Christopher J / Carley, Albert F / Taylor, Stuart H

Physical chemistry chemical physics : PCCP

2011 Volume 13, Issue 38, Page(s) 17395–17404

Abstract: ... for the selective oxidation of ethane to ethylene. Three distinct niobium phosphate catalysts were prepared, and ... of carbon oxides. It was also determined that the only primary product from ethane oxidation over this catalyst was ... with values around 75% and 85% respectively at 5% ethane conversion. The presence of phosphorous is required ...

Abstract	Several niobium phosphate phases have been prepared, fully characterized and tested as catalysts for the selective oxidation of ethane to ethylene. Three distinct niobium phosphate catalysts were prepared, and each was comprised predominantly of a different bulk phase, namely Nb(2)P(4)O(15), NbOPO(4) and Nb(1.91)P(2.82)O(12). All of the niobium phosphate catalysts showed high selectivity towards ethylene, but the best catalyst was Nb(1.91)P(2.82)O(12), which was produced from the reduction of niobium oxide phosphate (NbOPO(4)) by hydrogen. It was particularly selective for ethylene, giving ca. 95% selectivity at 5% conversion, decreasing to ca. 90% at 15% conversion, and only produced low levels of carbon oxides. It was also determined that the only primary product from ethane oxidation over this catalyst was ethylene. Catalyst activity also increased with time-on-line, and this behaviour was ascribed to an increase of the concentration of the Nb(1.91)P(2.82)O(12) phase, as partially transformed NbOPO(4), formed during preparation, was converted to Nb(1.91)P(2.82)O(12) during use. Catalysts with predominant phases of Nb(2)P(4)O(15) and NbOPO(4) also showed appreciable activity and selectivities to ethylene with values around 75% and 85% respectively at 5% ethane conversion. The presence of phosphorous is required to achieve high ethylene selectivity, as orthorhombic and monoclinic Nb(2)O(5) catalysts showed similar activity, but displayed selectivities to ethylene that were <20% under the same reaction conditions. To the best of our knowledge, this is the first time that niobium phosphates have been shown to be highly selective catalysts for the oxidation of ethane to ethylene, and demonstrates that they are worthy candidates for further study.
Language	English
Publishing date	2011-10-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/c1cp21136f
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Partial oxidation of ethane to oxygenates using Fe- and Cu-containing ZSM-5.

Forde, Michael M / Armstrong, Robert D / Hammond, Ceri / He, Qian / Jenkins, Robert L / Kondrat, Simon A / Dimitratos, Nikolaos / Lopez-Sanchez, Jose Antonio / Taylor, Stuart H / Willock, David / Kiely, Christopher J / Hutchings, Graham John

Journal of the American Chemical Society

2013 Volume 135, Issue 30, Page(s) 11087–11099

Abstract: Iron and copper containing ZSM-5 catalysts are effective for the partial oxidation of ethane ... 1), respectively. High conversion of ethane (ca. 56%) to acetic acid (ca. 70% selectivity) can be ... in which the oxidation of ethane gives a range of C2 oxygenates, with sequential C-C bond cleavage generating C1 products ...

Abstract	Iron and copper containing ZSM-5 catalysts are effective for the partial oxidation of ethane with hydrogen peroxide giving combined oxygenate selectivities and productivities of up to 95.2% and 65 mol kgcat(-1) h(-1), respectively. High conversion of ethane (ca. 56%) to acetic acid (ca. 70% selectivity) can be observed. Detailed studies of this catalytic system reveal a complex reaction network in which the oxidation of ethane gives a range of C2 oxygenates, with sequential C-C bond cleavage generating C1 products. We demonstrate that ethene is also formed and can be subsequently oxidized. Ethanol can be directly produced from ethane, and does not originate from the decomposition of its corresponding alkylperoxy species, ethyl hydroperoxide. In contrast to our previously proposed mechanism for methane oxidation over similar zeolite catalysts, the mechanism of ethane oxidation involves carbon-based radicals, which lead to the high conversions we observe.
Language	English
Publishing date	2013-07-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/ja403060n
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Article: Relationship between bulk phase, near surface and outermost atomic layer of VPO catalysts and their catalytic performance in the oxidative dehydrogenation of ethane

Ivars-Barceló, Francisco / Benjamín Solsona / Graham J. Hutchings / Jonathan K. Bartley / Pedro Amorós / Peter Sutter / Rut Sanchis / Stuart H. Taylor

Journal of catalysis. 2017 Oct., v. 354

2017

Abstract: ... of ethane to ethylene, a key potential reaction for a sustainable industrial and socioeconomic development ... higher selectivity to ethylene, reaching 90% selectivity at ca. 10% ethane conversion. To the best ... for the ethane ODH. In general, catalysts consisting of crystalline phases with vanadium present as V4+, i.e. (VO ...

Abstract	A set of vanadium phosphorous oxide (VPO) catalysts, mainly consisting of (VO)2P2O7, VO(PO3)2 or VOPO4·2H2O bulk crystalline phases, has been investigated for the oxidative dehydrogenation (ODH) of ethane to ethylene, a key potential reaction for a sustainable industrial and socioeconomic development. The catalytic performance on these VPO catalysts has been explained on the basis of the main crystalline phases and the corresponding surface features found by XPS and LEISS at 400°C, i.e. within the temperature range used for ODH reaction. The catalysts based on (VO)2P2O7 phase presented the highest catalytic activity and productivity to ethylene. Nevertheless, the catalysts consisting of VO(PO3)2 structure showed higher selectivity to ethylene, reaching 90% selectivity at ca. 10% ethane conversion. To the best of our knowledge, this is the highest selectivity reported on a vanadium phosphorous oxide at similar conversions for the ethane ODH. In general, catalysts consisting of crystalline phases with vanadium present as V4+, i.e. (VO)2P2O7 and VO(PO3)2, were found to be significantly more selective to ethylene than those containing V5+ phases. The surface analysis by XPS showed an inverse correlation between the mean oxidation state of vanadium near surface and the selectivity to ethylene. The lower averaged oxidation states of vanadium appear to be favoured by the presence of V3+ species near the surface, which was only found in the catalysts containing V4+ phases. Among those catalysts the one based on VO(PO3)2 phase shows the highest selectivity, which could be related to the most isolated scenario of V species (the lowest V content relative to P) found at the outermost surface by low energy ion scattering spectroscopy (LEISS), a “true” surface technique only sensitive to the outermost atomic layer.
Keywords	catalysts ; catalytic activity ; dehydrogenation ; energy ; ethane ; ethylene ; oxidation ; phosphorus ; socioeconomic development ; temperature ; vanadium ; X-ray photoelectron spectroscopy
Language	English
Dates of publication	2017-10
Size	p. 236-249.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1468993-5
ISSN	0021-9517
ISSN	0021-9517
DOI	10.1016/j.jcat.2017.08.020
Database	NAL-Catalogue (AGRICOLA)

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