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Article ; Online: Inflammatory Bowel Diseases: Is There a Role for Nutritional Suggestions?

Bertani, Lorenzo / Ribaldone, Davide Giuseppe / Bellini, Massimo / Mumolo, Maria Gloria / Costa, Francesco

2021 Volume 13, Issue 4

Abstract: Nutrition has an important impact on inflammatory bowel diseases (IBD). In particular, several studies have addressed its role in their pathogenesis, showing how the incidence of IBD significantly increased in recent years. Meanwhile, nutrition should be ...

Abstract	Nutrition has an important impact on inflammatory bowel diseases (IBD). In particular, several studies have addressed its role in their pathogenesis, showing how the incidence of IBD significantly increased in recent years. Meanwhile, nutrition should be considered a component of the treatment of the disease, both as a therapy itself, and especially in the perspective of correcting the various nutritional deficiencies shown by these patients. In this perspective, nutritional suggestions are very important even in the most severe forms of IBD, requiring hospitalization or surgical treatment. Although current knowledge about nutrition in IBD is increasing over time, nutritional suggestions are often underestimated by clinicians. This narrative review is an update summary of current knowledge on nutritional suggestions in IBD, in order to address the impact of nutrition on pathogenesis, micro- and macro-nutrients deficiencies (especially in the case of sarcopenia and obesity), as well as in hospitalized patients.
MeSH term(s)	Clinical Trials as Topic ; Hospitalization ; Humans ; Inflammatory Bowel Diseases/diet therapy ; Inflammatory Bowel Diseases/etiology ; Inflammatory Bowel Diseases/physiopathology ; Inflammatory Bowel Diseases/surgery ; Nutritional Physiological Phenomena ; Nutritional Support ; Outpatients
Language	English
Publishing date	2021-04-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13041387
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sex difference: an important issue to consider in epidemiological and clinical studies dealing with serum paraoxonase-1.

Trentini, Alessandro / Bellini, Tiziana / Bonaccorsi, Gloria / Cavicchio, Carlotta / Hanau, Stefania / Passaro, Angelina / Cervellati, Carlo

Journal of clinical biochemistry and nutrition

2019 Volume 64, Issue 3, Page(s) 250–256

Abstract: The aim of this study was to evaluate the influence of sex on serum paraoxonase-1 (PON1) activities and on its relationship with cardiovascular disease risk factors such as overall and central obesity. Arylesterase and lactonase activities of PON1 were ... ...

Abstract	The aim of this study was to evaluate the influence of sex on serum paraoxonase-1 (PON1) activities and on its relationship with cardiovascular disease risk factors such as overall and central obesity. Arylesterase and lactonase activities of PON1 were assessed in 374 women and 92 men. Both arylesterase and lactonase activities were significantly higher in women compared to men (
Language	English
Publishing date	2019-01-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	632945-7
ISSN	1880-5086 ; 0912-0009
ISSN (online)	1880-5086
ISSN	0912-0009
DOI	10.3164/jcbn.18-73
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Different Patterns of Locus Coeruleus MRI Alteration in Alzheimer's and Dementia with Lewy Bodies.

Galgani, Alessandro / Palermo, Giovanni / Lombardo, Francesco / Martini, Nicola / Bastiani, Luca / Vergallo, Andrea / Tommasini, Luca / Bellini, Gabriele / Baldacci, Filippo / Frosini, Daniela / Tognoni, Gloria / Gesi, Marco / Cademartiri, Filippo / Fornai, Francesco / Pavese, Nicola / Ceravolo, Roberto / Giorgi, Filippo Sean

Current Alzheimer research

2023 Volume 20, Issue 4, Page(s) 277–288

Abstract: Background: The integrity of Locus Coeruleus can be evaluated in vivo using specific Magnetic Resonance Imaging sequences. While this nucleus has been shown to be degenerated both in post-mortem and in vivo studies in Alzheimer's Disease, for other ... ...

Abstract	Background: The integrity of Locus Coeruleus can be evaluated in vivo using specific Magnetic Resonance Imaging sequences. While this nucleus has been shown to be degenerated both in post-mortem and in vivo studies in Alzheimer's Disease, for other neurodegenerative dementias such as Dementia with Lewy Bodies this has only been shown ex-vivo. Objective: To evaluate the integrity of the Locus Coeruleus through Magnetic Resonance Imaging in patients suffering from Dementia with Lewy Bodies and explore the possible differences with the Locus Coeruleus alterations occurring in Alzheimer's Dementia. Methods: Eleven patients with Dementia with Lewy Bodies and 35 with Alzheimer's Dementia were recruited and underwent Locus Coeruleus Magnetic Resonance Imaging, along with 52 cognitively intact, age-matched controls. Images were analyzed applying an already developed template-based approach; Locus Coeruleus signal was expressed through the Locus Coeruleus Contrast Ratio parameter, and a locoregional analysis was performed. Results: Both groups of patients showed significantly lower values of Locus Coeruleus Contrast Ratio when compared to controls. A different pattern of spatial involvement was found; patients affected by Dementia with Lewy bodies showed global and bilateral involvement of the Locus Coeruleus, whereas the alterations in Alzheimer's Dementia patients were more likely to be localized in the rostral part of the left nucleus. Conclusions: Magnetic Resonance Imaging successfully detects widespread Locus Coeruleus degeneration in patients suffering from Dementia with Lewy Bodies. Further studies, in larger cohorts and in earlier stages of the disease, are needed to better disclose the potential diagnostic and prognostic role of this neuroradiological tool.
Language	English
Publishing date	2023-07-24
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2205170-3
ISSN	1875-5828 ; 1567-2050
ISSN (online)	1875-5828
ISSN	1567-2050
DOI	10.2174/1567205020666230721144603
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Response to Ustekinumab Therapy Is Associated with an Improvement of Nutritional Status in Patients with Crohn's Disease.

Bertani, Lorenzo / D'Alessandro, Claudia / Fornili, Marco / Coppini, Francesca / Zanzi, Federico / Carmisciano, Luca / Geri, Francesca / Svizzero, Giovanni Baiano / Rosi, Emma Maria / De Bernardi, Alice / Ceccarelli, Linda / Mumolo, Maria Gloria / Baglietto, Laura / Bellini, Massimo / De Bortoli, Nicola / Costa, Francesco

Journal of clinical medicine

2023 Volume 12, Issue 19

Abstract: The presence of sarcopenia has been associated with the worst outcome of Crohn's disease (CD). At present, no studies have evaluated the impact of ustekinumab (UST) in terms of its effects on body composition. The aim of this prospective study was to ... ...

Abstract	The presence of sarcopenia has been associated with the worst outcome of Crohn's disease (CD). At present, no studies have evaluated the impact of ustekinumab (UST) in terms of its effects on body composition. The aim of this prospective study was to evaluate whether UST treatment could modify the parameters of body composition as assessed by bioelectrical impedance assay (BIA) in patients with CD. We prospectively enrolled consecutive patients with CD treated with UST, evaluating the therapeutic outcome at week 48 in terms of clinical remission and mucosal healing. BIA was performed at baseline and at week 48, assessing body cellular mass, total body water, phase angle, and body mass index. Out of 44 patients enrolled, 26 (59%) were in clinical remission and 22 (50%) achieved mucosal healing at the end of follow up. No significant differences were observed at baseline in all the BIA parameters between responders and non-responders. Phase angle increased over time in responders, while this was not observed in non-responders (test for the interaction between time and outcome,
Language	English
Publishing date	2023-09-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12196118
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sex Difference Impacts on the Relationship between Paraoxonase-1 (PON1) and Type 2 Diabetes.

Rosta, Valentina / Trentini, Alessandro / Passaro, Angelina / Zuliani, Giovanni / Sanz, Juana Maria / Bosi, Cristina / Bonaccorsi, Gloria / Bellini, Tiziana / Cervellati, Carlo

Antioxidants (Basel, Switzerland)

2020 Volume 9, Issue 8

Abstract: Type-2 diabetes (T2D) and its cardiovascular complications are related to sex. Increasing evidence suggests that paraoxonase 1 (PON1) activity, an antioxidant enzyme bound to high-density lipoproteins (HDL), is implicated in the onset and clinical ... ...

Abstract	Type-2 diabetes (T2D) and its cardiovascular complications are related to sex. Increasing evidence suggests that paraoxonase 1 (PON1) activity, an antioxidant enzyme bound to high-density lipoproteins (HDL), is implicated in the onset and clinical progression of T2D. Since we previously showed that PON1 is a sexual dimorphic protein, we now investigated whether sex might impact the relationship between PON1 and this chronic disease. To address this aim, we assessed PON1 activity in the sera of 778 patients, including controls (women, n = 383; men, n = 198) and diabetics (women, n = 79; men = 118). PON1 activity decreased in both women and men with T2D compared with controls (
Language	English
Publishing date	2020-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox9080683
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Article ; Online: Response to Ustekinumab Therapy Is Associated with an Improvement of Nutritional Status in Patients with Crohn’s Disease

Lorenzo Bertani / Claudia D’Alessandro / Marco Fornili / Francesca Coppini / Federico Zanzi / Luca Carmisciano / Francesca Geri / Giovanni Baiano Svizzero / Emma Maria Rosi / Alice De Bernardi / Linda Ceccarelli / Maria Gloria Mumolo / Laura Baglietto / Massimo Bellini / Nicola De Bortoli / Francesco Costa

Journal of Clinical Medicine, Vol 12, Iss 6118, p

2023 Volume 6118

Abstract: The presence of sarcopenia has been associated with the worst outcome of Crohn’s disease (CD). At present, no studies have evaluated the impact of ustekinumab (UST) in terms of its effects on body composition. The aim of this prospective study was to ... ...

Abstract	The presence of sarcopenia has been associated with the worst outcome of Crohn’s disease (CD). At present, no studies have evaluated the impact of ustekinumab (UST) in terms of its effects on body composition. The aim of this prospective study was to evaluate whether UST treatment could modify the parameters of body composition as assessed by bioelectrical impedance assay (BIA) in patients with CD. We prospectively enrolled consecutive patients with CD treated with UST, evaluating the therapeutic outcome at week 48 in terms of clinical remission and mucosal healing. BIA was performed at baseline and at week 48, assessing body cellular mass, total body water, phase angle, and body mass index. Out of 44 patients enrolled, 26 (59%) were in clinical remission and 22 (50%) achieved mucosal healing at the end of follow up. No significant differences were observed at baseline in all the BIA parameters between responders and non-responders. Phase angle increased over time in responders, while this was not observed in non-responders (test for the interaction between time and outcome, p -value = 0.009 and 0.007 for clinical remission and mucosal healing, respectively). The same differential increase was observed for body cellular mass (test for the interaction between time and outcome, p -value = 0.03 and 0.05 for clinical remission and mucosal healing, respectively). Total body water and BMI increased homogenously over time regardless of the outcomes (tests for the association with time, p -values of 0.01). To conclude, responsiveness to UST therapy seems to be associated with body composition modifications in patients with CD. In particular, the increase in phase angle in responders suggests that a significant improvement of nutritional status occurred in these patients.
Keywords	Crohn’s disease ; sarcopenia ; ustekinumab ; biologics ; BIA ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Vaginal Lactoferrin Administration Decreases Oxidative Stress in the Amniotic Fluid of Pregnant Women: An Open-Label Randomized Pilot Study.

Trentini, Alessandro / Maritati, Martina / Rosta, Valentina / Cervellati, Carlo / Manfrinato, Maria Cristina / Hanau, Stefania / Greco, Pantaleo / Bonaccorsi, Gloria / Bellini, Tiziana / Contini, Carlo

Frontiers in medicine

2020 Volume 7, Page(s) 555

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2020.00555
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Is Gluten the Only Culprit for Non-Celiac Gluten/Wheat Sensitivity?

Mumolo, Maria Gloria / Rettura, Francesco / Melissari, Sara / Costa, Francesco / Ricchiuti, Angelo / Ceccarelli, Linda / de Bortoli, Nicola / Marchi, Santino / Bellini, Massimo

Nutrients

2020 Volume 12, Issue 12

Abstract: The gluten-free diet (GFD) has gained increasing popularity in recent years, supported by marketing campaigns, media messages and social networks. Nevertheless, real knowledge of gluten and GF-related implications for health is still poor among the ... ...

Abstract	The gluten-free diet (GFD) has gained increasing popularity in recent years, supported by marketing campaigns, media messages and social networks. Nevertheless, real knowledge of gluten and GF-related implications for health is still poor among the general population. The GFD has also been suggested for non-celiac gluten/wheat sensitivity (NCG/WS), a clinical entity characterized by intestinal and extraintestinal symptoms induced by gluten ingestion in the absence of celiac disease (CD) or wheat allergy (WA). NCG/WS should be regarded as an "umbrella term" including a variety of different conditions where gluten is likely not the only factor responsible for triggering symptoms. Other compounds aside from gluten may be involved in the pathogenesis of NCG/WS. These include fructans, which are part of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs), amylase trypsin inhibitors (ATIs), wheat germ agglutinin (WGA) and glyphosate. The GFD might be an appropriate dietary approach for patients with self-reported gluten/wheat-dependent symptoms. A low-FODMAP diet (LFD) should be the first dietary option for patients referring symptoms more related to FODMAPs than gluten/wheat and the second-line treatment for those with self-reported gluten/wheat-related symptoms not responding to the GFD. A personalized approach, regular follow-up and the help of a skilled dietician are mandatory.
MeSH term(s)	Amylases/antagonists & inhibitors ; Celiac Disease/diet therapy ; Celiac Disease/etiology ; Diet/adverse effects ; Diet, Carbohydrate-Restricted/methods ; Diet, Gluten-Free/methods ; Disaccharides ; Fermentation ; Fructans/adverse effects ; Glutens/adverse effects ; Glycine/adverse effects ; Glycine/analogs & derivatives ; Humans ; Malabsorption Syndromes/diet therapy ; Malabsorption Syndromes/etiology ; Oligosaccharides ; Polymers ; Trypsin Inhibitors/adverse effects ; Wheat Germ Agglutinins/adverse effects ; Glyphosate
Chemical Substances	Disaccharides ; Fructans ; Oligosaccharides ; Polymers ; Trypsin Inhibitors ; Wheat Germ Agglutinins ; polyol ; Glutens (8002-80-0) ; Amylases (EC 3.2.1.-) ; Glycine (TE7660XO1C)
Language	English
Publishing date	2020-12-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12123785
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Low Fermentable Oligo- Di- and Mono-Saccharides and Polyols (FODMAPs) or Gluten Free Diet: What Is Best for Irritable Bowel Syndrome?

Bellini, Massimo / Tonarelli, Sara / Mumolo, Maria Gloria / Bronzini, Francesco / Pancetti, Andrea / Bertani, Lorenzo / Costa, Francesco / Ricchiuti, Angelo / de Bortoli, Nicola / Marchi, Santino / Rossi, Alessandra

Nutrients. 2020 Nov. 01, v. 12, no. 11

2020

Abstract: Irritable Bowel Syndrome (IBS) is a very common functional gastrointestinal disease. Its pathogenesis is multifactorial and not yet clearly defined, and hence, its therapy mainly relies on symptomatic treatments. Changes in lifestyle and dietary behavior ...

Abstract	Irritable Bowel Syndrome (IBS) is a very common functional gastrointestinal disease. Its pathogenesis is multifactorial and not yet clearly defined, and hence, its therapy mainly relies on symptomatic treatments. Changes in lifestyle and dietary behavior are usually the first step, but unfortunately, there is little high-quality scientific evidence regarding a dietary approach. This is due to the difficulty in setting up randomized double-blind controlled trials which objectively evaluate efficacy without the risk of a placebo effect. However, a Low Fermentable Oligo-, Di- and Mono-saccharides And Polyols (FODMAP) Diet (LFD) and Gluten Free Diet (GFD) are among the most frequently suggested diets. This paper aims to evaluate their possible role in IBS management. A GFD is less restrictive and easier to implement in everyday life and can be suggested for patients who clearly recognize gluten as a trigger of their symptoms. An LFD, being more restrictive and less easy to learn and to follow, needs the close supervision of a skilled nutritionist and should be reserved for patients who recognize that the trigger of their symptoms is not, or not only, gluten. Even if the evidence is of very low-quality for both diets, the LFD is the most effective among the dietary interventions suggested for treating IBS, and it is included in the most updated guidelines.
Keywords	diet ; gastrointestinal diseases ; gluten ; gluten-free foods ; guidelines ; irritable bowel syndrome ; lifestyle ; nutrients ; nutritional behavior ; nutritional intervention ; paper ; pathogenesis ; patients ; placebos ; polyols ; risk
Language	English
Dates of publication	2020-1101
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12113368
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Understanding Social Behaviour in a Health-Care Facility from Localization Data: A Case Study.

Bellini, Gloria / Cipriano, Marco / Comai, Sara / De Angeli, Nicola / Gargano, Jacopo Pio / Gianella, Matteo / Goi, Gianluca / Ingrao, Giovanni / Masciadri, Andrea / Rossi, Gabriele / Salice, Fabio

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 6

Abstract: The most frequent form of dementia is Alzheimer's Disease (AD), a severe progressive neurological pathology in which the main cognitive functions of an individual are compromised. Recent studies have found that loneliness and living in isolation are ... ...

Abstract	The most frequent form of dementia is Alzheimer's Disease (AD), a severe progressive neurological pathology in which the main cognitive functions of an individual are compromised. Recent studies have found that loneliness and living in isolation are likely to cause an acceleration in the cognitive decline associated with AD. Therefore, understanding social behaviours of AD patients is crucial to promote sociability, thus delaying cognitive decline, preserving independence, and providing a good quality of life. In this work, we analyze the localization data of AD patients living in assisted care homes to gather insights about the social dynamics among them. We use localization data collected by a system based on iBeacon technology comprising two components: a network of antennas scattered throughout the facility and a Bluetooth bracelet worn by the patients. We redefine the Relational Index to capture wandering and casual encounters, these being common phenomena among AD patients, and use the notions of Relational and Popularity Indexes to model, visualize and understand the social behaviour of AD patients. We leverage the data analyses to build predictive tools and applications to enhance social activities scheduling and sociability monitoring and promotion, with the ultimate aim of providing patients with a better quality of life. Predictions and visualizations act as a support for caregivers in activity planning to maximize treatment effects and, hence, slow down the progression of Alzheimer's disease. We present the Community Behaviour Prediction Table (CBPT), a tool to visualize the estimated values of sociability among patients and popularity of places within a facility. Finally, we show the potential of the system by analyzing the Coronavirus Disease 2019 (COVID-19) lockdown time-frame between February and June 2020 in a specific facility. Through the use of the indexes, we evaluate the effects of the pandemic on the behaviour of the residents, observing no particular impact on sociability even though social distancing was put in place.
MeSH term(s)	Alzheimer Disease/diagnosis ; COVID-19 ; Communicable Disease Control ; Humans ; Patient Identification Systems ; Quality of Life ; Social Behavior
Language	English
Publishing date	2021-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21062147
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